【个人简介】
张玉霞，博士，研究员，博士生导师，九三学社成员，现为广州医科大学附属妇女儿童医疗中心首席研究员。她先后荣获广州市医学“领军人才”（2021）、广东省“珠江学者”特聘教授（2019-2024）及国家自然科学基金“杰出青年基金”（2022-2026）等荣誉称号。拥有中国科学院微生物研究所博士学位（2007），曾于剑桥大学、墨尔本大学Walter & Eliza Hall研究所等国际知名机构从事博士后及高级研究工作。近五年主持国家杰出青年科学基金、国家自然科学基金重大项目、广州国家实验室专项等国家级及省部级科研项目十余项。
【研究方向】
1. 儿童慢病的区域免疫发病机制；2.感染免疫；3.免疫缺陷与自身炎症。
【科研项目】
1. 2027年1月-2031年12月，国家自然科学基金委员会，重点项目，TREM2+巨噬细胞驱动异常胆管反应促进肝纤维化的机制研究，82630016, 230万, 主持；
2. 2025年1月-2026年12月， 广州市科技，基础研究计划，MCM8介导的线粒体自噬在器官纤维化和神经退行性疾病中的作用机制及靶向治疗意义研究， 2025A03J4520, 200万, 主持；
3. 2025年1月-2029年12月, 国家自然科学基金委员会，重大项目：呼吸道病原入侵宿主黏膜组织的病理过程及致病机制，82495202，500万元，主持；
4. 2024年7月-2027年6月, 广州国家实验室与呼吸疾病国家重点实验室，联合资助项目，MACROD2促进甲型流感病毒感染诱发肺损伤的机制和靶向药物开发，GZNL2024B01002，300万元，主持；
5. 2024年7月-2026年6月， 广东省科技厅, 粤港科技创新联合资助专题，PAK1抑制剂作为广谱抗病毒药物的开发和成药性研究，20240508, 100万，主持；
6. 2024年1月-2028年12月, 广州国家实验室，专项项目，重要呼吸道病原介导的黏膜免疫和动态调控机制研究，GZNL2023A01009，400万元，参与；
7. 2022年1月-2026年12月, 国家自然科学基金委员会，国家杰出青年科学基金，儿童消化系统疾病的免疫机制与防治, 82125015, 400万元，主持；
8. 2022年4月-2025年3月, 广州市卫生健康委员会，广州市科技重点研发计划, B细胞激活因子（BAFF）介导胆道闭锁肝脏自身免疫损伤的机制研究，202206010002, 50万元，主持；
9. 2021年8月-2024年7月, 重庆国际免疫研究院，创新基础研究，靶向MCM8治疗非酒精性脂肪性肝病探索，2021YJC02, 250万元，主持；
10. 2021年1月-2022年12月, 国家自然科学基金委员会，重大研究计划集成项目，儿童肠肝免疫稳态的维持机制研究，92042303, 150万元，主持；
【代表性论文及著作】
1. Weiwei Liang#, Deshu Xu#, Li Zhang#, Yuhua Qu, Lanying Li, Kanghua Zhong, Meng Yao, Jianheng Zhu, Shang Wang, Liren Tan, Wenjiao Ding, Ruizhong Zhang, Feiyan Wang, Wenhao Zhou, Fan Bai, Hua Jiang, Yuxia Zhang*. Retinoic acid-driven expansion of CD16hiCD177+ neutrophils mediates steroid-resistant GI-GVHD. Blood. 2026 Jun 22:blood.2025032193.
2. Xian H#, Huang W#, Chen Z#, Li L, Xiong L, Zhu J, Jin H, Li X, Song L, Chen P, Ren L, Wang W, Fang R, Chen X, Lei W, Zhang D, Liao W, Huang Y, Lew AM, Cui J, Gong S, Huang J, Rosa Duque JS, Zhi M*, Geng L*, Zhou W*, Zhang Y*. (2026). RADX protects against intestinal inflammation by restraining IFI16-mediated innate immunity. EMBO molecular medicine, 18(9), 3570–3596.
