田允鸿，广州医科大学附属肿瘤医院放疗科，副主任，学术型博士研究生导师，医学博士，副主任医师，美国Emory大学博士后（3年）；广州市高层次人才；广州市高层次卫生人才“医学重点人才”；广州医科大学“南山人才（第五层次）”；羊城青年好医生。以第一作者身份发表相关SCI论文二十余篇，累积影响因子约100余分。
学习或科研经历：
(1) 2018-12至2021-1, 美国Emory大学, 博士后, 导师: Zixu Mao
(2) 2019-5至现在, 广州医科大学, 附属肿瘤医院, 副主任医师
(3) 2016-1至2019-4, 广州医科大学, 附属肿瘤医院, 主治医师
(4) 2014-7至2015-12, 广州医科大学, 附属肿瘤医院, 医师
研究方向与特色：
以鼻咽癌为代表的头颈肿瘤免疫微环境和放疗敏感性的相关研究；非编码RNA的相关研究。
研究成果：
主持国家自然科学基金两项：面上项目，81872195，Lnc-MRPL39-2:1在鼻咽癌上皮间充质转化过程中的作用和分子机制探讨，2019.01至2022.12，53万元。青年项目，81502342，MiR-124通过靶向作用于JAMA抑制鼻咽癌干细胞的机制研究，2016年01月-2018年12月，18万元，结题，主持。广东省自然科学基金：面上项目，外泌体circSLAIN1通过JAMA调控巨噬细胞极化促进鼻咽癌转移的分子机制研究，2023年06月-2025年06月，10万元，主持。参与国家及省级课题多项。
代表性论著：
(1) Tian Y#, Ai M#, Liu C#, Wu Y, Khan M, Wang B, et al. Upregulated Long Non-coding RNA Lnc-MRPL39-2:1 Induces the Growth and Invasion of Nasopharyngeal Carcinoma by Binding to HuR and Stabilizing β-Catenin mRNA. International Journal of Biological Sciences. 2023; 19: 2349-65. IF (2022): 10.750
(2) Tian Y#, Liu C#, Li Z#, Ai M#, Wang B, Du K, et al. Exosomal B7-H4 from irradiated glioblastoma cells contributes to increase FoxP3 expression of differentiating Th1 cells and promotes tumor growth. Redox biology. 2022; 56:102454. IF (2022): 10.787
(3) Khan M., Du, K., Ai, M., Wang, B., Lin, J., Ren, A., Chen, C., Huang, Z., Qiu, W., Yuan, Y. and Tian, Y*. PD-L1 expression as biomarker of efficacy of PD-1/PD-L1 checkpoint inhibitors in metastatic triple negative breast cancer: A systematic review and meta-analysis. Front Immunol. 14:1060308. IF (2022): 8.786
(4) Khan M, Ai M, Du K, Song J, Wang B, Lin J, Ren A，Chen C，Huang Z, Qiu W, Zhang J, Tian Y* and Yuan Y*. Pyroptosis relates to tumor microenvironment rmeling and prognosis: A pan-cancer perspective. Front Immunol.2022;13:1062225. IF (2022): 8.786
(5) Liu W, Zhang J, Xie T, Huang X, Wang B, Tian Y*, Yuan Y*. C1QTNF6 is a Prognostic Biomarker and Related to Immune Infiltration and Drug Sensitivity: A Pan-Cancer Analysis. Frontiers in pharmacology. 2022; 13:855485. IF (2022): 5.988
(6) Tian Yunhong#, Yan M#, Zheng J, Li R, Lin J, Xu A, et al. miR-483-5p decreases the radiosensitivity of nasopharyngeal carcinoma cells by targeting DAPK1. Laboratory investigation; a journal of technical methods and pathology 2019, 99(5):602-611. IF(2019): 3.7
(7) Tian Yunhong#, Lin Jie#, Tian Yunming#, Zhang Guoqian, et al. Efficacy and safety of anti-EGFR agents administered concurrently with standard therapies for patients with head and neck squamous cell carcinoma: A systematic review and meta-analysis of randomized controlled trials. International journal of cancer 2017. IF (2015): 6.5
(8) Tu Yn#, Tian Yunhong#, Fang Z#, Ruan Q, et al. Cytoreductive surgery combined with hyperthermic intraperitoneal chemoperfusion for the treatment of gastric cancer: A single-centre retrospective study, International Journal of Hyperthermia, 2016. 32(6). 587-594 IF (2015): 3.361
(9) Tian Yunhong#, Zou WH#, Xiao WW#, Zeng L, et al. Oligometastases in AJCC stage IVc nasopharyngeal carcinoma: A subset with better overall survival, Head & Neck 2016, 38(8):1152-1157 IF (2015): 2.760
