【个人简介】于宝丹,广州医科大学附属第一医院, 博士、副主任技师,中国民族卫生协会卫生健康技术推广专家委员会委员。从事临床流式细胞学检验工作。
【研究方向】肿瘤治疗耐药机制及疗效预测标志物的研究。
【科研项目】
(1)2023 年度广州医科大学科研能力提升项目,lnc-BLACAT1通过活化SMARCD3/Wnt信号轴促进NSCLC奥西替尼耐药的研究,2023.1-2024.12,7.5万元,在研,主持
(2)2023年广医大一流专业建设项目,以流式细胞术教学促进医学检验技术创新班本科生科研能力提升,2023.1-2024.12,1万元,在研,主持
(3)广东省自然科学基金项目,2018A030310169,葫芦素B基于miR17~92 Cluster /STAT3反馈调节环路逆转非小细胞肺癌吉非替尼耐药机制的研究,2018/7 -2021/7,10万元,已结题,主持
(4)广州市医药卫生科技一般引导项目,20171A011289,抑制HMGA2表达对衰老障碍导致的AML细胞耐药的逆转,2017/07-2019/06,3万元,已结题,主持。
【代表性论文及著作】
1、Baodan Yu, Chunping Liu, Pengfei Qin,et al. Blastic Plasmacytoid Dendritic Cell Neoplasm Presenting as a Mammary Gland Tumor in Pediatrics. International Journal of Surgical Pathology. INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY,2023. Int J Surg Pathol. 2023 Nov 13: 10668969231211338 .doi: 10.1177/10668969231211338.
2、Baodan Yu, Lixia Zheng, Huiqin Tang, Weixin Wang, Yongping Lin. Cucurbitacin B enhances apoptosis in gefitinib resistant non‑small cell lung cancer by modulating the miR‑17‑5p/STAT3 axis. Mol Med Rep. 2021. 24(4):710.
3、 Zheng, Lixia; Wu, Shao; Tan, Li; Tan, Huo; Yu, Baodan ; Chitosan-functionalised singlewalled carbon nanotube-mediated drug delivery of SNX-2112 in cancer cells., Journal of
Biomaterials Applications, 2016, 31(3): 379-386
4、Yu, Baodan; Tan, Li; Zheng, Runhui; Tan, Huo; Zheng, Lixia ; Targeted delivery and
controlled release of Paclitaxel for the treatment of lung cancer using single-walled carbon
nanotubes., Mater Sci Eng C Mater Biol Appl, 2016, 68: 579-584
5、Li Tan; Hongfa Xu; Guoshu Chen; Xiaoping Wei; Baodan Yu; Jingmei Ye; Lihua Xu; Huo Tan ;
Silencing of HMGA2 reverses retardance of cell differentiation in human myeloid leukaemia, Br J
Cancer, 2018, 118(3): 405-415