研究生院

陈敏
更新时间:2024-05-08

陈敏,男,博士,教授,现任广州医科大学附属第三医院胎儿医学与产前诊断科主任。担任国际妇产超声学会ISUOG中国区大使,ISUOG 患者信息委员会中国区负责人。国际妇产超声学会国际教学讲师团委员, ISUOG国际咨询委员会委员,中华医学会围产分会胎儿学组委员,广东省医师协会母胎医学分会常委等。

现系下列12份国际SCI 杂志:BJOG (英国妇产科杂志)、Prenatal diagnosis (PD) (产前诊断)、The Journal of Obstetrics and、Gynaecology Research (JOGR) (妇产科研究)、Ultrasound Obstet Gynecol(UOG)(妇产超声)、Journal of Maternal-Fetal and Neonatal Medicine(母胎新生儿医学)、Molecular Cytogenetics(分子细胞遗传学)、Chinese Medical Journal (CMJ)、BIOCELL、Journal of Human Genetics、Reproductive Sciences、BMC Pregnancy and Childbirth、Placenta、BMJ open审稿人。从事妇产科工作20余年,妇产科业务熟练,现主要研究方向为胎儿医学、产前诊断、产科超声、胎儿遗传学,发表SCI 论文90篇。

一、基本情况

姓名

(中文)陈敏

性别

国籍

中国

(外文)Min Chen

户籍

广州

出生地

云南省

邮政编码

510150

电子邮箱

edchen99@gmail.com

最高学历

博士

最高学位

博士

毕业院校

香港大学

从事专业

妇产科学:产前诊断与胎儿医学

产科超声遗传学

专业技术职称

教授

教学职称

教授(硕导、博导)

工作单位

及职务

广州医科大学附属第三医院 胎儿医学中心与产前诊断科 科室主任

教育经历

(从本科填起)

起止时间 院校 专业 学位

1990.09至1995.06 中山大学 临床医学 学士

1995.09至1997.06 中山大学 妇产科学 硕士

2001.08至2006.06 香港大学 妇产科学 博士

2016.08至2019.06 香港中文大学 医学遗传学 硕士

工作经历

起止时间 工作单位 任职情况

1997.09-2001.07 中山医科大学孙逸仙纪念医院妇产科 主治医师

2006.08-2007.12 香港大学医学院 研究员

2008.01-2010.08 香港中文大学妇产科系 助理教授

2010.08-2011.12 上海市第一妇婴保健院超声科 科主任

2012.01-至今 广州医科大学附属第三医院 科主任

胎儿医学中心和产前诊断科

2012.01-至今 香港中文大学妇产科系 兼职助理教授

二、主要学术成果

1.承担科研项目

名 称

时 间

项目编号

批准立项部门

排名及职责

长非编码RNA DSCR9对唐氏综合征中枢神经系统发育异常的调控机制研究

2017-01至2020-12

81671470

国家自然科学基金管理委员会

项目负责人,主持

国家重点研发计划“生殖健康及重大出生缺陷防控研究”专项“胎盘形成的分子机制”课题四:靶向胎盘的妊娠进程动态监测和妊娠结局预测

2018-12至2021-12

2018YFC1004104

国家科技部

课题骨干

无创性产前诊断胎儿微缺失微重复综合征的研究

2016.06至2019.06

2016A030313610

广东省自然科学基金管理委员会

项目负责人,主持

与DNA甲基化相关的长非编码RNA在开放性神经管缺陷疾病发生中的作用机制研究

2021-04至2023-03

202102010129

广州市科技局

项目负责人,主持

基于高通量测序的胎儿染色体微缺失、微重复及嵌合体无创产前检测研究

2016-04至2019-3

201604020078

广州市科信局重大项目

项目负责人,主持

遗传性疾病综合检测技术的继承研发和规模应用

2020-03至2020-08

202008

横向课题

项目负责人

2022(省自然省企联合基金)新一代胎儿遗传疾病无创产前检测技术:靶向富集全基因组同步测序技术(Targeted And Genmoe-wide simultaneous sequencing,TAG-seq)

2022-11至2025-10

2022A1515220043

省科技厅

项目负责人

(2021年度市科技局)与DNA甲基化相关的长非编码RNA在开放性神经管缺陷疾病发生中的作用机制研究

2021-04至2024-03

110213613

广州市科创委

项目负责人

2.获得科技奖励项目

名 称

时 间

等级

授奖部门

排名

罕见病实验诊断关键技术与规模应用

2020年2月

一等奖

广东省人民政府

第13

二代测序技术对胎儿疾病病因学的研究

2021年12月

三等奖

广东省医学会

第1

3.担任医学重点学科、重点实验室(含研究方向)和临床重点专科带头人或负责人

名称

时间

等级

立项部门

职责

产前诊断学

2018年-2022年

院级

广州医科大学附属第三医院

项目负责人

4.在SCI收录学术刊物上发表论文

1. Hui PW, Lam YH, Chen M, Tang MH, Yeung WS, Ng EH, Ho PC. Attitude of at-risk subjects towards preimplantation genetic diagnosis of alpha-and beta-thalassaemias in Hong Kong. Prenat Diagn. 2002 Jun;22(6):508-11.

