【个人简介】

马力，男，心胸外科副主任医师，医学硕士。现任广州医科大学附属妇女儿童医疗中心心外科专科主任，研究生导师。广东省医院协会第一届心脏血管微创外科管理专业委员会副主任委员，广东省胸部疾病学会心血管外科第二届专业委员会副主任委员，亚洲儿科和先天性心脏外科协会小儿心脏外科学会青年委员等。从事先天性心脏病的外科治疗工作17年。主刀各类心脏手术已超过5000余例，主要致力于新生儿、小婴儿及复杂重症先心病外科手术，诸如大动脉调转、PA/VSD/MAPCAs矫治术、一期矫治小儿主动脉弓疾病、完全性房室通道合并右室双出口矫治术、双根部调转术、双调转手术、Ross-Konno、改良Nikaidoh及Fontan类手术等。在省内较早开展小儿经胸微创房/室间隔缺损封堵术、腋下小切口体外循环手术（最小手术切口2.5cm）、小儿胸腔镜体外循环手术及先天性气管狭窄手术，最小体外循环手术年龄为出生8小时、体重为1.8kg。技术精湛，手术效果理想，赢得业内及患儿家属的赞誉和好评。

【研究方向】

研究方向：先天性心脏畸形发生机制和心肌缺血再灌注损伤。

【科研项目】

1.COL5A1通过WNT信号通路调控左心发育不良发生及进展的分子机制研究 广东省自然科学基金20万2022A1515012528（2022-2024）在研；

2.心外膜脂肪外泌体circ-HMGB2通过miR-190a-3p/PTEN 参与治疗心肌缺血/再灌注损伤的机制研究 广州市科技局28万 202201020647（2022-2023）结题。

【代表性论文及著作】

1. Ma L, Shi W, Ma X, Zou M, Chen W, Li W, Zou R, Chen X. Comprehensive analysis of differential immunocyte infiltration and the potential ceRNA networks during epicardial adipose tissue development in congenital heart disease. J Transl Med. 2020 Mar 2;18(1):111. doi: 10.1186/s12967-020-02279-y. PMID: 32122382; PMCID: PMC7053131.

2. Ma L, Zhou N, Zou R, Shi W, Luo Y, Du N, Zhong J, Zhao X, Chen X, Xia H, Wu Y. Single-Cell RNA Sequencing and Quantitative Proteomics Analysis Elucidate Marker Genes and Molecular Mechanisms in Hypoplastic Left Heart Patients With Heart Failure. Front Cell Dev Biol. 2021 Feb 25;9:617853. doi: 10.3389/fcell.2021.617853. PMID: 33718359; PMCID: PMC7946977.

3. Ma L, Zou R, Shi W, Zhou N, Chen S, Zhou H, Chen X, Wu Y. SGLT2 inhibitor dapagliflozin reduces endothelial dysfunction and microvascular damage during cardiac ischemia/reperfusion injury through normalizing the XO-SERCA2-CaMKII-coffilin pathways. Theranostics. 2022 Jun 27;12(11):5034-5050. doi: 10.7150/thno.75121. PMID: 35836807; PMCID: PMC9274739.

4. Ma L, Liao L, Zhou N, Tao H, Zhou H, Tan Y, Chen W, Cao F, Chen X. Transmembrane BAX inhibitor motif containing 6 suppresses presenilin-2 to preserve mitochondrial integrity after myocardial ischemia-reperfusion injury. Int J Biol Sci. 2023 Feb 13;19(4):1228-1240. doi: 10.7150/ijbs.81100. PMID: 36923943; PMCID: PMC10008687.

5. Ma L, Chang X, Gao J, Zhang Y, Chen Y, Zhou H, Zhou N, Du N, Li J, Bi J, Chen Z, Chen X, He Q. METTL3 boosts mitochondrial fission and induces cardiac fibrosis after ischemia/reperfusion injury. Int J Biol Sci. 2024 Jan 1;20(2):433-445. doi: 10.7150/ijbs.87535. PMID: 38169612; PMCID: PMC10758110.

6. Zou R, Tao J, Qiu J, Shi W, Zou M, Chen W, Li W, Zhou N, Wang S, Ma L, Chen X. Ndufs1 Deficiency Aggravates the Mitochondrial Membrane Potential Dysfunction in Pressure Overload-Induced Myocardial Hypertrophy. Oxid Med Cell Longev. 2021 Mar 3;2021:5545261. doi: 10.1155/2021/5545261. PMID: 33763166; PMCID: PMC7952157.

7. Zhou N, Liu L, Zou R, Zou M, Zhang M, Cao F, Liu W, Yuan H, Huang G, Ma L, Chen X. Circular Network of Coregulated Sphingolipids Dictates Chronic Hypoxia Damage in Patients With Tetralogy of Fallot. Front Cardiovasc Med. 2022 Jan 13;8:780123. doi: 10.3389/fcvm.2021.780123. PMID: 35097000; PMCID: PMC8792512.

8. Zou R, Shi W, Qiu J, Zhou N, Du N, Zhou H, Chen X, Ma L. Empagliflozin attenuates cardiac microvascular ischemia/reperfusion injury through improving mitochondrial homeostasis. Cardiovasc Diabetol. 2022 Jun 15;21(1):106. doi: 10.1186/s12933-022-01532-6. PMID: 35705980; PMCID: PMC9202214.

9. Lin R, Du N, Feng J, Li J, Li X, Cui Y, Ning S, Zhang M, Huang G, Wang H, Chen X, Ma L, Li J. Postoperative hypernatremia is associated with worse brain injuries on EEG and MRI following pediatric cardiac surgery. Front Cardiovasc Med. 2023 Dec 21;10:1320231. doi: 10.3389/fcvm.2023.1320231. PMID: 38188252; PMCID: PMC10768027.

10. Zou MH, Ma L, Cui YQ, Wang HZ, Li WL, Li J, Chen XX. Outcomes After Repair of Pulmonary Atresia With Ventricular Septal Defect and Major Aortopulmonary Collateral Arteries: A Tailored Approach in a Developing Setting. Front Cardiovasc Med. 2021 Apr 14;8:665038. doi: 10.3389/fcvm.2021.665038. PMID: 33937364; PMCID: PMC8079636.

【所获荣誉和奖励】

1.荣获2021年羊城好医生称号；

2.荣获2022年第二届广东实力中青年医生称号；

3.荣获2017-2022年度广州市医学会先进个人；

4.荣获广州市卫生健康委员会2023年度优秀人才称号；

5.荣获2024年广州好医生称号。