【个人简介】

侯亚萍，博士，主任技师，主要研究方向为产前筛查与诊断及分子遗传研究。从事无创DNA产前检测技术、高通量测序技术等产前诊断筛查及分子诊断技术的临床应用及科研工作十余年，具有丰富的一线临床及科研经验。任广东省医学会精准医学与分子诊断学分会委员。作为项目负责人或主要参与人参与国家自然科学基金、科技部863重大专项、广东省基础与应用基础研究基金、广东省医学科研基金等研究项目多项，其中作为项目负责人主持项目3项。以第一作者或主要参与人在国内外学术杂志发表论文30余篇，其中SCI论文近20篇。获中国出生缺陷干预救助基金会科技成果二等奖1项。主要代表性成果如下：

【研究方向】

产前筛查与诊断及分子遗传研究

【科研项目】

1. 国家自然科学基金面上项目, 82171856, 基于胎儿游离DNA靶向捕获测序结合贝叶斯模型进行巴氏水肿胎无创产前检测新技术的临床转化探索研究, 2022-01-01 至 2025-12-31, 80万元, 在研, 参与；

2. 广东省基础与应用基础研究基金区域联合基金项目，2019A1515111000，广东地区肥胖儿童肠道特异性菌群及其与肥胖相关因子甲基化水平的关系研究，2020/1-2023/12，结题，主持；

3. 广东省医学科学技术研究基金项目，A2020062，拓展性 NIPS 技术在胎儿染色体微缺失微重复综合征产前诊断中的应用研究，2020/7-2022/6，结题，主持；

4. 广东省医学科学技术研究基金项目，B2017057，染色体微阵列分析联合无创 DNA 产前检测在染色体微缺失微重复诊断中的应用研究，2017/7-2019/6，结题，主持；

5. 广东省医学科研基金项目，A2016225，中国人群耳聋基因筛查靶点选定，2016/07-2018/06，结题，参加。

【代表性论文及著作】

1.Hou YP, Deng FL, Guo J, Lv LJ, Ouyang HM, Wang XW, Luo YS, Chen XW, Wang FH. Distinct lipids profiles and associations with clinical indicators and gut microbiota in Prader-Willi syndrome children. Endocrinology, 2023, 164(7): bqad084.

2.Hou Y, Yang J, Deng F, Wang F, Peng H, Guo F, Wang D, Yin A. Association between cell-free DNA fetal fraction and pregnant character: a retrospective cohort study of 27,793 maternal plasmas. Sci Rep, 2023, 13(1): 11420.

3.Yang J, Wu J, Wang D, Hou YP, Guo F, Zhang Q, Peng H, Wang Y, Yin A. Combined fetal fraction to analyze the Z-score accuracy of noninvasive prenatal testing for fetal trisomies 13, 18, and 21. J Assist Reprod Genet. 2023, 40(4): 803-810.

4.Wang D, Peng H, Wang Y, Hou Y, Guo F, Zhu J, Hu T, Yang J. Performance of noninvasive prenatal testing for twin pregnancies in South China. J Assist Reprod Genet, 2023, 40(9): 2219-2231.

5.Hu R, Huang W, Zhou W, Luo X, Ren C, Huang H, Hou Y, Guo L, He W, Lu J. Phenotypic findings and pregnancy outcomes of fetal rare autosomal aneuploidies detected using chromosomal microarray analysis. Hum Genomics. 2022, 16(1): 64.

6.Yang JX, Hou YP, Guo FF, Peng HS, Wang DM, Li Y, OY HX, Wang YX, Lu J, Yin AH. Noninvasive prenatal detection of fetal sex chromosome abnormalities using the semiconductor sequencing platform (SSP) in Southern China. Journal of Assisted Reproduction and Genetics, 2021, 38 (3): 727-734.

7.Yang JX, Wu J, Peng HS, Hou YP, Guo FF, Wang DM, OY HX, Yi xia Wang, Yin AH. Performances of NIPT for copy number variations at different sequencing depths using the semiconductor sequencing platform. Human Genomics, 2021, 15(1):41.

8.Qi Y, Yang J, Hou YP, Hu R, Wang D, Peng H, Yin A. Potential influence of parental copy number variations on noninvasive prenatal testing (NIPT): two case reports. Mol Cytogenet. 2020, 13: 18.