2. Chen M, Lam YH, Tang MH, Lee CP, Sin SY, Tang R, Wong HS, Wong SF. The effect of ethnic origin on nuchal translucency at 10-14 weeks of gestation. Prenat Diagn. 2002 Jul;22(7):576-8.

3. Chen M, Lam YH, Lin CL, Chan KW, Hui PW, Tang MH, Lee CP, Khong PL. Sonographic features of ileal duplication cyst at 12 weeks. Prenat Diagn. 2002 Dec;22(12):1067-70.

4. Chen M, Lam YH, Lee CP, Tang MH.Ultrasound screening of fetal structural abnormalities at 12 to 14 weeks in Hong Kong. Prenat Diagn. 2004 Feb;24(2):92-7.

5. Chen M, Lee CP, Leung KY, Hui PW, Tang MH.Pilot study on the midsecond trimester examination of fetal nasal bone in the Chinese population.Prenat Diagn. 2004 Feb;24(2):87-91.

6. Chen M, Chan GS, Lee CP, Tang MH. Sonographic features of lethal multiple pterygium syndrome at 14 weeks. Prenat Diagn. 2005 Jun;25(6):475-8.

7. Chen M, Lee CP, Tang R, Chan B, Ou CQ, Tang MH. First-trimester examination of fetal nasal bone in the Chinese population. Prenat Diagn. 2006 Aug;26(8):703-6.

8. Chen M, Leung KY, Lee CP, Tang MH, Ho PC. Placental volume measured by three-dimensional ultrasound in the prediction of fetal alpha(0)-thalassemia: a preliminary report. Ultrasound Obstet Gynecol. 2006 Aug;28(2):166-72.

9. Chen M, Chan B, Lam TP, Shek T, Lee CP, Tang MH. Sonographic features of hemivertebra at 13 weeks' gestation. J Obstet Gynaecol Res. 2007 Feb;33(1):74-7.

10. Chen M, Lee CP, Lam YH, Ou CQ, Tang MH. First-trimester fetal limb biometry in Chinese population. Prenat Diagn. 2007 Feb;27(2):133-8.

11. Chen M, Lee CP, Lam YH, Tang RY, Chan BC, Wong SF, Tse LH, Tang MH. Comparison of nuchal and detailed morphology ultrasound examinations in early pregnancy for fetal structural abnormality screening: a randomized controlled trial. Ultrasound Obstet Gynecol. 2008 Feb;31(2):136-46;

12. Chen M, Ng L, Lau E, Lee CP, Tang MH, Lam YH. The effect of volume of chorionic villi on long-term cell culture. Fetal Diagn Ther. 2008;24(4):409-12.

13. Chen M, Xiong Y, Chau MM, Li RS, Lau TK. Comparison of conventional and PureWave Crystal transducer in obstetric sonography. J Matern Fetal Neonatal Med. 2009 Jul;22(7):616-21.

14. Chen M, Wang HF, Leung TY, Fung TY, Chan LW, Sahota DS, Lao TH, Lau TK. First trimester measurements of nasal bone length using three-dimensional ultrasound. Prenat Diagn. 2009 Aug;29(8):766-70.

15. Chen M, Meagher S, Simpson I, Lau TK. Sonographic features of anorectal atresia at 12 weeks. J Matern Fetal Neonatal Med. 2009 Oct;22(10):931-3.

16. Xiong Y, Wah YM, Chen M, Leung TY, Lau TK. Real-time three-dimensional echocardiography using a matrix probe with live xPlane imaging of the interventricular septum. Ultrasound Obstet Gynecol. 2009 Nov;34(5):534-7.

17. Chen M, Yang X, Leung TY, Sahota DS, Fung TY, Chan LW, Lao TT, Lau TK. Study on the applicability of frontomaxillary facial angle in the first-trimester trisomy 21 fetuses in Chinese population. Prenat Diagn. 2009 Dec;29(12):1141-4.

