研究生院

江华
更新时间:2024-11-21


江华1992年本科毕业于湖北医学院,1998年硕士毕业于湖北医科大,2003年博士毕业于上海第二医科大学。2003年7月起曾长期在上海儿童医学中心血液肿瘤科工作,期间曾获“上海儿童医学中心优秀住院医生”以及“上海儿童医学中心优秀青年医务工作者”等称号,并获得医院研究基金资助;2008年被推选进入医院“优秀人才培养计划(EPT)”;2013年6月来到广州市妇女儿童医疗中心工作,同年9月起担任血液肿瘤科主任。2019年获“广州市高层次卫生人才”称号。作为访问学者,于2007年3月至6月在美国st.Jude chidlren’s research hospital移植部从事临床和实验室研究工作;作为Research Fellow,于2009年6月至2010年12月在加拿大多伦多大学附属Toronto General Hospital实验血液学实验室从事细胞凋亡机制研究。


主要科研项目和成果:

1.国家自然科学基金面上项目,IGF2BP3介导的circRBM39 m6A甲基化通过诱导线粒体分裂促进AML发生的作用及机制研究,49万,82370172,2024.1-2027.12,主持。

2.广东省企联合项目,面上项目,表观遗传液体活检标志物在儿童急性白血病鉴别诊断中的筛选验证及应用研究,10万,2023A1515220005,2023.11-2026.10,主持。

3.广州市卫健委临床特色技术项目,基于PTCY的造血干细胞移植体系治疗儿童急性髓系白血病的临床研究,2022-2025,25万2023C-TS56,在研。

4.广州市科技计划项目,202102010262,基于脐带间充质干细胞治疗造血干细胞移植后肺部感染的治疗作用及其机制,2021/04/01-2023/03/31,30万,在研、主持。

5.广州市卫健委高新重大特色临床研究项目,2019TS56,半相合移植治疗儿童重型再生障碍性贫血2019-202150万,主持

6.国家自然科学基金面上项目,30973217、ZFX基因调控人造血干细胞自我更新作用机制及其应用研究2010/01-2013/1230万元主持。

7.上海市卫生局课题, 2007142儿童急性白血病sjTREC水平变化与化疗后感染相关性研究、2007/09-2009/093万元主持。

8.广东省自然科学基金项目,2015A030313769、Rita诱导急性白血病细胞凋亡作用机制及其应用研究、2015/08-2018/08、10万元主持。

9.广东省医学科研基金项目,A2015149、Rita诱导急性白血病细胞凋亡作用机制及其应用研究、2015/08-2017/081万元主持。

10.上海市教育委员会科研项目,门冬酰胺合成酶遗传多态性及其与白血病化疗相关性研究,2004/09-2006/09,04BC37,2万元,主持。


近3年主要著作和论文:

[1]Danqi Luo, Yuhua Qu, Dao Wang, Benshan Zhang, Ming Sun, Hao Xiong, Jun Lu, Rui Yang, Mingyi Zhao, Haiyan Liu, Hua Jiang. Comparison of upfront haploidentical hematopoietic stem cell transplantation and salvage haploidentical hematopoietic stem cell transplantation after immunosuppressive therapy in children with acquired severe aplastic anemia - a multicenter study. Front Immunol. 2024-01-01;15:1384640.(通讯作者)

[2]Yang, Xu; Yang, Lihua; Luo, Annie; Liu, Shanshan; Zhang, Xiaohong; Liu, Xiaoping; Liu, Xiaodan; Luo, Ailing; Cai, Mansi; Yan, Yaping; Wu, Xuedong; Huang, Ke; Xu, Ling; Jiang, Hua.IKZF3 polymorphisms contribute to the increased risk of acute lymphoblastic leukemia in children.Cancer, 2024, 130(6):973-984.(通讯作者)

[3]Hongfeng Luo#, Taohua Liu#, Yuhua Qu, Caiyun Kuang, Minhua Xiao, Jing Sun, Huimin Chen, Jinhui Wu, Xihong Liu, Hua Jiang. Gut microbiota trajectory in β-thalassemia major children who underwent allogeneic hematopoietic stem cell transplantation.TRANSPL INFECT DIS. 2023-10-01;25(5):e14111.(通讯作者)

[4]Xinhua Xiao, Peihong Wang, Weina Zhang, Jiayi Wang, Mansi Cai, Hua Jiang*, Yingli Wu*, Huizhuang Shan*. GNF-7, a novel FLT3 inhibitor, overcomes drug resistance for the treatment of FLT3ITD acute myeloid leukemia.Cancer Cell Int. 2023-11-30;23(1):302.(通讯作者)

[5]Decheng Deng, Ailing Luo, Ming Li, Yaping Yan, Mansi Cai, Shanshan Liu, Xiaodan Liu,Xueliang Wang , Xiaohong Zhang , Hua Jiang*, Xiaoping Liu* .New association between splicing factor-coding gene polymorphisms and the risk of acute lymphoblastic leukemia in southern Chinese children: A five-center case-control study.J GENE MED. 2023-04-01;25(4):e3474.(通讯作者)

[6]Wenjiao Ding, Dao Wang, Mansi Cai, Yaping Yan, Shanshan Liu, Xiaodan Liu, Ailing Luo, Decheng Deng, Xiaoping Liu, Hua Jiang*. PIWIL1 gene polymorphism and pediatric acute lymphoblastic leukemia relapse susceptibility among Chinese children: a five-center case-control study.Frontiers in Oncology .2023;13:1203002.(通讯作者)

