个人概况

马宁芳，女，教授，硕士、博士生导师，基础医学院，博士，毕业于中山大学 招生专业：肿瘤学

研究方向；

肿瘤基础研究，从发育角度研究肿瘤的成因、细胞异常分化及调控机制。

所获成就：

先后获得“广州市优秀教师”、“广东省南粤优秀教师”等称号。

社会兼职：

1.中国解剖学会理事会教育与继续教育工作委员会委员；

2.中国解剖学会理事会组织胚胎学专业委员会委员；

3.广东省解剖学会常务理事。

主持科研项目：

先后主持国家自然基金2项，羊城学者学术带头人项目1项，完成及参与完成广东省及广州市科研项目十余项，在Hepatology, Clinical cancer research，Oncogene等国内外权威学术期刊发表研究论文60余篇，获两项国家发明专利。

部分代表性第一和通讯作者论文：

1. Liu SS, Maguire EM, Bai YS, Huang L, Liu Y, Xu L, Fauzi I, Zhang SQ, Xiao Q,Ma NF. A Novel Regulatory Axis, CHD1L-MicroRNA 486-Matrix Metalloproteinase 2, Controls Spermatogonial Stem Cell Properties. Mol Cell Biol. 2019 Feb 4;39(4). pii: e00357-18.

2. Yang Li, Li-Ru He, Ying Gao, Ning-Ning Zhou, Yurong Liu, Xin-Ke Zhou, Ji-Fang Liu, Xin-Yuan Guan,Ning-Fang Maand Dan Xie. CHD1L contributes to cisplatin resistance by upregulating the ABCB1-NF-κB axis in human non-small-cell lung cancer. Cell Death Dis. 2019 Feb 4;10(2):99.

3. Xiaohui Zhao, Tian Xie, Ting Dai,Wenhui Zhao, Jing Li, Rui Xu, Chao Jiang,Peiqiong Li, Junyao Deng, Xiaobo Su, andNingfang Ma. CHP2 Promotes Cell Proliferation in Breast Cancer via Suppression of FOXO3a. Mol Cancer Res. 2018 Oct;16(10):1512-1522.

4. Liu SS, Bai YS, Feng L, Dong WW, Li Y, Xu LP,Ma NF. Identification of CHD1L as an Important Regulator for Spermatogonial Stem Cell Survival and Self-Renewal. Stem Cells Int. 2016; 2016:4069543.

5. Bai Y, Feng M, Liu S, Wei H, Li L, Zhang X, Shen C, Zhang S,Ma N. Differential gene expression in mouse spermatogonial stem cells and embryonic stem cells. Int J Mol Med. 2016;38(2):423-32.

6. Liu M, Chen L,Ma NF, Chow RK, Li Y, Song Y, Chan TH, Fang S, Yang X, Xi S, Jiang L, Li Y, Zeng TT, Li Y, Yuan YF, Guan XY. CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors. Hepatology. 2016; 63(5):1544-59.

7. Dou Dandan, Zhao Hao, Li Zili, Xu Liping, Xiong Xifeng, Wu Xingwu, Sun Yi, Zeng Sicong, Ouyang Qi, Zhou Di,Ma Ningfang, Lin Ge, and Hu Liang. CHD1L Promotes Neuronal Differentiation in Human Embryonic Stem Cells by Upregulating PAX6. Stem Cells and Development. 2017;26(22):1626-1636.

8. Xuan Li, Xiao-Qi Wu, Rong Deng, Dan-Dan Li, Jun Tang, Wen-Dan Chen, Jing-Hong Chen, Jiao Ji, Lin Jiao, Shan Jiang, Fen Yang, Gong-Kan Feng, Ravichandran Senthilkumar, Fei Yue, Hai-Liang Zhang, Rui-Yan Wu, Yan Yu, Xue-Lian Xu, Jia Mai, Zhi-Ling Li, Xiao-Dan Peng, Yun Huang, Xiang Huang,Ning-Fang Ma, Qian Tao, Yi-Xin Zeng & Xiao-Feng Zhu. CaMKII-mediated Beclin 1 phosphorylation regulates autophagy that promotes degradation of Id and neuroblastoma cell differentiation. Nature Communications, 2017;8(1):1159.

9. Zhu X, Huang L, Gong J, Shi C, Wang Z, Ye B, Xuan A, He X, Long D, Zhu X,Ma N, Leng S.NF-κB pathway link with ER stress-induced autophagy and apoptosis in cervical tumor cells. Cell Death Discov. 2017; 3:17059.

10. Tang DJ, Dong SS,Ma NF, Xie D, Chen L, Fu L, Lau SH, Li Y, Li Y, Guan XY. Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular carcinoma. Hepatology, 2010; 51(4):1255--63.

11.Ning-Fang Ma, Sze Hang Lau, Liang Hu, Dan Xie, Jun Wu, Jun Yang, Yi Wang, Meng-Chao Wu, Jackie Fung, Xueyan Bai, Chi-Hung Tzang, Mengsu Yang, Yan An Su, Xin-Yuan Guan. Association of HBV X protein with the development of hepatocellular carcinoma. Clinical Cancer Research，2008; 14(16):5061-5068

12.Ma NF, Hu L, Fung JM, Xie D, Zheng BJ, Chen L, Tang DJ, Fu L, Wu Z, Chen M, Fang Y, Guan XY. Isolation and characterization of a novel oncogene ALC1 within a commonly amplified region at 1q21 in hepatocellular carcinoma. Hepatology, 2008;47(2):503-510.