胡振华,博士,研究员,硕士导师,广州医科大学引进南山学者骨干人才(2023年)。博士毕业于英国爱丁堡大学生物信息学专业,具有包括医学、生物学和生物信息学在内的多学科交叉的教育及研究经历。相关研究成果以一作/并列一作发表在 Nature Cell Biology,Nature Communications (2 篇),以及 Clinicaland Translational Medicine 等国际知名生物学期刊。基金包括南山学者启动基金和新加坡 CDA 基金。
【研究方向】
1.滋养层细胞分化谱系保真的分子机制;
2.产科重大疾病的分子机制和关键靶基因的鉴定;
3.多能干性细胞获得和维持全能干性的分子机制和关键靶基因的鉴定;
4.妇科肿瘤的表观遗传机制和关键靶基因的鉴定。
【科研项目】
1.广州医科大学南山学者启动基金,2023年08月-2028年08年,300万,主持,在研;
2.新加坡科技局发展基金,2021年04月-2024年03月,23万新加坡币,主持,结题。
【代表性论文及著作】
1.Lau,M.#, Hu,Z.#, Tan,Y., Liu,J., Huang,H., Chan,J., and Tee,W.-W.( 2023). Regulation of global transcription by DNA topoisomerase I. Nature Communications.14(1):6464. (共一;IF:17.69)
2.Zhang,J.#, Hu,Z.#, Chung,H.H.#, Tian,Y., Lau,K.W., Zheng,S., Lim,Y.T., Sobota, R.M., Leong,H.F., Chen,B.J., Yeo,C.J., Tan,S.Y.X., Kang,J., Tan,D.E.K., Lakshmanan,M., and Tee,W.-W.(2023). Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis. Nature Communications. 14(1):2439 (共一;IF:17.69)
3.Zhang,Y.#, Lu,L.#, Hu,Z.#, Dai,Y., Ahmad,N., Ng,J., Chan,C., Hossain,M., Loh,A., Ward,J., Tan,P., Davila,S., Kumar,V., Hunziker,W., Lin,H., Yap,H., and Ng,KH(2022). Angiomotin mutation causes glomerulopathy and renal cysts by upregulating hepatocyte nuclear factor transcriptional activity. Clinical and Translational Medicine. (共一;IF:11.492)
4.Low,Y.X., Tan,D.E.K., Hu,Z., Tan,S.Y.X., and Tee,W.-W.(2021). Transposable Element Dynamics and Regulation during Zygotic Genome Activation in Mammalian Embryos and Embryonic Stem Cell Model Systems. Stem Cells International.2021(e1624669): DOI:10.1155/2021/1624669. (IF: 5.443)
5.Hu,Z.#, Tan,D.E.K.#, Chia,G.#, Tan,H., Leong,H.F., Chen,B.J., Lau,M.S., Tan,K.Y.S., Bi,X., Yang,D., Ho,TS., Wu,BJ., Bao,SQ., Wong,ESM., and Tee,W.-W.(2020). Maternal factor NELFA drives a 2C-like state in mouse embryonic stem cells. Nature Cell Biology. 22(2):175-186. (共一; IF:28.82)
6.Hu,Z., and Tee,W.-W.(2017). Enhancers and chromatin structures: regulatory hubs in gene expression and diseases. Bioscience Report. 37(2):BSR20160183. (综述; IF: 2.899)
7.Hu,Z., Wang,Y., Yu,L., Mahanty,S.K., Mendoza,N., and Elion,E.A.(2016). Mapping regions in Ste5 that support Msn5-dependent and -independent nuclear export. Biochemistry and Cell Biology. 94(2):109-128. (IF: 2.25)
【所获荣誉和奖励】
1.2023年荣获广州医科大学“南山学者骨干人才”