[7]Jiahua Li, Xueyan Zhang, Yiru Chen, Qingqing Zheng, Mingyi Zhao, and Hua Jiang. A Promising Insight: The Potential Influence and Therapeutic Value of the Gut Microbiota in GI GVHD. OXID MED CELL LONGEV. 2022-01-01;2022:2124627.(通讯作者)

[8]Yuhua Qu, Xu Yang*, Xiaohong Zhang, Shanshan Liu, Xiaoping Liu, Xiaodan Liu, Ailing Luo, Mansi Cai, Yaping Yan, Ling Xu* and Hua Jiang*. Mesenchymal stromal cell treatment improves outcomes in children with pneumonia post-hematopoietic stem cell transplantation: a retrospective cohort study. Stem Cell Research & Therapy (2022) 13:277.(通讯作者)

[9]Xinhua Xiao, Huizhuang Shan, Yangyang Niu, Peihong Wang, Donghe Li ,Yuyin Zhang, Jiayi Wang, Yingli Wu and Hua Jiang. TMPRSS2 Serves as a Prognostic Biomarker and Correlated With Immune Infiltrates in Breast Invasive Cancer and Lung Adenocarcinoma. Front. Mol. Biosci. 9:647826.(通讯作者)

[10]Lin Qiu, Rui Zhou, Ziyan Luo, Jiangxue Wu* and Hua Jiang*. CDC27-ODC1 Axis Promotes Metastasis, Accelerates Ferroptosis and Predicts Poor Prognosis in Neuroblastoma. Front Oncol.2022 ;12:774458.(通讯作者)

[11]Xiaodan Liu, Xiaoping Liu, Mansi Cai, Ailing Luo, Yingyi He, Sha Liu , Xiaohong Zhang , Xu Yang, Ling Xu* and Hua Jiang* .CircRNF220, not its linear cognate gene RNF220, regulates cell growth and is associated with relapse in pediatric acute myeloid leukemia. Molecular cancer 2021 20:139.(通讯作者)

[12]Xiaoping Liu, Libin Huang, Ke Huang, Lihua Yang, Xu Yang, Ailing Luo, Mansi Cai, Xuedong Wu, Xiaodan Liu, Yaping Yan, Jianyun Wen, Yun Cai, Ling Xu, and Hua Jiang. Novel associations between METTL3 gene polymorphisms and pediatric acute lymphoblastic leukemia: a five-center case-control study. Front Oncol. 2021; 11: 635251.(通讯作者)

[13]Yuhua Qu, Wenjiao Ding, Sha Liu, Xiaojing Wang, Pengfei Wang, Haiyan Liu, Han Xia, Yong Chen and Hua Jiang*. Metagenomic Next-Generation Sequencing vs. Traditional Pathogen Detection in the Diagnosis of Infection After Allogeneic Hematopoietic Stem Cell Transplantation in Children. Front. Microbiol. 13:868160.doi: 10.3389/fmicb.2022.868160.(通讯作者)

[14]Hui Zhang, Pengfei Wang, Zhuoyan Li, Yingyi He, Wenting Gan,Hua Jiang. Anti-CLL1 Chimeric Antigen Receptor T-Cell Therapy in Children with Relapsed/Refractory Acute Myeloid Leukemia. Clin Cancer Res.2021 Jul 01 ;27(13):3549-3555.(通讯作者)

[15]Chuwen Huang, Yuhua Qu, Sha Liu, Shushan Nie, Hua Jiang. Hematopoietic stem cell transplantation for thalassemia major using HLA fully-matched and mismatched donor grafts. Transl Pediatr,2021;10(6):1552-1565. (通讯作者)

[16]Zhao Zhang, Hua Jiang, Li Huang, Sixi Liu, Xiaoya Zhou, Yun Cai, Ming Li, Fei Gao, Xiaoting Liang, Kam-Sze Tsang, Guangfu Chen, Chui-Yan Ma, Yuet-Hung Chai, Hongsheng Liu, Chen Yang, Mo Yang, Xiaoling Zhang, Shuo Han, Xin Du, Ling Chen, Wuh-Liang Hwu, Jiacai Zhuo, Qizhou Lian. Lentivirus-modified hematopoietic stem cell gene therapy for advanced symptomatic juvenile metachromatic leukodystrophy: A long-term follow-up pilot study. PROTEIN CELL. 2024-06-25.(共一)

[17]Hua Jiang, Dong-Zhi Li. Early Onset of Severe Anemia Caused by Hb Calgary (HBB: C.194G>T): Another Case Report. HEMOGLOBIN. 2024-02-12;:1-3.(第一作者)

[18]Hua Jiang, Chuanqiang Niu, Yiqun Guo, Zhenyin Liu, Yizhou Jiang. Wedelolactone induces apoptosis and pyroptosis in retinoblastoma through promoting ROS generation. INT IMMUNOPHARMACOL. 2022-10-01;111:108855.(第一作者)

[19]Hua Jiang, Kan Wang, Muxia Yan, Qian Ye, Xiaojing Lin, Ling Chen, Yanrui Ye, Li Zhang, Junyan Liu, Tengyi Huang. Pathogenic and Virulence Factor Detection on Viable but Non-culturable Methicillin-Resistant Staphylococcus aureus. Front Microbiol.2021.12:630053.(第一作者)


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