研究生院

王俊
更新时间:2021-04-02

王俊 博士 招生学科:免疫学与病原微生物学PhD,广州市妇女儿童医疗中心儿研所PI,硕士生导师。曾先后在University of Kentucky 和美国Lawrence Berkeley National Laboratory从事博士后研究工作。申请人在多年的研究工作中,积累了扎实的儿童区域免疫、细胞信号转导、表观遗传学和临床医学转化的研究经验。2018年加入广州市妇女儿童医疗中心。 在多年的研究工作中,积累了扎实的儿童组织区域免疫、细胞信号转导、表观遗传学和临床医学转化的研究经验。近五年来,绘制了新生儿胆道闭锁的肝脏单细胞免疫图谱,并提出新的治疗策略(Cell,第一作者, 2020);阐述了儿童炎症性肠病的肠黏膜单细胞图谱(Cell, 2019, 共同第一作者);蛋白翻译调控机制成果发表于Nature Communications (第一作者,2017)。目前主持国自然基金面上项目一项,作为合作单位项目负责人参与国自然重大研究计划集成项目一项。


研究领域:

运用单细胞组学、生物化学和分子生物学、免疫遗传学等手段研究儿童慢病(肿瘤和免疫缺陷病)的组织区域特征,探索新的治疗靶点和策略。


在研项目:

1 国家自然科学基金面上项目,32070918,《DAP5增强IRES-依赖的MCL1翻译和Th17存活促进肠道炎症的机制研究》2021/01-2024/12,58万,在研,主持。

2 国家自然科学基金委员会重大研究计划集成项目,91842304, 《肺脏γδ T细胞的区域免疫特征及其在抗病毒免疫反应中的功能研究》2019/01-2022/12300万,在研,合作单位项目负责人。


代表性论文

(1) Jun Wang#, Yanhui Xu#, Zhanghua Chen#, Jiankun Liang#, Zefeng Lin#, Huiying Liang#, Yiping Xu, Qi Wu, Xuanjie Guo, Junli Nie, Bingtai Lu, Bing Huang, Huifang Xian, Xiaohui Wang, Qiang Wu, Jixiao Zeng, Chengwei Chai, Meixue Zhang, Yuzhen Lin, Li Zhang, Shanmeizi Zhao, Yanlu Tong, Xiaoqiong Gu, Liang Zeng, Zhuang-gui Chen, Shuhong Yi, Tong Zhang, David Delfouneso, Yan Zhang, Stephen L Nutt, Andrew M Lew, Liwei Lu, Fan Bai*, Huimin Xia*, Zhe Wen* and Yuxia Zhang*. Liver immune profiling reveals pathogenesis and therapeutics for biliary atresia. Cell, 2020. DOI:https://doi.org/10.1016/j.cell.2020.10.048.

(2) Bing Huang# , Zhanghua Chen# , Lanlan Geng#, Jun Wang#, Huiying Liang#, Yujia Cao, Huan Chen, Wanming Huang, Meiling Su, Hanqing Wang, Yanhui Xu, Yukun Liu, Lu B, Huifang Xian, Huiwen Li, Huilin Li, Lu Ren, Jing Xie, Liping Ye, Hongli Wang, Junhong Zhao, Peiyu Chen, Li Zhang, Shanmeizi Zhao S, Ting Zhang, Banglao Xu, Di Che, Wenyue Si, Xiaoqiong Gu, Liang Zeng , Yong Wang , Dingyou Li, Yifan Zhan, David Delfouneso, Andrew M. Lew, Jun Cui, Wai Ho. Tang, Yan Zhang, Sitang Gong*, Fan Bai*, Min Yang*, Yuxia Zhang*. Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways. Cell, 2019;179(5):1160-1176.e24. doi: 10.1016/j.cell.2019.10.027. IF:38.6

(3) Jun Wang#Qing Ye#Yanan Cao#Yubin GuoXiuping HuangWentin MiSide LiuChi WangHsin-Sheng YangBinhua P. ZhouB. Mark EversQing-Bai She *. Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1, Nature Communications, 2017; 8(1):2207. (IF:12.12)

(4) Bingtai Lu#, Ming Liu#, Jun Wang#, Huifeng Fan#, Diyuan Yang, Li Zhang, Xiaoqiong Gu, Junli Nie, Zhenjun Chen, Alexandra J. Corbett, Michael J. Zhan, Shengbo Zhang, Vanessa L. Bryant, Andrew M. Lew, James McCluskey, Hai-bin Luo, Jun Cui, Yuxia Zhang*, Yifan Zhan*, Gen Lu*. IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia. Mucosal Immunol., 2020 Feb 28. doi: 10.1038/s41385-020-0273-y. (IF: 6.73)

(5) Dalong Sun#, Longzhi Liu#, Jing Chen#, Guangxi Zhao, Pingping Dong, Bingrui Wu, Jun Wang*, Ling Dong*. Establishment of a 12-gene expression signature to predict colon cancer prognosis. PeeJ, 2018;6:e4942. (IF:2.38)

(6) Jun Wang*, Donglin Yang; Zhongzhu Chen, Benfu Gou.Gou*. Associations of body mass index with cancer incidence among populations, genders, and menopausal status: A systematic review and meta-analysis, Cancer Epidemiology, 2016;42: 1-8. (IF:2.18)

(7) Jun Wang, Jiang Hu, Qian Qian; Hongwei Xue*. LC2 and OsVIL2Promote Rice Flowering by Photoperoid-Induced Epigenetic Silencing of OsLF, Molecular Plant, 2013; 6(2): 514-527. (IF: 12.08)


 
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