
【个人简介】
涂兆伟,研究员,博士研究生导师。北京师范大学生命科学学院本科,中国科学院动物研究所博士,瑞典哥德堡大学、美国辛辛那提儿童医院博士后。2017年加入广州医科大学附属第三医院妇产科研究所,主要研究方向为母胎互作与妊娠疾病发生。
【学科专业及研究方向】
妇产科学:早期妊娠建立与维持
【科研项目】
1. 国家自然科学基金面上项目, 染色质重塑蛋白CHD8调控滋养层干细胞染色质可及性确保胎盘正常发育及功能的分子机制研究,2026-01-01至2029-12-31,49万,在研,主持。
2. 国家自然科学基金面上项目, 转录因子WT1介导孕酮受体PR活性参与子宫接受态建立和胚胎着床的机制研究,2023-01-01至2026-12-31,54万,在研,主持。
3. 国家自然科学基金青年C类项目,Ezrin介导的子宫上皮细胞转化在胚胎植入过程中的作用及机制研究,2019-01-01至2023-12-31,21万,已结题,主持。
4. 广州市科技计划市校企联合资助项目,滋养层细胞染色质重塑异常导致子痫前期发生的机制研究,2023-04-01至2025-03-31, 36万元,已结题,主持。
【代表性论文及著作】
(1) Yuanyuan Huang1#, Zhenhua Hu1,2#, Jiali Liao1#, Lijun Huang1, Jinyu Liu1, Chen Tu1, Yuchen Li1, Lulu Xie1, Shilei Bi1, Xiaobo Fang1, Jingsi Chen1, Lili Du1, Wei Sun1, Haibin Wang3*, Shuang Zhang1*, Dunjin Chen1*, Zhaowei Tu1*. (2026). CHD8-dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs. Advanced Science.
(2) Lijun Huang#, Zhaowei Tu#, Liudan Wei, Wei Sun, Yifan Wang, Shilei Bi, Fang He, Lili Du, Jingsi Chen, Julia Kzhyshkowska, Haibin Wang, Dunjin Chen*, Shuang Zhang*. (2023). Generating Functional Multicellular Organoids from Human Placenta Villi. Advanced Science, Jul 12;e2301565.
(3) Yingyu Liang, Siying Lai, Lijun Huang, Yulian Li, Shanshan Zeng, Shuang Zhang, Jingsi Chen, Wenbo Deng, Yu Liu, Jingying Liang, Pei Xu, Mingxing Liu, Zhongtang Xiong, Dunjin Chen*, Zhaowei Tu*, Lili Du*. (2023). JAZF1 safeguards human endometrial stromal cells survival and decidualization by repressing the transcription of G0S2. Communications Biology, May 27;6(1):568.
(4) Zhaowei Tu, Cuiqing Fan, Ashely K Davis, Mengwen Hu, Chen Wang, Akhila Dandamudi, Katie Seu, Theodosia Kalfa, Q. Richard Lu, Yi Zheng. (2022). Autism associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes expression of Rho GTPase signaling genes. Cell Reports, Jul 12;40(2):111072.
(5) Tu, Z, Wang, C., Davis, A.K., Hu, M., Zhao, C., Xin, M., Lu, R., and Zheng, Y. (2021). Chromatin remodeler CHD8 governs hematopoietic stem/progenitor survival by regulating ATM-mediated P53 protein stability. Blood, 138:221-233.
(6) Wang, Lina#; Tu, Zhaowei#; Liu, Chao#; Liu, Hongbin; Kaldis, Philipp; Chen, Zijiang*; Li, Wei*; Dual roles of TRF1 in tethering telomeres to the nuclear envelope and protecting them from fusion during meiosis, Cell Death and Differentiation, 2018, 25(6): 1174-1188.
(7) Zhaowei Tu#, Mustafa Bilal Bayazit#, Hongbin Liu, Jingjing Zhang, Kiran Busayavalasa, Sanjiv Risal, Jingchen Shao, Ande Satyanarayana, Vincenzo Coppola, Lino Tessarollo, Meenakshi Singh, Chunwei Zheng, Chunsheng Han, Zijiang Chen, Philipp Kaldis*, Jan-Ake Gustafsson*, Kui Liu*, Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation,Proc Natl Acad Sci USA,2017.1.17,114(3):592~597.
(8) Tu, Z,Wang, Q,Cui, T,Wang, J,Ran, H,Bao, H,Lu, J,Wang, B,Lydon, J P,DeMayo, F,Zhang, S,Kong, S*,Wu, X*,Wang, H*,Uterine RAC1 via Pak1-ERM signaling directs normal luminal epithelial integrity conducive to on-time embryo implantation in mice.,Cell Death and Differentiation,2016.1.01,23(1):169~181.
【所获荣誉和奖励】
1.2021年荣获全国妇幼健康科学技术奖,自然科学一等奖,获奖项目(胚胎植入的分子调控路径,7/15)