胡昊，男，研究员，研究方向：采用医学系统生物学手段研究儿童神经发育性疾病的致病原因。
2005年毕业于中国科学院上海生物化学研究所，获分子生物学博士。2006年任中国科学院国家基因研究中心研究助理，2007至2008年在中国科学院上海计算生物学研究所从事博士后研究，2009年至2012年任德国马克斯普朗克分子遗传学研究所科学家，2013年至2015年任德国马克斯普朗克分子遗传学研究所课题组长（PI）。2016、2022年度广州市高层次卫生重点人才，2019年广州市岭南英杰工程后备人才，广东省医学会罕见病学分会委员，广东省生物信息学学会委员，广东省临床医学会儿童心理健康促进专业委员会副主委。
长期致力于采用系统生物学思路研究儿童神经发育性疾病的病因。主要研究手段包括高通量组学技术，大数据分析和模式生物研究。目前研究重点集中于脑性瘫痪这种发病率较高、社会影响面较大的疾病，探讨胚胎发育时期和婴幼儿时期基因表达网络受到扰动时对中枢神经系统认知和运动功能的损伤机制。已鉴定超过200个神经发育性疾病相关基因包括若干新基因，并在细胞模型和动物模型的构建和研究上取得一定成果。未来将进一步深入挖掘神经发育相关基因网络，鉴定关键节点和模块，为疾病的精准诊断和防治提供理论依据。自2011年以来发表SCI文章70余篇，以主要作者发表Nature一篇，Brain一篇，Molecular Psychiatry两篇，American Journal of Human Genetics两篇，PLoS Genetics一篇，iScience一篇，Human Mutation一篇，European Journal of Human Genetics一篇。主持国家自然科学基金面上项目两项，广州市科创委重大项目一项，累计经费600万元。
代表作：
1.Li N, Zhou P, Tang H, He L, Fang X, Zhao J, Wang X, Qi Y, Sun C, Lin Y, Qin F, Yang M, Zhang Z, Liao C, Zheng S, Peng X, Xue T, Zhu Q, Li H, Li Y, Liu L, Huang J, Liu L, Peng C, Kaindl AM, Gecz J, Han D, Liu D, Xu K,Hu H. In-depth analysis reveals complex molecular aetiology in a cohort of idiopathic cerebral palsy.Brain. 2021 Jun 2:awab209.
2.Zhou P, Qi Y, Fang X, Yang M, Zheng S, Liao C, Qin F, Liu L, Li H, Li Y, Ravindran E, Sun C, Wei X, Wang W, Fang L, Han D, Peng C, Chen W, Li N, Kaindl AM,Hu H. Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m6A-methylation of Npdc1 and Cend1.iScience. 2021 May 24;24(6):102645.
3.Li N, Zhou P, Yang M, Fang X, Krämer N, Mughal TA, Abbasi AA, Yang Y, Kaindl AM,Hu H. Zebrafish modeling mimics developmental phenotype of patients with RAPGEF1 mutation.Clin Genet. 2021 Aug;100(2):144-155.
4.Sun C, Yang M, Qin F, Guo R, Liang S,Hu H. Generation of an induced pluripotent stem cell line SYSUi-003-A from a child with epilepsy carrying GRIN2A mutation.Stem Cell Res. 2020 Mar;43:101706.
5.Hu H, Kahrizi K, Musante L, Fattahi Z, Herwig R, Hosseini M, Oppitz C, Abedini SS, Suckow V, Larti F, Beheshtian M, Lipkowitz B, Akhtarkhavari T, Mehvari S, Otto S, Mohseni M, Arzhangi S, Jamali P, Mojahedi F, Taghdiri M, Papari E, Soltani Banavandi MJ, Akbari S, Tonekaboni SH, Dehghani H, Ebrahimpour MR, Bader I, Davarnia B, Cohen M, Khodaei H, Albrecht B, Azimi S, Zirn B, Bastami M, Wieczorek D, Bahrami G, Keleman K, Vahid LN, Tzschach A, Gärtner J, Gillessen-Kaesbach G, Varaghchi JR, Timmermann B, Pourfatemi F, Jankhah A, Chen W, Nikuei P, Kalscheuer VM, Oladnabi M, Wienker TF, Ropers HH, Najmabadi H. Genetics of intellectual disability in consanguineous families.Mol Psychiatry.2019 Jul;24(7):1027-1039.
