个人概况
姓 名：任艺 性 别： 女
民 族：汉族 导师层次：硕导/博导
技术职称：教授 导师类型：学术型
最后学历：博士 最后学位：博士
工作单位：广州医科大学基础医学院 邮 箱：yren05@gzhmu.edu.cn
个人简介
英国帝国理工学院博士毕业。广州医科大学南山学者杰出人才，曾任佛罗里达州立大学医学院终身正教授，神经炎症与神经免疫学杰出教授，英国皇家学会Dorothy Hodgkin研究基金获得者。现任广州医科大学基础医学院和广州医科大学附属第一医院神经科教授。一直致力于神经损伤与修复领域的研究。持续获得美国国立卫生、美国科学院及多家基金会资助，科研成果发表在 Nature Neuroscience (被Faculty1000列为推荐文章), Proc. Natl. Acad. Sci. USA （2篇）, Journal of Experimental Medicine, Cancer Research 等期刊，谷歌学术引用超10,100次，H指数为48.
研究方向
神经炎症及神经免疫
主持科研项目
Active Grant Support
1. NIH R01NS12646801 2022 - 2027
Exploring the therapeutic mechanisms of proinflammatory myelin-laden macrophages retention in the injured spinal lesion core
Role: Principal Investigator
2. NIH R21NS123595 2022 - 2026 (NCE)
Emerging role of exosomes derived from peripheral immune cells in regulation of neuroinflammation in response to neural injury
Role: Principal Investigator
3. National Science Foundation (NSF) DMS- 2054014 2021-2026 (NCE)
Developing statistical learning methods for revealing the molecular signatures of microvascular changes in neural injury
Role: Principal Investigator
Previous Grant Support
1. National Science Foundation (NSF) DMS-166172 2017 – 2024
Statistical Methods for RNA-seq based Transcriptomic Analysis of Macrophage Function in Spinal Cord Injury
Role: Principal Investigator
2. Bryon Riesch Paralysis Foundation 2021 – 2024
Multipronged approaches to facilitate lesion healing by targeting disease-promoting macrophages in the injured spinal cord
Role: Principal Investigator
3. Florida Department of Health 21L10 2021-2023
Modeling Human Pediatric Brain Tumor Microenvironment
Role: Co- Principal Investigator
4. National Institute of Health R01 GM072611 2018-2023
Statistical Methods for Ultrahigh Dimensional Biomedical Data
Role: Co-Principal Investigator
5. Florida State University College of Medicine 2020-2021
Exosomes from myelin-laden macrophages deliver myelin-enriched miRNAs to glia, promoting their activation in spinal cord injury
Role: Principal Investigator
6. Florida State University Office of Research Development 2022-2021
Targeting macrophage activation-induced microvascular injury to treat COVID-19
Role: Principal Investigator
7. National Institute of Health R03 CA202334-01A1 2017-2019
Microdevice-armed macrophage for treating cancer
Role: Co-Principal Investigator
8. National Science Foundation (NSF). 2015-2018
Biomanufacturing: Development of a Universal Technique for Functionalizing Therapeutic Cells with Microdevices.
Role: Co-Principal Investigator
9. New Jersey Commission on Spinal Cord Research CSCR13IRG006 2013-2018
Myelin debris-derived lipid accumulation modulates the function of macrophages in spinal cord injury
Role: Principal Investigator
10. National Institute of Health R01 GM100474 2011-2016
Novel Quantitative Methods for Genome-wide Analysis of Stem Cell induced Macrophage Activation
Role: Consortium Principal Investigator
11. National Science Foundation DMS-0714589 2007-2015 (NCE)
Development of Bioinformatic methods for studying Gene expression network between inflammation and neuronal regeneration
Role: Principal Investigator
12. Joyce and Les Goodman Scholar 2007-2013
Stem cell research.
Role: Principal Investigator
13. New Jersey Commission on Spinal Cord Research 07-3068-SCR-E-0 2007-2011
The role of macrophage migration inhibitory factor in spinal cord injury
Role: Principal Investigator
14. Princeton NIH subcontract 2007-2010
The Role of Macrophage migration inhibitory factor (MIF) in neuroblastoma angiogenesis
Role: Principal Investigator
15. Hong Kong S.K.Yee Medical Foundation 2003-2006
Improving the survival and quality of life of children with cancers in China
Role: Co-Investigator
16. Hong Kong Research Grant Council 2002-2004
Lipopolysaccharide potentiates phagocyte clearance of neutrophils undergoing apoptosis
Role: Principal Investigator
17. British Royal Society 1995-2000
CD36 gene transfer to confer phagocytosis capacity
Role: Principal Investigator
代表性第一和通讯作者论文
Total google citations over 10,100 times, H-index 48
* Corresponding author
1. Wang X*, Cheng ZJ, Tai WJ, Shi MJ, Ayazi M, Liu Y, Sun L, Yu CY, Fan ZM, Guo B, He XJ, Sun DM, Young W, Ren Y.* Targeting foamy macrophages by manipulating ABCA1 expression to facilitate lesion healing in the injured spinal cord. Brain, Behavior, and Immunity. 2024 Apr 16:S0889-1591(24)00358-1. doi: 10.1016/j.bbi.2024.04.013.
