【个人简介】

陈贲，医学博士，副教授、副研究员、主治医师，广州医科大学南山学者，附属脑科医院认知中心主任，德国德累斯顿工业大学访问学者，近5年以第一/通讯作者发表SCI论文36篇，获发明专利1项、实用新型专利4项；主持国自然等5项课题，获广东省科学技术奖科技进步奖二等奖、中国仪器仪表学会科技进步二等奖等奖项。获中国医师协会精神科医师分会“青年精神科医师希望之星”等荣誉，任Journal of Alzheimer‘s Disease、Frontier in Neurology、Psychoradiology 等期刊编委 ，广东省保健协会睡眠与心理分会常委等职务。研究领域为嗅觉受损作为阿尔茨海默病、老年抑郁症的早筛标志物与干预靶点。

【研究方向】

老年认知与情绪障碍；嗅觉

【科研项目】

1.内嗅皮层功能增强在减轻主观认知下降人群的气味识别受损中的fMRI研究，国家自然科学基金青年科学基金项目， 82101508，2022.1-2024.12，30万元，主持，在研

2.主观认知下降人群的嗅觉信息上行与下行加工异常的fMRI 研究，广州市基础研究计划基础与应用基础研究项目（一般项目），202201010491，2022-04-01 至2024-3-31，5万元，主持，结题

3.主观认知下降人群的内嗅皮层功能增强代偿气味阈值介导的气味识别受损的fMRI研究, 广州市中医药和中西医结合科技项目, 20222A011013,2022-05-01 至2024-04-30, 1.5万元，主持，结题

4.伴嗅觉识别受损的老年抑郁症患者的内嗅-海马环路功能紊乱与痴呆风险研究，2023A03J0840，广州市卫生健康委员会，基础研究计划/市校（院）企联合资助项目重点项目，2023-04-01至2025-03-31，50万，主持，在研

5.海马-内侧隔核胆碱能环路介导嗅觉训练改善阿尔茨海默病记忆受损的机制研究，2024A1515011035，广东省自然科学基金-面上项目，2024-01-01 至 2026-12-31，15万，主持，在研

【代表性论文及著作】

1.Ben Chen, Haishan Shi, Le Hou , Xiaomei Zhong, Yanhua Wang, Zhangying Wu, Qi Peng, Dong Zheng, Yuefen Zhang, Yan Tan, Ziyan Fang, Xinru Chen , Xinni Luo, Sha Liu, Yuping Ning*. Medial temporal lobe atrophy as a predictor of poor cognitive outcomes in general paresis. Early Intervention in Psychiatry. 2017;13:30-38.

2.Ben Chen, Xiaomei Zhong, Naikeng Mai, Qi Peng, Zhangying Wu, Cong Ouyang, Weiru Zhang , Wanyuan Liang, Yujie Wu, Sha Liu, Lijian Chen, Yuping Ning*. Cognitive Impairment and Structural Abnormalities in Late Life Depression with Olfactory Identification Impairment: an Alzheimer’s Disease-Like Pattern. International Journal of Neuropsychopharmacology. 2018;21(7):640-648.

3.Ben Chen, Xiaomei Zhong, Naikeng Mai, Qi Peng, Min Zhang, Xinru Chen, Zhangying Wu, Laiquan Zou, Wanyuan Liang, Cong Ouyang, Yujie Wu, Yuping Ning*. Interactive Effect of Depression and Cognitive Impairment on Olfactory Identification in Elderly People. Journal of Alzheimer’s Disease. 2018;66(4):1645-1655.

4.Ben Chen*, Joshi Akshita, Pengfei Han, Divesh Thaploo, Hagen H. Kitzler, Thomas Hummel. Aberrancies of Brain Network Structures in patients with Anosmia. Brain Topography. 2020;33(3),403-411.

5.Ben Chen*, Rita Klarmann, Matthias Israel, Yuping Ning, Romain Colle, Thomas Hummel. Difference of olfactory deficit in patients with acute episode of schizophrenia and major depressive episode. Schizophrenia Research. 2019;212:99-106.

6.Ben Chen*, Antje Haehner, Mehmet Kibris Mahmut, Thomas Hummel. Faster olfactory adaptation in patients with olfactory deficits: an analysis of results from odor threshold testing. Rhinology. 2020;58(5):489-494.

7.Ben Chen#, Qiang Wang#, Xiaomei Zhong#, Lena Heyne, Yuping Ning*, Thomas Hummel. Can we assess the sense of smell through a face mask? International Forum of Allergy & Rhinology. 2020;10(11):1264-1265.

