个人概况

姓  名：MahmoudAL-Azab              性  别 :  男

国  家：也门                       导师层次 ：硕导

技术职称：教授                       导师类型 ：学术型

最后学历：博士研究生                     最后学位 ：博士学位  

工作单位：广州医科大学                  邮   箱：azab.m12@gmail.com

个人简介

Professor Mahmoud AL-Azab is a distinguished professor of Guangzhou Medical University and a Nanshan scholar. Dr. AL-Azab Mahmoud received his Ph.D. from Dalian Medical University in 2019 and then did postdoctoral research at the Guangzhou Women and Children Medical Center jointly with Institute of Immunology and Infection, Shanghai, Chinese Academy of Sciences. He joined Guangzhou Medical University in November 2024. Professor Mahmoud AL-Azab has strong academic background in immunology, medical microbiology, and cellular signaling pathways. His area of expertise is the exploring of the underling mechanisms of inflammatory diseases, autoimmune and autoinflammatory diseases, in order to introduce the possible therapeutic strategies. His work published at Nature Immunology, Nature Communications, Nature Reviews Immunology, and Nature Cardiovascular Research journals.  

Since he started job at Guangzhou Women and Children’s Medical Center-China, he worked on a project focusing to understand the role of NAS-TLRs regulator, UNC93B1, in the underline mechanisms of systemic lupus erythematosus. In another project, the work focused to discover the role of REXO2 exonuclease in the pathogenesis of persistent skin rash. In this project, a novel human interferonopathy caused by a dominant negative mutation in REXO2 was identified.  

As a Nan Shan scholar backbone talent professor at Guangzhou Medical University, he is working in promising projects focusing to understand the role of UNC93B1 in age-associated autoreactive B cells development, the role of neutrophils in model with IRF2 knock out, and Rexo2 as a target in immunotherapy.

研究方向

Innate Immunity先天免疫病;Autoimmunity自身免疫病;Inflammation炎症

代表性第一和通讯作者论文：

1. Al-Azab M, Idiiatullina E, Liu Z, Lin M, Hrovat-Schaale K, Xian H, Zhu J, Yang M, Lu B, Zhao Z, Liu Y, Chang J, Li X, Guo C, Liu Y, Wu Q, Chen J, Lan C, Zeng P, Cui J, Gao X, Zhou W, Zhang Y, Zhang Y, Masters SL. Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus. Nat Immunol. 2024 Jun;25(6):969-980. doi: 10.1038/s41590-024-01846-5. Epub 2024 Jun 3. PMID: 38831104. https://pubmed.ncbi.nlm.nih.gov/38831104/

2. Two rare UNC93B1 variants contribute to childhood-onset lupus. Nat Immunol25, 951–952 (2024). https://doi.org/10.1038/s41590-024-01850-9, Research Briefing.

3. Idiiatullina E, Al-Azab M (Co-first author), Lin M, Hrovat-Schaale K, Liu Z, Li X, Guo C, Chen X, Li Y, Gao S, Cui J, Zhou W, Liu L, Zhang Y, Masters SL. Heterozygous de novo dominant negative mutation of REXO2 results in interferonopathy. Nat Commun. 2024 Aug 6;15(1):6685. doi: 10.1038/s41467-024-50878-w. PMID: 39107301; PMCID: PMC11303720. https://pubmed.ncbi.nlm.nih.gov/39107301/