个人概况
周蕾，男，博士，研究员，硕士研究生导师
单位：广州医科大学附属第三医院
邮箱: zhoul@gzhmu.edu.cn
研究领域及专长
1.骨科相关水凝胶植入材料的研究
2.骨组织修复的电学和免疫治疗
3.难愈性骨组织损伤修复重建
科研项目
1.国家自然科学基金，面上项目，2025-01-01至2028-12-31，50万，在研，主持
2.广州市科技计划，市校（院）联合资助项目，2023-04-01至2025-5-31，20万元，主持
3.国家自然科学基金，青年科学基金项目，2020-01-01至2022-12-31，25万，结题，主持
科研论文
近年的研究工作主要从骨科临床实际需求出发，开展医工结合特色研究，以解决骨科医疗中的实际问题。研究兴趣主要集中在化学、材料、生命、临床医学等多学科的前沿交叉领域，取得了一系列原创性、创新性的研究成果，迄今已在国际著名SCI 期刊共发表科研论文60多篇，其中以第一/通讯作者（含并列）在Advanced Functional Materials（2篇）, ACS Nano（4篇）, Nano Energy（2篇）, Advanced Sciences（2篇）, Bioactive Materials（5篇）, Biomaterials, Chemical Engineering Journal, Advanced Healthcare Materials（2篇)等本领域知名期刊发表SCI论文30余篇（IF大于10的论文22篇，均为近5年发表），入选ESI高被引论文5篇，研究工作得到Nature, Nat. Rev. Mater., Chem. Rev., Chem. Soc. Rev.等国际权威学术期刊正面引用和评价。所发表论文共被引用3000余次（Google scholar 统计），H-index为29。
第一/通讯作者代表性论文具体如下：
(1)Chaoyao Wen, Yihang Gong, Haoyan Chen, Yu Tian, Hui Yu, Xudan Xin, Le Wang, Chuyang Xiang, Yisheng Chen, Tianhua Xiao, Chengyun Ning, Xuebin Yang, Lei Zhou*, Guoxin Tan*, Wet Tissue Interfacial Water Triggers Ultrafast In Situ Gelation of Sprayable Dry Powder for Postoperative Anti-Adhesion, Advanced Functional Materials, 2024, 2409231 (IF= 18.5)
(2)Lei Zhou#, Cong Dai#, Lei Fan#, Yuhe Jiang, Can Liu, Zhengnan Zhou, Pengfei Guan, Yu Tian, Jun Xing, Xiaojun Li, Yian Luo, Peng Yu, Chengyun Ning, and Guoxin Tan*, Injectable Self-Healing Natural Biopolymer-Based Hydrogel Adhesive with Thermoresponsive Reversible Adhesion for Minimally Invasive Surgery, Advanced Functional Materials, 2021, 31(14), 2007457 (IF= 18.5) (ESI 高被引论文)
(3)Cairong Xiao, Lei Fan, Shiqi Zhou, Xinchang Kang, Pengfei Guan, Rumin Fu, Changhao Li, Jian Ren, Zhengao Wang, Peng Yu, Yan Wang*, Chunlin Deng*, Lei Zhou*, Chengyun Ning, One-Dimensional Ferroelectric Nanoarrays with Wireless Switchable Static and Dynamic Electrical Stimulation for Selective Regulating Osteogenesis and Antiosteosarcoma, ACS Nano, 2022, 16(12), 20770-20785(IF= 15.8)
(4)Lei Zhou#, Lei Fan#, Xin Yi, Zhengnan Zhou, Can Liu, Ruming Fu, Cong Dai, Zhengao Wang, Xiuxing Chen, Peng Yu, Dafu Chen, Guoxin Tan*, Qiyou Wang*, Chengyun Ning*, Soft Conducting Polymer Hydrogels Cross-Linked and Doped by Tannic Acid for Spinal Cord Injury Repair, ACS Nano, 2018, 12(11): 10957-10967 (IF= 15.8)
(5)Lei Zhou#, Lei Fan#, Feng-Miao Zhang#, Yuhe Jiang, Min Cai, Cong Dai, Yi-An Luo, Ling-Jie Tu, Zheng-Nan Zhou, Xiao-Jun Li, Cheng-Yun Ning, Kai Zheng*, Aldo R.Boccaccini*, Guo-Xin Tan*. Hybrid gelatin/oxidized chondroitin sulfate hydrogels incorporating bioactive glass nanoparticles with enhanced mechanical properties, mineralization, and osteogenic differentiation. Bioactive Materials. 2021, 6(3):890-904. (IF= 18.0) (ESI 高被引论文)
(6)Rumin Fu#, Lingjie Tu#, Youjun Guan, Zhengao Wang, Chunlin Deng, Peng Yu, Guoxin Tan*, Chengyun Ning*, Lei Zhou*, Intrinsically Piezoelectric Elastomer Based on Crosslinked Polyacrylonitrile for Soft Electronics. Nano Energy, 2022, 103A: 107784. (IF= 16.8)
