个人概况

姓  名：沈二霞                         性  别：女

民  族：汉族                            技术职称：教授          

导师类型：硕导、博导、博士后合作导师          最后学历：博士 

最后学位：博士                         工作单位：基础医学院 

邮  箱：erxia_shen@gzhmu.edu.cn

个人简介

广州市高层次人才，广州医科大学“南山学者“，临床医学学士、免疫学博士、哈佛大学 Dana-Farber institute 肿瘤免疫系博士后。课题组长期从事 T 细胞和 NK 细胞分化和功能调控机制，及在相关疾病中的作用。实验室现有多种转基因小鼠和工具鼠、临床标本资源，已搭建实验所需多种模型如骨髓嵌合模型、过继转移模型。主持国家自然基金（3 项），广东省自然、省科技及市科技等多项基金。以第一作者或通许作者发表包括 PNAS、Cell reports 等高影响力文章 20 多篇。

研究方向

1. NK细胞发育分化和功能调控机制

2. T细胞发育分化和功能调控机制

主持科研项目

1. 主持国家级 国家自然基金面上项目，32370932，转录因子Blimp1调控自然杀伤细胞发育和功能的机制研究。立项时间：2023.项目时间：2024.01-2027.12，50万元，在研，主持。

2. 主持国家级 国家自然基金面上项目，转录因子Blimp1维持滤泡调节性T细胞（TFR）的系别稳定和功能的机制研究及在狼疮鼠中的作用，55万元，结题。

3. 主持国家级 国家自然基金青年项目，骨桥蛋白对小鼠CD27-IL-17+γδT 细胞功能和发育的调控及机制研究，24万元，结题。

4. 主持市级 广州市属高校项目，OPN-i-Bcl6轴调控滤泡辅助性CD4+T细胞的早期分化及在SLE中的作用研究， 8万元，结题。

5. 主持市级 广州市科技，细胞内骨桥蛋白调控早期滤泡辅助性CD4+T细胞的分化及其在类风湿性关节炎中的作用研究，20万元，结题。

6. 主持省级 广东省科技计划， IL-33/sT2在川崎病小鼠模型中的作用， 5万元，结题。

7. 主持省级广东省科技计划，pVAX–IL-35 质粒诱导调节性T 细胞缓解川崎病模型小鼠的实验研究，，5万元，结题。

8. 主持省级 广东省自然科学基金博士科研启动项目，银屑病IL-21升高机制及其诱导CD4+T细胞分化为Th22的机制研，3万元，结题。

部分代表性第一和通讯作者论文：

1. Liu G#, Huang T#, Gao XJ#, Ding RL, Zheng Y, Tang YP*, Bu J*, Shen EX*. Expression of Co-Inhibitory Molecules on Lymphocytes of Patients With Psoriasis. J Dermatol. 2025 Sep 24. doi: 10.1111/1346-8138.17937. PMID: 40988543.

2. Huang J#, Liang W, Zhang R, Zhao Y, Shi R, Chen X, Zheng Y, Li X, Liu D, Wang H, Liu J, Liao Y, Zhang X, Jiang Z, Fu C, Huang T, Shan X, Wang W, Bu J*, Peng T*, Shen E*. Pou2af1 Deficiency Aggravates DSS-Induced Colitis via Impaired Germinal Center Responses and Altered Gut Microbiota. Inflamm Bowel Dis. 2025 Sep 1;31(9):2521-2534. doi: 10.1093/ibd/izaf089. PMID: 40556523.

3. Zheng Y#, Gao XJ, Huang JJ, Chen XM, Liao Y, Liu JM, Zheng YL, Zhao YY, Ding RL, Li XM, Bu J*, Shen EX*. The safety assessment of ustekinumab on psoriasis and psoriatic arthritis: A real-world analysis based on the FDA adverse event reporting system database. Int Immunopharmacol. 2025 Apr 4;151:114339. doi: 10.1016/j.intimp.2025.114339. PMID: 39987634.

4. Yue LiaoZ#, Yanling Zheng#, Ruizhi Zhang#, Xiangming Chen, Jijun Huang, Jiamin Liu，Yuyang Zhao, Yu Zheng, Xueyan Zhang, Zhiyan Gao, Jin Bu*, Tieli Peng*, Xiaomin Li*，Erxia Shen*. Regulatory roles of transcription factors T-bet and Eomes in group 1 ILCs. Int Immunopharmacol. https://doi.org/10.1016/j.intimp.2024.113229.

5. Qi Zhang#, Ting Huang# , Xiaomin Li# , Guanfang Liu, Luhua Xian, Xueying Mao , Ting Lin, Cheng Fu , Xiangming Chen, Wenting Liang, Yanling Zheng , Yuyang Zhao, Qiwen Lin, Xiuzhang Xu, Yu Lin, Jin Bu, Changyou Wu , Maohua Zhou*, Erxia Shen*. Prognostic impact of enhanced CD96 expression on NK cells by TGF-β1 in AML. Int Immunopharmacol. 2024 Nov 15:141:112958.  

