【个人简介】

孙新园，男，南山学者骨干人才特聘教授，三级研究员，硕士、博士研究生导师、临床医学博士后合作导师，南山新锐人才，广州市卫生健康委员会优秀人才，广州市高层次人才青年后备人才，国际尿石症联盟（IAU）青年委员，广东省医师协会泌尿外科医师分会委员。长期从事泌尿系结石机制及天然药物防治研究，累计在ACS Nano, Journal of Controlled Release、Phytomedicine、Communications Biology、Small、Chemical Engineering Journal、Nano Today等期刊发表SCI论文30余篇。主持国家、省市级课题6项，参与国家重点研发计划1项，获得教育部高等学校科学研究优秀成果奖科学技术进步奖二等奖一项。

【研究方向】

泌尿系结石；聚焦泌尿系结石发病分子机制，开展天然活性药物的筛选、功能化改造及精准防治药物创制研究。

【科研项目】

1) 广州医科大学高水平大学建设人才科研启动经费，02-412-B205002-1010004，2019-10-2024.10，200万，已结题，主持

2) 广州医科大学附属第一医院南山人才工程项目南山新锐人才经费，2023.8.1 -2027.7.31. 100万，在研，主持

3）国家自然科学基金青年科学基金项目，21701050，2018年01月01日-2020年12月31日，28万，已结题，主持

4）中国博士后科学基金，2017M612837，2017.6-2019.12，5万，已结题，主持

5)广东省基础与应用基础研究基金自然科学基金, 2026A1515012043, 2026.01.01-2028.12.31, 10 万，在研，主持

6）广州市基础研究计划市校（院）联合资助基础与应用基础研究项目，202102010306，2021.04.01-2023.03.31，20万，已结题，主持

【代表性论文及著作】

[1] Xue-Wu Chen#, Jun Long#, Xiao-Peng Zheng#, Bang-Xian Yu, Guang-Zhao Wang, Wen-Qi Wu, Yong-Da Liu, Guo-Hua Zeng*, Ling-Hong Huang*, Xin-Yuan Sun*, Mitochondria-Targeted Metal Polyphenol Networks Inhibit Crystalline Nephropathy by Modulating SerpinE1 and Remodeling the Pathological Mineralization Microenvironment. ACS Nano, 2026, 20(20):14488-14513.

[2] Huang Linghong #, Zhang Quan #, Long Jun, Liu Zonghua *, Sun Xinyuan*. Construction of novel magnetic systems for cancer immunotherapy via cancer-immunity cycle circuits. Journal of Controlled Release, 2025, 378: 38-59.

[3] Gu L-Q, Chen X-W, Long J, Wang G-Z, Wang Y, Huang L-H, Ouyang J-M*, Sun X-Y*. Ultrasmall self-assembled crystal-modulating amplifier suppresses crystalline nephropathy via dual modulation of mineralization microenvironment and oxidative stress homeostasis. Chemical Engineering Journal, 2026, 533: 173943.

[4] Zhang Q#, Yu B‐X#, Long J, Chen X‐W, Huang F, Wu W‐Q, Liu Y‐D, Zeng G‐H*, Huang L‐H*, Sun X‐Y*, An ultrasmall self-assembled gallic acid-based natural multifunctional defense networks for therapeutic application in calcium oxalate nephropathies. Small, 2025, 21(13): 2500270.

[5] Li Chun-Yao*, Zhang Quan*, Shi Xin-Yu*, Long Jun, Yu Bang-Xian, Chen Xue-Wu, Huang Ling-Hong#, Sun Xin-Yuan#. Structural characterization of polysaccharides from Lygodium japonicum (Thunb.) Sw. and its inhibition ability in calcium oxalate renal stone. Phytomedicine, 2025, 142:156734.

[6] Yu B X*, Long J*, Liang Y P*, Zhang Q, Liu Y, Zeng G H, Liu Y D#, Sun X Y#. Therapeutic potential of Desmodium styracifolium polysaccharide in attenuating nano-calcium oxalate induced renal injury and fibrosis. Communications Biology, 2025, 8(1): 1330.

[7] Deng J W#, Li C Y#, Huang Y P#, Liu W F, Zhang Q, Long J, Wu W Q, Huang L H*, Zeng G H*, Sun X Y*. Mechanism of Porphyra Yezoensis Polysaccharides in Inhibiting Hyperoxalate-Induced Renal Injury and Crystal Deposition. Journal of Agricultural and Food Chemistry, 2024, 72, 12, 6372–6388.

[8] Sun X-Y, Zhang H, Chen J-Y, Zeng G-H*, Ouyang J-M*. Porphyra yezoensis polysaccharide and potassium citrate synergistically inhibit calcium oxalate crystallization induced by renal epithelial cells and cytotoxicity of the formed crystals. Materials Science & Engineering C-Materials for Biological Applications, 2021, 119: 111448.

[9] Huang Linghong#, Sun Xinyuan#, Song Ting#, Long Jun, Chen Xuewu, Dong Renfeng*, Liu Zonghua*, Guo Zhong*. The swarmable magnetic-driven nanorobots for facilitating trans-intestinal mucosal delivery of oral vaccines to enhance mucosal and systemic immune responses. Nano Today, 2025, 62: 102721.

[10] Huang L*, Sun X*, Zuo Q, Song T, Liu N#, Liu Z#, Xue W#. A pH-responsive PROTAC-based nanosystem triggers tumor-specific ferroptosis to construct in situ tumor vaccines. Materials Today Bio, 2025, 31: 101523.

【所获荣誉和奖励】

1. 2022年荣获教育部高等学校科学研究优秀成果奖科学技术进步奖二等奖，项目名称：泌尿系结石的早期诊断及防治关键技术创新与应用，2022-546-R02.

本团队长期招收临床医学专业-学术型研究生及博士后，科研经费充足，平台条件优越。诚邀优秀人才加入！联系邮箱：sunxinyuan1985@163.com