
基本信息:
张强弩 男,汉族
肿瘤病理学博士
研究员,特聘教授
博士生导师(学术型)
招生学科:临床医学(100200)-肿瘤学(100214)
电子邮箱:2024991007@gzhmu.edu.cn
工作单位:广州医科大学附属第三医院 中心实验室
研究方向:
主要从事大数据+多组学驱动的肝癌基础研究和临床转化探索,具体研究方向包括:(1)缺氧微环境诱导的肝癌多组学分子景观变化及其在肝癌进展、靶向药物耐受中的作用机制研究;(2)糖、脂肪酸及氨基酸代谢重编程与肝癌免疫微环境的关系;(3)肝癌的时空演进、癌-胚重编程及去分化机制研究;(4)肝癌多组学相关数据库的设计、构建以及大数据分析软件的开发。
获得人才称号:
(1) 深圳市级才称号(2021)
(2) 广东省级人才称号(2025)
(3) 广州医科大学南山学者(2024)
近五年代表性文章:
(1)Chuli Fu, Wenyun Fu, Zuotian Huang, Xiaoyan He, Teng Wei, Wen Jin, Geyan Wu, Zhengwei Zhao, Kunxiong Guo, Jincui Yang,Jing Li, Shuhui Xu, Xuelong Zheng, Xiaoqiang Chen, Ling Ran, Xiaoli Pan, Kezhen Zong, Zhongjun Wu*, Junyao Xu*, Guang-Rong Yan*, Qiangnu Zhang*, Long-Chain Fatty Acid Redistribution Induced by SLC27A2 Deficiency Facilitates Hypoxic Adaptation and Immunosuppression in Hepatocellular Carcinoma. Cancer Research (IF=22), 85(23): 2025, 通讯作者
(2)Xiaoyan He, Zhengwei Zhao, Teng Wei, Lisi Zheng, Jincui Yang, Xinrong He, Yicai Cheng, Xiaoyi Zhan, Zejuan Li, Kelin Wu, Stephanie Roessler, Yunting Jian, Chuli Fu, Guang-Rong Yan, Junyao Xu, Qiangnu Zhang*, SLC27A5 deficiency-induced reduction in long-chain fatty acid uptake is a pro-tumorigenic metabolic adaptation and confers sensitivity to glutaminase inhibition in hepatocellular carcinoma. Cancer letters (IF=11), 655:218616,2026, 通讯作者
(3)Qiangnu Zhang; Teng Wei; Wen Jin; Lesen Yan; Lulin Shi; Siqi Zhu; Yu Bai; Yuandi Zeng; Zexin Yin; Jilin Yang; Wenjian Zhang; Meilong Wu; Yusen Zhang; Gongze Peng; Stephanie Roessler; Liping Liu ; Deficiency in SLC25A15, a hypoxia-responsive gene, promotes hepatocellular carcinoma by reprogramming glutamine metabolism, Journal of hepatology (IF=40), 2024, 80: 293-308 第一作者
(4)Qiangnu Zhang, Yusen Zhang, Chuli Fu, Xiaoyan He, Zuotian Huang, Geyan Wu,Teng Wei, Wen Jin, Lesen Yan, Meilong Wu, Gongze Peng, LinLan Fan, Mingyue Li, Yuehua Guo, Jiangang Bi, Yu Bai,Stephanie Roessler, Guang-Rong Yan*, Liping Liu*, CSTF2 Supports Hypoxia Tolerance in Hepatocellular Carcinoma by Enabling m6A Modification Evasion of PGK1 to Enhance Glycolysis, Cancer Research (IF=22), 2025. 第一作者
(5)Qiangnu Zhang; Teng Wei; Lesen Yan; Siqi Zhu; Wen Jin; Yu Bai; Yuandi Zeng; Xiaofei Zhang; Zexin Yin; Jilin Yang; Wenjian Zhang; Meilong Wu; Yusen Zhang; Liping Liu ; Hypoxia-Responsive lncRNA AC115619 Encodes a Micropeptide That Suppresses m6A Modifications and Hepatocellular Carcinoma Progression, Cancer Research (IF=22), 2023, 83(15): 2496-2512 第一作者
(6)Qiangnu Zhang; Lingfeng Xiong; Teng Wei; Quan Liu; Lesen Yan; Jiaojuan Chen; Lu Dai; Lulin Shi; Wenjian Zhang; Jilin Yang; Stephanie Roessler; Liping Liu ; Hypoxia-responsive PPARGC1A/BAMBI/ACSL5 axis promotes progression and resistance to lenvatinib in hepatocellular carcinoma, Oncogene(IF=9.3), 2023, 42(19): 1509-1523 第一作者
主持基金项目/课题:
(1)国家自然科学基金委员会-面上项目,缺氧敏感的uORF来源微肽HK2-48aa调控β-catenin乙酰化促进肝癌进展的作用和机制研究(82472716),49万,在研,主持
(2)国家自然科学基金委员会-面上项目, uORF来源穿膜肽TCEA1-45aa诱导肝癌细胞去分化表型向肝细胞传递的机制研究(82674309),在研,主持
(3)广州医科大学,南山学者科研启动经费,300万,在研,主持,2024年03月至2029年03月