9.Yang J,Peng CF,Qi Y,Rao XQ,Guo F,Hou Y,He W,Wu J,Chen YY,Zhao X,Wang YN,Peng H,Wang D,Du L,Luo MY,Huang QF,Liu HL,Yin A. Noninvasive Prenatal Detection of Hemoglobin Bart hydrops fetalis via maternal plasma dispensed with parental haplotyping using the Semiconductor Sequencing Platform. Am J Obstet Gynecol, 2020, 222(2): 185.e1-185.e17.

10.Hou Y, Yang J, Qi Y, Guo F, Peng H, Wang D, Wang Y, Luo X, Li Y, Yin A. Factors affecting cell-free DNA fetal fraction: Statistical analysis of 13661 maternal plasmas for non-invasive prenatal screening. Hum Genomics, 2019, 13(1): 62.

11.Qi Y, Yang J, Hou Y, Guo F, Peng H, Wang D, Du Q, Yin A. The significance of trisomy 7 mosaicism in noninvasive prenatal screening. Hum Genomics, 2019, 13(1): 18.

12.Yang J, Qi Y, Hou Y, Guo F, Peng H, Wang D, Haoxin OY, Wang Y, Huang H, Yin A. Performance of Non-invasive prenatal testing for trisomies 21 and 18 in twin pregnancies. Mol Cytogenet, 2018, 11: 47.

13.Hou YP, He QQ, Ouyang HM, Peng HS,Wang Q,Li J, Lv XF, Zheng YN, Li SC, Liu HL, Yin AH. Human Gut Microbiota Associated with Obesity in Chinese Children and Adolescents. Biomed Res Int, 2017, 2017: 7585989.

14.Yang J, Qi Y, Guo F, Hou Y,Peng H,Wang D,Oy H, Yin AH. A case of placental trisomy 18 mosaicism causing a false negative NIPT result. Molecular Cytogenetics, 2017, 10: 40.

15.Hou Y, Wang F, Cheng L, Luo T, Xu J, Wang H. Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents. Neurosci Bull, 2016, 32(5): 455-462.

16.Zhang C, Yin A, Li H, Wang R, Wu G, Shen J, Zhang M, Wang L, Hou Y, Ouyang H, Zhang Y, Zheng Y, Wang J, Lv X, Wang Y, Zhang F, Zeng B, Li W, Yan F, Zhao Y, Pang X, Zhang X, Fu H, Chen F, Zhao N, Hamaker BR, Bridgewater LC, Weinkove D,Clement K, Dore J, Holmes E, Xiao H, Zhao G, Yang S, Bork P, Nicholson JK, Wei H, Tang H, Zhang X, Zhao L. Dietary modulation of gut microbiota contributes to alleviation of both genetic and simple obesity in children. EBioMedicine, 2015, 2(8): 968-984.

17.Hou YP, Chen HY, He Q, Jiang W, Luo T, Duan JH, Mu N, He YS, Wang HQ. Changes in methylation patterns of multiple genes from peripheral blood leucocytes of Alzheimer's disease patients. Acta Neuropsychiatr, 2013, 25(2): 66-76.

18.郭芳芳, 侯亚萍, 胡听听, 彭海山, 杨洁霞. CNV-seq结合QF-PCR在孕早期流产物检测中的临床应用价值. 现代妇产科进展, 2023, 32(03): 166-170.

19.杨洁霞, 王东梅, 侯亚萍, 郭芳芳, 彭海山, 胡听听, 吴菁. cffDNA浓度低NIPT检测失败样本的相关因素和妊娠结局分析. 中国产前诊断杂志(电子版), 2023, 15(03): 31-36.

20.侯亚萍，杨洁霞，齐一鸣，郭芳芳，彭海山，王东梅，欧阳浩新，尹爱华. 无创 DNA 产前检测在胎儿染色体非整倍体疾病筛查中的应用. 检验医学与临床，2018, 15(11): 1542-1544, 1548.

21.侯亚萍，杨洁霞，齐一鸣，郭芳芳，彭海山，王东梅，欧阳浩新，尹爱华. 广东地区 6668 例孕妇无创 DNA 产前检测结果分析. 中国妇幼保健杂志，2017, 32(6): 1241-1244.

22.卢建, 侯亚萍, 黄伟伟, 李怡, 周伟宁, 尹爱华. 471例NIPT阳性孕妇产前诊断结果分析.中国产前诊断杂志(电子版), 2017, 9(04): 14-17.

【所获荣誉和奖励】

1．“遗传病诊断技术规范化实施在广东省出生缺陷防治中应用及转化研究”获2022年中国出生缺陷干预救助基金会科技成果奖二等奖。