马磊,肿瘤学博士,主任医师,研究生导师。肿瘤内科副主任。广州医科大学消化学系委员,广东省胸部疾病学会委员,广东省抗癌协会肉瘤专业委员会委员,广东省精准医学学会委员,广州市老年病医学会委员。曾承担广东省自然科学基金、广东省科技计划、广东省医学科研基金等多项省市级科研项目。研究方向为肿瘤耐药机制和逆转手段。
已发表论文:
1. Long non-coding RNA XIST promotes cell growth and invasion through regulating miR-497/MACC1 axis in gastric cancer. Oncotarget, 2017, 8 (3), 4125-35.
2. Reciprocal regulation of Hsa-miR-1 and long noncoding RNA MALAT1 promotes triple-negative breast cancer development. 2016 June 37(6),7383-94
3. The role of MALAT1/miR-1/slug axis on radioresistance in nasopharyngeal carcinoma. Tumor Biology. 2016 March 37(6),4025-33.
4. Decreased expression of miR-204 is associated with poor prognosis in patients with breast cancer. Int J Clin Exp Pathol. 2014 May 15;7(6):3287-92.
5. The putative tumor suppressor microRNA-497 modulates gastric cancer cell proliferation and invasion by repressing eIF4E. Biochem Biophys Res Commun. 2014 Jun 27;449(2):235-40.
6. Honokiol Suppresses Renal Cancer Cells' Metastasis Via Dual-Blocking Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties through Modulating miR-141/ZEB2 Signaling. Mol Cells. 2014 May 31;37(5):383-8.
7. Down-regulation of miRNA-204 by LMP-1 enhances CDC42 activity and facilitates invasion of EBV-associated nasopharyngeal carcinoma cells. FEBS Lett. 2014 May 2;588(9):1562-70.
8. miR-124 radiosensitizes human glioma cells by targeting CDK4. J Neurooncol. 2013 Sep;114(3):263-74.
9. Cancer stem-like cell properties are regulated by EGFR/AKT/β-catenin signaling and preferentially inhibited by gefitinib in nasopharyngeal carcinoma. FEBS J. 280(9):2027-41, 2013.
10. Esophageal cancer tumorspheres involve cancer stem-like populations with elevated aldehyde dehydrogenase enzymatic activity. Mol Med Rep. 6(3):519-24, 2012 .