李明川，博士，教授，“南山学者”骨干人才。主要研究方向为磷脂代谢在癌症、抗癌药物心肌毒性中的作用和分子机制。近年累积发表研究论文20余篇，其中以第一作者或通讯作者在Circulation、Cardiovascular Research、Frontiers in Pharmacology、BBA-Molecular Cell Research等期刊发表论文8篇。主持国家自然科学基金青年基金项目，广东省基础与应用基础研究基金项目。担任《解放军医学》、Frontiers in Cardiovascular Research杂志青年编委，Oxidative Medicine and Cellular Longevity、Journal of Pharmacy and Pharmacology、FEBS Open Bio等杂志审稿人。
联系方式：mingchuanli@gzhmu.edu.cn
学习经历
2013.01-2017.01，意大利都灵大学，博士
2009.09-2012.07，西安交通大学，硕士
2005.09-2009.07，西安交通大学，学士
工作经历
2023.03至今，广州医科大学 附属肿瘤医院，教授
2019.08-2023.02，暨南大学 生命科学技术学院，副教授
2017.01-2018.12，意大利都灵大学 分子生物技术中心，博士后
主要研究成果
[1] Li M, Sala V, De Santis MC, Cimino J, Cappello P, Pianca N, Di Bona A, Margaria JP, Martini M, Lazzarini E, Pirozzi F, Rossi L, Franco I, Bornbaum J, Heger J, Rohrbach S, Perino A, Tocchetti CG, Lima BHF, Teixeira MM, Porporato PE, Schulz R, Angelini A, Sandri M, Ameri P, Sciarretta S, Lima-Júnior RCP, Mongillo M, Zaglia T, Morello F, Novelli F, Hirsch E, Ghigo A. Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth. Circulation. 2018, 138(7):696-711. (IF: 23.054)
[2] Huang J, Wu R, Chen L, Yang Z, Yan D#, Li M#. Understanding Anthracycline Cardiotoxicity From Mitochondrial Aspect. Frontiers in Pharmacology. 2022, 13: 811406. #Corresponding Authors (IF: 5.810)
[3] Zhu B, Zhong W, Cao X, Pan G, Xu M, Zheng J, Chen H, Feng X, Luo C, Lu C, Xiao J, Lin W, Lai C, Li M, Du X, Yi Q, Yan D. Loss of miR-31-5p drives hematopoietic stem cell malignant transformation and restoration eliminates leukemia stem cells in mice. Science Translational Medicine. 2022, 14(629):eabh2548. (IF: 17.956)
[4] Zhong W, Cao X, Pan G, Niu Q, Feng X, Xu M, Li M, Huang Y, Yi Q, Yan D. ORP4L is a prerequisite for the induction of T-cell leukemogenesis associated with human T-cell leukemia virus 1. Blood. 2022, 139(7):1052-1065. (IF: 22.113)
[5] Li M, Russo M, Pirozzi F, Tocchetti CG, Ghigo A. Autophagy and cancer therapy cardiotoxicity: From molecular mechanisms to therapeutic opportunities. BBA-Molecular Cell Research. 2020, 1867(3):118493. (IF: 4.739)
[6] Russo M, Guida F, Paparo L, Trinchese G, Aitoro R, Avagliano C, Fiordelisi A, Napolitano F, Mercurio V, Sala V, Li M, Sorriento D, Ciccarelli M, Ghigo A, Hirsch E, Bianco R, Iaccarino G, Abete P, Bonaduce D, Calignano A, Berni Canani R, Tocchetti CG. The novel butyrate derivative phenylalanine-butyramide protects from doxorubicin-induced cardiotoxicity. European Journal of Heart Failure. 2019, 21(4):519-528. (IF：13.965)
[7] Ghigo A, Laffargue M, Li M, Hirsch E. PI3K and Calcium Signaling in Cardiovascular Disease. Circulation Research. 2017, 121(3):282-292. (IF: 15.862)
[8] Li M*, Murabito A*, Ghigo A, Hirsch E. PI3Ks in Diabetic Cardiomyopathy. Journal of Cardiovascular Pharmacology. 2017, 70(6):422-429. *equal contributors (IF: 2.371)
[9] Ghigo A*, Li M*, Hirsch E. New signal transduction paradigms in anthracycline-induced cardiotoxicity. BBA-Molecular Cell Research. 2016, 1863(7):1916-25. *equal contributors (IF: 4.739)
[10] Li M, Hirsch E. Akt activation by PHLPP1 ablation prevents pathological hypertrophy by promoting angiogenesis. Cardiovascular Research. 2015, 105:129–130. (IF: 10.787)
[11] Ghigo A, Li M. Phosphoinositide 3-kinase: Friend and foe in cardiovascular disease. Frontiers in Pharmacology. 2015, 6:169. (IF：3.845)
[12] Li M-C*, Liu Q-Q*, Zhang Y-L, Wang L-L, Lu X-Y. Heterologous expression of human costimulatory molecule B7-2 and construction of B7-2 Immobilized PHA nanoparticles as immune activation agent. BMC Biotechnology. 2012, 12:43. *equal contributors (IF: 2.303)
*Equal first contributors, #Corresponding Authors.
承担课题：
[1] 广州医科大学“南山学者”骨干人才配套经费，2023.03-2028.03，主持
[2] 国家自然科学基金青年基金项目，2021.01-2023.12，主持
[3] 广东省基础与应用基础研究基金联合基金青年基金项目，2020.01-2022.12，主持
学术任职：
广东省生物物理学会第九届理事会监事
中国病理生理学会会员
