【个人简介】

硕士导师，副研究员，广州市高层次人才，南山新锐人才。负责国家呼吸中心免疫部和质谱中心建设与管理。立足于临床检验诊断工作的同时，应用代谢组学、基因组学等探索呼吸道疾病生物标志物及其作用机制，在慢性呼吸道疾病的诊断与管理取得了多项创新性研究成果。先后探索了呼吸慢病的早期筛查和早期干预治疗，系统阐明了哮喘免疫治疗疗效标志物等科学问题，揭示了过敏性疾病治疗的分子机制，形成了多组学诊断体系。发表SCI论文78篇，其中第一（含并列）和通讯（共同通讯）30多篇，发表于Cellular and Molecular Life Sciences，Pediatric Allergy and Immunology，Allergy等高水平杂志。承担医院优秀青年人才培养计划，国家自然基金青年项目，省级项目2项，市级项目4项，校院级项目5项，并参与了11项国家、省、市级研究项目。2022年获得广东省医学会科技奖二等奖，2021年获得广东省预防医学会科学技术奖一等奖，专利授权4项。

【研究方向】

多组学探索呼吸道疾病生物标志物；质谱方法学建立与临床转化。

【科研项目】

1. 广州医科大学附属第一医院南山人才工程项目，南山新锐人才项目，2022111708151837，建设精准医疗质谱检测平台，2023/8/1-2027/7/31，主持。

2. 广东省中医药局科研项目，20231236，甘草酸甘体外调节新冠疫苗应答免疫功能研究，2022/11/1-2025/10/31，主持。

3. 成果培育及临床转化应用培育专项，ZH202105，建立新冠疫苗体液免疫标准流程和评估体系， 2021/09/01-2023/08/31，主持。

4. 广州市基础研究计划市校（院）联合资助项目，202201020524，新冠疫苗免疫后的中和抗体免疫检测方法学研究，2021/11/01至2023/10/31，主持。

5. 国家自然科学基金面上项目，81871736，尘螨过敏儿童治疗的代谢组学与免疫调节协同机制研究，2019/1/1-2022/12/31，参加。

6. 国家自然科学基金青年项目，81601394，屋尘螨变应原免疫治疗诱发交叉变应原特异性IgG4抗体的保护作用及机理，2017/1/1-2019/12/31，主持。

【代表性论文及著作】

1. Mingtao Liu#, Zhiman Liang#, Zhangkai J Cheng#, Li Liu#, Qiwen Liu, Yiyin Mai, Huihuang Chen, Baoying Lei, Shangwei Yu, Huihui Chen, Peiyan Zheng*, Baoqing Sun*.SARS-CoV-2 neutralising antibody therapies: Recent advances and future challenges. Rev Med Virol. 2023 Jun 15;e2464.

2. Zheng Peiyan, Baolin Liao, Jiao Yang, Hu Cheng, Zhangkai J. Cheng, Huimin Huang, Wenting Luo, Yiyue Sun, Qiang Zhu, Yi Deng, and et al. 2023. "Utilizing Protein–Peptide Hybrid Microarray for Time-Resolved Diagnosis and Prognosis of COVID-19" Microorganisms 11, no. 10: 2436.

3. Tingting Liu#, Zhifeng Huang#, Huiqing Zhu#, Nairui An, Hui Gan, Mingshan Xue, Peiyan Zheng*, Baoqing Sun*. Association between urban garbage exposure and allergic diseases among sanitation practitioners: A cross-sectional study, World Allergy Organization Journal, 16:100754.

4. Liu M^†, Gan H^†, Liang Z^†, Liu L, Liu Q, Mai Y, Chen H, Lei B, Yu S, Chen H, Zheng P^* and Sun B^* (2023) Review of therapeutic mechanisms and applications based on SARS-CoV-2 neutralizing antibodies. Front. Microbiol. 14:1122868. doi: 10.3389/fmicb.2023,1122868.

5. Peiyan Zheng^†, Jing Ma^†, Jiao Yang^†, Baolin Liao^†, Zhangkai J. Cheng^†, Mingshan Xue, Shiyun Li, Yanting Fang, Runpei Lin, Guizhen Zhang, Huimin Huang^*, Fengyu Hu^*, Hongwei Ma^*, Baoqing Sun^*. Evaluating SARS-CoV-2 Antibody Reactivity to Natural Exposure and Inactivated Vaccination with Peptide Microarrays, 2023, Frontiers in Immunology, 14:1079960.doi:10.3389/fimmu.2023.1079960.

6. Peiyan Zheng#, Shixue Sun#, Jingxian Wang#, Zhangkai Jason Cheng, Kuan Cheok Lei, Mingshan Xue, Teng Zhang, Huimin Huang，Xiaohua Douglas Zhang*, and Baoqing Sun*, Integrative omics analysis identifies biomarkers of Idiopathic pulmonary fibrosis, Cellular and Molecular Life Sciences, 2022, 79(1):66.