2. Poppell M, Hammel G and Ren Y*. Immune Regulatory Functions of Macrophages and Microglia in Central Nervous System Diseases. Int J Mol Sci. 2023 Mar 21;24(6):5925. doi: 10.3390/ijms24065925.
3. Ayazi M, Zivkovic S, Hammel G, Stefanovic B and Ren Y*. Fibrotic Scar in CNS Injuries: From the Cellular Origins of Fibroblasts to the Molecular Processes of Fibrotic Scar Formation. Cells. 2022 Aug 2;11(15):2371. doi: 10.3390/cells11152371.
4. Hammel G, Zivkovic S, Ayazi M, and Ren Y*. Consequences and mechanisms of myelin debris uptake and processing by cells in the central nervous system. Cellular Immunology. 2022. 104591. Aug. doi.org/10.1016/j.cellimm.
5. Liu Y, Hammel G, Shi MJ, Cheng ZJ, Zivkovic S, Wang XQ, Xu PY, He XJ, Guo B, Ren Y*, Zuo L*. Myelin debris stimulates NG2/CSPG4 expression in bone marrow-derived macrophages in the injured spinal cord. Front. Cellular Neurosci. 2021. 19;15:651827. doi: 10.3389/fncel.2021.651827.
6. Zivkovic S, Ayazi M, Hammel G, Ren Y*. For better or for worse: a look into neutrophils in traumatic spinal cord injury. Front. Cellular Neurosci. 2021. 22;15:648076. doi: 10.3389/fncel.2021.648076.
7. Ban Y, Dong WJ, Zhang LX, Zhou T, Altiti AS, Ali K, Mootoo D, Blaho VA, Hla T, Ren Y* and Ma XJ*. Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis. Front. Immunol. 2019. 19;10:404.
8. Zhou T, Zheng YM*, Sun L, Badea SR, Jin YH, Liu Y, Rolfe A, Sun H, Wang X, Cheng ZJ, Huang ZS, Zhao N, Sun X, Li JH, Fan JQ, Lee C, Megraw M, Wu WT, Wang GX* and Ren Y*. Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury. Nature Neurosci. 2019. 22(3):421-435 (Highlighted at Faculty 1000, DOI: 10.3410/f.734888686.793558531)
9. Zhou QS, Xiang HK, Li A, Lin W, Huang ZS, Guo JX, Wang PJ, Chi YJ, Xiang K, Xu YS, Zhou LB, So KF, Chen XM, Sun X, Ren Yi*. Activating Adiponectin Signaling with Exogenous AdipoRon Reduces Myelin Lipid Accumulation and Suppresses Macrophage Recruitment after Spinal Cord Injury. J. Neurotrauma. 2019. 19;36(6):903-918.
10. Rolfe A, Bosco D, Broussard E and Ren Y*. In Vitro Phagocytosis of Myelin Debris by Bone Marrow-Derived Macrophages. JoVE. 2017 Dec 30;(130). doi: 10.3791/56322.
11. Cheng ZJ, Bosco DB, Sun L, Chen XM, Xu YS, Tai WJ, Didier R, Li JH, Fan JQ, He XJ and Ren Y*. Neural stem cell-conditioned medium suppresses inflammation and promotes spinal cord injury recovery. Cell transplantation. 2017. 26:469-482.
12. Sun X, Jones Z, Chen XM, Zhou LB, So KF and Ren Y*. Multiple organ dysfunction and systemic inflammation after spinal cord injury: a complex relationship. J. Neuroinflammation. 2016. 6;13(1):260.
13. Jones Z and Ren Y*. Sphingolipids in spinal cord injury. Int. J. Physiol. Pathophysiol. Pharmacol. 2016;8(2):52-69.
14. Rolfe AJ, Bosco DB, Wang JY, Nowakowski RS, Fan JQ and Ren Y*. Bioinformatic Analysis Reveals the Expression of Unique Transcriptomic Signatures in Zika Virus Infected human Neural Stem Cells. Cell & Bioscience. 2016. 6:42. DOI 10.1186/s13578-016-0110-x.
