【个人简介】

贺振华，男，中共党员，中美联合培养外科学博士，肿瘤学博士后；现任广东省妇幼保健院神经外科科主任，主任医师，神经外科学术/专业型硕士研究生导师，甘肃省委组织部陇原青年创新创业人才。主持完成多项国家级及省部级科研课题，迄今以第一作者或通讯作者发表SCI论文11篇。长期从事神经外科临床、基础研究及教学工作，能够熟练开展小儿神经外科各级手术。擅长儿童各型颅脑及脊髓肿瘤，先天性脊髓拴系综合症，痉挛性脑瘫的SDR手术，儿童癫痫外科手术，颅缝早闭头颅畸形，脊髓空洞症，先天性脑积水、蛛网膜囊肿的微创手术。

【研究方向】

1.神经系统肿瘤的发生及其对放射治疗敏感性的研究

2.神经管发育畸形发病机制及诊疗策略

【科研项目】

主持课题：

1.广州市卫健委：《核干因子诱导核糖体生物合成促肿瘤效应的机制研究》主持，纵向300万

【代表性论文及著作】

1.       He Zhenhua, Jingmin Yuan, Fuhui Shen, Fangang Zeng, Ping Qi, Zhenxing Zhai, Zhiping Wang. Atorvastatin Enhances Inhibitory Effects of Irradiation on Tumor Growth by Reducing MSH2 Expression both in Prostate Cancer Cells and Xenograft Tumor Models. Anticancer Agents Med Chem. 2022, 22: 1328-1339.

2.       He Zhenhua, Fuhui Shen, Ping Qi, Zhenxing Zhai, Zhiping Wang. miR-541-3p enhances the radiosensitivity of prostate cancer cells by inhibiting HSP27 expression and downregulating β-catenin. Cell Death Discov. 2021 Jan 18;7(1):18.

3.       He Zhenhua, Jingmin Yuan, Fuhui Shen, Fangang Zeng, Ping Qi, Wang Zhiping, Zhai Zhenxing. Atorvastatin Enhances Effects of Radiotherapy on Prostate Cancer Cells and Xenograft Tumor Mice Through Triggering Interaction Between Bcl-2 and MSH2. Med Sci Monit. 2020 Sep;26:e923560.

4.       He Zhenhua, Cheng H, Wu H, Sun G, Yuan Jingmin. Risk factors for postoperative delirium in patients undergoing microvascular decompression. Plos One. 2019; 14:e0215374.

5.       J Yuan, H Wu, N Chen, F Shen, P Jiao, Z Lan, W Yang, X Zhang, Q Li, He Zhenhua#. Combined Hyperactive Dysfunction Syndrome of the Cranial Nerves Complicated by Essential Hypertension: A Case Report. Medicine. 2019; 98(33):e16849. (#corresponding author)

6.       P Qi*, He Zhenhua *, L Zhang，Y Fan，Z Wang. Rottlerin -induced autophagy leads to the apoptosis in bladder cancer cells. Oncology Letters. 2016;12:4577-4583. (*co-first)

7.       He Zhenhua, Z Lan, A Xiong, GK Hou, Y Pan, Q Li, Xinding Zhang. Endoscopic decompression of the optic canal for traumatic optic neuropathy. Chi J of Trauma. 2016; 19:330-332.

8.       He Zhenhua, Yuan Jingmin, Qi P, Zhang L, Wang Zhiping. Atorvastatin induced autophagic cell death in prostate cancer cell in vitro. Molecular Medicine Reports. 2015;11:4403-4408.

9.       He Zhenhua, Li Q, Yuan J, Zhang X, Gao R, Han Y, Yang W, Shi X, Lan Z. Evaluation of transcranial surgical decompression of the optic canal as a treatment option for traumatic optic neuropathy. Clin Neurol Neurosurg. 2015;134:130-135.

10.       He Zhenhua, An C, Zhang X, He X, Li Q. The efficacy analysis of endoscopic third ventriculostomy in infantile hydrocephalus. J Korean Neurosurg Soc. 2015; 57:119-122.

11.       He Zhenhua, Mangala LS, Theriot CA, Rohde LH, Wu H, Zhang Y. Cell killing and radiosentizing effects of atorvastatin in PC3 prostate cancer cells." J Radiat Res. 2012;53:225-233.

12.       He Zhenhua, Zhang Y, Mehta SK, Pierson DL, Wu Honglu, Rohde LH. Expression Profile of Apoptosis Related Genes and Radio-sensitivity of Prostate Cancer Cells. J Radiat Res. 2011;52:743-751.

【所获荣誉和奖励】

1.获第三届广东省小儿外科中青年医师手术视频大赛一等奖；

2.获得2015年中华医学会中华神外好青年全国英语大赛三等奖。