7. Peiyan Zheng#, Xiqing Bian#, Yingying Zhai#, Cheng Li, Chuangli Hao, Huimin Huang, Wenting Luo, Zhifeng Huang, Chenxi Liao, Mingshan Xue, Na Li, Ming-Quan Guo, Baoqing Sun*, Jian-Lin Wu*. Metabolomics reveals a correlation between hydroxyeicosatetraenoic acids and allergic asthma: Evidence from three years' immunotherapy, Pediatric Allergy and Immunology. 2021; 32 (8): 1654-1662. (Editor´s Choice Article)

8. Peiyan Zheng#, Xiaoqing Liu#, Lili Lin, Huiqing Wu, Xiaoming Zhao*, Baoqing Sun*, Efficacy of mite allergen immunotherapy in allergic rhinitis and the immune synergistic effect on cross allergens, Immunotherapy, 2021, https://doi.org/10.2217/imt-2020-0326.

9. Peiyan Zheng#, Xiaomao Zheng#, Hasegawa Takehiro, Zhangkai Jason Cheng, Jingxian Wang, Mingshan Xue, Quanming Lin, Zhifeng Huang, Huimin Huang, Chenxi Liao, Baoqing Sun*, The prognostic value of value of Krebs von den Lungen-6 and surfactant protein-A levels in the patients with interstitial lung disease, Journal of Translational internal Medicine, 2021, 9(3):216-223. DOI: 10.2478/jtim-2021-0040.

10. Peiyan Zheng,†,Guanyu Yan,†,YidaZhang,†, Huimin Huang, Wenting Luo, Mingshan Xue, Na Li, Jian-Lin Wu,* and BaoqingSun,* Metabolomics Reveals Process of Allergic Rhinitis Patients with Single- and Double- Species Mite Subcutaneous Immunotherapy, Metabolites, 2021; 11(9):613.

11. Baolin Liao†, Zhao Chen†,Peiyan Zheng†, Linghua Li†, Jianfen Zhuo, Fang Li, Suxiang Li, Dingbin Chen, Chunyan Wen, Weiping Cai, Shanhui Wu, Yanhong Tang, Linwei Duan, Peilan Wei, Fangli Chen, Jinwei Yuan, Jinghong Yang, Jiaxin Feng, Jingxian Zhao, Jincun Zhao, Baoqing Sun*, Airu Zhu*, Yimin Li* and Xiaoping Tang*. Detection of anti-SARS-CoV-2-S2 IgG is more sensitive than anti-RBD IgG in identifying asymptomatic COVID-19 patients, Frontiers in Immunology, 2021, 12: 724763.

12. Cheng, Zhangkai J.#, Mingshan Xue#, Peiyan Zheng#, Jiali Lyu, Zhiqing Zhan, Haisheng Hu, Yong Zhang, Xiaohua D. Zhang, and Baoqing Sun. 2021. "Factors Affecting the Antibody Immunogenicity of Vaccines against SARS-CoV-2: A Focused Review" Vaccines 9, no. 8: 869. https://doi.org/10.3390/vaccines9080869.

13. Chen Huang#, Dongliang Leng#, Peiyan Zheng#, Min Deng, Lu Li, Ge Wu, Baoqing Sun*, Xiaohua Douglas Zhang* ,Comprehensive transcriptome analysis of peripheral blood unravels key lncRNAs implicated in ABPA and asthma, Peer J,2021,9: e11453.

14. Miaomiao Zhang#, Peiyan Zheng#, Yuan Wang*, Baoqing Sun*. Two predicted models based on ceRNAs and immune cells in lung adenocarcinoma. Peer J,9:e11029. 2021.3.23 .

15. Jingxian Wang#; Peiyan Zheng#; Zhifeng Huang, Huimin Huang, Mingshan Xue, Chenxi Liao, Nanshan Zhong*; Baoqing Sun*. Serum SP-A and KL-6 levels can predict the improvement and deterioration of patients with interstitial pneumonia with autoimmune features. BMC Pulmonary Medicine. 2020, 20(1): 315. DOI：10.1186/s12890-020-01336-y.

16. Peiyan Zheng#, Chen Huang#, Dongliang Leng, Baoqing Sun*, Xiaohua Douglas Zhang*. Transcriptome analysis of peripheral whole blood identifies crucial lncRNAs implicated in childhood asthma. BMC Medical Genomics. 2020,13(1):136. DOI : 10.1186/s12920-020-00785-y.

【所获荣誉和奖励】

2022年获得广东省医学会科技奖二等奖;

2021年获得广东省预防医学会科学技术奖一等奖.