6.Ravindran E*,Hu H*, Yuzwa SA, Hernandez-Miranda LR, Kraemer N, Ninnemann O, Musante L, Boltshauser E, Schindler D, Hübner A, Reinecker HC, Ropers HH, Birchmeier C, Miller FD, Wienker TF, Hübner C, Kaindl AM. Homozygous ARHGEF2 mutation causes intellectual disability and midbrain-hindbrain malformation.PLoS Genet. 2017 Apr 28;13(4):e1006746. (*equal contribution)
7.Hu H, Haas S, Chelly J, Esch HV, Raynaud M, Brouwer AD, Zemojtel T, Weinert S, Froyen G, Frints S, Laumonnier F, Love M, Richard H, Emde A, Bienek M, Jensen C, Hambrock M, Fischer U, Langnick C, Feldkamp M, Wissink-Lindhout W, Lebrun N, Castelnau L, Rucci J, Montjean R, Billuart P, Shaw M, Corbett M, Gardner A, Willis-Owen S, Tan CK, Friend K, Belet S, Roozendaal KV, Jimenez-Pocquet M, Moizard M, Ronce N, Sun R, O'Keeffe S, Chenna R, Mysickova A, Göke J, Hackett A, Field M, Haan E, Nelson J, Turner G, Baynam G, Gillessen-Kaesbach G, Müller U, Steinberger D, Budny B, Badura-Stronka M, Latos-Bieleńska A, Ousager L, Wieacker P, Criado GR, Bondeson M, Dufke A, Cohen M, Maldergem LV, Vincent-Delorme C, Echenne B, Simon-Bouy B, Kleefstra T, Willemsen M, Fryns J, Devriendt K, Ullmann R, Vingron M, Wrogemann K, Wienker T, Tzschach A, Bokhoven HV, Gecz J, Jentsch TJ, Chen W, Ropers HH, Kalscheuer V. X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes.Mol Psychiatry.2016 Jan;21(1):133-48.
8.Hu H*, Wienker TF, Musante L, Kalscheuer VM, Kahrizi K, Najmabadi H, Ropers HH.Integrated sequence analysis pipeline provides one-stop solution for identifying disease-causing mutations.Hum Mutat. 2014 Dec;35(12):1427-35. (*corresponding author)
9.Hirata H*, Nanda I*, van Riesen A*, McMichael G*,Hu H*, Hambrock M, Papon MA, Fischer U, Marouillat S, Ding C, Alirol S, Bienek M, Preisler-Adams S, Grimme A, Seelow D, Webster R, Haan E, MacLennan A, Stenzel W, Yap TY, Gardner A, Nguyen LS, Shaw M, Lebrun N, Haas SA, Kress W, Haaf T, Schellenberger E, Chelly J, Viot G, Shaffer LG, Rosenfeld JA, Kramer N, Falk R, El-Khechen D, Escobar LF, Hennekam R, Wieacker P, Hübner C, Ropers HH, Gecz J, Schuelke M, Laumonnier F, Kalscheuer VM. ZC4H2 mutations are associated with arthrogryposis multiplex congenita and intellectual disability through impairment of central and peripheral synaptic plasticity.Am J Hum Genet. 2013 May 2;92(5):681-95. (*equal contribution)
10.Najmabadi H,Hu H*, Garshasbi M*, Zemojtel T, Abedini SS, Chen W, Hosseini M, Behjati F, Haas S, Jamali P, Zecha A, Mohseni M, Püttmann L, Vahid LN, Jensen C, Moheb LA, Bienek M, Larti F, Mueller I, Weissmann R, Darvish H, Wrogemann K, Hadavi V, Lipkowitz B, Esmaeeli-Nieh S, Wieczorek D, Kariminejad R, Firouzabadi SG, Cohen M, Fattahi Z, Rost I, Mojahedi F, Hertzberg C, Dehghan A, Rajab A, Banavandi MJ, Hoffer J, Falah M, Musante L, Kalscheuer V, Ullmann R, Kuss AW, Tzschach A, Kahrizi K, Ropers HH. Deep sequencing reveals 50 novel genes for recessive cognitive disorders.Nature. 2011 Sep 21;478(7367):57-63. (*equal contribution)
11.Hu H, Eggers K, Chen W, Garshasbi M, Motazacker MM, Wrogemann K, Kahrizi K, Tzschach A, Hosseini M, Bahman I, Hucho T, Mühlenhoff M, Gerardy-Schahn R, Najmabadi H, Ropers HH, Kuss AW. ST3GAL3 mutations impair the development of higher cognitive functions.Am J Hum Genet.2011 Sep 9;89(3):407-14.
