洪宏海，医学博士、副主任技师、副研究员、硕导、博导。中山大学中山医学院分子医学专业博士，现任广州医科大学附属第三院检验科室副主任。2018年在美国印第安纳大学医学院做访问学者，2020年在美国杜兰大学进行博士后研究工作。主要研究方向：肿瘤标志物筛选及肿瘤转移和凋亡发病机制。发表 SCI论文二十余篇。主持国自然基金、省自然科学基金、省教育厅项目、市科技等项目。获得广州市卫生高层次“医学骨干”、“南山学者”青年后备人才、“毅文人才”起航人才称号。目前担任中华医学会检验医学分会青年教师创新联盟委员会委员、中国妇幼保健协会临床诊断与实验医学青年委员会委员、广东省医疗行业协会医学检验管理分会委员、广东省保健协会检验分会委员、广东省胸部疾病学会医学检验专业委员会委员、广东省医师协会检验医师分会委员、Journal of Oncology Research杂志联合主编、Journal of Alzheimers’ Disease杂志associate editor、Cell Biology杂志、Clinical Medicine Research杂志编委等。
科研项目
近5年主持国家级、省级、厅级、市级和校级等多个科研项目，研究经费充足：
1. 国家自然科学基金青年项目
2. 广东省自然科学基金博士启动项目
3. 广东省教育厅特色创新项目
4. 广州市校联合科技计划项目
5. 广州医科大学博士启动项目
6. 广州市卫生计生科技项目
7. 广州医科大学大学生开放实验室项目
代表性论著：
(1) Haofan Yin#, Wentao Li#, Laiming Mo#, Shaotuan Deng, Weijia Lin, Caiqi Ma, Zhaofan Luo*, Chuanghua Luo*, Honghai Hong*. Adipose triglyceride lipase promotes the proliferation of colorectal cancer cells via enhancing the lipolytic pathway. J Cell Mol Med. 2021 Feb 23. doi: 10.1111/jcmm.16349.
(2) Chuipu Cai#, Qihui Wu#, Honghai Hong#, Liying He, Zhihong Liu, Yong Gu, Shijie Zhang, Qi Wang, Xiude Fan*, Jiansong Fang*. In silico identification of natural products from Traditional Chinese Medicine for cancer immunotherapy. Sci Rep. 2021 Feb 8;11(1):3332. doi: 10.1038/s41598-021-82857-2.
(3) Caiqi Ma#, Zhijian Huang#, Zhikun Wu#, Chunguang Di, Xueping Lin, Mao Huang*, Honghai Hong*, Haofan Yin*. Overexpression of FUBP1 is associated with human cervical carcinoma development and prognosis. Life Sci. 2021 Mar 15;269:119098. doi: 10.1016/j.lfs.2021.119098.
(4) Haofan Yin#, Jinye Xie#, Ping Jiang#, Xi Jiang, Deyu Duan, Junhua Qi, Zhaofan Luo*, Caiqi Ma*, Honghai Hong*. Chiauranib selectively inhibits colorectal cancer with KRAS wild-type by modulation of ROS through activating the p53 signaling pathway. Am J Cancer Res. 2020 Nov 1;10(11):3666-3685.
(5) Wei Liu#, Gang Huang#, Xiaoying Su#, Siyi Li, Qun Wang, Yuying Zhao, Yao Liu, Jingshan Luo, Ye Li, Chuwen Li, Dongsheng Yuan, Honghai Hong*, Xiaojia Chen*, Tongkai Chen*. Zebrafish: A Promising Model for Evaluating the Toxicity of Carbon Dot-Based Nanomaterials. ACS Appl Mater Interfaces. 2020 Oct 28;12(43):49012-49020. doi: 10.1021/acsami.0c17492.
(6) Qihui Wu#, Xiude Fan#, Honghai Hong#, Yong Gu, Zhihong Liu, Shuhuan Fang, Qi Wang, Chuipu Cai*, Jiansong Fang*. Comprehensive assessment of side effects in COVID-19 drug pipeline from a network perspective. Food Chem Toxicol. 2020 Nov;145:111767. doi: 10.1016/j.fct.2020.111767.