(7)Can Liu, Lei Fan, Ming Guan, Qiangqiang Zheng, Jiale Jin, Xinchang Kang, Zhongyang Gao, Xiaoqian Deng, Yifan Shen, Guangyu Chu, Jingyao Chen, Zhiqiang Yu*, Lei Zhou*, Yue Wang*, A Redox Homeostasis Modulatory Hydrogel with GLRX3+ Extracellular Vesicles Attenuates Disc Degeneration by Suppressing Nucleus Pulposus Cell Senescence, ACS Nano, 2023, 17, 14, 13441-13460(IF= 15.8)
(8)Yongdong Shi, Youjun Guan, Mingjie Liu, Xinchang Kang, Yu Tian, Weicheng Deng, Peng Yu, Chengyun Ning, Lei Zhou*, Rumin Fu*, Guoxin Tan*, Tough, Antifreezing, and Piezoelectric Organohydrogel as a Flexible Wearable Sensor for Human-Machine Interaction. ACS Nano, 2024, 18(4), 3720-3732.(IF= 15.8) (ESI 高被引论文)
(9)Cairong Xiao, Renxian Wang, Rumin Fu, Peng Yu, Jianxun Guo, Guangping Li, Zhengao Wang, Honggang Wang, Jingjun Nie, Weifeng Liu, Jinxia Zhai, Changhao Li, Chunlin Deng, Dafu Chen*, Lei Zhou*, Chengyun Ning*. Piezo-enhanced near infrared photocatalytic nanoheterojunction integrated injectable biopolymer hydrogel for anti-osteosarcoma and osteogenesis combination therapy. Bioactive Materials, 2024, 34, 381-400 (IF= 18.0)
(10)Lei Fan#, Can Liu#, Xiuxing Chen#, Lei Zheng, Yan Zou, Huiquan Wen, Pengfei Guan, Fang Lu, Yian Luo, Guoxin Tan, Peng Yu, Dafu Chen, Chunlin Deng, Yongjian Sun*, Lei Zhou*, Chengyun Ning*. Exosomes‐Loaded Electroconductive Hydrogel Synergistically Promotes Tissue Repair after Spinal Cord Injury via Immunoregulation and Enhancement of Myelinated Axon Growth. Advanced Science, 2022, 9(13): 2105586. (IF= 14.3) (ESI 高被引论文)
(11)Yihang Gong#, Wenjie Chen#, Xiuxing Chen#, Yizhan He, Hua Jiang, Xijian Zhang, Lijie Pan, Beibei Ni, Fan Yang, Yan Xu, Qi Zhang*, Lei Zhou*, Yusheng Cheng*. An Injectable Epigenetic Autophagic Modulatory Hydrogel for Boosting Umbilical Cord Blood NK Cell Therapy Prevents Postsurgical Relapse of Triple‐Negative Breast Cancer. Advanced Science, 2022, 9(23): 2201271. (IF= 14.3)
(12)Rumin Fu, Xinxiang Zhong, Cairong Xiao, Jian Lin, Youjun Guan, Yu Tian, Zhengnan Zhou, Guoxin Tan, Huabin Hu*, Lei Zhou*, Chengyun Ning*. A stretchable, biocompatible, and self-powered hydrogel multichannel wireless sensor system based on piezoelectric barium titanate nanoparticles for health monitoring. Nano Energy, 2023,114: 108617. (IF= 16.8)
(13)Xinchang Kang, Xiaojun Li, Can Liu, Min Cai, Pengfei Guan, Yian Luo, Youjun Guan, Yu Tian, Kunyu Ren, Chengyun Ning, Lei Fan, Guoxin Tan, Lei Zhou*, A shape-persistent plasticine-like conductive hydrogel with self-healing properties for peripheral nerve regeneration, Journal of Materials Science & Technology, 2023, 142, 134-143. (IF= 11.2)
