【个人简介】

广州医科大学附属第二医院神经内科，二级教授，主任医师，博士生导师。

现任广东省脑科学应用学会副会长，广东省卒中学会常务理事。

【研究方向】

主要从事脑血管病诊疗防治的基础与临床研究，近年来在急性脑缺血发病机制和神经保护研究方面开展了多项原创研究。

【科研项目】

1、国家自然科学基金委员会，面上项目，82471309, rno_piR_017990通过m6A修饰抑制Syt11 mRNA表达调控自噬小体成熟在脑缺血耐受中的作用，2025-01-01至2028-12-31，47万元，在研，主持。

2、国家自然科学基金委员会，面上项目，82071281，KDM2A调控胞核内β-catenin的稳定性在大鼠短暂全脑缺血耐受中的机制，2021-01-01至2024-12-31，55万元，在研，主持。

3、国家自然科学基金委员会，面上项目，81873745，Piwil2/piRNA介导CREB2基因启动子甲基化在大鼠短暂全脑缺血耐受中的机制，2019-01至2022-12，58万元，已结题，主持。

4、国家自然科学基金委员会，面上项目，81571140，Drp1转录后修饰减轻线粒体损伤后的坏死性凋亡介导大鼠脑缺血耐受的分子机制，2016-01至2019-12，57万元，已结题，主持。

5、国家自然科学基金委员会，面上项目，81371303，Hsp27的翻译后调控在短暂全脑缺血后低氧后处理神经保护中的分子机制，2014-01至2017-12，70万元，已结题，主持。

6、广东省科技厅，广东省自然科学基金面上项目，2021A1515011269，低氧后处理通过FKN/CX3CR1信号轴调控小胶质细胞激活介导脑缺血耐受的机制，2021-01至2023-12，10万元, 已结题，主持。

7、广东省科技厅，省自然科学基金一般项目，2015A030313461，激活Rab7 促进自噬成熟在成年大鼠短暂全脑缺血耐受中的作用，2016-01至2019-01，10万元，已结题，主持。

【代表性论文及著作】

1. Peng L, Chen M, Zuo X, Wu X, Gong M, Qin Z, Sun W, Xu E*. Targeting microglial C1q alleviates blood-brain barrier disruption in the thalamus after cortical infarction. J Neuroinflammation. 2026 Apr 20;23(1):181.

2. Chen M, Duan S, Chai G, Zhan L, Peng L, Sun W, Xu E*. Hypoxic Postconditioning Offers Neuroprotection Against Transient Cerebral Ischemia via Down-Regulation of rno_piR_011022. CNS Neurosci Ther. 2025 Feb;31(2):e70295.

3. Zuo Y, Xue J, Wen H, Zhan L, Chen M, Sun W, Xu E*. Inhibition of SCFKDM2A/USP22-dependent nuclear β-catenin ubiquitylation mediates cerebral ischemic tolerance. Commun Biol. 2025;8(1):214.

4. Peng L, Li K, Li D, Zuo X, Zhan L, Chen M, Gong M, Sun W, Xu E. The p75 neurotrophin receptor attenuates secondary thalamic damage after cortical infarction by promoting angiogenesis. CNS Neurosci Ther. 2024 Jul;30(7):e14875.

5. Zhan L, Qiu M, Zheng J, Lai M, Lin K, Dai J, Sun W, Xu E*. Fractalkine/CX3CR1 axis is critical for neuroprotection induced by hypoxic postconditioning against cerebral ischemic injury. Cell Commun Signal. 2024 Sep 26;22(1):457.

6. Zuo Y, Zhan L, Wen H, Xue J, Tan Y, Sun W, Xu E*.Stabilization of nuclear B-catenin by inhibiting KDM2A mediates cerebral ischemic tolerance. FASEB J. 2023; 37(3):e22796.

7. Wen H, Zuo Y, Li L, Zhan L, Xue J, Sun W, Xu E*. Hypoxic postconditioning restores mitophagy against transient global cerebral ischemia via Parkin-induced posttranslational modification of TBK1. Neurobiol Dis. 2023 Apr;179:106043.

8. Li K, Peng L, Xing Q, Zuo X, Huang W, Zhan L, Li H, Sun W, Zhong X, Zhu T, Pan G, Xu E*. Transplantation of hESCs-Derived Neural Progenitor Cells Alleviates Secondary Damage of Thalamus after Focal Cerebral Infarction in Rats. Stem Cells Transl Med，2023,12(8):553-568.

9. Lu X, Zhan L, Chai G, Chen M, Sun W, Xu E*. 1Hypoxic Preconditioning Attenuates Neuroinflammation via Inhibiting NF-κB/NLRP3 Axis Mediated by p-MLKL after Transient Global Cerebral Ischemia. Mol Neurobiol. 2024 Feb;61(2):1080-1099.