18. Chen M, Leung TY, Sahota DS, Fung TY, Chan LW, Law LW, Chau MC, Lao TH, Lau TK. Ultrasound screening for fetal structural abnormalities performed by trained midwives in the second trimester in a low-risk population--an appraisal. Acta Obstet Gynecol Scand. 2009;88(6):713-9.

19. Sahota DS, Leung TY, Chan LW, Law LW, Fung TY, Chen M, Lau TK. Comparison of first-trimester contingent screening strategies for Down syndrome. Ultrasound Obstet Gynecol. 2010 Mar;35(3):286-91.

20. Yang X, Chen M, Wang HF, Leung TY, Borenstein M, Nicolaides K, Sahota DS, Lau TK. Learning curve in measurement of fetal frontomaxillary facial angle at 11-13 weeks of gestation. Ultrasound Obstet Gynecol. 2010 May;35(5):530-4.

21. Xiong Y, Wah YM, Chen M, Fung TY, Leung TY, Lau TK. Assessment of the fetal interventricular septum using real-time three-dimensional echocardiography with Live 3D imaging. Ultrasound Obstet Gynecol. 2010 Jun;35(6):754-5.

22. Sahota DS, Leung TY, Chen M, Chan LW, Fung TY, Lau TK. Comparison of likelihood ratios of first-trimester nuchal translucency measurements: multiples of median, delta or mixture. Ultrasound Obstet Gynecol. 2010 Jul;36(1):15-9.

23. Law LW, Sahota DS, Chan LW, Chen M, Lau TK, Leung TY. Effect of long-term storage on placental growth factor and fms-like tyrosine kinase 1 measurements in samples from pregnant women. J Matern Fetal Neonatal Med. 2010 Dec;23(12):1475-80.

24. Chen M, Wang HF, Leung TY, Sahota DS, Borenstein M, Nicolaides K, Lao TT, Lau TK. Frontomaxillary facial angle at 11 + 0 to 13 + 6 weeks in Chinese population.J Matern Fetal Neonatal Med. 2011 Mar;24(3):498-501.

25. Yang XH, Chen M, Leung TY, Wong SM, Lau TK. Use of three-dimensional (3D) sonography to assess the true midsagittal plane of fetal spine. J Matern Fetal Neonatal Med. 2011 Feb;24(2):297-300.

26. Sahota DS, Chen M, Leung TY, Chan LW, Fung TY, Ting YH, Lau TK. Assessment of sonographer nuchal translucency measurement performance--central tendency and dispersion. J Matern Fetal Neonatal Med. 2011 Jun;24(6):812-6.

27. Law LW, Sahota DS, Chan LW, Chen M, Lau TK, Leung TY. Serum placental growth factor and fms-like tyrosine kinase 1 during first trimester in Chinese women with pre-eclampsia--a case-control study. J Matern Fetal Neonatal Med. 2011 Jun;24(6):808-11.

28. Chen PW, Chen M, Leung TY, Lau TK. Effect of image settings on nuchal translucency thickness measurement by a semi-automated system. Ultrasound Obstet Gynecol. 2012 Feb;39(2):169-74.

29. Pan M, Chen M, Leung TY, Sahota DS, Ting YH, Lau TK. Outcome of monochorionic twin pregnancies with abnormal umbilical artery Doppler between 16 and 20 weeks of gestation. J Matern Fetal Neonatal Med. 2012 Mar;25(3):277-80.

30. Xiong Y, Chen M, Chan LW, Ting YH, Fung TY, Leung TY, Lau TK. A novel way of visualizing the ductal and aortic arches by real-time three-dimensional ultrasound with live xPlane imaging. Ultrasound Obstet Gynecol. 2012 Mar;39(3):316-21.

31. Xiong Y, Chen M, Chan LW, Ting YH, Fung TY, Leung TY, Lau TK. Scan the fetal heart by real-time three-dimensional echocardiography with live xPlane imaging. J Matern Fetal Neonatal Med. 2012 Apr;25(4):324-8.

32. Pan M, Chen M, Leung TY, Sahota DS, Lao TT, Lau TK. Can we use the frontomaxillary facial angle in the first trimester to predict facial cleft? Prenat Diagn. 2012 May;32(5):491-3.

33. Chen M, Chen H, Yang X, Wang HF, Yeung Leung T, Singh Sahota D, Lao TT, Lau TK. Normal range of intracranial translucency (IT) assessed by three-dimensional ultrasound at 11 + 0 to 13 + 6 weeks in a Chinese population. J Matern Fetal Neonatal Med. 2012 May;25(5):489-92.