15. Guo L, Rolfe AJ, Wang X, Tai W, Cheng Z, Cao K, Chen X, Xu Y, Sun D, Li J, He X, Young W, Fan J, Ren Y*. Rescuing macrophage normal function in spinal cord injury with embryonic stem cell conditioned media. Mol. Brain. 2016. 9(1): 48.
16. Lai XH, Xu YS, Chen XM and Ren Y*. Macrophage cell death upon intracellular bacterial infection. Macrophage. 2015. 2:e779. PMID: 26690967
17. Wang Xi, Cao K, Sun X, Chen YX, Duan ZX, Sun Li, Guo L, Bai P, Sun DM, Fan JQ, He XJ, Young W and Ren Y*. Macrophages in spinal cord injury: phenotypic and functional change from exposure to myelin debris. Glia. 2015. 63: 635–651. PMID: 25452166
18. Zhou X, He XJ and Ren Y*. Function of microglia and macrophages in secondary damage after spinal cord injury. Neural Regeneration Research. 2014. 9:1787-1795. Invited review. PMID: 25422640
19. Chen TX, Wang Xi, Guo L, Wu MM, Duan ZX, Lv J, Tai WJ, Renganathan H, Didier R, Li JH, Sun DM, Chen XM, He XJ, Fan JQ, Young W and Ren Y*. Embryonic stem cells promoting macrophage survival and function are crucial for teratoma development. Frontiers in Immunology. 2014. 5:1-16. PMID: 25071759
20. Ren Y* and Young W. Managing inflammation after spinal cord injury through manipulation of macrophage function. Neural Plasticity. 2013. Vol. 2013: Article ID 945034. PMCID: PMC3833318. Invited review. PMID: 24288627
21. Wang X, Fan JQ, Lin, L, Cao K, Duan ZX, Chen TX, Zhang XJ, Shao CS, Tadmori I, Li TY, Sun DM, Zheng SS, Meinhardt A, Young W, Bucala R and Ren Y*. MIF Produced by Bone Marrow-Derived Macrophages Contributes to Teratoma Progression after Embryonic Stem Cell Transplantation. Cancer Res. 2012. 71:2867-2878. PMID: 22461508
22. Sun X, Wang X, Chen TX, Li TY, Cao K, Lu A, Chen YX, Sun DM, Luo JH, Fan JQ, Young W and Ren Y*. Myelin activates FAK/Akt/NF-κB pathways and provokes CR3-dependent inflammatory response. PLoS ONE. 2010. 5(2):e9380. PMID: 20186338
23. Li W, Xie Y, Sun R, Liu Q, Young J, Yu WY, Che CM, Tam P and Ren Y*. Inhibition of Akt sensitizes neuroblastoma cells to gold(III) porphyrin 1a, a novel anti-tumor drug induced apoptosis and growth inhibition. British J. Cancer. 2009. 101:342-349. PMID: 19550420
24. Xie Y, Fan JQ, Chen JH, Huang FP, Cao B, Tam PKH and Ren Y*. A novel function for dendritic cell: clearance of VEGF via VEGF receptor-1. Biochem. Biophys. Res. Commun. 2009. 380: 243-248. PMID: 19167346
25. Ren Y*, Xie Y, Jiang GP, Fan JQ, Yeung J, Li W, Tam T and Savill J. Apoptotic cells protect mice against LPS-induced shock. J. Immunol. 2008. 180: 4978-4985. PMID: 18354223
26. Xie Y, Chan HM, Fan JQ, Chen YX, Young J, Li W, Miao XP, Yuan ZW, Wang HM, Tam P and Ren Y*. Involvement of Visinin Like Protein-1 (VSNL-1) in Regulating Proliferative and Invasive Properties of Neuroblastoma. Carcinogenesis. 2007. 28(10):2122-30. PMID: 17615261
27. Fan JQ and Ren Y. Statistical Analysis of DNA Microarray Data in Cancer Research. Clin. Cancer Res. 2006. 12(15):4469-4473. PMID: 16899590
28. Ren Y*, Chan HM, Fan JQ, Chen YX, Xie Y, Li W, Jiang GP, Liu Q, Meinhardt A and Tam P. Inhibition of Tumor Growth and Metastasis in vitro and in vivo by Targeting Macrophage Migration Inhibitory Factor in Human Neuroblastoma. Oncogene. 2006 Jun 15; 25(25):3501-8. PMID: 16449971