3. Fang R, Wang W, Zhang L, Huang J, Huang L, Wu H, Qi Y, Li L, Tan L, Zhang M, Zhu J, Peng X, Zhong K, Zou M, Yang X, Wang Q, Nie C, Tang C, Tang N, Geng L, Chen H, Vince JE, Kanegane H, Zhao X, Xian H, Zhou W*, Zhi M*, Zhang Y*, Chen Z*. XIAP Deficiency Impairs Colonic Tuft Cell Development and Predisposes to Crohn's Disease. MedComm (2020). 2026 Apr 25;7(5):e70745.
4. Yanhui Xu#, Xixi Chen#, Rongli Fang#, Xiaolei Wang#, Yanfang Zhang#, Huifang Ren, Yunnan Xiao, Yu Ning, Xiaotian Li, Chengwei Chai, Wen Lei, Kanghua Zhong, Jiankun Liang, Qifeng Liang, Yuanyuan Luo, Qiuming He, Zefeng Lin, Zhenhua Luo, Ming Liu, Weiwei Liang, Tingting Chen, Xiaoqiong Gu, Jinbao Liu, Junqiang Lv, Zhi Yao, Hai-Biao Gong, Wan-Yang Sun, Rong-Rong He, Andrew M Lew, Huimin Xia, Yuzhang Wu, Wenhao Zhou*, Zhe Wen*, Zhanghua Chen*, and Yuxia Zhang1*. A dysregulated hepcidin-iron axis impairs antiviral immunity and induces lethal liver pathology in neonates. Immunity. 2026 Jan 13;59(1):79-97.e11.
5. Cong Dong#, Bingtai Lu#, Changhao Zhong#, Changxing Ou#, Xiaojing Yang#, Lingwei Wang#, Xiaoyu Zuo#, Lingna Xue, Chenyang Lu, Shang Wang, Junjie Wen, Jianjuan Ma, Zhenan Deng, Yiyi Liu, Liuheyi Ma, Ming Liu, Andrew M Lew, Manali Mukherjee, Parameswaran Nair, Nanshan Zhong, Rongchang Chen*, Zhanghua Chen*, Yuxia Zhang*, Qingling Zhang*. Airway immune profiles and therapeutic implications of IGF1 in eosinophilic granulomatosis with polyangiitis. Nature Communication. 2026 Jan 7;17(1):1346.
6. Xixi Chen#, Yanhui Xu#, Huifang Ren#, Xiaolei Wang#, Andrew M. Lew, Yuxia Zhang* and Zhe Wen*. Single-cell transcriptome analysis reveals mechanism of phosphodiesterase inhibitor in neonatal mouse infection-associated liver injury treatment. hLife. 2025
7. Mahmoud Al-Azab#, Elina Idiiatullina#, Meng Lin, Katja Hrovat-Schaale, Huifang Xian, Jianheng Zhu, Mandy Yang, Bingtai Lu, Ziyang Liu, Zhiyao Zhao, Yiyi Liu, Jingjie Chang, Xiaotian Li, Caiqin Guo, Ping Zeng, Jun Cui, Xia Gao, Yan Zhang, Yuxia Zhang*, and Seth L. Masters* Genetic variants in UNC93B1 cause childhood-onset systemic lupus erythematosus. Nature Immunology. 2024 Jun; 25(6):969-980
8. Elina Idiiatullina#, Mahmoud Al-Azab#, Meng Lin, Ziyang Liu, Xiaotian Li, Caiqin Guo, Xixi Chen, Jun Cui, Li Liu*, Yuxia Zhang*, Seth L. Masters*. Heterozygous de novo dominant negative mutation of REXO2 results in interferonopathy. Nature Communication. 2024 15，6685
9. Bingtai Lu#, Yanfang Zhang#, Jun Wang#, Diyuan Yang#, Ming Liu, Liuheyi Ma, Weijing Yi, Yufeng Liang, Yingyi Xu, Huifeng Fan, Wei Liu, Jue Tang, Sengqiang Zeng, Li Cai, Li Zhang, Junli Nie, Fen Zhang, Xiaoqiong Gu, Gen Lu* and Yuxia Zhang*. PD-1+CD4 T cells promote receptor editing and suppress autoreactivity of CD19+CD21low B cells in the lungs of children with adenovirus pneumonia. Mucosal Immunology. 2024 Jul 20:S1933-0219（24）00071-0
10. Ming Liu#, Bingtai Lu#, Yue Li1#, Shuofeng Yuan3#, Zhen Zhuang#, Guangyu Li, Liuheyi Ma, Jianheng Zhu, Jinglu Zhao, Chris Chung-Sing Chan, Vincent Kwok-Man Poon3, Kenn Ka-Heng Chik, Zhiyao Zhao, Huifang Xian, Jingxian Zhao, Jincun Zhao*, Jasper Fuk-Woo Chan*, Yuxia Zhang*. P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation. Signal Transduction & Targeted Therapy. 2023 Oct 9;8(1):385.
