【个人简介】

李磊，博士，广州医科大学附属第三医院生殖医学中心副主任/胚胎实验室负责人

【学科专业及研究方向】

妇产科学：1.配子及早期胚胎发育异常的机制和干预策略研究；2辅助生殖技术的优化和安全性研究

【科研项目】

1. 国家自然科学基金面上项目，2027-01-01至2030-12-31，49万，在研，主持。

2. 广州市科技局市校联合项目，2025-01-01至2026-12-31，20万，在研，主持。

3. 广州医科大学附属第三医院“毅文人才”计划，2026-04-20至2031-4-19，50万，在研，主持。

【代表性论文及著作】

1. Man Wu, Lei Li, Tianxin Zhao, Yuling Mao, Jiajing Lin, Xiaomin Li, Yanling Bai,Feixue Han, Shuyan Chen, Tianwen Penga, Chen Liao, Xin Ye, Hongfei Ke, Zhiying Huang, Ming Yued, You Chee, Youqiang Song f, Zhicong Chen, Geng An. Polystyrene microplastics disrupt the blood-testis barrier via CEBPB-drivenlysosomal autophagy and induce ferroptosis-like injury in human sperm, compromising embryo development. Journal of Hazardous Materials, 2026.

2. Zheng Gao, Qingting Liu, Lei Li, Ting Hu, Xukun Lu, Yu Wu, DanDan Qin, Chen Gu, Jinhong Li, Chengpeng Xu,Dan Zhou, Fan Zhou, YanLing Bai, Xiangjin Kang, Jianqiao Liu, Dong Deng, Lei Li. TCL1A mediates DNA methylation defects in recurrent hydatidiform mole with NLRP7 pathogenic variants. Nature Communications, 2026.

3. Siying Lai, Lizi Zhang, Yang Luo, Zhongjia Gu, Zhenping Yan, Yuliang Zhang, Yingyu Liang, Minshan Huang, Jingying Liang, Shifeng Gu, Jingsi Chen, Lei Li, Dunjin Chen, Lili Du. A sonographic endometrial thickness <7mm in women undergoing in-vitro fertilization increases the risk of placenta accreta spectrum. Am J Obstet Gynecol.2024.

4. Teng Wang, JunHua Peng, Jiaqi Fan, Ni Tang, Rui Hua, Xueliang Zhou, Zhihao Wang, Longfei Wang, Yanling Bai, Xiaowan Quan, Zimeng Wang, Li Zhang, Chen Luo, Weiqing Zhang, Xiangjin Kang, Jianqiao Liu, Lei Li, Lin Li. Single-cell multi-omics profiling of human preimplantation embryos identifies cytoskeletal defects during embryonic arrest, Nature Cell Biology, 2024.

5. Xi Zhang, Li Li, Wenhong Zhang, Yang Luo, Yuling Mao, Hongzi Du, Lei Li. Embryo development and live birth resulted from artificial oocyte activation after microdissection testicular sperm extraction with ICSI in patients with non-obstructive azoospermia. Frontiers in Endocrinology. 2023.

6. Rui Chen, Ni Tang, Hongzi Du, Yaxin Yao, Yangyun Zou, Jing Wang, Dunmei Zhao, Xueliang Zhou, Yang Luo, Lei Li, Yuling Mao. Clinical application of noninvasive chromosomal screening for elective single-blastocyst transfer in frozen-thawed cycles, Journal of Translational Medicine, 2022.

7. Jianfang Huang, Yuling Mao, Quanxin Li, Honghai Hong, Ni Tang, Xiangjin Kang, Yuling Huang, Jianqiao Liu, Qing Gong, Yachao Yao, Lei Li. Kallistatin prevents ovarian hyperstimulation syndrome by regulating vascular leakage. J Cell Mol Med. 2022.

8. Yuling Mao, Ni Tang, Yang Luo, Ping Yin, Lei Li. Effects of vitrified cryopreservation duration on IVF and neonatal outcomes. J Ovarian Res. 2022.

【所获荣誉和奖励】

无