牛晓华,男,广州医科大学硕士研究生导师、副研究员、博士。2009年毕业于北京医科大学医学部,2009年-2013年赴美国Cleveland Clinic及Thomas Jefferson University从事博士后研究与学习。
长期从事肿瘤发生发展的表观遗传学研究,主要研究集中在肾癌VHL基因突变,与HIF1α和HIF2α转录因子的相互作用,以及HIF调控JARID1C的表达, JARID1C对H3K4Me3的调控,以及JARID1C与铁死亡之间的相互关系。
近年来,获得国家自然基金青年项目一项。在国内外医学杂志发表论文20余篇。
发表文章:
(1)Niu X(#); Zhang T; Liao L; Zhou L; Linder DJ; Zhou M; Rini B; Yan Q; Yang H(*),The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C., Oncogene, 2012.2.9, 31(6): 776~786
(2)Sun, Xiaofang(#); Niu, Xiaohua; Chen, Ruochan; He, Wenyin; Chen, De; Kang, Rui; Tang, Daolin,Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis., Hepatology, 2016.8, 64(2): 488~500
(3)Zhuo, De Xiang(#); Niu, Xiao Hua(#); Chen, Yi Cheng; Xin, Dian Qi; Guo, Ying Lu; Mao, Ze Bin(*),Vitamin D(3) Up-regulated Protein 1(VDUP1) Is Regulated by FOXO3A and miR-17-5p at the Transcriptional and Post-transcriptional Levels, Respectively, in Senescent Fibroblasts, JOURNAL OF BIOLOGICAL CHEMISTRY, 2010.10.8, 285(41): 31491~31501
(4)Niu, Xiaohua(#); He, Wenyin; Song, Bing; Ou, Zhanhui; Fan, Di; Chen, Yuchang; Fan, Yong; Sun, Xiaofang(*),Combining Single Strand Oligodeoxynucleotides and CRISPR/Cas9 to Correct Gene Mutations in beta-Thalassemia-induced Pluripotent Stem Cells., Journal of Biological Chemistry, 2016.8.5, 291(32): 16576~16585
(5)Ou, Zhanhui(#); Niu, Xiaohua; He, Wenyin; Chen, Yuchang; Song, Bing; Xian, Yexing; Fan, Di; Tang, Daolin; Sun, Xiaofang,The Combination of CRISPR/Cas9 and iPSC Technologies in the Gene Therapy of Human beta-thalassemia in Mice., Scientific Reports, 2016.9.1,6: 32463~32463
科研项目:
1.国家自然科学基金青年项目,JARID1C依赖去甲基化酶活性抑制HIF2α靶基因表达和肾癌增殖的机制研究,2016.01-2018.12,项目负责人。