研究生院

陈凌
更新时间:2021-04-03


陈凌博士,教授,博士生导师,广州医科大学特聘教授,呼吸疾病国家重点实验室特聘研究员。中国科学院广州生物医药与健康研究院首任创始院长(2004-2008)、国家杰出青年科学基金(外籍)获得者。主要从事疫苗、抗体、肿瘤药物的研发工作,累计在国际知名生物医学期刊发表了100多篇SCI论文,2018年至今作为通讯作者发表SCI论文超过30篇,申请了多项国内/国际专利。

1979-1985就读于上海第一医学院医学系,1984年考取赴美留学CUSBEA项目。1985-1991年在美国印第安那大学(Indiana University)医学院生物化学和分子生物学系主攻生物化学和分子生物学,获博士学位。1992-1993年在美国哈佛大学医学院(Harvard Medical School)Dana-Farber癌症研究所从事博士后研究。1994-1996年在哈佛大学医学院担任讲师(Instructor)1997-2001年在美国默克(Merck)制药公司担任资深研究员(Senior Research Fellow),广州恩宝生物医药有限公司董事长。主要成果包括默克实验室的艾滋病疫苗的第一发明人, 该疫苗曾被专家评为最具希望成功的艾滋病疫苗,并进入大规模临床II期试验。腺病毒载体新冠疫苗第一发明人,共获得艾滋病疫苗,癌症的分子化疗,人类乳突状瘤病毒和子宫颈癌疫苗,腺病毒及腺病毒载体疫苗等约三十多项国际专利发明。研究工作涉及生物医药的前沿领域,包括癌症、传染病等疾病的药物开发和疫苗研究。在国际一流科学期刊Nature, Nature Communications, Journal of Clinical Investigation, Cancer Research, Journal of Virology, Vaccine等发表了100余篇具有应用及转化医学价值的论文。


2018年以来部分SCI文章(通讯作者)

1. Yu L#, Liu X#, Ye X#, Su W, Zhang X, Deng W, Luo J, Xiang M, Guo W, Zhang S, Xu W, Yan Q, Wang Q, Cui Y, Wu C, Guo W, Niu X, Zhang F, Lei C, Qu L, Chen L*, Feng L*. 2021. Monoclonal antibodies against Zika virus NS1 protein confer protection via Fcg receptor-dependent and -independent pathways. mBio 2021, 12: e03179-20.

2. Feng L#, Wang Q#, Shan C#, Yang C, Feng Y, Wu J, Liu X, Zhou Y, Jiang R, Hu P, Liu X, Zhang F, Li P, Niu X, Liu Y, Zheng X, Luo J, Sun J, Gu Y, Liu B, Xu Y, Li C, Pan W, Zhao J, Ke C, Chen X, Xu T, Zhong N, Guan S*, Yuan Z*, Chen L*. An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques. Nat Commun. 2020, 11: 4207.

3. Feng Y#, Yi C#, Liu X#, Qu L, Su W, Shu T, Zheng X, Ye X, Luo J, Hao M, Sun X, Li L, Liu X, Yang C, Guan S, Chen L*, Feng L*. Human desmoglein-2 and human CD46 mediate Ad55 infection but human desmoglein-2 plays the major roles. J Virol.2020,94(17): e00747-20.

4. Sun B#, Feng Y#, Mo X#, Zheng P, Wang Q, Li P, Peng P, Liu X, Chen Z, Huang H, Zhang F, Luo W, Niu X, Hu P, Wang L, Peng H, Huang Z, Feng L, Li F*, Zhong N*, Chen L*. Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients. Emerg Microbes Infect 2020; 9(1): 940-8.

5. Wang Y#, Lv Y,# Niu X, Dong J, Feng P, Li Q, Xu W, Li J, Li C, Li J, Luo J, Li Z, Liu Y, Tan Y-J, Pan W*, Chen L*. 2020. L226Q mutation on inflfluenza H7N9 virus hemagglutinin increases receptor-binding avidity and leads to biased antigenicity evaluation. J Virol 94:e00667-20.

6. Niu X#, Li S#, Li P, Pan W, Wang Q, Feng Y, Mo X, Yan Q, Ye X, Luo J, Qu L, Weber D, Byrne-Steele ML, Wang Z, Yu F, Li F, Myers RM, Lotze MT, Zhong N, Han J* and Chen L*. Longitudinal Analysis of T and B Cell Receptor Repertoire Transcripts Reveal Dynamic Immune Response in COVID-19 Patients. Front. Immunol. 2020, 11:582010

7. Niu X#, Yan Q#, Yao Z#, Zhang F, Qu L, Wang C, Wang C, Lei H, Chen Z, Liang R, Luo J, Wang Q, Zhao L, Zhang Y, Luo K, Wang L, Wu H, Liu T, Li P, Zheng Z, Tan Y, Feng L, Zhang Z, Han J, Zhang F*, Chen L*. Longitudinal analysis of the antibody repertoire of a Zika virus-infected patient revealed dynamic changes in antibody response. Emerg Microbes Infect. 2020, 9: 111-123.

