【个人简介】

杨彬珧，女，云南大理人，医学博士，副研究员，硕士研究生生导师。2014年获得华中科技大学同济医学院劳动卫生与环境卫生学博士学位后，在广州医科大学进行为期两年的博士后研究工作。2017年3月至今，入职广州医科大学附属第五医院前沿医学交叉研究中心。

【研究方向】

肿瘤分子流行病学，目前重点探讨环境暴露特别是多环芳烃（PAHs）暴露对肺癌的影响及其机制。

【科研项目】

1.国家自然科学基金-青年项目，81903381，血浆外泌体lncRNA-IGFBP4-1调控糖酵解在肺腺癌发生、预后中的作用和机制研究, 2020-1-01至2022-12-31，20万元，已结题，主持。

2.广东省自然科学基金自由项目，2018A030313606，LincRNA00691在多环芳烃诱导肺腺癌发生过程中的作用及机制研究，2018-5-30至2021-5-30，10万元，已结题，主持。

3.2018年广州医科大学高水平大学学术骨干培育计划项目，2018-1-01至2022-12-30, 40万元，已结题，主持。

4.中国博士后科学基金面上项目，2015M572293，LncRNA-RAB1A-2调控RAB39A影响非小细胞肺癌发病的研究,2014-11-01至2016-11-30，5万元，已结题，主持。

【代表性论文及著作】

1.Siqin Chen, Yuefeng He, Xingyue Yin, Qinghua He, Xiaomei Li, Maosheng Yan, Suli Huang, Jiachun Lu and Binyao Yang. Joint effects of polycyclic aromatic hydrocarbons, smoking, and XPC polymorphisms on damage in exon 2 of KRAS gene among young coke-oven workers. Front. Public Health 2022(8).

2.Siqin Chen, Yuefeng He, Maosheng Yan, Yun Zhou, Qinghua He, Jingwen Tan, Binyao Yang. The interaction effects of FEN1 rs174538 polymorphism and polycyclic aromatic hydrocarbon exposure on damage in exon 19 and 21 of EGFR gene in coke oven workers. Environmental Science and Pollution Research 2021(6):1-12.

3.Yu, K., Binyao Yang (Co-first author), H. Jiang, J. Li, K. Yan, X. Liu, L. Zhou, H. Yang, X. Li, X. Min, C. Zhang, X. Luo, W. Mei, S. Sun, L. Zhang, X. Cheng, M. He, X. Zhang, A. Pan, F. B. Hu and T. Wu. A multi-stage association study of plasma cytokines identifies osteopontin as a biomarker for acute coronary syndrome risk and severity. Scientific Reports 2019(1): 5121.

4.Di Wu, Binyao Yang (Co-first author), Jiansong Chen , Huali Xiong , Yinyan Li , Zihua Pan , Yi Cao , Jinbin Chen, Tiegang Li, Shiyu Zhou, Xiaoxuan Ling, Yongfang Wei, Guangjian Li, Yifeng Zhou, Fuman Qiu, Lei Yang, Jiachun Lu. Upregulation of long non-coding RNA RAB1A-2 induces FG bF1 expression worsening lung cancer prognosis. Cancer letters, 2018,438(2018): 116-125.

5.BinyaoYang, Lisha Zhang, Yi Cao, Shuai Chen, Jun Cao, Di Wu, Jiansong Chen, Huali Xiong, Zihua Pan, Fuman Qiu, Jinbin Chen, Xiaoxuan Ling, Maosheng Yan, Suli Huang, Shiyu Zhou, Tiegang Li, Lei Yang, Yunchao Huang, Jiachun Lu. Overexpression of lncRNA IGFBP4–1 reprograms energy metabolism to promote lung cancer progression. Molecular cancer, 2017, 16: 154.

6.BinyaoYang, Qifei Deng, Wangzhen hang, Yingying Feng, Xiayun Dai, Wei Feng, Xiaosheng He, Suli Huang, XiaoZhang, Xiaohai Li, Dafeng Lin, Meian He, Huan Guo, Huizhen Sun, JingYuan, Jiachun Lu, Frank B. Hu, Xiaomin Zhang, Tangchun Wu^*, Exposure to polycyclic aromatic hydrocarbons, plasma cytokines, and heart rate variability. Scientific reports, 2016, 6: 19272.      

7.Binyao Yang, Zengnan Mo, Chen Wu, Handong Yang, Xiaobo Yang, Yunfeng He, Lixuan Gui, Li Zhou, Huan Guo, Xiaomin Zhang, Jing Yuan, Xiayun Dai, Jun Li, Gaokun Qiu, Suli Huang, Qifei Deng, Yingying Feng, Lei Guan, Die Hu, Xiao Zhang, Tian Wang, Jiang Zhu, Xinwen Min, Mingjian Lang, Dongfeng Li, Frank B Hu, Dongxin Lin, Tangchun Wu, Meian He, A genome-wide association study identifies common variants influencing serum uric acid concentrations in a Chinese population. BMC medical genomics, 2014, 7(1): 10.

【所获荣誉和奖励】

1.2020年荣获为广州医科大学“南山学者”后备人才。

2.2019年荣获广州市高层次人才青年后备人才证书。

3.2018年荣获广州医科大学第五临床学院“优秀教师”荣誉称号。