(10) Tian Yunhong#, Xie Q#, He jie, et al. Radioactive I-125 seeds inhibit cell growth and epithelial-mesenchymal transition in human glioblastoma multiforme via a ROS-mediated signaling pathway, BMC cancer, 2015. 15(1) IF (2015): 3.265
(11) Tian Yunhong#, Tian Yunming, et al. Junctional adhesion molecule-A, an epithelial-mesenchymal transition inducer, correlates with metastasis and poor prognosis in human nasopharyngeal cancer, Carcinogenesis, 2015. 36(1). 41-48 IF (2015): 4.874
(12) Tian YM#, Tian Yunhong#, Zeng L#, Liu S, et al. Prognostic model for survival of local recurrent nasopharyngeal carcinoma with intensity-modulated radiotherapy, British Journal of Cancer, 2014. 110(2). 297-303 IF (2014): 4.836
教育经历：
2018/12至2021/01, 美国Emory大学, 博士后, 合作导师: Zixu Mao
2011/09-2014/06，南方医科大学，肿瘤研究所，博士，导师：姚开泰院士
2008/09-2011/06，南方医科大学，放疗科，硕士，导师：袁亚维
2003/09-2008/06，江西医学院，临床医学系，学士
工作背景：
2019/08-至今，广州医科大学附属肿瘤医院，放疗科，副主任医师
2015/12-2019/05，广州医科大学附属肿瘤医院，放疗科，主治医师
2014/7-2015/11，广州医科大学附属肿瘤医院，放疗科，医师
科研项目（主持国家自然科学基金2项：面上项目和青年项目各一项）:
1. 国家自然科学基金委员会，面上项目，81872195，Lnc-MRPL39-2:1在鼻咽癌上皮间充质转化过程中的作用和分子机制探讨，2019.01至2022.12，53万元，主持
2. 国家自然科学基金委员会，基金项目，81502342，MiR-124通过靶向作用于JAMA抑制鼻咽癌干细胞的机制研究，2016年01月-2018年12月，18万元，主持
3. 广东省自然科学基金，面上项目，外泌体circSLAIN1通过JAMA调控巨噬细胞极化促进鼻咽癌转移的分子机制研究，2023年06月-2025年06月，10万元，主持
4. 国家自然科学基金委员会，面上项目，81773354，NR_040402经小胶质细胞极化介导放射性脑损伤的作用及其机制探讨，2018年01月-2021年12月，65万元，第一参与人
5. 国家自然科学基金委员会，青年项目，81602530，EBV-miR-BART7-3p靶向SMAD7促进鼻咽癌细胞“干性”的作用及分子机制，2017年01月-2019年12月，18万元，第二参与人
科研成果：
近几年以第一作者或通讯作者在 Redox biology, International Journal of Biological Sciences, Int J Cancer和British Journal of Cancer 等杂志上发表 SCI 论文近20篇，累积影响因子近100分（其中影响因子>10两篇：发表于2022年和2023年，均为第一作者）
(1) Tian Y#, Ai M#, Liu C#, Wu Y, Khan M, Wang B, et al. Upregulated Long Non-coding RNA Lnc-MRPL39-2:1 Induces the Growth and Invasion of Nasopharyngeal Carcinoma by Binding to HuR and Stabilizing β-Catenin mRNA. International Journal of Biological Sciences. 2023; 19: 2349-65. IF (2022): 10.750
(2) Tian Y#, Liu C#, Li Z#, Ai M#, Wang B, Du K, et al. Exosomal B7-H4 from irradiated glioblastoma cells contributes to increase FoxP3 expression of differentiating Th1 cells and promotes tumor growth. Redox biology. 2022; 56:102454. IF (2022): 10.787
(3) Khan M., Du, K., Ai, M., Wang, B., Lin, J., Ren, A., Chen, C., Huang, Z., Qiu, W., Yuan, Y. and Tian, Y*. PD-L1 expression as biomarker of efficacy of PD-1/PD-L1 checkpoint inhibitors in metastatic triple negative breast cancer: A systematic review and meta-analysis. Front Immunol. 14:1060308. IF (2022): 8.786
(4) Du K., Zou, J., Wang, B., Liu, C., Khan, M., Xie, T., Huang, X., Shen, P., Tian, Y*. and Yuan, Y*. (2022). A Metabolism-Related Gene Prognostic Index Bridging Metabolic Signatures and Antitumor Immune Cycling in Head and Neck Squamous Cell Carcinoma. Front Immunol 13, 857934. IF (2022): 8.786
(5) Khan M, Ai M, Du K, Song J, Wang B, Lin J, Ren A，Chen C，Huang Z, Qiu W, Zhang J, Tian Y* and Yuan Y*. Pyroptosis relates to tumor microenvironment rmeling and prognosis: A pan-cancer perspective. Front Immunol.2022;13:1062225. IF (2022): 8.786
(6) Liu W, Liu C, Chen C, Huang X, Yi Q, Tian Y*, Peng B*, Yuan Y*. Construction and Verification of a Glycolysis-Associated Gene Signature for the Prediction of Overall Survival in Low Grade Glioma. Frontiers in genetics. 2022; 13:843711. IF (2022): 4.722