34. Zhen L, Yang X, Ting YH, Chen M, Leung TY. The influence of image setting on intracranial translucency measurement by manual and semi-automated system. Prenat Diagn. 2013 Sep;33(9):889-93.

35. Chen M, Lee CP, Lam YH, Tang RY, Chan BC, Wong SF, Tse LH, Tang MH. Cystic hygroma detected in the first trimester scan in Hong Kong. J Matern Fetal Neonatal Med.2014 Mar;27(4):342-5.

36. Huang X , Zheng J , Chen M , Zhao Y , Zhang C , Liu L , Xie W , Shi S , Wei Y , Lei D , Xu C , Wu Q , Guo X , Shi X , Zhou Y , Liu Q , Gao Y , Jiang F , Zhang H , Su F , Ge H , Li X , Pan X , Chen S , Chen F , Fang Q , Jiang H , Lau TK , Wang W . Non-invasive prenatal testing of trisomies 21 and 18 by massively parallel sequencing of maternal plasma DNA in twin pregnancies. Prenat Diagn 2014 Apr;34(4):335-40

37. Lin SM,Chen M, MA SK, Lam YH, Wong KY,Tang MH. Intrauterine therapy in a fetus with congenital dyserythropoietic anaemia type Ⅰ. J Obstet Gynaecol. 2014 May;34(4):352-3.

38. Liu W, Chen M, Wei J, He W, Li Z, Sun X, Shi Y. Modification of PCR conditions and design of exon-specific primers for the efficient molecular diagnosis of PKD1 mutations. Kidney Blood Press Res.2014;39(6):536-45.

39. Wei J, Xie Y, He W, Liu W, Jian W, Chen M, Wang D, Wang X, Sun X. Clinical outcome: a monosomy 18p is better than a tetrasomy 18p. Cytogenet Genome Res.2014;144(4):294-8.

40. Liu W, Zhang H, Wang J, Yu G, Qiu W, Li Z, Chen M, Choy KW, Sun X. Prenatal diagnosis of complete maternal uniparental isodisomy of chromosome 4 in a fetus without congenital abnormality or inherited disease-associated variations. Mol Cytogenet. 2015 Nov 4;8:85.

41. Liu W, Zhang R, Wei J, Zhang H, Yu G, Li Z, Chen M, Sun X. Rapid Diagnosis of Imprinting Disorders Involving Copy Number Variation and Uniparental Disomy Using Genome-Wide SNP Microarrays. Cytogenet Genome Res.2015;146(1):9-18.

42. Li Y, Choy KW, Xie HN, Chen M, He WY, Gong YF, Liu HY, Song YQ, Xian YX, Sun XF, Chen XJ. Congenital hydrocephalus and hemivertebrae associated with de novo partial monosomy 6q (6q25.3→qter). Balkan J Med Genet. 2015 Dec 30;18(1):77-84.

43. Song YQ, Chen M, Yang ZL, He WY, Liu WQ, Li Y, Gong YF, Wang JY, Sun XF, Chen XJ. Prenatal diagnosis of hemivertebrae-A likely association with 7q deletion. Taiwan J Obstet Gynecol. 2016 Feb;55(1):112-6.

44. Zhang H, Liu W, Chen M, Li Z, Sun X, Wang C. Implementation of a High-Resolution Single-Nucleotide Polymorphism Array in Analyzing the Products of Conception. Genet Test Mol Biomarkers. 2016 Jul;20(7):352-8.

45. Cao Y, Li Z, Rosenfeld JA, Pursley AN, Patel A, Huang J, Wang H, Chen M, Sun X, Leung TY, Cheung SW, Choy KW. Contribution of genomic copy-number variations in prenatal oral clefts: a multicenter cohort study. Genet Med. 2016 Oct;18(10):1052-5.

46. Zhai J, Cai W, Li C, Chen M, Huang L, Zhong M. Survey of attitudes of Chinese perinatologists and obstetricians toward non-invasive prenatal genetic testing. J Obstet Gynaecol Res. 2016 Nov;42(11):1445-1450.

47. Chen M, Lu S, Lai ZF, Chen C, Luo K, Yuan Y, Wang YS, Li SQ, Gao Y, Chen F, Asan, Chen DJ. Targeted sequencing of maternal plasma for haplotype-based non-invasive prenatal testing of spinal muscular atrophy. Ultrasound Obstet Gynecol. 2017 Jun;49(6):799-802.

48. Liu Q, Wu J, Shen W, Wei R, Jiang J, Liang J, Chen M, Zhong M, Yin A. Analysis of amino acids and acyl carnitine profiles in low birth weight, preterm,

and small for gestational age neonates. J Matern Fetal Neonatal Med. 2017 Nov;30(22):2697-2704.

