沈二霞，女，教授，硕导、博导、博士后合作导师，学历：博士
单位：广州医科大学基础医学院，招生专业：免疫学
电子邮件：erxia_shen@gzhmu.edu.cn
研究方向：1. CD4+T细胞向滤泡辅助T细胞的分化及在自身免疫病的作用（人和小鼠）。2.利用条件敲除小鼠，研究调节性T细胞在自身免疫性疾病和肿瘤中的作用及调控制剂；
3.如何调控人和鼠的自然杀伤细胞（NK）抗肿瘤和抗感染。
所获荣誉：1.广州市高层次人才；2.广东省教育厅青年骨干教师培养对象（育苗工程）；3.南山学者第五层次人才
主持科研项目
1.主持国家级国家自然基金面上项目，转录因子Blimp1维持滤泡调节性T细胞（TFR）的系别稳定和功能的机制研究及在狼疮鼠中的作用，55万元，在研。
2.主持国家级国家自然基金青年项目，骨桥蛋白对小鼠CD27-IL-17+γδT细胞功能和发育的调控及机制研究，24万元，结题。
3.主持市级广州市属高校项目，OPN-i-Bcl6轴调控滤泡辅助性CD4+T细胞的早期分化及在SLE中的作用研究，8万元，结题。
4.主持市级广州市科技，细胞内骨桥蛋白调控早期滤泡辅助性CD4+T细胞的分化及其在类风湿性关节炎中的作用研究，20万元，结题。
5.主持省级广东省科技计划，IL-33/sT2在川崎病小鼠模型中的作用，5万元，结题。
6.主持省级广东省科技计划，pVAX–IL-35质粒诱导调节性T细胞缓解川崎病模型小鼠的实验研究，，5万元，结题。
7.主持省级广东省自然科学基金博士科研启动项目，银屑病IL-21升高机制及其诱导CD4+T细胞分化为Th22的机制研，3万元，结题。
部分代表性第一和通讯作者论文：
1.Bu Jin#, Ding Ruilian, Zhou Liangjia, Chen Xiangming,Shen Erxia*. Epidemiology of Psoriasis and Comorbid Diseases: A Narrative Review. Front Immunol. 2022;13:880201. Published 2022 Jun 10. doi:10.3389/fimmu.2022.880201.
2.Guanfang Liu#, Qi Zhang#, Jingying Yang#, Xiaomin Li, Luhua Xian, Wenmin Li, Ting Lin, Juan Cheng, Qiwen Lin, Xiuzhang Xu, Qin Li, Yu Lin, Maohua Zhou*,Erxia Shen*. Increased TIGIT expressing NK cells with dysfunctional phenotype in AML patients correlated with poor prognosis. Cancer Immunology, Immunotherapy. 2022 Feb;71(2):277-287. doi: 10.1007/s00262-021-02978-5.
3.Zhang Qi#, Chen Lan#, Ji Xiaofang, Tang Juanjuan, Fu Cheng, Huang Ting,Shen Erxia*, and Li Zi*. Inhibition of COX-2 ameliorates murine liver schistosomiasis japonica through splenic cellular immunoregulation. Parasites & Vectors,2022 Apr 23;15(1):144.
4.4.Jin Bu*, Yu Lin, Li-Qiong Qing, Gang Hu, Pei Jiang, Hai-Feng Hu*,Er-Xia Shen*. Prediction of skin disease using a new cytological taxonomy based on cytology and pathology with deep residual learning method. Sci Rep 11, 13764 (2021). https://doi.org/10.1038/s41598-021-92848-y.
5.Erxia Shen#, Hardis Rabe#, Lin Luo# et al. Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor. Cell Reports, 2019, 29, 1848–1861.
6.Erxia Shen#, Qin Wang #, Hardis Rabe, Wenquan Liu, Harvey Cantor*, and Jianmei W. Leavenworth*. Chromatin remodeling by the NuRD complex regulates development of follicular helper and regulatory T cells. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6780-6785.
7.Wang M#, Bu J #, Zhou M, Sido J, Lin Y, Liu G, Lin Q, Xu X, Leavenworth JW*,Shen E*. CD8+T cells expressing both PD-1 and TIGIT but not CD226 are dysfunctional in Acute Myeloid Leukemia (AML) patients，Clin Immunol. 2018 May;190:64-73.
8.Erxia Shen, Mengjie Wang, Hairui Xie, Ruqiong Zou, Qiwen Lin, Lili lai, Fujun Li, Zhimei Liang, Yanran Xu, and Maohua Zhou. Existence of Th22 in children and evaluation of IL-22 + CD4 + T, Th17, and other T cell effector subsets from healthy children compared to adults. BMC Immunol. 2016 Jun 23;17(1):20.
9.Zhou M, Zou R, Gan H, Liang Z, Li F, Lin T, Luo Y, Cai X, He F,Shen E*.The effect of aging on the frequency, phenotype and cytokine production of human blood CD4 + CXCR5 + T follicular helper cells: comparison of aged and young subjects. Immun Ageing. 2014 Aug 23;11:12.
10.Shen E, Zhao K, Wu C, Yang B*. The suppressive effect of CD25+Treg cells on Th1 differentiation requires cell-cell contact partially via TGF-β production. Cell Biol Int. 2011;35(7), 705–712.
11.Shen E, Lu L, Wu C*. TLR7/8 ligand, R-848, inhibits IgE synthesis by acting directly on B lymphocytes. Scand J Immunol. 2008; 67(6):560-568.
12.Shen E#, Li L#, Li L, Feng L, Lu L, Yao Z, Lin H, Wu C*. PIKA as an adjuvant enhances specific humoral and cellular immune responses following the vaccination of mice with HBsAg plus PIKA. Cell Mol Immunol. 2007; 4(2):113-120.