10. Zhan L, Chen M, Pang T, Li X, Long L, Liang D, Peng L, Sun W, Xu E*. Attenuation of Piwil2 induced by hypoxic postconditioning prevents cerebral ischemic injury by inhibiting CREB2 promoter methylation. Brain Pathol. 2023 Jan;33(1):e13109.

11. Li K, Jiang J, Shi Z, Zhan L, Peng L, Sun W, Tang Y, Zuo X, Xu E*. Neuroprotective Effects of Rhodiola Sacra on Transient Global Cerebral Ischemia Through Activating AMPK/Nrf2 Pathway in Rats. Antioxid Redox Signal. 2022 Mar;36(7-9):567-591.

12. Zhan L, Lu X, Xu W, Sun W, Xu E*. Inhibition of MLKL-dependent necroptosis via downregulating interleukin-1R1 contributes to neuroprotection of hypoxic preconditioning in transient global cerebral ischemic rats. J Neuroinflammation. 2021 Apr 20;18(1):97.

13. Wen H, Li L, Zhan L, Zuo Y, Li K, Qiu M, Li H, Sun W, Xu E*.Hypoxic postconditioning promotes mitophagy against transient global cerebral ischemia via PINK1/Parkin-induced mitochondrial ubiquitination in adult rats.Cell Death Dis. 2021; 12(7):630.

10. Zuo X, Hu S, Tang Y, Zhan L, Sun W, Zheng J, Han Y*, Xu E*.Attenuation of secondary damage and Aβ deposits in the ipsilateral thalamus of dMCAO rats through inhibition of Cathepsin B by bis(propyl)-cognitin, a multifunctional dimer. Neuropharmacology. 2020;162:107786.

11. Zhan L, Liu D, Wen H, Hu J, Pang T, Sun W, Xu E*. Hypoxic postconditioning activates the Wnt/β-catenin pathway and protects against transient global cerebral ischemia through Dkk1 Inhibition and GSK-3β inactivation. FASEB J. 2019; 33 (8):9291-9307.

12. Zhan L, Lu Z, Zhu X, Xu W, Li L, Li X, Chen S, Sun W, Xu E*. Hypoxic preconditioning attenuates necroptotic neuronal death induced by global cerebral ischemia via Drp1-dependent signaling pathway mediated by CaMKIIα inactivation in adult rats. FASEB J. 2019; 33(1):1313-1329.

13. Jin J, Tang Y, Li K, Zuo X, Zhan L, Sun W, Xu E*. Bone Marrow Stromal Cells Alleviate Secondary Damage in the Substantia Nigra After Focal Cerebral Infarction in Rats. Front cell Neurosci 2019; 13:338. doi:10.3389/fncel.2019.00338

14. Wen H, Liu L, Zhan L, Liang D, Li L, Liu D, Sun W, Xu E*. Neuroglobin mediates neuroprotection of hypoxic postconditioning against transient global cerebral ischemia in rats through preserving the activity of Na+/K+ ATPases.Cell Death Dis. 2018; 9(6):635.

15. Li K, Zhou H, Zhan L, Shi Z, Sun W, Liu D, Liu L, Liang D, Tan Y, Xu W, Xu E*. Hypoxic preconditioning maintains GLT-1 against transient global cerebral ischemia through upregulating Cx43 and inhibiting c-Src. Front Mol Neurosci. 2018; 1:34.

16. Zuo X, Hou Q, Jin J, Chen X, Zhan L, Tang Y, Shi Z, Sun W, Xu E*. Inhibition of cathepsins B induces neuroprotection against secondary degeneration in ipsilateral substantia nigra after focal cortical infarction in adult male rats. Front Aging Neurosci.2018; 10:125.

17. Zhan L, Liu L, Li K, Wu B , Liu D, Liang D, Wen H, Wang Y, Sun W, Liao W, Xu E*. Neuroprotection of hypoxic postconditioning against global cerebral ischemia through influencing posttranslational regulations of heat shock protein 27 in adult rats. Brain Pathol.2017; 27 (6): 822-838.

18. Zhan L, Chen S, Li K, Liang D, Zhu X,Liu L,Lu Z,Sun W, Xu E*. Autophagosome maturation mediatedby Rab7 contributes to neuroprotection of hypoxic preconditioning against global cerebral ischemia in rats. Cell Death Dis.2017; 20; 8(7): e2949.

【所获荣誉和奖励】

1、2004年获广东省科技进步奖三等奖和2019年获广东省医学科技进步二等奖各1项。

2、2006年和2013年先后两次荣获广州市优秀教师称号。