【个人简介】

博士、副主任医师、硕士研究生导师、博士后合作导师

【研究方向】

肠炎、非酒精性脂肪肝及肠道菌群

【代表性论文及著作】

1. 2026年度广东省基础与应用基础研究基金自然科学基金面上项目：糖酵解-AMPK乳酸化轴促Th17细胞分化在免疫检查点抑制剂相关结肠炎的机制研究2026.1-2029.12

2. METTL3介导的m6A修饰调控糖酵解依赖性M1/M2失衡在炎症性肠病中的作用及机制研究2025-2026第13批中国博士后科学基金站中特别资助项目：口服靶向巨噬细胞的基于阳离子多聚肽自组装纳米载体携带 miR-146b 治疗 小鼠 IBD 模 型的研究2020-20232020年国家自然科学基金青年项目：m6A甲基化修饰调控Th17 细胞分化在NAFLD中的作用,2020.1-2022.12年

3. 第66批国家博士后科学基金面上资助：表观遗传修饰调控Th17细胞分化影响NAFLD的进展，2020.1-2022.12年

4. 2021年度广东省基础与应用基础研究基金自然科学基金面上项目：白介素17通过肠道菌群影响非酒精性脂肪性肝炎发生发展的机制研究2021.1-2023.12

【科研项目】

1、 He S, Qiu J, Li R, et al. Engineered Ti₃C₂ MXene nanosystems for macrophage-targeted therapy of metabolic dysfunction-associated steatohepatitis. npj 2D Materials and Applications 2026.

2、 He S, Qiu J, Tao H, et al. Surface-Engineered Titanium Carbide MXenzyme Boosts ROS-Scavenging and Anti-Inflammation Activities for Inflammatory Bowel Disease. ACS Appl Mater Interfaces 2026.

3、 He, S.; Lv, Y.; Jiang, Y.; Tao, H.; Chen, X.; Peng, L. Recombination of miR-146b by Lactococcus lactis for Remolding Macrophages and the Microbiome in the Treatment of Murine Colitis. Journal of agricultural and food chemistry 2025. DOI: 10.1021/acs.jafc.4c11183.

4、 He, S.; Lv, Y.; Gao, Z.; Peng, L. The Nb4C3 MXenzyme Attenuates MASH by Scavenging ROS in a Mouse Model. International journal of nanomedicine 2025, Volume 20, 5645-5659. DOI: 10.2147/ijn.S500891.

5、 He, S.; Lv, Y.; Qiu, J.; Cui, S.; Gao, Z.; Peng, L. Ta4C3 MXene Slows Progression of Fatty Liver Disease through Its Anti-Inflammatory and ROS-Scavenging Effects. ACS applied materials & interfaces 2025, 17 (11), 17217-17229. DOI: 10.1021/acsami.4c20945.

6、 He S, Song W, Cui S, Li J, Jiang Y, Chen X, Peng L. Modulation of miR-146b by N6-methyladenosine modification remodels tumor-associated macrophages and enhances anti-PD-1 therapy in colorectal cancer. Cellular Oncology 2023, 46(6): 1731-1746.

7、 He S, Li J, Yao Z, Gao Z, Jiang Y, Chen X, Peng L. Insulin alleviates murine colitis through microbiome alterations and bile acid metabolism. Journal of translational medicine 2023, 21(1).

8、 Shuying He, Shudan Cui, Wen Song, Yonghong Jiang, Hongsheng Chen, Dongjiang Liao, Xinpeng Lu JL, Xueqing Chen, Peng L. Interleukin-17 Weakens the NAFLD/NASH Process by Facilitating Intestinal Barrier Restoration Depending on the Gut Microbiota. mBio 2022, 13(2).

9、 He S, Tang J, Diao N, Liao Y, Shi J, Xu X, Xie F, Bai L. Parathyroid hormone-related protein activates HSCs via hedgehog signalling during liver fibrosis development. Artificial Cells, Nanomedicine, and Biotechnology 2019, 47(1): 1984-1994.

10、 Shuying He, Minmin Xue, Cuiping Liu, Xiaoping Xu, Fang Xie, Lan Bai. Parathyroid hormone-like hormone induces epithelial-to-mesenchymal transition of intestinal epithelial cells by activating the transcription factor Runx2, Am J Pathol. 2018,188(6):1374-1388.

11、 Shuying He, Weihong Guo, Feihong Den, Kequan Chen, Yonghong Jiang, Xueqing Chen, Liang Peng. Targeted Delivery of microRNA146b mimicto hepatocytes by Lactosylated PDMAEMA nanoparticles for the Treatment of NAFLD，Artificial Cells Nanomedicine and Biotechnology, 2018,0(0):1-12.

12、 Feihong Deng; Shuying He; Shudan Cui; Yanqiang Shi; Yuyong Tan; Zhijun Li; Chongyang Huang; Deliang Liu *; Fachao Zhi *; Liang Peng * A Molecular Targeted Immunotherapeutic Strategy for Ulcerative Colitis via Dual-Targeting Nanoparticles Delivering miR-146b to Intestinal Macrophages, J Crohns Colitis,2018,0(0).

13、 Tang Jing #; Liao Yan #; He Shuying #; Shi Jie #; Peng Liang #; Xu Xiaoping; Xie Fang; Diao Na; Huang Jinlan; Xie Qian; Lin Chuang; Luo Xiaoying; Liao Kaili; Ma Juanjuan; Li Jingyi; Zhou Daichao; Li Zhijun; Xu Jun; Zhong Chao; Wang Guozhen; Bai Lan *. Autocrine parathyroid hormone-like hormone promotes intrahepatic cholangiocarcinoma cell proliferation via increased ERK/JNK-ATF2-cyclinD1 signaling, Journal of Translational Medicine, 2017,15(1):238-251.

【所获荣誉和奖励】

2022年广州市高层次人才青年后备人才

2023年广州市卫生健康优秀人才