49. Chen M, Wang J, Luo Y, Huang K, Shi X, Liu Y, Li J, Lai Z, Xue S, Gao H, Chen A, Chen D. Identify Down syndrome transcriptome associations using integrative analysis of microarray database and correlation-interaction network. Hum Genomics. 2018 Jan 19;12(1):2.

50. Jian W, Du QT, Lai ZF, Li YF, Li SQ, Xiong ZT, Chen DJ, Chen M, Chen JS. Prenatal diagnose of a fetus with Harlequin ichthyosis in a Chinese family. Taiwan J Obstet Gynecol. 2018 Jun;57(3):452-455.

51. Choy KW, Wang H, Shi M, Chen J, Yang Z, Zhang R, Yan H, Wang Y, Chen S, Chau MHK, Cao Y, Chan OYM, Kwok YK, Zhu Y, Chen M, Leung TY, Dong Z. Prenatal Diagnosis of Fetuses With Increased Nuchal Translucency by Genome Sequencing Analysis.Front Genet. 2019 Aug 16;10:761.

52. Chen M, Chen C, Li Y, Yuan Y, Lai Z, Guo F, Wang Y, Huang X, Li S, Wu R, Peng Z, Sun J, Chen D. Haplotype-Based noninvasive prenatal diagnosis for duchenne muscular dystrophy: A pilot study in South China. Eur J Obstet Gynecol Reprod Biol. 2019 Sep;240:15-22.

53. Ji X, Li J, Huang Y, Sung PL, Yuan Y, Liu Q, Chen Y, Ju J, Zhou Y, Huang S, Chen F, Han Y, Yuan W, Fan C, Zhao Q, Wu H, Feng S, Liu W, Li Z, Chen J, Chen M, Yao H, Zeng L, Ma T, Fan S, Zhang J, Yuen KY, Cheng SH, Chik IWS, Liu NT, Zhu J, Lin S, Cao J, Tong S, Shan Z, Li W, Hekmat MR, Garshasbi M, Suela J, Torres Y, Cigudosa JC, Ruiz FJP, Rodríguez L, García M, Bernik J, Traven E, Reš U, Tul N,Tseng CF, Zhao D, Sun L, Pan Q, Shen L, Dai M, Wang Y, Wang J, Yang H, Yin Y, Duan T, Zhu B, Choolani M, Jin X, Chen Y, Mao M. Identifying occult maternal malignancies from 1.93 million pregnant women undergoing noninvasive prenatal Screening tests. Genet Med. 2019 Oct;21(10):2293-2302.

54. Li H, Du B, Jiang F, Guo Y, Wang Y, Zhang C, Zeng X, Xie Y, Ouyang S, Xian Y, Chen M, Liu W, Sun X. Noninvasive prenatal diagnosis of β-thalassemia by relative haplotype dosage without analyzing proband. Mol Genet Genomic Med. 2019 Nov;7(11): e963.

55. Chen M, Jiang F, Guo Y, Yan H, Wang J, Zhang L, Zeng X, Li S, Li Y, Li N, Zhang C, Zhu W, Du B, Wang Y, Lan Z, Luo X, Luo F, Chen D. Validation of fetal DNA fraction estimation and its application in noninvasive prenatal testing for aneuploidy detection in multiple pregnancies. Prenat Diagn. 2019 Dec;39(13):1273-1282.

56. Xu J, Chen M, Liu QY, Hu SQ, Li LR, Li J, Ma RM. Detecting trisomy in products of conception from first-trimester spontaneous miscarriages by next-generation sequencing (NGS). Medicine (Baltimore). 2020 Jan;99(5): e18731.

57. Xue S, Yan H, Chen J, Li N, Wang J, Liu Y, Zhang H, Li S, Zhang W, Chen D, Chen M. Genetic Examination for Fetuses with Increased Fetal Nuchal Translucency by Genomic Technology. Cytogenet Genome Res. 2020;160(2):57-62.

58. Li YT, Chen JS, Jian W, He YD, Li N, Xie YN, Wang J, Zhang VW, Huang WR, Jiang FM, Ye XQ, Chen DJ, Chen M. L1CAM mutations in three fetuses diagnosed by medical exome sequencing. Taiwan J Obstet Gynecol. 2020 May;59(3):451-455.

59. Chen M, Chen C, Huang X, Sun J, Jiang L, Li Y, Zhu Y, Tian C, Li Y, Lu Z, Wang Y, Zeng F, Yang Y, Song X, Peng Z, Yin C, Chen D. Noninvasive prenatal diagnosis for Duchenne muscular dystrophy based on the direct haplotype phasing. Prenat Diagn. 2020 Jul;40(8):918-924.