6. Chen X#, Fu C#, Zheng YL#, Li X, Liao Y, Zheng Y, Liang W, Zhao Y, Huang J, Huang T, Bu J*, Shen E*. Intermittent fasting alleviates IMQ-induced psoriasis-like dermatitis via reduced γδT17 and monocytes in mice. Advances in Medical Sciences. 2024 May 17;316(5):176.  

7. Zhao Y#, Yang J#, Zhang Q, Chen X, Liang W, Zheng Y, Huang J, Liao Y, Fu C, Huang T, Li X, Zheng Y, Bu J*, Shen E*. Fasting alleviates bleomycin-induced lung inflammation and fibrosis via decreased Tregs and monocytes. Archives of Dermatological Research. 2024 Jul 8;69(2):303-311.  

8. Ding RL#, Fu C,# Zheng Y, Bu J*, Shen EX*. The Association Between Psoriasis and Trace Element Serum Levels and Dietary Intake: Results from USA National Health and Nutrition Examination Survey 2011–2014. Clin Cosmet Investig Dermatol. 2024 Jun;17:1449-1458.

9. Zhang R#, Zhao Y#, Chen X#, Zhuang Z, Li X, Shen E*. Low-dose IL-2 therapy in autoimmune diseases: An update review. Int Rev Immunol. 2024 May;43(3):113-137. doi: 10.1080/08830185.2023.2274574.

10. Bu Jin^#, Ding Ruilian, Zhou Liangjia, Chen Xiangming, Shen Erxia*. Epidemiology of Psoriasis and Comorbid Diseases: A Narrative Review. Front Immunol. 2022;13:880201.

11. Guanfang Liu#, Qi Zhang#, Jingying Yang#, Xiaomin Li, Luhua Xian, Wenmin Li, Ting Lin, Juan Cheng, Qiwen Lin, Xiuzhang Xu, Qin Li, Yu Lin, Maohua Zhou*, Erxia Shen*. Increased TIGIT expressing NK cells with dysfunctional phenotype in AML patients correlated with poor prognosis. Cancer Immunology, Immunotherapy. 2022 Feb;71(2):277-287.

12. Zhang Qi^#, Chen Lan^#, Ji Xiaofang, Tang Juanjuan, Fu Cheng, Huang Ting, Shen Erxia*, and Li Zi*. Inhibition of COX-2 ameliorates murine liver schistosomiasis japonica through splenic cellular immunoregulation. Parasites & Vectors, 2022 Apr 23;15(1):144.

13. Jin Bu*, Yu Lin, Li-Qiong Qing, Gang Hu, Pei Jiang, Hai-Feng Hu*, Er-Xia Shen*. Prediction of skin disease using a new cytological taxonomy based on cytology and pathology with deep residual learning method. Sci Rep 11, 13764 (2021).

14. Erxia Shen#, Hardis Rabe#, Lin Luo# et al. Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor. Cell Reports, 2019, 29, 1848–1861.

15. Erxia Shen #, Qin Wang #, Hardis Rabe, Wenquan Liu, Harvey Cantor*, and Jianmei W. Leavenworth*. Chromatin remodeling by the NuRD complex regulates development of follicular helper and regulatory T cells. Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6780-6785.

16. Wang M#, Bu J #, Zhou M, Sido J, Lin Y, Liu G, Lin Q, Xu X, Leavenworth JW*, Shen E*. CD8+T cells expressing both PD-1 and TIGIT but not CD226 are dysfunctional in Acute Myeloid Leukemia (AML) patients，Clin Immunol. 2018 May;190:64-73.

17. Erxia Shen, Mengjie Wang, Hairui Xie, Ruqiong Zou, Qiwen Lin, Lili lai, Fujun Li, Zhimei Liang, Yanran Xu, and Maohua Zhou. Existence of Th22 in children and evaluation of IL-22 + CD4 + T, Th17, and other T cell effector subsets from healthy children compared to adults. BMC Immunol. 2016 Jun 23;17(1):20.

18. Zhou M, Zou R, Gan H, Liang Z, Li F, Lin T, Luo Y, Cai X, He F, Shen E *.The effect of aging on the frequency, phenotype and cytokine production of human blood CD4 + CXCR5 + T follicular helper cells: comparison of aged and young subjects. Immun Ageing. 2014 Aug 23;11:12.

19. Shen E, Zhao K, Wu C, Yang B*. The suppressive effect of CD25+Treg cells on Th1 differentiation requires cell-cell contact partially via TGF-β production. Cell Biol Int. 2011;35(7), 705–712.

20. Shen E, Lu L, Wu C*. TLR7/8 ligand, R-848, inhibits IgE synthesis by acting directly on B lymphocytes. Scand J Immunol. 2008; 67(6):560-568.

21. Shen E#, Li L#, Li L, Feng L, Lu L, Yao Z, Lin H, Wu C*. PIKA as an adjuvant enhances specific humoral and cellular immune responses following the vaccination of mice with HBsAg plus PIKA. Cell Mol Immunol. 2007; 4(2):113-120.