【个人简介】

陈枫虹，医学博士，主任医师，博士生导师，博士后合作导师，广医二院耳鼻咽喉科主任，教研室主任，规培基地主任

学习工作经历：

2008年硕士毕业于中山大学中山医学院临床医学七年制

2008-2024 中山大学附属第一医院耳鼻咽喉科副主任医师

2012-2015 中山大学临床医学耳鼻咽喉科学博士

2017-2019 美国西南医学中心免疫学博士后

2023 美国哈佛布列根妇女医院过敏科访问学者（短期）

2024.2-至今 广州医科大学附属第二医院耳鼻喉科科室主任，主任医师

【研究方向】

慢性鼻窦炎和鼻息肉，特别是难治性慢性鼻窦炎，伴哮喘的慢性鼻窦炎，变应性鼻炎免疫治疗。

【科研项目】

1.国家自然科学基金面上项目, IL-13与SPLUNC1交互调节作用调控eotaxin-3表达促进鼻息肉的嗜酸性粒细胞炎症，2023-01至2026-12，52万，在研，主持。

2.国家自然科学基金青年项目, LL37-DNA复合物对鼻息肉中树突状细胞和Th1/Th17极化的调控，2018-01至2020-12，20万，已结题，主持。

3.广东省自然科学基金-博士启动, 抗菌肽LL-37促进中性粒细胞性鼻息肉中Th1/17极化和机制研究，2016-06至2019-06，10万，已结题，主持。

【代表性论文及著作】

1.Type I interferon suppresses memory Th2 cell cytokine secretion from allergic subjects.Chen F, Rowe RK, Gill MA, Farrar JD. Allergy. 2020 Mar;75(3):695-698. doi: 10.1111/all.14056. Epub 2019 Oct 8.

2.经鼻内镜低温等离子辅助下鼻咽纤维血管瘤切除术及疗效分析.陈枫虹,刘文冬,陈靖媛,陈楚欣,郭圆媛,史剑波.临床耳鼻咽喉头颈外科杂志,2024年38卷6期,DOI:10.13201/j.issn.2096-7993.2024.06.10

3.Guo Y, Nie Z, Chen C, Xu Z, Liu W, Lai Y, Fan Y, Shi J, Chen F. Outcomes of endoscopic sinus surgery in patients with central compartment atopic disease. World Allergy Organ J. 2024 Jan 24;17(2):100859. doi: 10.1016/j.waojou.2023.100859. eCollection 2024 Feb.

4.Cong Li 1, Bo Zhang 2, Min Yan 2, Yueqi Li 3, Jingyuan Chen 3, Zhiying Nie 4, Yuanyuan Guo 4, Jianbo Shi 3, Fenghong Chen 5，Cluster analysis of patients with chronic rhinosinusitis and asthma after endoscopic sinus surgery. Ann Allergy Asthma Immunol, . 2023 Mar;130(3):325-332.e7. doi: 10.1016/j.anai.2022.11.013. Epub 2022 Nov 25.

5.Zhiying Nie , Zhaofeng Xu , Yunping Fan , Yuanyuan Guo, Chuxin Chen, Wendong Liu, Yueqi Li , Yinyan Lai , Jianbo Shi ,Fenghong Chen .Clinical characteristics of central compartment atopic disease in Southern China.International Forum of Allergy & Rhinology. 2023 Mar;13(3):205-215. doi: 10.1002/alr.23069. Epub 2022 Sep 21.

6.LL-37 promotes neutrophil extracellular trap formation in chronic rhinosinusitis with nasal polyps. Cao Y, Chen F, Sun Y, Hong H, Wen Y, Lai Y, Xu Z, Luo X, Chen Y, Shi J, Li H. Clin Exp Allergy. 2019 Jul;49(7):990-999. doi: 10.1111/cea.13408. Epub 2019 May 29.

7.The effects of endoscopic sinus surgery on pulmonary function in chronic rhinosinusitis patients with asthma: a systematic review and meta-analysis. Cao Y, Hong H, Sun Y, Lai Y, Xu R, Shi J, Chen F. Eur Arch Otorhinolaryngol. 2019 May;276(5):1405-1411. doi: 10.1007/s00405-019-05337-4. Epub 2019 Feb 25.

8.Prediction models for postoperative uncontrolled chronic rhinosinusitis in daily practice. Xiaoyao Tao, Fenghong Chen, Yueqi Sun, Shulian Wu, Haiyu Hong, Jianbo Shi, Rui Xu. Laryngoscope. 2018 Dec;128(12):2673-2680. doi: 10.1002/lary.27267.

9.基于百度指数分析中国变应性鼻炎流行的时空特征. 曹玉洁 徐睿 陶逍遥 史剑波 陈枫虹. 中华耳鼻咽喉头颈外科杂志2019 年12月第54 卷第12期

10.Hong H, Chen F, Sun Y, Yang Q, Gao W, Cao Y, Fan Y, Shi J, Li H. Nasal IL25 predicts the response to oral-corticosteroid in chronic rhinosinusitis with nasal polyps (CRSwNP). J Allergy Clin Immunol. 2018 May;141(5):1890-1892. doi: 10.1016/j.jaci.2017.10.050. Epub 2018 Jan 11.

