王立富，男，1988年11月生，教授，博士生导师。中山大学中山医学院病原生物学专业博士。2021年8月以南山学者骨干人才加入广州医科大学金域检验学院工作。主要围绕“外泌体介导的病原体与宿主相互作用”开展研究工作，近5年累计发表论文29篇，其中以第一作者/通讯作者身份在Journal of extracellular vesicles、Molecular Therapy、Theranostics、Bioengineering & Translational Medicine等期刊发表SCI论文14篇，1篇IF>20, 3篇IF>10。申请发明专利6项。承担了包括国家自然科学基金在内的省部级以上科研4项。受邀担任Frontiers in Immunology杂志客座编辑。
【联系邮箱】wanglf @gzhmu.edu.cn
【研究方向】
（1） 外泌体介导的病原体与宿主相互作用
（2） 基于虫源性分子的自身免疫性疾病药物研发
【主要科研项目】
（1） 国家自然科学基金—青年基金项目，项目编号: 81902081，2020.01-2022.12，20万，主持。
（2） 广东省自然科学基金—面上项目，项目编号: 2020A1515010571，2020.01-2022.12，10万，主持。
（3） 中国博士后科学基金—面上项目（一等资助），项目编号: 2018M640858，2018.12-2021.06，8万，主持。
（4） 中国博士后科学基金—面上项目（特别资助），项目编号: 2019T120771，2019.01-2021.04，18万，主持。
（5） 广州医科大学高水平大学建设人才启动项目，200万，2021.08-2026.08，主持。
【主要论文及著作（代表性）】
1. Lifu Wang#, Yao Liao#, Ruibing Yang#, Zilong Yu#, Lichao Zhang, Zifeng Zhu, Xiaoying Wu, Jia Shen, Jiahua Liu, Lian Xu, Zhongdao Wu*, Xi Sun1*. Sja-miR-71a in Schistosome egg-derived extracellular vesicles suppresses liver fibrosis caused by schistosomiasis via targeting semaphorin 4D. J. Extracell. Vesicles, 2020, 9, 1785738. （IF=25.844）
2. LifuWang#, ZifengZhu#, YaoLiao, LichaoZhang, ZilongYu, RuibingYang, JiWu, ZhongdaoWu*, XiSun*. Host Liver-Derived Extracellular Vesicles Deliver miR-142a-3p Induces Neutrophil Extracellular Traps via Targeting WASL to Block the Development of Schistosoma japonicum. Molecular Therapy, 2022. （IF=11.454）
3. Lifu Wang, Hui Xie, Lian Xu, Qi Liao, Shuo Wan, Zilong Yu, Datao Lin, Beibei Zhang, Zhiyue Lv, Zhongdao Wu*and Xi Sun*. rSj16 Protects against DSS-Induced Colitis by Inhibiting the PPAR-alpha Signaling Pathway. Theranostics, 2017, 7(14): 3446-3460.（IF=11.554）
4. Lifu Wang, Yao Liao, Ruibing Yang, Zifeng Zhu, Lichao Zhang, Zhongdao Wu, Xi Sun*. An engineered probiotic secreting Sj16 ameliorates colitis via Ruminococcaceae/butyrate/retinoic acid axis. Bioeng Transl Med, 2021, 10;1002. (IF=10.713)
5. Lifu Wang, Zilong Yu, Shuo Wan, Feng Wu, Wei Chen, Beibei Zhang, Datao Lin, Jiahua Liu, Hui Xie, Xi Sun* and Zhongdao Wu*. Exosomes Derived from Dendritic Cells Treated with Schistosoma japonicum Soluble Egg Antigen Attenuate DSS-induced Colitis. Frontiers in Pharmacology, 2017, 8: 651. （IF=5.811）
6. Lichao Zhang#, Xiaoying Wu#, Ruibing Yang, Fang Chen, Yao Liao, Zifeng Zhu, Zhongdao Wu, Xi Sun*, Lifu Wang*. Effects of Berberine on the Gastrointestinal Microbiota. Frontiers in Cellular and Infection Microbiology, 2021, 19;10:588517.（IF=5.294）
7. Lichao Zhang, Xiaoying Wu, Ruibing Yang, Fang Chen, Jiahua Liu, Yunyi Hu, Zhongdao Wu, Lifu Wang*, Xi Sun. Recombinant protein Schistosoma japonicum-derived molecule attenuates dextran sulfate sodium-induced colitis by inhibiting miRNA-217-5p to alleviate apoptosis. World J Gastroenterol. 2021, 14;27(46):7982-7994. （IF=5.742）
8. Zhengyu Wu#, Lifu Wang#, Yanlai Tang and Xi Sun*. The Parasite-Derived Protein for Treatment of Allergy and Autoimmune Disease. Frontiers in microbiology, 2017, 8:2164.（IF=5.642）
9. Lifu Wang, Zhitao Li, Jia Shen, Zhen Liu, Jinyi Liang, Xiaoying Wu, Xi Sun* and Zhongdao Wu*. Exosome-like vesicles derived by Schistosoma japonicum adult worms mediates M1 type immune-activity of macrophage. Parasitology research, 2015, 114(5): 1865-1873.（IF=2.282）
10. Lifu Wang, Lian Xu, Shiqi Luo, Hui Xie, Wei Chen, Zhongdao Wu* and Xi Sun*. Diagnosis of Strongyloides stercoralis by morphological characteristics combine with molecular biological methods. Parasitology research, 2017, 116(4): 1159-1163.（IF=2.282）
11. Beibei Zhang#, Lifu Wang#, Jiahua Liu, Lian Xu, Langui Song, Xiaoying Wu, Xi Sun* and Zhongdao Wu*. Case Report: A rare case of urinary myiasis induced by the fourth instar larvae of Telmatoscopus albipunctatus. Plos NTD,2017, 11(12):e0006016.（IF=4.411）
12. Jia Shen#, Lifu Wang#, Mei Peng, Zhen Liu, Beibei Zhang, Tao Zhou, Xi Sun, Zhongdao Wu. Recombinant Sj16 protein with novel activity alleviates hepatic granulomatous inflammation and fibrosis induced by Schistosoma japonicum associated with M2 macrophages in a mouse model. Parasites & vectors, 2019, 12(1): 457.（IF=3.111）
13. Ruibing Yang#, Yao Liao#, Lifu Wang#, Ping He, Yuanjia Hu, Dongya Yuan*, Zhongdao Wu* and Xi Sun *. Exosomes Derived from M2b Macrophage Attenuate DSS-Induced Colitis. Frontiers in Immunology, 2019, 10: 2346. (IF=7.652）
14. Xi Sun#, Lifu Wang#, Ying Feng#, Hui Xie, Xiaoying Zheng, Ai He, Md Robiul Karim, Zhiyue Lv* and Zhong-Dao Wu*. A case report: A rare case of infant gastrointestinal canthariasis caused by larvae of Lasioderma serricorne (Fabricius, 1792) (Coleoptera: Anobiidae). Infectious diseases of poverty, 2016, 5(1): 34.（IF=4.524）