8. Qing Yang#, Fengling Feng#, Pingchao Li#, Enxiang Pan, Chunxiu Wu, Yizi He, Fan Zhang, Jin Zhao, Ruiting Li, Liqiang Feng, Fengyu Hu, Linghua Li, Huachun Zou, Weiping Cai, Thomas Lehner, Caijun Sun*, Ling Chen*. Arsenic Trioxide Impacts Viral Latency and Delays Viral Rebound after Termination of ART in Chronically SIV-Infected Macaques. Advanced Science (Weinh). 2019, 6: 1900319.

9. Niu X#, Zhao L#, Qu L#, Yao Z, Zhang F, Yan Q, Zhang S, Liang R, Chen P, Luo J, Xu W, Lv H, Liu X, Lei H, Yi C, Li P, Wang Q, Wang Y, Yu L, Zhang X, Bryan AL, Davidson E, Doranz BJ, Feng L, Pan W, Zhang F*, Chen L*. Convalescent patient-derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model. Emerg Microbes Infect. 2019, 8: 749-759.

10. Zhang S, Yi C, Li C, Zhang F, Peng J, Wang Q, Liu X, Ye X, Li P, Wu M, Yan Q, Guo W, Niu X, Feng L, Pan W, Chen L*, Qu L*. Chloroquine inhibits endosomal viral RNA release and autophagy-dependent viral replication and effectively prevents maternal to fetal transmission of Zika virus. Antiviral Research. 2019, 169: 104547.

11. Feng Y#, Sun X#, Ye X, Wang J, Zheng X, Liu X, Yi C, Hao M, Wang Q, Li F, Xu W, Li L, Li C, Zhou R, Chen L*, Feng L*. Hexon and fiber of adenovirus type 14 and 55 are major targets of neutralizing antibody but only fiber-specific antibody contributes to cross-neutralizing activity. Virology 2018; 518: 272-83.

12. Zhang Y#, Feng Y#, Li L#, Ye X, Wang J, Wang Q, Li P, Li N, Zheng X, Gao X, Li C, Li F, Sun B, Lai K, Su Z, Zhong N, Chen L*, Feng L*. Immunization with an adenovirus-vectored TB vaccine containing Ag85A-Mtb32 effectively alleviates allergic asthma. J Mol Med (Berl) 2018; 96(3-4): 249-63.

13. Ye X#, Xiao L#, Zheng X#, Wang J, Shu T, Feng Y, Liu X, Su W, Wang Q, Li C, Chen L*, Feng L*. Seroprevalence of Neutralizing Antibodies to Human Adenovirus Type 4 and 7 in Healthy Populations From Southern China. Front Microbiol 2018; 9: 3040.

14. Feng Y, Li C, Hu P, Wang Q, Zheng X, Zhao Y, Shi Y, Yang S, Yi C, Wu C, Qu L, Feng Y, Xu W, Li Y, Sun C, Gao FG, Xia X, Feng L*, Chen L*. An adenovirus serotype 2-vectored ebolavirus vaccine generates robust antibody and cell-mediated immune responses in mice and rhesus macaques. Emerg Microbes Infect 2018; 7(1): 101.

15. Pan E#, Feng F#, Li P, Yang Q, Ma X, Wu C, Zhao J, Yan H, Chen R, Chen L* and Sun C*. Immune Protection of SIV Challenge by PD-1 Blockade During Vaccination in Rhesus Monkeys. Front. Immunol.2018, 9:2415.

16. Zhang F, Wang L, Niu X, Li J, Luo J, Feng Y, Yang Y, He P, Fan W, Liang R, Zheng Z, Pan W, Li C, Tan YJ, Yu H, Chen L* and Li P*. Phenotypic Characterization of Chinese Rhesus Macaque Plasmablasts for Cloning Antigen-Specific Monoclonal Antibodies. Front. Immunol. 2019, 10:2426

17. Liu X#, Qu L#, Ye X#, Yi C, Zheng X, Hao M, Wan Su W, Zhipeng Yao Z, Chen P, Zhang S, Feng Y, Wang Q, Yan Q, Li P, Li H, Li F, Pan W, Niu X, Xu R, Feng L*, Chen L*. Incorporation of NS1 and prM/M are important to confer effective protection of adenovirus-vectored Zika virus vaccine carrying E protein. NPJ Vaccines. 2018, 3:29.


 
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