师宪平，广州医科大学教授、博士生导师。在中山大学获得生物化学博士学位，美国加州大学Cedars Sinai Medical Center进行博士后研究工作。先后被评为广东省“特支计划”百千万工程青年拔尖人才，广州市高层次人才，广州医科大学“南山学者”。担任中国病理生理心血管学会委员；国家自然科学基金项目、广东省科技部项目评审专家；Nucleic Acids Research、Cell Death & Disease等杂志审稿人。近年来致力于肿瘤相关基因表达调控与肿瘤分子靶向治疗研究，以第一/通讯作者在Nucleic Acids Research、Clinical Cancer Research、Journal of Hematology & Oncology等国际专业杂志发表论文。以项目负责人先后主持国家自然科学基金项目、省市各级科研项目20余项。

研究领域：

课题组致力于肿瘤相关基因表达调控与肿瘤靶向治疗研究，针对临床上肿瘤治疗过程中的难点与核心问题，从基因表达调控层面出发，探讨其调控肿瘤发生进展的分子机制，进而筛选有应用潜力的分子靶标进行肿瘤靶向治疗的尝试。具体包括，1）超级增强子驱动的核心转录调控在肿瘤发生、复发转移与耐药中的作用机制与应用。通过结合超级增强子谱、mRNA表达谱和核心转录调控环路等多个层面的数据，全面展示肿瘤发生发展过程中超级增强子介导的转录调控网络，深入探讨超级增强子驱动的核心转录调控环路介导肿瘤转录重编程的过程，揭示其驱动肿瘤发生发展的特异性转录调控事件与相关分子机制；2）泛素-蛋白酶体降解系统质控紊乱与肿瘤的发生发展。 探讨去泛素化酶在肿瘤发生发展中的重要作用，筛选、设计合成系列去泛素化酶抑制剂进行小分子靶向治疗的功能与机制研究。

部分代表性论文：

1)Jiang, Liling^#; He, Qingyan^#; Chen, Xin^#; Liu, Aochu; Ding, Wa; Zhang, Haichuan; Chen, Xinmei; Zhou, Huan; Meng, Yi; Liu, Bingyuan; Peng, Guanjie; Wang, Chunyan*; Liu, Jinbao*; Shi, Xianping*. Inhibition of proteasomal deubiquitinases USP14 and UCHL5 overcomes tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Clinical and Translational Medicine. 2022, 12(9):e1038.

2)Ding, Wa#; Wang, Jinxiang#; Wu, Junzheng#; Liu, Aochu#; Jiang, Liling; Zhang, Haichuan; Meng, Yi; Liu, Bingyuan; Peng, guanjie; Lou, Enzhe; Mao, Qiong; Zhou, Huan; Tang, Daolin; Chen, Xin*; Liu, Jinbao*; Shi, Xianping*.Targeting proteasomal deubiquitinases USP14 and UCHL5 with b-AP15 reduces 5-fluorouracil resistance in colorectal cancer cells. Acta Pharmacologica Sinica. 2023, 44(12): 2537-2548.

3)Sun, Yuening^#; Chen, Xin^#; Liao, Siyan^#; Liu, Aochu; Zhou, Huan; Jiang, Liling; Ding, Wa; Mei, Wenjie*; Liu, Jinbao*; Shi, Xianping*. Stabilization of　MYC　G-quadruplex DNA　by ruthenium (II) complex overcomes imatinib resistance in chronic myeloid leukemia cells harboring T315I mutation.　Genes & Diseases. 2022. 10(2):399-402.

4)Shi, Xianping^#*; Zheng, Yueyuan^#, Jiang, Liling^#; Zhou, Bo^#; Yang, Wei; Li, Liyan; Ding, Lingwen; Huang, Moli; Gery, Sigal; Lin, De-Chen*; Koeffler, H Phillip. EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma. Nucleic Acids Research. 2020, 48(20):11434-11451.