(14)Lei Fan#, Cairong Xiao#, Pengfei Guan#, Yan Zou, Huiquan Wen, Can Liu, Yian Luo, Guoxin Tan, Qiyou Wang, Yangfan Li*, Peng Yu*, Lei Zhou*, Chengyun Ning, Extracellular Matrix‐Based Conductive Interpenetrating Network Hydrogels with Enhanced Neurovascular Regeneration Properties for Diabetic Wounds Repair. Advanced Healthcare Materials, 2022, 11(1): 2101556. (IF= 10.0)
(15)Xinchang Kang, Pengfei Guan, Cairong Xiao, Can Liu, Youjun Guan, Yeying Lin, Yu Tian, Kunyu Ren, Yanting Huang, Rumin Fu, Chengyun Ning, Lei Fan*, Guoxin Tan*, Lei Zhou*, Injectable Intrinsic Photothermal Hydrogel Bioadhesive with On‐Demand Removability for Wound Closure and MRSA‐Infected Wound Healing, Advanced Healthcare Materials, 2023, 12(13): 2203306. (IF= 10.0) (ESI 高被引论文)
(16)Yian Luo#, Lei Fan#, Can Liu#, Huiquan Wen, Shihuan Wang, Pengfei Guan, Dafu Chen, Chengyun Ning, Lei Zhou*, Guoxin Tan*, An injectable, self-healing, electroconductive extracellular matrix-based hydrogel for enhancing tissue repair after traumatic spinal cord injury, Bioactive Materials, 2022, 7(1), 98-111. (IF= 18.0) (ESI 高被引论文)
(17)Lei Fan#, Pengfei Guan#, Cairong Xiao#, Huiquan Wen, Qiyou Wang, Can Liu, Yian Luo, Limin Ma, Guoxin Tan, Peng Yu*, Lei Zhou*, Chengyun Ning, Exosome-functionalized polyetheretherketone-based implant with immunomodulatory property for enhancing osseointegration. Bioactive Materials, 2021, 6(9): 2754-2766. (IF= IF= 18.0)
(18)Min Cai#, Xiaojun Li#, Meng Xu, Shiqi Zhou, Lei Fan, Jingyan Huang, Cairong Xiao, Yichen Lee, Bo Yang, Le Wang, Ross William Crawford, Yin Xiao, Lei Zhou*, Chengyun Ning*, Yan Wang*. Injectable Tumor Microenvironment-Modulated Hydrogels with Enhanced Chemosensitivity and Osteogenesis for Tumor-Associated Bone Defects Closed-Loop Management. Chemical Engineering Journal, 2022: 138086. (IF= 13.3)
(19)Yusheng Cheng#, Yihang Gong#, Xiuxing Chen#, Qi Zhang#, Xijian Zhang#, Yizhan He, Lijie Pan, Beibei Ni, Fan Yang, Yan Xu, Lei Zhou*, Yang Yang*, Wenjie Chen*. Injectable adhesive hemostatic gel with tumor acidity neutralizer and neutrophil extracellular traps lyase for enhancing adoptive NK cell therapy prevents post-resection recurrence of hepatocellular carcinoma. Biomaterials, 2022, 284: 121506. (IF= 12.8)
授权发明专利
1.谭帼馨，刘燕，周蕾，欧阳孔友，一种钛基导电水凝胶复合涂层材料的制备方法，2017-9-26，中国，授权专利号：ZL201510961064.2
2.刘燕，谭帼馨，周蕾，复合水凝胶的制备方法与应用、复合水凝胶修复材料及其制备方法，2019-03-22，中国，授权专利号： ZL201610680225 .5
3.宁成云，易新，周蕾，周文浩，邢君，胡诗迁，一种导电聚合物水凝胶复合材料及其制备方法与应用，2020-5-22，中国，授权专利号：ZL201710799584.7
4.宁成云，付如民，周蕾，一种具有力电响应的弹性体及其制备方法和应用，2020-12-22, 中国，授权专利号：ZL201810876437.X
5.宁成云，翟锦霞, 周蕾， 代聪，陈俊祺，一种铌酸钾钠纳米粒子复合水凝胶及其制备方法与应用，2021-01-19, 中国，授权专利号：ZL201810837226.5
6.周正难，谭帼馨，代聪，周蕾，宁成云，一种电活性双层类骨膜材料及其制备方法，2021-01-26, 中国，授权专利号：ZL201810223484 .4
7.宁成云，何佳鹏，谭帼馨，周蕾，刘燕，于鹏，一种高强度双网络抗菌生物水凝胶的制备方法，2019-12-10, 中国，授权专利号：ZL201611074698 .7
学术任职
广东省生物医学工程学会骨科材料与器械临床转化青年分会 常务委员
广东省精准医学应用学会医工结合分会 常务委员
Adv. Mater., Adv. Funct. Mater., Adv. Sci., Bioact. Mater., Small.等SCI期刊审稿人
