赵林平,医学博士,南山学者“骨干人才”,研究员,硕士研究生导师,2022年7月至今,任职于广州医科大学附属第五医院前沿医学交叉研究中心。主要从事纳米药物的构建及其抗肿瘤机制研究,近五年以第一作者或通讯作者在ACS Nano,Nano Letters,Advanced Science,Biomaterials,Journal of Controlled Release,Aggregate等国际知名期刊发表SCI论文19篇。参与工作发表在ACS Nano,Biomaterials,Small,Acta Biomaterialia等SCI期刊上20余篇。主持国家自然科学基金-青年基金项目,广东省自然科学基金-面上项目,广东省普通高校特色创新类项目,广州市科技计划基础与应用基础研究项目,广州医科大学高水平大学建设人才引进项目等,参与项目包括国家重点研发计划-青年科学家项目,国家自然科学基金-青年科学基金项目等。学术任职:《Nano TransMed》、《Exploration》青年编委。
联系邮箱:zlp2022@gzhmu.edu.cn
【研究方向】
1.开发肿瘤靶向药物载体和新型无载体纳米药物;
2.开发新型蛋白质靶向降解纳米药物;
3. 探索光动力治疗、免疫治疗和化疗等新型联合治疗策略,开展抗肿瘤等相关领域的应用。
【代表性论文】
1.Zhao L P, Zheng R R, Rao X N, et al. Chemotherapy-Enabled Colorectal Cancer Immunotherapy of Self-Delivery Nano-PROTACs by Inhibiting Tumor Glycolysis and Avoiding Adaptive Immune Resistance. Adv. Sci. 2024, e2309204.
2.Zhao L P, Zheng R R, Kong R J, et al. Self-delivery ternary bioregulators for photodynamic amplified immunotherapy by tumor microenvironment reprogramming. ACS Nano 2022, 16, 1182-1197.
3. Zhao L P, Zheng R R, Huang J Q, et al. Self-delivery photo-immune stimulators for photodynamic sensitized tumor immunotherapy. ACS Nano 2020, 14, 17100-17113.
4. Zhao L P, Zheng R R, Chen H Q, et al. Self-delivery nanomedicine for O2-economized photodynamic tumor therapy. Nano Lett. 2020, 11, 2062-2071.
5. Zhao L P, Rao X N, Zheng R R, et al. Carrier-free nano-PROTACs to amplify photodynamic therapy induced DNA damage through BRD4 degradation. Nano Lett. 2023, 23, 6193-6201.
6. Zhao L P, Zheng R R, Liu L S, et al. Self-delivery oxidative stress amplifier for chemotherapy sensitized immunotherapy. Biomaterials 2021, 275, 120970.
7. Zhao L P, Rao X N, Huang C Y,et al. Epigenetic reprogramming of carrier free photodynamic modulator to activate tumor immunotherapy by EZH2 inhibition. Biomaterials 2023, 293, 121952.
8. Zhao L P, Rao X N, Zheng R R, et al. Targeting glutamine metabolism with photodynamic immunotherapy for metastatic tumor eradication. J. Control. Release. 2023, 357, 460-471.
9. Zhao L P, Huang C Y, Zheng R R, et al. Photodynamic amplified immune checkpoint-blockade therapy of self-delivery bioregulator via epigenetic reprogramming. Chem. Eng. J. 2023, 453, 139729.
10. Zhao L P, Chen S Y, Zheng R R, et al. Self-delivery nanomedicine for glutamine-starvation enhanced photodynamic tumor therapy. Adv. Healthc. Mater. 2022, 11, e2102038.