11.Hong H, Chen F, Zheng X, Liao W, Liao Z, Cao Y, He H, Zhu Z, Fan Y. Decreased frequency of adenoidectomy by a 12-week nasal budesonide treatment. Ther Clin Risk Manag. 2017 Oct 3;13:1309-1316. doi: 10.2147/TCRM.S144659. eCollection 2017. (共一) 2.2，1178-203X

12.Chen F, Hong H, Sun Y, Hu X, Zhang J, Xu G, Zhao W, Li H, Shi J. Nasal interleukin 25 as a novel biomarker for patients with chronic rhinosinusitis with nasal polyps and airway hypersensitiveness: A pilot study. Ann Allergy Asthma Immunol. 2017 Sep 1. pii: S1081-1206(17)30553-7. doi: 10.1016/j.anai.2017.07.012.

13.Hong H, Chen F, Sun Y, Hu X, Wei Y, Fan Y, Zhang J, Wang D, Xu R, Li H, Shi J. Local IL-25 contributes to Th2-biased inflammatory profiles in nasal polyps. Allergy. 2018 Feb;73(2):459-469. DOI: 10.1111/all.13267. (共一)

14.Hong H, Chen F, Qiao Y, Yan Y, Zhang R, Zhu Z, et al. GSK-3beta activation index is a potential indicator for recurrent inflammation of chronic rhinosinusitis without nasal polyps. J Cell Mol Med. 2017 Jul 17. doi: 10.1111/jcmm.13274. (共一) 4.499

15.Zheng R, Chen FH, Gao WX, Wang D, Yang QT, Wang K, et al. The TH2-polarizing function of atopic interleukin 17 receptor B-positive dendritic cells up-regulated by lipopolysaccharide. Ann Allergy Asthma Immunol 2017;118(4):474-482 e471. (共一)

16.Liu J, Chen FH, Qiu SQ, Yang LT, Zhang HP, Liu JQ, et al. Probiotics enhance the effect of allergy immunotherapy on regulating antigen specific B cell activity in asthma patients. Am J Transl Res 2016;8(12):5256-5270. (共一)，2.829

17.Chen FH, Deng J, Hong HY, Xu R, Guo JB, Hou WJ, et al. Extensive versus functional endoscopic sinus surgery for chronic rhinosinusitis with nasal polyps and asthma: A 1-year study. Am J Rhinol Allergy 2016;30(2):143-148

18.Chen F, Luo X, Xu R, Deng J, Zuo K, Li H, Shi J. Evaluation of airway hyperresponsiveness in chronic rhinosinusitis: values of sinus computed tomography. Ann Allergy Asthma Immunol 2014; 113(6): 609-613

19.Chen FH, Zuo KJ, Feng SY, Guo JB, Fan YP, Shi JB, Li HB. A modified surgical procedure for endoscopic optic nerve decompression for the treatment of traumatic optic neuropathy. N Am J Med Sci. 2014 Jun; (6):270-3. doi: 10.4103/1947-2714.134372

20.Xu R, Chen FH, Zuo KJ, Ye,XL, Yang QT, Shi JB, Chen HX, Li HB. Endoscopic optic nerve decompression for patients with traumatic optic neuropathy: is nerve sheath incision necessary? ORL J Otorhinolaryngol Relat Spec. 2014;76(1):44-9. doi: 10.1159/000358305. (并列第一）

21.Chen FH, Zuo KJ, Guo YB, Li ZP, Xu G, Xu R, Shi JB. Long-term results of endoscopic sinus surgery-oriented treatment for chronic rhinosinusitis with asthma. Laryngoscope. 124（1）: 24-8，2014.

22.Chen FH, Rui X, Deng J,et al. Endoscopic sandwich technique for moderate nasal septal perforations. Laryngoscope. 122(11):2367-72, 2012

23.Shi JB, Chen FH, Fu QL, et al. Frontal sinus cerebrospinal fluid leaks: repair in 15 patients using an endoscopic surgical approach. ORL J Otorhinolaryngol Relat Spec. 2010;72(1):56-62. (共同第一)

24.陈枫虹，徐睿，左可军等. 慢性鼻-鼻窦炎合并哮喘患者的功能性鼻内镜鼻窦手术疗效分析. 中华耳鼻咽喉头颈外科杂志.46(6):444-448，2011

25.Zuo KJ, Guo JB, Chen FH, Xu R, Xu G, Li HB. Clinical characteristics and surrogate markers of eosinophilic chronic rhinosinusitis in Southern China. Eur Arch Otorhinolaryngol. 2014 Sep; 271(9):2461-8. doi: 10.1007/s00405-014-2910-0.

【所获荣誉和奖励】

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