60. Chen M, Chen J, Wang C, Chen F, Xie Y, Li Y, Li N, Wang J, Zhang VW, Chen D. Clinical application of medical exome sequencing for prenatal diagnosis of fetal structural anomalies. Eur J Obstet Gynecol Reprod Biol. 2020 Aug; 251:119-124.

61. Lin H, Zhang Y, Zhang R, Chen F, Yang T, Mai H, Liu S, Hao Y, Chen M. Langerhans cell histiocytosis: A rare aetiology for fetal pleural effusion. Taiwan J Obstet Gynecol. 2020 Sep;59(5):777-779.

62. Yan H, Zhu X, Chen J, Cao Y, Kwok YKY, Chen Z, Leung TY, Chen M, Choy KW. Noninvasive prenatal sequencing for multiple Mendelian monogenic disorders among fetuses with skeletal dysplasia or increased nuchal translucency. Prenat Diagn. 2020 Oct;40(11):1459-1465.

63. Tan H, Xie Y, Chen F, Chen M, Yu L, Chen D, Chen J. Novel and recurrent variants identified in fetuses with central nervous system abnormalities by trios-medical exome sequencing. Clin Chim Acta. 2020 Nov; 510:599-604.

64. Yang J, Chen M, Ye X, Chen F, Li Y, Li N, Wu W, Sun J. A cross-sectional survey of pregnant women's knowledge of chromosomal aneuploidy and microdeletion and microduplication syndromes. Eur J Obstet Gynecol Reprod Biol. 2021 Jan; 256:82-90.

65. Ding W, Lu J, Zhou Y, Wei W, Zhou Z, Chen M. Knowledge, attitudes, practices, and influencing factors of anxiety among pregnant women in Wuhan during the outbreak of COVID-19: a cross-sectional study. BMC Pregnancy Childbirth. 2021 Jan 25;21(1):80.

66. Cao D, Sun J, Li N, Li Z, Liu W, Chen M. Monozygotic twins discordant for homologous Robertsonian translocation trisomy 21 of 46, XX, + 21, der (21;21) (q10; q10) in a twin-to-twin transfusion syndrome, case report. BMC Pregnancy Childbirth. 2021 Jan 30;21(1):101.

67. Ye X, Lin S, Song X, Tan M, Li J, Wang J, Yan H, Zhang H, Li S, Chen D, Chen M. Identification of copy number variants by NGS-based NIPT at low sequencing depth. Eur J Obstet Gynecol Reprod Biol. 2021 Jan; 256:297-301.

68. Chen M, Su F, Wang J, Zhou L, Liu Q, Chai X, Yuan Y, Cen M, Wu Y, Wang Y, Chen F, Zhang Y, Chen D, Gao Y. Temporal persistence of residual fetal cell-free DNA from a deceased cotwin after selective fetal reduction in dichorionic diamniotic twin pregnancies. Prenat Diagn. 2021 Jan 13.

69. Chen M, Lin SM, Li N, Li Y, Li Y, Zhang L. An induced pluripotent stem cell line (GZHMCi003-A) derived from a fetus with exon 3 heterozygous deletion in RUNX2 gene causing cleidocranial dysplasia. Stem Cell Res. 2021 Mar; 51:102166.

70. Zhu X, Chen M, Wang H, Guo Y, Chau MHK, Yan H, Cao Y, Kwok YKY, Chen J, Hui ASY, Zhang R, Meng Z, Zhu Y, Leung TY, Xiong L, Kong X, Choy KW. Clinical utility of expanded non-invasive prenatal screening and chromosomal microarray analysis in high-risk pregnancy. Ultrasound Obstet Gynecol. 2021 Mar;57(3):459-465.

71. Li Y, Yan H, Chen J, Chen F, Jian W, Wang J, Ye X, Li Y, Li N, Chiu PCN, Chen M. The application of late amniocentesis: a retrospective study in a tertiary fetal medicine center in China. BMC Pregnancy Childbirth. 2021 Mar 30;21(1):266.

72. Li N, Lin SM, Li Y, Sun J, Zhang L, Chen M. An induced pluripotent stem cell line (GZHMCi004-A) derived from a fetus with heterozygous G380R mutation in FGFR3 gene causing achondroplasia. Stem Cell Res. 2021 May; 53:102322.