11. Meng Lin#, Huifang Xian#, Zhanghua Chen#, Shang Wang#, Ming Liu, Weiwei Liang, Qin Tang, Yao Liu, Wanming Huang, Di Che, Caiqin Guo, Elina Idiiatullina, Rongli Fang, Mahmoud AL-Azab, Jingjie Chang, Rongze Wang，Xiaojun Li, Xiaoyu Zuo, Yan Zhang, Jincun Zhao, Yaping Tang, Shouheng Jin, Zhengjie He, Du Feng, Liwei Lu, Kang Zhang, Yan Wu, Fan Bai, Andrew M Lew, Jun Cui, Yuzhang Wu*, Xiaoqiong Gu* and Yuxia Zhang*. MCM8 mediated mitophagy protects vascular health in response to nitric oxide signaling in a mouse model of Kawasaki disease. Nature Cardiovascular Research. 2023; 2, 778-792
12. Sebastian A Hughes, Meng Lin, Ashley Weir, Bing Huang, Liya Xiong, Ngee Kiat Chua, Jiyi Pang, Jascinta P Santavanond, Rochelle Tixeira, Marcel Doerflinger, Yexuan Deng, Chien‐Hsiung Yu, Natasha Silke, Stephanie A Conos, Daniel Frank, Daniel S Simpson, James M Murphy, Kate E Lawlor, Jaclyn S Pearson, John Silke, Marc Pellegrini, Marco J Herold, Ivan KH Poon, Seth L Masters, Mingsong Li, Qin Tang, Yuxia Zhang*, Maryam Rashidi*, Lanlan Geng*, James E Vince*. Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1b release in X-linked inhibitor of apoptosis (XIAP) deficiency. The EMBO Journal. 2023; e110468
13. Yifan Zhan#, Yuxia Zhang#, Shengbo Zhang#, Hannah Coughlan, Pedro L Baldoni, Nicolas Jacquelot, Wang HJ Cao, Simon Preston, Cynthia Louis, Jai Rautela, Marc Pellegrini, Ian P Wicks, Warren S Alexander, Leonard C Harrison, Andrew M Lew, Gordon K Smyth, Stephen L Nutt*, Michaël Chopin*. Differential requirement for the Polycomb repressor complex 2 in dendritic cell and tissue-resident myeloid cell homeostasis. Science Immunology. 2021, 6(63).