(7) Yong Xia#, Honghai Hong#, Yao Feng#, Meiling Liu, Xingfei Pan*, Dexiong Chen*. The dynamics of antibodies to SARS-CoV-2 in a case of SARS-CoV-2 infection. Int J Infect Dis. 2020 Jul;96:359-360. doi: 10.1016/j.ijid.2020.05.042.
(8) Honghai Hong#, Yousheng Mo#, Dongli Li#, Zhiheng Xu, Yanfang Liao, Ping Yin, Xinning Liu, Yong Xia, Jiansong Fang*, Qi Wang*, Shuhuan Fang*. Mol Ther Nucleic Acids. 2020 Jun 5;20:140-154. doi: 10.1016/j.omtn.2020.02.008.
(9) Meiling Liu#, Xuegao Yu#, Liying Lin#, Jiankai Deng, Kanglong Wang, Yong Xia*, Xiaohua Tang*, Honghai Hong*. ATGL promotes the proliferation of hepatocellular carcinoma cells via the p-AKT signaling pathway. J Biochem Mol Toxicol. 2019 Nov;33(11):e22391. doi: 10.1002/jbt.22391.
(10) Wenxuan Jian#, Shuhuan Fang#, Tongkai Chen#, Jiansong Fang, Yousheng Mo, Dongli Li, Sha Xiong, Wei Liu, Lei Song, Jiangang Shen, Yong Xia, Qi Wang, Honghai Hong*. A novel role of HuR in -Epigallocatechin-3-gallate (EGCG) induces tumour cells apoptosis. J Cell Mol Med. 2019 May;23(5):3767-3771. doi: 10.1111/jcmm.14249.
(11) Honghai Hong, Haihui Yang, Yong Xia*. Circulating miR-10a as Predictor of Therapy Response in Rheumatoid Arthritis Patients Treated with Methotrexate. urr Pharm Biotechnol. 2018;19(1):79-86. doi: 10.2174/1389201019666180417155140.
(12) Honghai Hong#, Yingmin Zeng#, Wenxuan Jian#, Lei Li#, Liying Lin, Yousheng Mo, Meiling Liu*, Shuhuan Fang*, Yong Xia*, CDK7 inhibition suppresses rheumatoid arthritis inflammation via blockage of NF-kappaB activation and IL-1beta/IL-6 secretion, J Cell Mol Med, 2018, 22(2): 1292~1301
(13) Shuhuan Fang #, Honghai Hong #, Lei Li #, Dan He, Zumin Xu, Shaoyuan Zuo, Jing Han, Qiyuan Wu, Zhiyu Dai, Weibin Cai, Jianxing Ma#, Chunkui Shao#, Guoquan Gao#, Xia Yang#, Plasminogen kringle 5 suppresses gastric cancer via regulating HIF-1alpha and GRP78, Cell Death Dis, 2017, 8(10): e3144~e3144
(14) Honghai Hong, Yang Li, Baochang Su*, Identification of Circulating miR-125b as a Potential Biomarker of Alzheimer's Disease in APP/PS1 Transgenic Mouse, J Alzheimers Dis, 2017, 59(4): 1449~1458
(15) Lei Li#, Honghai Hong#, Shiping Chen#, Caiqi Ma, Hanyan Liu, Yachao Yao*, Activation of AMPK/MnSOD signaling mediates anti-apoptotic effect of hepatitis B virus in hepatoma cells, World J Gastroenterol, 2016, 22(17): 4345~4353
(16) Honghai Hong#, Ti Zhou#, Shuhuan Fang#, Minghan Jia, Zumin Xu, Zhiyu Dai, Cen Li, Shuai Li, Lei Li, Ting Zhang, Weiwei Qi, Adham Sameer A Bardeesi, Zhonghan Yang, Weibin Cai*, Xia Yang*, Guoquan Gao*, Pigment epithelium-derived factor (PEDF) inhibits breast cancer metastasis by down-regulating fibronectin, Breast Cancer Res Treat, 2014, 148(1): 61~72