8. Ben Chen*, Alexander Pfister, Philipp Nahrath, Thomas Hummel. Odor perception depends on airflow, odor solubility and intranasal application site. Rhinology. 2020;58(6):635-637.

9.Simona Negoias#, Ben Chen#*, Emilia Iannilli, Yuping Ning, Hagen H Kitzler, Thomas Hummel, Stephanie Krueger. Odor-related brain hyper-reactivity in euthymic bipolar disorder: An fMRI and ERP study. Psychiatry Research. 2019;278:218-227.

10.Qiang Wang#, Ben Chen#, Xiaomei Zhong#, Huarong Zhou, Min Zhang, Naikeng Mai, Zhangying Wu, Xingxiao Huang, Antje Haehner, Xinru Chen, Lavinia Alberi Auber, Qi Peng, Thomas Hummel, Yuping Ning*. Olfactory dysfunction is already present in subjective cognitive decline and deepens with disease severity in the Alzheimer’s disease spectrum. Journal of Alzheimer’s Disease. 2021;79(2):585-595.

11.Ben Chen#, Xiaomei Zhong#, Min Zhang, Naikeng Mai, Zhangying Wu, Xinru Chen, Qi Peng, Huarong Zhou, Qiang Wang, Mingfeng Yang, Si Zhang, Lavinia Alberi Auber, Ilona Croy, Thomas Hummel, Yuping Ning*. The additive effect of late-life depression and olfactory dysfunction on the risk of dementia was mediated by hypersynchronization of the hippocampus/fusiform gyrus. Translational Psychiatry. 2021,;11(1):172.

12.Yunpeng Zang #*, Ben Chen#, Thomas Hummel. Assessment of odor perception related to stimulation modes in a mock MRI scanner. Journal of neuroscience methods. 2020;341.108754.

13. Ben Chen*, Cara Benzien, Vanda Faria, Yuping Ning, Mandy Cuevas, Jana Linke, Ilona Croy, Antje Haehner, Thomas Hummel. Symptoms of depression in patients with chemosensory disorders. ORL-Journal for Oto-Rhino-Laryngology Head and Neck Surgery, 2021;83(3):135-143.

14.Ben Chen* , Carla Masala, Anna Oleszkiewicz , Verena Englmeier, Nadine Gunder, Susanne Menzel, Antje Hähner , Thomas Hummel. Nonlinear association between chemosensory dysfunction and body mass index. Journal of Sensory Studies.

15.Ben Chen*, Melanie Espin, Robert Haussmann, Claudia Matthes, Markus Donix, Thomas Hummel, Antje Haehner. The effect of olfactory training on olfaction, cognition, and brain function in patients with mild cognitive impairment. Journal of Alzheimer's Disease. 2021. 85(2):745-754.

16.Min Zhang, Ben Chen, Xiaomei Zhong, Huarong Zhou, Qiang Wang, Naikeng Mai, Zhangying Wu, Xinru Chen, Qi Peng, Si Zhang, Minfeng Yang, Gaohong Lin, Yuping Ning. Neuropsychiatric symptoms exacerbate the cognitive impairments in patients with late-life depression. Frontiers in Psychiatry. 2021, 12:757003.

17.Ben Chen#, Qiang Wang ,Xiaomei Zhong, Naikeng Mai, Min Zhang, Huarong Zhou, Antje Haehner, Xinru Chen , Zhangying Wu, Lavinia Alberi Auber, Dongping Raoa, Wentao Liu, , Jinhong Zheng, Lijing Lin, Nanxi Li, Sihao Chen, Bingxin Chen, Thomas Hummel, Yuping Ning. Structural and functional abnormalities of olfactory-related regions in subjective cognitive decline, mild cognitive impairment and Alzheimer's disease. International Journal Of Neuropsychopharmacology. 2021; 25(5):361-374.

18.Qiang Wang, Ben Chen#, Xiaomei Zhong, Huarong Zhou, Min Zhang, Naikeng Mai, Zhangying Wu, Xinru Chen, Mingfeng Yang, Si Zhang, Gaohong Lin, Thomas Hummel, Yuping Ning. Neuropsychiatric symptoms mediated the relationship between odour identification and cognition in Alzheimer's disease spectrum: a structural equation model analysis. Frontiers In Aging Neuroscience 2022. 12;13:732840.

19.Meiling Liu#, Ben Chen#, Xiaomei Zhong#, Min Zhang, Qiang Wang, Huarong Zhou, Zhangying Wu, Le Hou, Qi Peng, Si Zhang, Minfeng Yang, Gaohong Linand Yuping N*. Differences in Odor Identification in Early-Onset and Late-Onset Depression. Brain Science. 2022. 16;12(2):276.

