个人概况

钟文彬，博士，教授，“南山学者”优秀人才，博士生导师，博士后合作导师。主要研究方向是恶性血液肿瘤发生发展及耐药的分子机理。聚焦细胞能量代谢和脂质代谢，利用动物模型和多组学技术，筛选鉴定白血病细胞生存、免疫逃逸和耐药等恶性行为的重要调控因子，发现新的治疗靶标并进行临床应用转化研究。以第一作者或通讯作者在国际学术期刊Science Translational Medicine，Blood，Nature Communications，Circulation Research，Cell Reports，J Biol Chem等发表研究论文10多篇。

联系方式：Email: winbeyz@163.com；Tel: 15913146856。

工作经历

2023.3至今：广州医科大学，附属肿瘤医院，教授

2018.3-2023.2：暨南大学，生命科学技术学院，教授

2015.9-2018.2：暨南大学，生命科学技术学院，研究助理

研究领域

1、细胞代谢重构与血液细胞恶性转化机理

2、白血病细胞生存、免疫逃逸和耐药的分子机理

3、新型抗白血病靶向药物研发

科研项目

1、国家自然科学基金面上项目，2024-2027，49万

2、国家自然科学基金青年项目，2020-2022，24万

3、广州医科大学“南山学者”启动基金，2023-2027，500万

4、暨南大学高层次人才科研配套经费，2018-2021，100万

5、暨南大学中央高校基本科研业务费，2019-2021，15万

学术任职

1、中国生物化学与分子生物学会脂质与脂蛋白专业委员会 委员

2、广东省抗癌协会肿瘤代谢专业委员会 委员

代表性论著（*第一作者，#通讯作者）

1、Chen, H., Lu, C., Tan, Y., Marion Weber-Boyvat, Zheng, J., Xu, M., Xiao, J., Liu, S., Tang, Z., Lai, C., Li, M., Vesa M Olkkonen, Yan, D.#, Zhong, W#. (2023) Oculocerebrorenal syndrome of Lowe (OCRL) controls leukemic T-cell survival by preventing excessive PI(4,5)P2 hydrolysis in the plasma membrane. J Biol Chem. 299(6):104812. (IF: 5.4, 2区TOP)

2、Zhong，W.*, Cao X.*, Pan G., Niu Q., Feng X., Xu M., Li M., Huang Y., Yi Q., Yan D. (2022) Oxysterol-binding protein-related protein 4L (ORP4L) is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1 (HTLV-1). Blood. 139 (7): 1052–1065. (IF: 25.4, 1区)

3、Zhu B.*, Zhong W.*, Pan G.*, Cao X.*, Xu M.*, Zheng J., Chen H., Feng X., Luo C., Lu C., Lin W., Lai C., Du X., Yi Q., Yan D. (2022) Loss of miR-31-5p drives hematopoietic stem cell deterioration and restoration eliminates leukemia stem cells. Sci Transl Med 14(629):eabh2548. (IF: 19.3，1区), 新华社报道 （http://www.news.cn/english/20220127/bfa3590bda504df9ad495cd1bcff974b/c.html）.

4、Zhong W#, Lin W, Yang Y, Chen D, Cao X, Xu M, Pan G, Chen H, Zheng J, Feng X, Yang LH, Lai C, Olkkonen VM, Xu J, Cui S, Yan D. (2022) An acquired PI(4)P transport initiates T-cell deterioration. Nat Commun. 29;13(1):4390. (IF：17.6，1区)。

5、Xu, M., Zhu, B., Cao, X., Li, S., Li, D., Zhou, H., Olkkonen, V. M., Zhong, W.#, Xu, J.#, and Yan, D.# (2020) OSBP-Related Protein 5L Maintains Intracellular IP3/Ca(2+) Signaling and Proliferation in T Cells by Facilitating PIP2 Hydrolysis. J Immunol 204, 1134-1145. (IF: 5.4，2区TOP)

