【个人简介】

教授、主任医师、硕士/博士/博士后导师，广州医科大学附属第三医院副院长，广州医科大学附属第三医院生殖医学中心副主任，男科学科带头人。外科学博士，毕业于中山大学，美国康奈尔大学医学院显微男科中心学习。

学术任职：广州市医院协会副会长；中华医学会生殖医学分会青年委员；广东省医学会生殖医学分会常委；广东省医学会男科学分会常委；广东省医师协会男科学分会副主委；中国人体健康科技促进会副主委。

电子邮件：angeng0505@outlook.com；通讯地址：广州市荔湾区多宝路63号。

【所获荣誉和奖励】

广东省杰出青年医学人才、广东省高校千百十计划人才、广州高层次引进杰出专家、广州市高层次卫生医学重点人才、2024年荣获年广州地区十大“青年医学尖兵”称号。2023年获得广州地区临床高新技术项目首席专家。

【学科专业及研究方向】

长期致力于非梗阻性无精子症的病因、诊断和治疗；干细胞和组织工程方面的研究。广东省内率先开展睾丸显微取精术（micro-TESE）联合睾丸组织冷冻技术治疗非梗阻性无精子症（NOA），目前已超过3000多例。开展“全球首例”3D打印海绵体生物支架修复阴茎海绵体缺损并成功生育子代。研究成果发表在Nature Communications, Cell Stem Cell, Nature Cell Biology, Materials Horizons, J Hazard Mater, Fertility and Sterility, Human Reproduction 等杂志。主持国家重大研发计划重点专项，国家自然科学基金面上项目，广东省自然科学基金和广州市科技攻关重点专项等科研项目。主译《男性不育显微外科和男性健康》，作为第一执笔专家组织编写《睾丸显微取精术围手术期中国专家共识》，编写中华医学会《生殖医学词条》男性不育症部分；参编2022年研究生教材《妇产科学》（人卫出版社），《无精子症诊疗中国专家共识》、《少精子症中国专家共识》、《中国男性生育力保存专家共识》、《坎贝尔-沃尔什泌尿外科学男科学分册》等。

【科研项目】

主持的国家级、省级、市级和校级等多个项目：

1.国家重点研发计划专项；

2.国家自然科学基金面上、青年项目；

3.广东省自然科学基金面上项目；

4.广州市科技攻关重点专项；

5.广东省自然科学基金博士启动项目；

6.广州医科大学博士启动项目；

7.广州医科大学重大临床研究项目；

8.广州医科大学附属第三医院临床研究资助项目。

【代表性论文及著作】（*为通讯作者）：

（1） Shaoquan Zhan^#, Geng An^#, Jiayu Gan^#, Hongzi Du, Xin Fu, Chunyan Wang, Yuling Mao, Xiangjin Kang, Jianqiao Liu*, Hanyan Liu*. Comparison of fresh testicular sperm aspiration and use of either thawed pre-frozen sperm or oocyte freezing: impact on cumulative live birth rates for couples experiencing ejaculation failure. Hum Reprod 2025, 40(2).

（2） Tianwen Peng^#, Muyuan Chai^#, Zhicong Chen, Man Wu, Xiaomin Li, Feixue Han, Shuyan Chen, Chen Liao, Ming Yue, You-Qiang Song, Hongkai Wu, Long Tian*, Geng An*. Exosomes from Hypoxia Preconditioned Muscle-Derived Stem Cells Enhance Cell-Free Corpus Cavernosa Angiogenesis and Reproductive Function Recovery. Adv Healthc Mater 2024, 13(28).

（3） Yaping Huang^#, Lin Li^#, Geng An^#, Xinyan Yang^#, Manman Cui^#, Xiuling Song, Jing Lin, Xiaoling Zhang, Zhaokai Yao, Cong Wan, Cai Zhou, Jiexiang Zhao, Ke Song, Shaofang Ren, Xinyu Xia, Xin Fu, Yu Lan, Xuesong Hu, Wen Wang, Mei Wang, Yi Zheng, Kai Miao, Xiaochun Bai, Andrew P Hutchins, Gang Chang, Shuai Gao, Xiao-Yang Zhao*. Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination. Nat Cell Biol 2023, 25(10).

（4） Xin Ye^#, Tianwen Peng^#, Zhicong Chen^#, Chen Liao, Xiaomin Li, Yu Lan, Xin Fu, Geng An*. Semen parameters' mediation effect on the association between advanced paternal age and IVF clinical outcomes: A 10-year retrospective cohort study. Maturitas 2023, 173(0).

