杨翌，广州医科大学附属第三医院副研究员，硕士生导师。

工作学习经历：

2009年-2014年吉林大学生物化学与分子生物学专业理学博士；

2014年-2016年广州生物医药与健康研究院 博士后基因编辑技术开发及疾病模型的建立；

2017年-2018年英国桑格研究所 访问学者高潜能干细胞及单细胞技术研究

2018年-至今广州医科大学“高水平大学建设工程”引进人才

研究方向：利用基因编辑技术、单细胞测序技术开展遗传疾病的致病机制解析与基因治疗

主要成果：

以第一作者在Cell Research、Protein Cell、Molecular therapy等国际刊物发表SCI论文5篇，主持国家自然科学基金项目。欢迎感兴趣的同学报考。

Email：492123490@qq.com

代表性论文：

1.Yi Yang^#; Han Wu^#; Xiangjin Kang^#; Yanhui Liang; Ting Lan; TianjieLi; Tao Tan; Jiangyun Peng; Quanjun Zhang; Geng An; Yali Liu; Qian Yu; ZhenglaiMa; Ying Lian; Boon Seng Soh; Qingfeng Chen; Ping Liu; Yaoyong Chen; XiaofangSun; Rong Li; Xiumei Zhen; Ping Liu; Yang Yu^*; Xiaoping Li^*; YongFan^*,Targeted elimination of mutant mitochondrial DNA in MELAS-iPSCs by mitoTALENs. Protein & Cell, 2018.1.9, 9(3): 283~297

2.Yali Liu^#,Yi Yang^#, Xiangjin Kang^#, Bin Lin, Qian Yu, Bing Song, Gao Ge, Yaoyong Chen, Xiaofang Sun, Xiaoping Li^*, Lei Bu^*, and Yong Fan^*. One-step biallelic and scarless correction of a β-thalassemia mutation in patient-specific iPSCs without drug selection. [J]. Molecular Therapy：Nucleic Acids, 6 March 2017 Volume 6, p57–67

3.Yi Yang^#, Kepin Wang^#, Han Wu, Qin Jin, Degong Ruan, Zhen Fan, Qishuai Liu, ShimeiGuo,Lei Bu, Yong Fan, Xiaofang Sun,Xiaoping Li^*,Liangxue Lai^*. Genetically humanized pigs exclusively expressing human insulin through custom endonucleases mediated seamless engineering [J]. Journal of Molecular Cell Biology, 2016. 8(2):174-7

4.Yi Yang^#, Songcai Liu^#, Yunyun Cheng, Linyan Nie, Chen Lv, Gang Wang, Yu Zhang, Linlin Hao. Highly Efficient and Rapid Detection of the Cleavage Activity of Cas9/gRNA via a Fluorescent Reporter. Applied Biochemistry and Biotechnology. 2016，180(4):655-667

5.Xiaoping Li^#,Yi Yang^#, Lei Bu, Xiaogang Guo, Chengcheng Tang, Jun Song, Nana Fan, Bentian Zhao, Zhen Ouyang, Zhaoming Liu, Yu Zhao, Xiaoling Yi, Longquan Quan, Songcai Liu, Zhenguo Yang, Hongsheng Ouyang, Y Eugene Chen, Zhong Wang^*, Liangxue Lai^*. Rosa26-targeted swine models for stable gene over-expression and Cre-mediated lineage tracing[J]. Cell research, 2014. 24（4）：501-504。