6、Cao, X., Chen, J., Li, D., Xie, P., Xu, M., Lin, W., Li, S., Pan, G., Tang, Y., Xu, J., Olkkonen, V. M., Yan, D.#, and Zhong, W.# (2019) ORP4L couples IP3 to ITPR1 in control of endoplasmic reticulum calcium release. FASEB J 33, 13852-13865. (IF: 5.8，2区TOP)

7、Pan, G., Cao, X., Liu, B., Li, C., Li, D., Zheng, J., Lai, C., Olkkonen, V. M., Zhong, W.#, and Yan, D. #(2018) OSBP-related protein 4L promotes phospholipase Cbeta3 translocation from the nucleus to the plasma membrane in Jurkat T-cells. J Biol Chem 293, 17430-17441. (IF: 5.4, 2区TOP)

8、       Zhu, B., Cao, X., Zhang, W., Pan, G., Yi, Q., Zhong, W.#, and Yan, D.# (2019) MicroRNA-31-5p enhances the Warburg effect via targeting FIH. FASEB J 33, 545-556. (IF: 5.8，2区TOP，ESI高被引论文)

9、Zhong, W.*, Xu, M.*, Li, C., Zhu, B., Cao, X., Li, D., Chen, H., Hu, C., Li, R., Luo, C., Pan, G., Zhang, W., Lai, C., Wang, T., Du, X., Chen, H., Xu, G., Olkkonen, V. M., Lei, P., Xu, J., and Yan, D. (2019) ORP4L Extracts and Presents PIP2 from Plasma Membrane for PLCbeta3 Catalysis: Targeting It Eradicates Leukemia Stem Cells. Cell Rep 26, 2166-2177 e2169. (IF: 9.9，1区)，中国科学报报道（https://news.sciencenet.cn/sbhtmlnews/2019/2/343620.shtm）.

10、Zhong, W.*, Pan, G.*, Wang, L.*, Li, S., Ou, J., Xu, M., Li, J., Zhu, B., Cao, X., Ma, H., Li, C., Xu, J., Olkkonen, V. M., Staels, B., and Yan, D. (2016) ORP4L Facilitates Macrophage Survival via G-Protein-Coupled Signaling: ORP4L-/- Mice Display a Reduction of Atherosclerosis. Circ Res 119, 1296-1312. (IF: 23.2，1区，编辑评述文章)

11、Zhong, W.*, Yi, Q., Xu, B., Li, S., Wang, T., Liu, F., Zhu, B., Hoffmann, P. R., Ji, G., Lei, P., Li, G., Li, J., Li, J., Olkkonen, V. M., and Yan, D. (2016) ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival. Nat Commun 7, 12702. (IF: 17.6，1区)

12、Zhong, W.*, Qin, S.*, Zhu, B., Pu, M., Liu, F., Wang, L., Ye, G., Yi, Q., and Yan, D. (2015) Oxysterol-binding protein-related protein 8 (ORP8) increases sensitivity of hepatocellular carcinoma cells to Fas-mediated apoptosis. J Biol Chem 290, 8876-8887. (IF: 5.4，2区TOP)

13、Zhong, W.*, Zhou, Y.*, Li, J., Mysore, R., Luo, W., Li, S., Chang, M. S., Olkkonen, V. M., and Yan, D. OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle. Exp Cell Res 322, 227-235, (2014). (IF: 4.1)

14、 Ma, H.*, Zhong, W.*, Jiang, Y., Fontaine, C., Li, S., Fu, J., Olkkonen, V. M., Staels, B., and Yan, D. Increased atherosclerotic lesions in LDL receptor deficient mice with hematopoietic nuclear receptor Rev-erbalpha knock- down. J Am Heart Assoc 2, e000235, (2013). (IF: 6.1)

15、Zhong, W.*, Zhou, Y., Li, S., Zhou, T., Ma, H., Wei, K., Li, H., Olkkonen, V. M., and Yan, D. OSBP-related protein 7 interacts with GATE-16 and negatively regulates GS28 protein stability. Exp Cell Res 317, 2353-2363, (2011).  (IF: 4.1)