20.Mingfeng Yang#, Ben Chen#, Xiaomei Zhong#, Huarong Zhou, Naikeng Mai, Min Zhang, Zhangying Wu, Qi Penga, Qiang Wang, Meiling Liu, Si Zhang, Gaohong Lin, Thomas Hummelc, Yuping Ning*. Disrupted olfactory functional connectivity in patients with late-life depression. Journal of Affective Disorders. 2022. 12;S0165-0327(22)00253-1

21.Si Zhang#, Ben Chen#, Xiaomei Zhong#, Min Zhang, Qiang Wang, Zhangying Wu, Le Hou, Huarong Zhou, Xinru Chen, Meiling Liu, Mingfeng Yang, Gaohong lin, Thomas Hummel, Yuping Ning*. Interactive Effect of Agitation and Cognitive Impairment on Odor Identification in Patients with Late-Life Depression. Frontiers in Psychiatry, 2022. 13:839012

22.Gaohong Lin#, Zhangying Wu#, Ben Chen#, Min Zhang, Qiang Wang, Meiling Liu, Si Zhang, Mingfeng Yang, Yuping Ning *, Xiaomei Zhong *. Altered Microstate Dynamics and Spatial Complexity in Late-Life Schizophrenia. Frontiers in Psychiatry. 2022;13:907802.

23.Haehner A#*, Chen B#*, Espin M, Haussmann R, Matthes C, Desser D, Loessner L, Brandt MD, Donix M, Hummel T. Training with Odors Impacts Hippocampal Thickness in Patients with Mild Cognitive Impairment. Journal Of Alzheimers Disease. 2022;88(2):743-755.

24.Xiaomei Zhong#, Ben Chen#, Le Hou#, Qiang Wanga, Meiling Liu, Mingfeng Yang, Min Zhang, Huarong Zhou, Zhangying Wu, Si Zhang, Gaohong Lin, Yuping Ning*. Shared and specific dynamics of brain activity and connectivity in amnestic and nonamnestic mild cognitive impairment. CNS Neuroscience & Therapeutics, 2022, 28(12):2053-2065.

25.Qiang Wang#, Ben Chen#, Xiaomei Zhong#, Le Hou, Min Zhang, Mingfeng Yang, Zhangying Wu, Xinru Chen, Naikeng Mai, Huarong Zhou, Gaohong lin, Si Zhang, Yuping Ning*. Static and dynamic functional connectivity variability of the anterior-posterior hippocampus with subjective cognitive decline. Alzheimer's Research & Therapy, 2022, 3;14(1):122.

26.Ben Chen#, Mingfeng Yang#, Xiaomei Zhong*, Qiang Wang, Huarong Zhou, Meiling Liu, Min Zhang, Le Hou, Zhangying Wu, Si Zhang, Gaohong Lin, Yuping Ning. Disrupted dynamic functional connectivity of hippocampal subregions mediated the slowed information processing speed in late-life depression. Psychological Medicine, 2023, 53(14):1-11.

27.Ben Chen*, Anabel Stein, Falk-Tony Olesch, Thomas Hummel. Odor deprivation influences human olfactory function. Physiol Behav. 2023,19;262:114090.

28.Mingfeng Yang#, Ben Chen#, Huarong Zhou, Naikeng Mai, Min Zhang, Zhangying Wu, Qi Peng, Qiang Wang, Meiling Liu, Si Zhang, Gaohong Lin, Jingyi Lao, Yijie Zeng, Xiaomei Zhong*, Yuping Ning*. Relationships Among Short Self-Reported Sleep Duration, Cognitive Impairment, and Insular Functional Connectivity in Late-Life Depression. Journal Of Alzheimers Disease. 2023

29.Gaohong Lin#, Ben Chen#, Mingfeng Yang#, Zhangying Wu, Kaijie Qiu, Min Zhang, Qiang Wang, Si Zhang, Jingyi Lao, Yijie Zeng, Yuping Ning* and Xiaomei Zhong*. Lower Dorsal Lateral Prefrontal Cortex Functional Connectivity in Late-Life Depression with Suicidal Ideation. The American journal of geriatric psychiatry. 2023

30.Ben Chen, Anika Bossen, Falk-Tony Olesch, Thomas Hummel. A Life Without Smell: Olfactory Function in People Working in Odorless Rooms. Laryngoscope. 2023.

