【个人简介】
刘亚平,博士,特聘教授,博士生导师,广东省高层次人才,广州市卫生健康委员会优秀人才,广州医科大学附属脑科医院睡眠与节律医学中心主任,香港中文大学客座助理教授。历任香港中文大学博士后(2016-2018)、牛津大学博士后(2018-2020),以及香港中文大学助理教授(2020-2023)。兼任中国睡眠研究会青委会常委以及生理与药理专委会委员、广东省医学会睡眠医学分会副主任委员。
【研究方向】
长期从事各类睡眠障碍的临床诊疗与研究,特别聚焦于睡眠障碍与神经退行性疾病。
【科研项目】
1.国家自然科学基金面上项目,82371494,褪黑素通过调节Sirt1/Nrf2-NLRP3通路延缓α-突触核蛋白病进展的机制研究,2024年1月1日至2026年12月31日,49万,在研,主持。
2.2024年度市校(院)企联合资助基础与应用基础研究项目,SL2023A03J00366,基于多模态临床评估的快速眼动睡眠行为障碍临床表型、发病机制以及干预策略研究,2024年1月1日至2025年12月31日,200万,在研,主持
3.香港医疗卫生研究基金,10210686,Multimodal brain connectomics markers of idiopathic rapid eye movement (REM) sleep behavior disorder and their prediction towards α-synucleinopathy,2023年1月1日至2025年12月31日,港币148.6万,在研,主持。
4.香港医疗卫生研究基金,08191416,Neural correlates of impulsivity in idiopathic REM sleep behavior disorder: a functional Magnetic Resonance Imaging case-control study. Health and Medical Research Fund,2021年12月1日至2014年11月30日,港币112万,在研,主持。
5.香港中文大学知识转化研究项目,KPF21GWP26,Risk screening for prodromal Parkinson’s disease in elderly using smartphone,2021年4月1日至2023年3月31日,港币40万,已结题,主持。
【代表性论文及著作】
1.Wang J#, Huang B#, Zhou L, Tang S, Feng H, Chan JW, Chau SW, Zhang J, Li SX, Mok V, Wing YK*, Liu Y*(最后通讯). Visuospatial Dysfunction Predicts Dementia-First Phenoconversion in Isolated REM Sleep Behavior Disorder. J Neurol Neurosurg Psychiatry. 2024; Epub ahead of print. doi:10.1136/jnnp-2024-333865 (IF = 11.1)
2.Zhou L, Li SX, Chau SW, Huang B, Wang J, Tang S, Chan JW, Zhang J, Yu MW, Tsang JC, Hu MTM, Mok VC, Wing YK*, Liu Y*(最后通讯). Altered impulsivity across drug-naïve parkinsonism, isolated REM sleep behavior disorder, and their high-risk relatives. Ann Neurol. 2023. doi: 10.1002/ana.26836 (IF = 11.2)
3.Liu Y, Zhang J, Chau SW, Man Yu MW, Chan NY, Chan JW, Li SX, Huang B, Wang J, Feng H, Zhou L, Mok V, Wing YK. Evolution of Prodromal REM Sleep Behavior Disorder to Neurodegeneration: A Retrospective, Longitudinal Case-control Study. Neurology. 2022;99(6):e627-e637. (IF = 10.1)
4.Liu Y, Lawton MA, Lo C, Bowring F, Klein JC, Querejeta-Coma A, Scotton S, Welch J, Razzaque J, Barber T, Ben-Shlomo Y, Hu MT. Longitudinal Changes in Parkinson's Disease Symptoms with and Without Rapid Eye Movement Sleep Behavior Disorder: The Oxford Discovery Cohort Study. Mov Disord. 2021;36(12):2821-2832. (IF = 8.6)
5.Liu Y# (共一排一) , Zhang J#, Lam SP, Zhou J, Yu MWM, Li SX, Chan JW, Postuma RB, Mok VCT, Wing YK. A case-control-family study of idiopathic rapid eye movement sleep behavior disorder. Ann Neurol. 2019;85(4):582-592. (IF = 11.2)
6.Liu Y#, Feng H#, Du J, Yang L, Xue H, Zhang J, Liang YY*, Liu Y* (最后通讯). Associations between accelerometer-measured circadian rest-activity rhythm, brain structural and genetic mechanisms, and dementia. Psychiatry Clin Neurosci. 2024. doi: 10.1111/pcn.13671 (IF = 11.9)
7.Zhou L, Huang B, Wang J, Chau SWH, Chan JWY, Zhang J, Yu MWM, Tsang JCC, Li SX, Mok V, Wing YK*, Liu Y*(最后通讯). Early- and late-onset of isolated rapid eye movement sleep behavior disorder: a retrospective cohort study. Sleep Med. 2023; 105:1-8.
8.Huang B, Zhang J, Wang J, Chau SWH, Chan JWY, Yu MWM, Li SX, Zhou L, Mok V, Wing YK*, Liu Y*(最后通讯). Isolated dream-enactment behaviours as a prodromal hallmark of rapid eye movement sleep behaviour disorder. J Sleep Res. 2022:e13791.
9.Liu Y#(共一排一), Partinen E#, Chan NY, Dauvilliers Y, Inoue Y, De Gennaro L, Plazzi G, Bolstad CJ, Nadorff MR, Merikanto I, Bjorvatn B, Han F, Zhang B, Cunha AS, Mota-Rolim S, Léger D, Matsui K, Espie CA, Chung F, Morin CM, Sieminski M, Thomas P, Holzinger B, Partinen M, Wing YK. Dream-enactment behaviours during the COVID-19 pandemic: an international COVID-19 sleep study. J Sleep Res. 2022:10.1111/jsr.13613.
10.Liu Y, Zhang J, Lam SP, Yu MW, Li SX, Zhou J, Chan NY, Wang J, Feng H, Chan Anne, Mok VCT, Wing YK. Electromyography activity level in rapid eye movement sleep predicts neurodegenerative diseases in idiopathic rapid eye movement sleep behavior disorder: a 5-year longitudinal study. Sleep Med. 2019;56:128-134.
11.Liu Y, Zhang J, Li SX, Chan NY, Yu MWM, Lam SP, Chan JWY, Li AM, Wing YK. Excessive daytime sleepiness among children and adolescents: prevalence, correlates, and pubertal effects. Sleep Med. 2018, 24;53:1-8.
12.Liu Y, Zhang J, Lam SP, Yu MW, Li SX, Zhou J, Chan JW, Chan NY, Li AM, Wing YK. Help-Seeking Behaviors for Insomnia in Hong Kong Chinese: A Community-Based Study. Sleep Med. 2016; 21:106-13.
13.Liu Y, Zhang J, Lam V, Ho CK, Zhou J, Li SX, Lam SP, Yu MW, Tang X, Wing YK. Altered Sleep Stage Transitions of REM Sleep: A Novel and Stable Biomarker of Narcolepsy. J Clin Sleep Med. 2015;11(8):885-94.
【所获荣誉和奖励】
1.2017年荣获第8届世界睡眠医学大会青年科学家奖;
2.2024年荣获广东省高层次人才项目。
【联系方式】
yapingliu@gzhmu.edu.cn 或:yaping.liu@cuhk.edu.hk