14. Jun Wang#, Yanhui Xu#, Zhanghua Chen#, Jiankun Liang#, Zefeng Lin#, Huiying Liang#, Yiping Xu, Qi Wu, Xuanjie Guo, Junli Nie, Bingtai Lu, Bing Huang, Huifang Xian, Xiaohui Wang, Qiang Wu, Jixiao Zeng, Chengwei Chai, Meixue Zhang, Yuzhen Lin, Li Zhang, Shanmeizi Zhao, Yanlu Tong, Liang Zeng, Xiaoqiong Gu, Zhuang-gui Chen, Shuhong Yi, Tong Zhang, David Delfouneso, Yan Zhang, Stephen L Nutt, Andrew M Lew, Liwei Lu, Fan Bai*, Huimin Xia*, Zhe Wen*, Yuxia Zhang*. Liver immune profiling reveals pathogenesis and therapeutics for biliary atresia. Cell. 2020; 183（1-7）
15. Lingli Zhou, Tao Liu, Bing Huang, Man Luo, Zhanghua Chen, Zhiyao Zhao, Jun Wang, Daniel Leung, Xingtian Yang, Koon Wing Chan, Yukun Liu, Liya Xiong, Peiyu Chen, Hongli Wang, Liping Ye, Hanquan Liang, Seth L Masters, Andrew M Lew, Sitang Gong, Fan Bai, Jing Yang, Pamela Pui-Wah Lee, Wanling Yang, Yan Zhang, Yu-Lung Lau, Lanlan Geng*, Yuxia Zhang*, Jun Cui*.Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development. Journal of Allergy & Clinical Immunology. 2021 Jan;147(1):267-279.
16. Xiaoyan Liu, Zhe Li, Shuai Liu, Jing Sun, Zhanghua Chen, Min Jiang, Qingling Zhang, Yinghua Wei, Xin Wang, Yi-You Huang, Yinyi Shi, Yanhui Xu, Huifang Xian, Fan Bai, Changxing Ou, Bei Xiong, Andrew M Lew, Jun Cui, Rongli Fang, Hui Huang, Jincun Zhao*, Xuechuan Hong*, Yuxia Zhang*, Fuling Zhou*, Hai-Bin Luo*. Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19. Acta Pharmaceutica Sinica Bulletin. 2020; 10(7):1205-1215
17. Ming Liu, Bingtai Lu, Ping Zeng, Bing Huang, Yanhui Xu, Hanquan Liang, Diyuan Yang, Sida Yang, Hai-bin Luo, Andrew M Lew, Seth L Masters, Lanlan Geng*, Huasong Zeng*, Yuxia Zhang*. Compound heterozygous mutations of IL12RB1 in a patient with selective defects in Th17 differentiation. Journal of Clinical Immunology. 2020; 40(4):647-652
18. Bingtai Lu, Ming Liu, Jun Wang, Huifeng Fan, Diyuan Yang, Li Zhang, Xiaoqiong Gu, Junli Nie, Zhenjun Chen, Alexandra J Corbett, Michael J Zhan, Shengbo Zhang, Vanessa L Bryant, Andrew M Lew, James McCluskey, Hai-bin Luo, Jun Cui, Yuxia Zhang*, Yifan Zhan*, Gen Lu*.IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia. Mucosal Immunology. 2020; 13(5):824-835
19. Bing Huang, Zhanghua Chen, Lanlan Geng, Jun Wang, Huiying Liang, Yujie Cao, Huan Chen, Wanming Huang, Meiling Su, Hanqing Wang, Yanhui Xu, Yukun Liu, Bingtai Lu, Huifang Xian, Huiwen Li, Huilin Li, Lu Ren, Jing Xie, Liping Ye, Hongli Wang, Junhong Zhao, Peiyu Chen, Li Zhang, Shanmeizi Zhao, Ting Zhang, Banglao Xu, Di Che, Wenyue Si, Xiaoqiong Gu, Liang Zeng, Yong Wang, Dingyou Li, Yifan Zhan, David Delfouneso, Andrew M Lew, Jun Cui, Wai Ho Tang, Yan Zhang, Sitang Gong*, Fan Bai*, Min Yang*, Yuxia Zhang*. Mucosal profiling of pediatric-onset colitis and IBD reveals common pathogenics and therapeutic pathways. Cell. 2019; 179(5):1160-1176
【所获荣誉和奖励】
1. 广东省“珠江学者特聘教授”（2019）
2. 广州市高层次人才-优秀专家（2020）
3. 2019年度中国医学重大进展（2021）
4.广州市医学“领军人才”（2021）