31.Ting Su#, Ben Chen#, Mingfeng Yang, Qiang Wang, Huarong Zhou, Min Zhang, Zhangying Wu, Gaohong Lin, Danpeng Wang, Yue Li, Xiaomei Zhong, Yuping Ning. Disrupted functional connectivity of the habenula links psychomotor retardation and deficit of verbal fluency and working memory in late-life depression. CNS Neuroscience & Therapeutics

32.Ben Chen#, Mingfeng Yang#, Meiling Liu, Qiang Wang, Huarong Zhou, Min Zhang, Le Hou, Zhangying Wu, Si Zhang, Gaohong Lin, Xiaomei Zhong, Yuping Ning, Differences in olfactory functional connectivity in early-onset depression and late-onset depression, Psychoradiology, 2023,3, kkad030

33.Ben Chen#, Ting Su#, Mingfeng Yang, Qiang Wang, Huarong Zhou, Guili Tan, Siting Liu, Zhangying Wu, Xiaomei Zhong , Yuping Ning. Static and dynamic functional connectivity of the habenula in late-life depression patient with suicidal ideation. Journal of Affective Disorders. 2024 356:499-506.

34.Shuang Liang#, Ben Chen#, Meiling Liu, Qiang Wang, Mingfeng Yang, Gaohong Lin, Danyan Xu, Yijie Zeng, Jingyi Lao, Jiafu Li, Qin Liu, Kexin Yao, Zhangying Wu, Min Zhang, Wenyue Shi , Linglong Qin , Xiaomei Zhong, Yuping Ning. Olfactory Dysfunction as a Marker for Cognitive Impairment in General Paresis of the Insane: A Clinical Study. Med Sci Monit. 2024 Jul 25;30:e944243

35.Jiafu Li#, Ben Chen#, Qiang Wang, Danyan Xu, Hanna Lu, Gaohong Lin, Mingfeng Yang, Jingyi Lao, Yijie Zeng, Shuang Liang, Kexin Yao, Qin Liu, Yuanling Huang, Xiaoxi Liu, Xiaomei Zhong, Yuping Ning. Chemosensory anhedonia facilitates depressive symptoms and cognitive impairment in late-life depression. Geriatrics & Gerontology International.

36.Danyan Xu#, Ben Chen#, Mingfeng Yang, Gaohong Lin, Min Zhang, Zhangying Wu, Huarong Zhou, Xiaolei Shi, Qi Peng, Yijie Zeng, Jingyi Lao, Qiang Wang, Shuang Liang, Jiafu Li, Kexin Yao, Qin Liu, Yanhong Ou, Xiaomei Zhong*, Yuping Ning. Odor identification dysfunction in late-life depression with suicidal ideation.

37.  陈贲, 施海姗, 钟笑梅, 侯乐, 王华丽, 王艳华, 陈辛茹, 罗新妮, 吴章英, 彭琪, 李丽娟, 宁玉萍. 麻痹性痴呆患者认知功能障碍与精神行为症状的随访研究. 中华精神科杂志 2017;50(3):226-230.

专利

1.一种鼻后嗅觉测试瓶 实用新型  ZL2020 2 2079959.2  宁玉萍 陈贲 钟笑梅

2.一种用于鼻后嗅觉测试及康复训练的橡皮球 实用新型 ZL 2020 2 2565121.4 陈贲 陈煜

3.一种用于嗅觉识别测试的多腔嗅瓶 实用新型 ZL 2022 2 0473490.7 陈贲 宁玉萍 钟笑梅

4. 一种用于嗅觉训练的四腔嗅笔，实用新型 ZL.202220473127.5 陈贲 宁玉萍 钟笑梅

5. 一种鼻后嗅觉测试的嗅笔，发明专利，ZL 2020 1 0997367.0 宁玉萍 陈贲 钟笑梅

【所获荣誉和奖励】

1.2021年 广东省科技进步奖二等奖 阿尔茨海默病早期预警与诊断系统研发及应用（第6完成人）

2.2021年 中国仪器仪表学会科学技术进步二等奖 阿尔茨海默病早期预警与诊断系统研发及应用（第6完成人）

3.2024 中国医师协会精神科医师分会 青年精神科医师希望之星

4.2021年度广州市医学会医学优秀学术论文 二等奖

5.2022年第八届中国老年医学与科技创新大会暨中国老年精神医学与心理健康学术会议青年研究论坛 优秀论文一等奖

6.2021年广东省医师协会精神科医师分会年会 优秀论文一等奖

7.2020年广州医科大学优秀博士论文

8.2020年 中华精卫奖学金 博士二等奖

9.2020年 广东省优秀学生

10.2018年 中国老年医学学会认知障碍分会英语学术演讲比赛三等奖

11.2019年 广东省第十七次精神病学学术会议优秀论文三等奖

12.2018年 广东省第十六次精神病学学术会议优秀论文三等奖