
主治医师、副研究员,硕士生导师,广东省医学会血液病学分会青年委员会委员。2020年博士毕业于上海交通大学医学院附属瑞金医院,获内科学(血液病)博士学位,长期从事血液系统恶性肿瘤的临床及基础研究工作。主要研究方向为血液恶性肿瘤的发病机制、白血病耐药机制以及靶向治疗研究,主持国家自然科学基金1项,2项广州市科技项目,担任Frontiers in Immunology期刊专题编辑,Frontiers in Immunology、Journal of Translational Medicine等SCI期刊审稿人。在Nature Communications、Signal Transduction and Targeted Therapy、Journal of Hematology & Oncology、Cancer Research、Advanced Science、Cell Death & Disease等国际知名期刊发表SCI论文多篇,其中以第一作者或通讯作者发表SCI论文十余篇(含10篇IF>5,5篇IF>10 ),以第一发明人及第三发明人获授权国家发明专利2项。2023 年度广州市卫生健康委员会优秀人才。
【研究方向】
血液恶性肿瘤的发病机制、白血病耐药机制以及靶向治疗研究。
【科研项目】
AR413治疗Ph阳性急性B淋巴细胞白血病的分子机制研究,国家自然科学青年基金,2022年01月至 2024年 12月,30万,已结题,主持。
【代表性论文及著作】
(1)Xiao Xinhua; Li Huiliang, Liu Wei; Wu Yingli et al; Identification of 11(13)-dehydroivaxillin as a potent therapeutic agent against non-Hodgkin's lymphoma, Cell Death & Disease, 2017, 8 (8).(第一作者)
(2)Yue Zongwei; Xiao Xinhua; Wu Jinbao; Chen Guoqiang; Wu Yingli; Lei Xiaoguang el al; ent-Junger mannenone C Triggers Reactive Oxygen Species-Dependent Cell Differentiation in Leukemia Cells, Journal of Natural Products, 2018, 81(2): 298-306. (共同第一作者)
(3)Shan Huizhuang; Li Xiangyun; Xiao Xinhua; Dai Yuting; Xu Hanzhang; Wu Yingli et al; USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia, Signal Transduction and Targeted Therapy, 2018, 3 (3). (共同第一作者)
(4)Xinhua Xiao; Ping Liu; Donghe Li; Ruibao Ren et al; Combination therapy of BCR-ABL-positive B cell acute lymphoblastic leukemia by tyrosine kinase inhibitor dasatinib and c-JUN N-terminal kinase inhibition, Journal of Hematology & Oncology, 2020, 13(1). (第一作者)
(5)Peihong Wang, Xinhua Xiao, Chenxuan Liu, Ping Liu, Ruibao Ren et al. A dual inhibitor overcomes drug-resistant FLT3-ITD acute myeloid leukemia. Journal of Hematology & Oncology, 2021 Jul 3;14(1):105. (共同第一作者)
(6)Xinhua Xiao, Hua Jiang, Yingli Wu, Huizhuang Shan et al. GNF-7 overcomes drug resistance for the treatment of FLT3ITD acute myeloid leukemia. 2023 Cancer Cell International. (第一作者)
(7)Peihong Wang, Yvyin Zhang, Rufang Xiang, Jie Yang, Caixia Wang, Xinhua Xiao, Shunqing Wang. Foretinib, a novel FLT3 inhibitor, exerts excellent therapy effect on FLT3 mutant acute myeloid leukemia. Cancer Res. 2024 Mar 15;84(6):905-918. (共同通讯作者)
(8)Huizhuang Shan, Jiaguo Yuan, Luhua Xian, Wenmin Li, Yanfei Luo, Yingli Wu, Xinhua Xiao. USP24 promotes hepatocellular carcinoma progression by deubiquitinating and stabilizing YAP1. Cancer Cell Int. 2025 Apr 26;25(1): (通讯作者)
(9)Huizhuang Shan, Youping Zhang, Xinhua Xiao, Wenxuan Wu, Ziwei Zhang, Liming Lu, Yingli Wu et al. Int J Biol Sci. 2026 Jan 1;22(2):1036-1052. (共同第一作者)
【所获荣誉和奖励】
2023 年度广州市卫生健康委员会优秀人才