
【个人简介】
姓 名:李楚文
性 别: 男
政治面貌:中共党员
职称职务: 副教授
导师资格: 硕士生导师
学习经历:2007年-2011年,本科,广州中医药大学 中药资源与开发
2011年-2014年,硕士,广州中医药大学 中药学
2014年-2018年,博士,澳门大学,生物医药
工作经历:2019年至今,广州医科大学 药学院
社会任职:中国中医药信息学会科技创新与成果转化分会 理事
广东省药理学会中药药理专业委员会 委员
杂志Frontiers in Pharmacology,Review Editor
论文情况、专利情况、承担项目等情况:发布相关表论文20余篇。获批专利2项。主持国家自然科学基金青年项目,广东省联合基金,广州市科技计划青年项目,广东省教育厅青年人才项目等。
【联系邮箱】
lichuwen@gzhmu.edu.cn
【研究方向】
基于表观遗传和肠道菌群筛选改善焦虑抑郁的中药药效物质基础。
【主要科研项目】
国家自然科学基金,青年项目,82104374,2022/01-2024/12,30万,在研,主持。
广州市科技计划项目,2041/1-2025/12,10万,在研,主持。
广东省基础与应用基础研究基金项目,2021/10-2023/09,10万,结题,主持。
【所获荣誉和奖励】
无
【主要论文及著作(代表性)】
[1] Huang B, Hao M, Li C, et al. Acetyltanshinone iia reduces the synthesis of cell cycle-related proteins by degrading p70s6k and subsequently inhibits drug-resistant lung cancer cell growth [J]. Pharmacol Res, 2022,179: 106209.
[2] Zou Z C, Fu J J, Dang Y Y, et al. Pinocembrin-7-methylether protects sh-sy5y cells against 6-hydroxydopamine-induced neurotoxicity via modulating nrf2 induction through akt and erk pathways [J]. Neurotox Res, 2021,39(4): 1323-1337.
[3] Dang Y Y, Luo H, Li Y M, et al. Curcumin prevents as (3+)-induced carcinogenesis through regulation of gsk3beta/nrf2 [J]. Chin Med, 2021,16(1): 116.
[4] Zhuo J, Chen B, Sun C, et al. Patchouli alcohol protects against chronic unpredictable mild stress-induced depressant-like behavior through inhibiting excessive autophagy via activation of mtor signaling pathway [J]. Biomed Pharmacother, 2020,127: 110115.
[5] Li C W, Deng M Z, Gao Z J, et al. Effects of compound k, a metabolite of ginsenosides, on memory and cognitive dysfunction in db/db mice involve the inhibition of er stress and the nlrp3 inflammasome pathway [J]. Food Funct, 2020,11(5): 4416-4427.
[6] Wu X, Tang B, Liao X, et al. Suppressive effects of the supercritical-carbon dioxide fluid extract of chrysanthemum indicum on chronic unpredictable mild stress-induced depressive-like behavior in mice [J]. Food Funct, 2019,10(2): 1212-1224.
[7] Li C, Bian Y, Feng Y, et al. Neuroprotective effects of bhdpc, a novel neuroprotectant, on experimental stroke by modulating microglia polarization [J]. ACS Chem Neurosci, 2019,10(5): 2434-2449.
[8] Li C, Zhang C, Zhou H, et al. Inhibitory effects of betulinic acid on lps-induced neuroinflammation involve m2 microglial polarization via camkkbeta-dependent ampk activation [J]. Front Mol Neurosci, 2018,11: 98.
[8] Li C, Zhang C, Zhou H, et al. Inhibitory effects of betulinic acid on lps-induced neuroinflammation involve m2 microglial polarization via camkkbeta-dependent ampk activation [J]. Front Mol Neurosci, 2018,11: 98.
[9] Li C, Tang B, Feng Y, et al. Pinostrobin exerts neuroprotective actions in neurotoxin-induced parkinson's disease models through nrf2 induction [J]. J Agric Food Chem, 2018,66(31): 8307-8318.
[10] Zhang C, Li C, Chen S, et al. Berberine protects against 6-ohda-induced neurotoxicity in pc12 cells and zebrafish through hormetic mechanisms involving pi3k/akt/bcl-2 and nrf2/ho-1 pathways [J]. Redox Biol, 2017,11: 1-11.