（5） Tianwen Peng^#, Chen Liao^#, Xin Ye^#, Zhicong Chen, Xiaomin Li, Yu Lan, Xin Fu, Geng An*. Machine learning-based clustering to identify the combined effect of the DNA fragmentation index and conventional semen parameters on in vitro fertilization outcomes. Reprod Biol Endocrinol 2023, 21(1).

（6） Jie Huang^#, Xiaobin Tang^#, Zhicong Chen^#, Xiaomin Li, Yongqing Zhang, Xiangjie Huang, Delong Zhang, Geng An*, Hyeon Jeong Lee*. Rapid azoospermia classification by stimulated Raman scattering and second harmonic generation microscopy. Biomed Opt Express 2023, 14(11).

（7） Chen Liao^#, TianWen Peng^#, XiaoMin Li, ZhiCong Chen, MuYe Wang, Xin Ye, Yu Lan, Xin Fu, Geng An*. Identification of ferroptotic genes and phenotypes in idiopathic nonobstructive azoospermia. Syst Biol Reprod Med 2023, 69(6).

（8） Yu Lan^#, Haiyan Zheng^#, Xin Fu, Tianwen Peng, Chen Liao, Jianan Liu, Min Liu, Geng An*. Clinical Outcomes and Live Birth Rate Resulted From Microdissection Testicular Sperm Extraction With ICSI-IVF in Non-Obstructive Azoospermia: A Single-Center Cohort Study. Front Endocrinol 2022, 13(0).

（9） Tianxin Zhao^#, Lianju Shen^#, Xin Ye^#, Gaochen Bai, Chen Liao, Zhicong Chen, Tianwen Peng, Xiaomin Li, Xiangjin Kang, Geng An*. Prenatal and postnatal exposure to polystyrene microplastics induces testis developmental disorder and affects male fertility in mice. J Hazard Mater 2022, 445(0).

（10） Tianwen Peng^#, Chen Liao, Xin Ye, Zhicong Chen, Yu Lan, Xin Fu, Geng An*. Gonadotropins treatment prior to microdissection testicular sperm extraction in non-obstructive azoospermia: a single-center cohort study. Reprod Biol Endocrinol 2022, 20(1).

（11） Ke Song^#, Xinyan Yang^#, Geng An^#, Xinyu Xia^#, Jiexiang Zhao, Xiaoheng Xu, Cong Wan, Tianyuan Liu, Yi Zheng, Shaofang Ren, Mei Wang, Gang Chang, Shane J F Cronin, Josef M Penninger, Tao Jing, Xianghong Ou, Shuan Rao*, Zhaoting Liu*, XiaoYang Zhao*. Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models. Nat Commun 2022, 13(1).

（12） Geng An^#, Feixiang Guo^#, Xuemin Liu^#, Zhifang Wang^#, Ye Zhu, Yong Fan, Chengkai Xuan, Yan Li, Hongkai Wu, Xuetao Shi*, Chuanbin Mao*. Functional reconstruction of injured corpus cavernosa using 3D-printed hydrogel scaffolds seeded with HIF-1α-expressing stem cells. Nat Commun 2020, 11(1).

（13） Feixiang Guo^#, Aiping Fang^#, Yong Fan, Xin Fu, Yu Lan, Min Liu, Shuqi Cao, Geng An*. Role of treatment with human chorionic gonadotropin and clinical parameters on testicular sperm recovery with microdissection testicular sperm extraction and intracytoplasmic sperm injection outcomes in 184 Klinefelter syndrome patients. Fertil Steril 2020, 114(5).

（14） Zhifang Wang^#, Geng An^#, Ye Zhu, Xuemin Liu, Yunhua Chen, Hongkai Wu, Yingjun Wang, Xuetao Shi*, Chuanbin Mao*. 3D-printable self-healing and mechanically reinforced hydrogels with host-guest non-covalent interactions integrated into covalently linked networks. Mater Horiz 2019, 6(4).

（15） Mei Wang^#, Xixi Liu^#, Gang Chang^#, Yidong Chen^#, Geng An^#, Liying Yan, Shuai Gao, Yanwen Xu, Yueli Cui, Ji Dong, Yuhan Chen, Xiaoying Fan, Yuqiong Hu, Ke Song, Xiaohui Zhu, Yun Gao, Zhaokai Yao, Shuhui Bian, Yu Hou, Jiahao Lu, Rui Wang, Yong Fan, Ying Lian, Wenhao Tang, Yapeng Wang, Jianqiao Liu, Lianming Zhao, Luyu Wang, Zhaoting Liu, Renpei Yuan, Yujia Shi, Boqiang Hu, Xiulian Ren, Fuchou Tang*, Xiao-Yang Zhao*, Jie Qiao*. Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis. Cell Stem Cell 2018, 23(4).