73. Yang J, Chen M, Wu H, Shen W, Han J, Fu Y, Sun J, Wu W. Knowledge and attitudes toward expanded carrier screening between the medical staff and general population in China. Eur J Obstet Gynecol Reprod Biol. 2021 Aug; 263:198-204.

74. Li Y, Zhong L, Lee CL, Chiu PCN, Chen M. Identification of Adrenomedullin-Induced S-Nitrosylated Proteins in JEG-3 Placental Cells. Reprod Sci. 2021 Aug 30. doi: 10.1007/s43032-021-00663-7. Epub ahead of print. PMID: 34462873.

75. Jiang F, Liu W, Zhang L, Guo Y, Chen M, Zeng X, Wang Y, Li Y, Xian J, Du B, Xie Y, Ouyang S, Li S, Yang Y, Zhang C, Luo F, Sun X. Noninvasive prenatal testing for β-thalassemia by targeted nanopore sequencing combined with relative haplotype dosage (RHDO): a feasibility study. Sci Rep. 2021 Mar 11;11(1):5714.

76. Chen C, Chen M, Zhu Y, Jiang L, Li J, Wang Y, Lu Z, Guo F, Wang H, Peng Z, Yang Y. Noninvasive prenatal diagnosis of monogenic disorders based on direct haplotype phasing through targeted linked-read sequencing. BMC medical genomics. 2021 Dec;14(1):1-11.

77. Li N, Sun J, Wang J, Jian W, Lu J, Miao Y, Li Y, Chen F, Chen D, Ye X, Chen M. Selective termination of the fetus in multiple pregnancies using ultrasound-guided radiofrequency ablation. BMC Pregnancy Childbirth. 2021 Dec 10;21(1):821. doi: 10.1186/s12884-021-04285-4.

78. Yang J, Chen M, Shen W, Wu H, Shou J, Sun J, Wu W. Knowledge, attitudes, and practices of healthcare professionals working in prenatal diagnosis toward expanded non-invasive prenatal testing in China. Prenat Diagn. 2021 Dec 9. doi: 10.1002/pd.6075.

79. Zeng Y, Li L, Mao M, Liang X, Chen M, Xia Y, He W. Establishment of reference intervals of complete blood count for twin pregnancy. BMC Pregnancy Childbirth. 2021 Oct 26;21(1):714. doi: 10.1186/s12884-021-04192-8. PMID: 34702210; PMCID: PMC8547077.

80.Yang J, Chen M, Shen W, Wu H, Shou J, Sun J, Wu W. Knowledge, attitudes, and practices of healthcare professionals working in prenatal diagnosis toward expanded non-invasive prenatal testing in China. Prenat Diagn. 2022 Jan;42(1):3-14.

81.Yang J, Zhang L, Li Y, Chen M Identifying key m6A-methylated lncRNAs and genes associated with neural tube defects via integrative MeRIP and RNA sequencing analyses. Front Genet. 2022 Nov 22;13:974357.

82.Lee CL, Chen Z, Zhang Q, Guo Y, Ng VWY, Zhang B, Bai K, Ruan D, Kan ASY, Cheung KW, Mak ASL, Yeung WSB, Su R, Yang Q, Chen M, Du MR, Jian Z, Fan X, Chiu PCN. Dysregulation of the CD147 complex confers defective placental development: A pathogenesis of early-onset preeclampsia. Clin Transl Med. 2022 Jun;12(6):e826.

83.Sun J, Li N, Jian W, Cao D, Yang J, Chen M. Clinical application of cervical shear wave elastography in predicting the risk of preterm delivery in DCDA twin pregnancy. BMC Pregnancy Childbirth. 2022 Mar 14;22(1):202.

84.Li J, Ju J, Zhao Q, Liu W, Yuan Y, Liu Q, Zhou L, Han Y, Yuan W, Huang Y, Xie Y, Li Z, Chen J, Huang S, Chen R, Li W, Tan M, Wang D, Zhou S, Zhang J, Zeng F, Yu N, Su F, Chen M, Ge Y, Huang Y, Jin X. Effective Identification of Maternal Malignancies in Pregnancies Undergoing Noninvasive Prenatal Testing. Front Genet. 2022 Feb 10;13:802865.

85.Zhu L, Cao D, Chen M, Zhang H, Sun X, Liu W. Prenatal diagnosis of Roberts syndrome in a Chinese family based on ultrasound findings and whole exome sequencing: a case report. BMC Med Genomics. 2022 Jan 29;15(1):16.

86.Jian W, Yuan H, Liu Y, Sun J, Chen F, Li Y, Chen M. Prenatal diagnosis of Noonan syndrome in a set of monozygotic twins- a case report. BMC Pregnancy Childbirth. 2023 Jan 6;23(1):10.