(7) Liu W, Zhang J, Xie T, Huang X, Wang B, Tian Y*, Yuan Y*. C1QTNF6 is a Prognostic Biomarker and Related to Immune Infiltration and Drug Sensitivity: A Pan-Cancer Analysis. Frontiers in pharmacology. 2022; 13:855485. IF (2022): 5.988
(8) Tian Yunhong, Tian Yunming, Tu Y, Zhang G, Zeng X, Lin J, Ai M, Mao Z, Zheng R, Yuan Y*: microRNA-124 inhibits stem-like properties and enhances radiosensitivity in nasopharyngeal carcinoma cells via direct repression of expression of JAMA. Journal of cellular and molecular medicine 2020 Journal of cellular and molecular medicine 2020. IF (2020): 4.5
(9) Tian Yunhong#, Yan M#, Zheng J, Li R, Lin J, Xu A, et al. miR-483-5p decreases the radiosensitivity of nasopharyngeal carcinoma cells by targeting DAPK1. Laboratory investigation; a journal of technical methods and pathology 2019, 99(5):602-611. IF(2019): 3.7
(10) Tian Yunhong#, Lin Jie#, Tian Yunming#, Zhang Guoqian, et al. Efficacy and safety of anti-EGFR agents administered concurrently with standard therapies for patients with head and neck squamous cell carcinoma: A systematic review and meta-analysis of randomized controlled trials. International journal of cancer 2017. IF (2015): 6.5
(11) Tian Yunhong#, Cai L#, Tian Y#, Tu Y, et al. miR156a Mimic Represses the Epithelial-Mesenchymal Transition of Human Nasopharyngeal Cancer Cells by Targeting Junctional Adhesion Molecule A, PloS One, 2016, 11(6): e0157686 IF (2015): 3.057
(12) Tu Yn#, Tian Yunhong#, Fang Z#, Ruan Q, et al. Cytoreductive surgery combined with hyperthermic intraperitoneal chemoperfusion for the treatment of gastric cancer: A single-centre retrospective study, International Journal of Hyperthermia, 2016. 32(6). 587-594 IF (2015): 3.361
(13) Tian Yunhong#, Zou WH#, Xiao WW#, Zeng L, et al. Oligometastases in AJCC stage IVc nasopharyngeal carcinoma: A subset with better overall survival, Head & Neck 2016, 38(8):1152-1157 IF (2015): 2.760
(14) Tian Yunhong#, Xie Q#, He jie, et al. Radioactive I-125 seeds inhibit cell growth and epithelial-mesenchymal transition in human glioblastoma multiforme via a ROS-mediated signaling pathway, BMC cancer, 2015. 15(1) IF (2015): 3.265
(15) Tian Yunhong#, Tian Yunming, et al. Junctional adhesion molecule-A, an epithelial-mesenchymal transition inducer, correlates with metastasis and poor prognosis in human nasopharyngeal cancer, Carcinogenesis, 2015. 36(1). 41-48 IF (2015): 4.874
(16) Tian Yunhong#, Tian YM, Luo X, Zhou T, et al. Identification and characterization of microRNAs related to salt stress in broccoli, using high-throughput sequencing and bioinformatics analysis, BMC plant biology, 2014, 14(1):226 IF (2014): 3.813
(17) Tian YM#, Tian Yunhong#, Zeng L#, Liu S, et al. Prognostic model for survival of local recurrent nasopharyngeal carcinoma with intensity-modulated radiotherapy, British Journal of Cancer, 2014. 110(2). 297-303 IF (2014): 4.836
(18) Tian Yunhong#, Xie Q#, Tian Yunming, et al. Radioactive I-125 Seed Inhibits the Cell Growth, Migration, and Invasion of Nasopharyngeal Carcinoma by Triggering DNA Damage and Inactivating VEGF-A/ERK Signaling, PLoS One, 2013, 8(9): e74038 IF (2013): 3.534
