姓名:罗争意性别:男
职称:副研究员导师资格:硕士研究生导师
单位:广州医科大学附属脑科医院
学历:博士毕业院校:南方医科大学
招生专业:精神病与精神卫生学
电子邮件:luozhengyii@163.com
通信地址:广州市荔湾区芳村明心路36号
研究方向
从事神经生物学及神经系统疾病研究,主要集中在抑郁症及焦虑症等情绪障碍的发病机理的研究。
主持科研项目
国家级:1、钙通道Cav1.2点突变通过增加mGluR5导致神经元兴奋/抑制失衡引起认知障碍,58万元,在研。
2、PV神经元亚型调控焦虑障碍发生的机制及干预手段研究,70万(科技创新2030-“脑科学与类脑研究”重大项目(项目骨干),在研。
省级:1. Erbin通过PV中间神经元调节恐惧记忆的研究,10万元,结题。
2. Cav1.2钙通道G402S突变通过抑制mPFC锥体神经元兴奋性导致社交障碍,10万元,在研
3.生酮饮食通过上调Parabacteroides菌增加5-HTP提高mPFC兴奋性抗抑郁的机制研究,15万元,在研
市级:生酮饮食通过肠道菌群增加色氨酸代谢改善抑郁和焦虑的机制研究,100万元,在研。
部分代表性第一和通讯作者论文:
1) Luo, Z. Y. #, L. Huang#, S. Lin, Y. N. Yin, W. Jie, N. Y. Hu, Y. Y. Hu, Y. F. Guan, J. H. Liu, Q. L. You, Y. H. Chen, Z. C. Luo, S. R. Zhang, X. W. Li, J. M. Yang, Y. M. Tao, L. Mei and T. M. Gao (2020). "Erbin in Amygdala Parvalbumin-Positive Neurons Modulates Anxiety-like Behaviors."Biol Psychiatry87(10): 926-936.
2) Ying Li#, Zheng-Yi Luo #, Yu-Ying Hu, Yue-Wei Bi, Jian-Ming Yang, Wen-Jun Zou,Yun-Long Song, Shi Li, Tong Shen, Shu-Ji Li, Lang Huang, Ai-Jun Zhou,Tian-Ming Gao*, Jian-Ming Li* (2020). "The gut microbiota regulates autism-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice."Microbiome8, 120,2020.
3) Yuan, C. #, Luo Z. Y. #, Y. Zhou, S. Lei, C. Xu, C. Peng, S. Li, X. Li, X. Zhu and T. Gao (2018). "Removal of hERG potassium channel affinity through introduction of an oxygen atom: Molecular insights from structure-activity relationships of strychnine and its analogs."Toxicol Appl Pharmacol360: 109-119.
4)Shunchang Fang#; Zhengyi Luo; Zicheng Wei; Yuxin Qin; Jieyan Zheng; Hongyang Zhang; Jianhua Jin; Jiali Li; Chenjian Miao; Shana Yang; Yonglin Li, Zirui Liang; Xiao-Dan Yu; Xiao Min Zhang; Wei Xiong; Hongying Zhu; Wen-Biao Gan; Lianyan Huang*; Boxing Li*, Sexually dimorphic control of affective state processing and empathic behaviors. Neuron, 2024, Available online 1 March 2024.
5)Li Boxing#*; Benjamin Suutari; Simon D. Sun; Luo Zhengyi; Wei Chuanchuan; Nicolas Chenouard; Natanial Mandelberg; Zhang Guoan; Brie Wamsley; Tian Guoling; Sandrine Sanchez; You Sikun; Huang Lianyan; Thomas Neubert; Gordon Fishell; Richard W. Tsien*, Neuronal inactivity co-opts LTP machinery to drive potassium channel splicing and homeostatic spike widening,Cell,181, 1547-1565 e15,2020.