87.Zhang L, Lin S, Huang K, Chen A, Li N, Shen S, Zheng Z, Shi X, Sun J, Kong J, Chen M. Effects of HAR1 on cognitive function in mice and the regulatory network of HAR1 determined by RNA sequencing and applied bioinformatics analysis. Front Genet. 2023 Mar 8;14:947144. doi: 10.3389/fgene.2023.947144. PMID: 36968607; PMCID: PMC10030831.

88.Kong J, Li S, Li Y, Chen M. Effects of Salvia miltiorrhiza active compounds on placenta-mediated pregnancy complications. Front Cell Dev Biol. 2023 Jan 13;11:1034455. doi: 10.3389/fcell.2023.1034455. PMID: 36711034; PMCID: PMC9880055.

89.Chen M, Liu T, Li W, Li Y, Zhong P, Yan H, Kong J, Liang W. Empowering Cartilage Restructuring with Biodegradable Magnesium Doped-Silicon Based-Nanoplatforms: Sustained Delivery and Enhanced Differentiation Potential. Int J Nanomedicine. 2024 Jan 17;19:491-506. doi: 10.2147/IJN.S446552. PMID: 38250188; PMCID: PMC10800145.

5.参加教育部、卫生部普通高等院校教材编写或专著情况(2017-2021)

编写教材(或专著)书目

编写教材(或专著)级别

编写时间

编撰职务

字数

1.母胎心血管病学(第39章) 人卫

其他教材

2020年

专家编委

6000字

1. Fetal Therapy: Scientific Basis and Critical Appraisal of Clinical Benefits (pp. 418-425) 英国剑桥大学出版社

其他教材

2020年

专家编委

6200字

2. 母胎医学 人卫

卫生部、教育部教材

2021年

专家编委

9850字

三.参加省级及以上学术团体名称及任职情况(含国内国外)

名 称

等级

时间

职务

ISUOG (国际妇产超声学会)

国际级

2011年

中国区大使

ISUOG 患者信息委员会

国际级

2021年

中国区负责人

国际妇产超声学会国际教学讲师团

国际级

2011年

委员

世界华人医师协会妇产科分会母胎医学组专家委员会

国际级

2018年8月

委员兼秘书

世界中联围产医学 专业委员会

国际级

2016年12月

事会常务理事

国家自然科学基金委员会

国家级

2020年

系统评议专家

中国研究型医院学会孕产期母儿心脏病专业委员会

国家级

2018年6月

副主任委员

中国医师协会医学遗传医师分会遗传病产前诊断专业委员会

国家级

2017年10月

委员

中国医师协会妇产科分会母胎医学专委会

国家级

2016年11月

委员

广东省临床医学会-胎儿医学专业委员会

省级

2017年10月

副主任委员

广东省预防医学会社会医学与卫生管理学专业委员会

省级

2020年12月

常务委员

广东省地贫防治协会预防专委会

省级

2021年4月

常务委员

广东省医师协会围产医师分会第二届委员会

省级

2016年12月

常务委员

广东省医学会医学人工智能分会第一届委员会

省级

2021年5月

常务委员

广东省健康管理学会胎儿医学专业委员会第一届委员会

省级

2021年9月

副主任委员

广东省预防医学会出生缺陷预防与控制专业委员会

省级

2021年9月

副主任委员

广东和谐医调委

省级

2017年12月

专家顾问

广东省医学会产前诊断分会

省级

2017年8月

委员

BMC Pregnancy and Childbirth 编辑委员会

国际级

2020

委员

Frontiers in Medicine (Obstetrics and Gynecology specialty section)

编辑委员会委员

国际级

2022

委员

广东省医学会医学人工智能分会第一届委员会

省级

2021

常务委员

四.获得人才荣誉称号情况(市级及以上人才项目)

人才荣誉称号

级别(国家、国家部委、广东省、广州市)

时间

备注

第二届“羊城好医生”

广州市

2016年


五.区以下医疗卫生机构工作,援疆、援藏、援外,参加抗击新冠病毒肺炎等情况

时间

地点

任务

获得荣誉

2020.10.09-2021.02.01

新疆喀什

援疆

广州医科大学附属第三医院2020年度“脱贫攻坚杰出贡献奖”

 
©1958- 广州医科大学
技术支持:信息与现代教育技术中心

广州市番禺区新造镇(番禺校区),广州市东风西路195号(越秀校区)

【招生】37103094,【学生】37103085
【培养】37103086,【就业】37103092
【院长邮箱】gy_yjsy@gzhmu.edu.cn