29. Fan JQ, Chen YX, Chan HM, Tam P and Ren Y*. Removing intensity effects and identifying significant genes for Affymetrix arrays in MIF-suppressed neuroblastoma cells. Proc. Natl. Acad. Sci. USA. 2005 Dec. 102 (49):17751-17756. PMID: 16314559
30. Ren Y*, Cao B, Law S, Xie Y, Lee PY, Cheung L, Chen YX, Huang X, Chan HM, Zhao P, Luk L, Vande Woude G and John Wong. Hepatocyte Growth Factor Promotes Cancer Cell Migration and Angiogenic Factors expression: A Prognostic Marker of Human Esophageal Squamous Cell Carcinomas. Clin. Cancer Res. 2005.Sep. 11(17): 6190-6197. PMID: 16144920
31. Ren Y*, Law S, Huang X, Lee PY, Li Z, Bacher M, Srivastava G and Wong J. Macrophage Migration Inhibitory Factor Stimulates Angiogenic Factors Expression, Correlates with Differentiation and Lymph Node Status in Patients with Esophageal Squamous Cell Carcinoma. Ann. Surg. 2005. 242 (1): 55-63. PMID: 15973102
32. Ren Y*, Lin CL, Li Z, Chen YX, Huang X, Lui V, Nicholls J, Lan HY and Tam P. Up-regulation of macrophage migration inhibitory factor in infants with acute neonatal necrotizing enterocolitis. Histopathology. 2005. 46(6):659-67. PMID: 15910597
33. Ren Y*, He QY, Fan JQ, Jones B, Zhou Y, Xie Y, Cheung CY, Wu A, Chiu JF, Peiris JSM and Tam P. The Use of Proteomics in the Discovery of Serum Biomarkers from Patients with Severe Acute Respiratory Syndrome (SARS). Proteomics. 2004 Nov; 4(11):3477-84. PMID: 15378763
34. Fan JQ, Tam P, Vande Woude G and Ren Y*. Normalization and significant analysis of cDNA microarrays using within-array replications applied to tumor cells response to MIF. Proc. Natl. Acad. Sci. USA. 2004. 101 (5): 1135-1140. PMID: 14739336
35. Ren Y*, Chen HM, Li Z, Lin CL, Nicholls J, Chen ZF, Lee PY, Lui V, Bacher M and Tam P. Up-regulation of macrophage migration inhibitory factor contributes to induced N-Myc expression by activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma. Oncogene. 2004 23(23):4146-54. PMID: 15064733
36. Ren Y*, Poon RTP, Tsui HT, Li Z, Lau C, Yu WC and Fan ST. Interleukin-8 serum levels in patients with hepatocellular carcinoma: correlations with clinico-pathological features and prognosis. Clin. Cancer Res. 2003 Dec 9: 5996-6001. PMID: 14676125
37. Ren Y, Tang JL, MoK T, Chan AWK, Wu A and Lau CS*. Increased apoptotic blood neutrophils and macrophages and decreased clearance of apoptotic neutrophils in systemic lupus erythematosus. Arthritis & rheumatism. 2003 Oct 48 (10): 2888-97. PMID: 14558095
38. Ren Y*, Tsui HT, Poon RTP, Li Z, Chen YX, Lau C, Bacher M and Fan ST. Macrophage migration inhibitory factor: roles in regulating tumor cell migration and expression of angiogenic factors in hepatocellular carcinoma. Int. J. Cancer. 2003. 107; 22-29. PMID: 12925952.
39. Ren Y, Stuart L, Lindberg FP, Rosenkranz AR, Chen Y, Mayadas TN and Savill J*. Nonphlogistic clearance of late apoptotic neutrophils by macrophages: efficient phagocytosis independent of b2 intergrins. J. Immunol. 2001 April; 166: 4743-4750. PMID: 11254736
40. Ren Y, Savill J*. Apoptosis: The importance of being eaten. Cell Death. Differ.1998; 5(7): 563-8. PMID: 10200510
41. Ren Y, Silverstein RL, Allen J and Savill J*. CD36 gene-transfer confers capacity for phagocytosis of cells undergoing apoptosis. J. Exp. Med. 1995; 181(5): 1857-62. PMID: 7536797
42. Ren Y, Savill J*. Proinflammatory cytokines potentiate thrombospondin-mediated phagocytosis of neutrophils undergoing apoptosis. J. Immunol. 1995; 154(5): 2366-74. PMID: 7532668