5)Lin, Lehang^#; Huang, Moli^#*; Shi, Xianping^#; Mayakonda, Anand; Hu, Kaishun; Jiang, Yan Yi; Guo, Xiao; Chen, Li; Pang, Brendan; Doan, Ngan; Said, Jonathan W; Xie, Jianjun; Gery, Sigal; Cheng, Xu; Lin, Zhaoyu; Li, Jinsong; Berman, Benjamin P; Yin, Dong*; Lin, De-Chen*; Koeffler, H Phillip. Super-enhancer- associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1. Nucleic Acids Research. 2019, 47(3): 1255-1267.

6)Jiang, Liling; Sun, Yuening; Wang, Jinxiang; He, Qingyan; Chen, Xinmei; Lan, Xiaoying; Chen, Jinghong; Dou, Q Ping; Shi, Xianping*; Liu, Jinbao*. Proteasomal cysteine deubiquitinase inhibitor b-AP15 suppresses migration and induces apoptosis in diffuse large B cell lymphoma. Journal of Experimental & Clinical Cancer Research. 2019, 38(1): 453.

7)Lan, Xiaoying; Zhao, Chong; Chen, Xin; Zhang, Peiquan; Zang, Dan; Wu, Jinjie; Chen, Jinghong; Long, Huidan; Yang, Li; Huang, Hongbiao; Bing Z, Carter; Wang, Xuejun; Shi, Xianping*; Liu, Jinbao*. Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinibviaboth Bcr/Abl-dependent and -independent mechanisms. Journal of Hematology & Oncology. 2016, 9(1):129.

8)Shi, Xianping^#; Chen, Xin^#; Li, Xiaofen; Lan, Xiaoying; Zhao, Chong; Liu, Shouting; Huang, Hongbiao; Liu, Ningning; Liao, Siyan; Song, Wenbin; Zhou, Ping; Wang, Shunqing; Xu, Li; Wang, Xuejun; Dou, Q. Ping; Liu, Jinbao*. Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent Bcr-Abl downregulation. Clinical Cancer Research. 2014, 20(1): 151-163.

9)Lan, Xiaoying^#; Hu, Min^#; Jiang, Liling^#; Wang, Jiamin^#; Meng, Yi; Chen, Xinmei;Liu, Aochu; Ding,Wa;Zhang, Haichuan; Zhou, Huan; Liu, Bingyuan; Peng, Guanjie; Liao, Siyan; Chen, Xin*; Liu, Jinbao*; Shi, Xianping*. Piperlongumine overcomes imatinib resistance by inducing proteasome inhibition in chronic myelogenous leukemia cells. Journal of Ethnopharmaco. 2023，301:115815.

10)Peng, Guanjie^#; Liu, Bingyuan^#; Zheng, Mohan; Zhang, Luowanyue; Li, Huiqin; Liu, Mengni; Liang, Yuan; Chen, Tianjian; Luo, Xiaotong; Shi, Xianping*; Ren, Jian*; Zheng, Yueyuan*. TSCRE: a comprehensive database for tumor-specific cis-regulatory elements. NAR Cancer. 2024. 6(1):zcad063.

部分代表性项目：

1.国家自然科学基金面上项目，82170177，核心转录调控环路促进慢性髓系白血病急髓变的作用与机制研究，2021.12-2025.12，55万，在研，主持

2.国家自然科学基金面上项目，81670154，USP14对Bcr-Abl降解的调控及其在慢粒白血病伊马替尼耐药中的作用，2017.12-2020.12，57万，结题，主持

3.国家自然科学基金面上项目，81470355，去泛素化酶抑制剂克服肿瘤硼替佐米耐药的机制研究，2014.12-2018.12，70万，结题，主持

4.国家自然基金青年项目，81100378，重构小分子化合物SNS-032靶向Bcr-Abl酪氨酸激酶对抗慢粒格列卫耐药的作用机理，2011.12-2014.12，24万，结题，主持

成果奖项

1. 高等学校科学研究自然科学奖二等奖，教育部（2020）

2. 中华医学科技奖三等奖（2017）

3. 广州市科学技术进步奖一等奖（2016）

课题组风采展示

招生专业： 基础医学、肿瘤学、生化与分子生物学

电子邮件： xianping.shi@gzhmu.edu.cn