【个人简介】

教授、主任医师、博士生导师

国家呼吸医学中心胸外科行政副主任

呼吸疾病全国重点实验室 PI

美国胸外科学会（AATS） member

哈佛大学医学院 博士后

哈佛大学附属麻省总医院 Research Fellow

广东省药学会胸外科分会主委

作为气管亚专科带头人，带领团队对胸部疾病尤其是气管外科疾病的临床诊治以及系统研究进行深入工作，立足于国家呼吸医学中心、呼吸疾病国家重点实验室、国家重点临床专科，致力于提高中心国际核心竞争力，扩大中心全球影响力。

(一）国际上首次提出“无管化肺外科日间手术”概念，“无管化胸腔镜技术”的应用加速整体术后康复，该技术体系得到国际认可并推广应用

1、2017年，于《欧洲胸心血管外科》杂志完成全球首个最大病例报道。

2、 2017年，被美国麻醉学会评选为“世界胸科领域年度“最值得关注的学术进展之一”，成果被斯坦福、北卡、匹兹堡大学三位教授代表学会撰文评议发表于《J Cardiothorac Vasc Anesth》。

3、2018年，作为亚太唯一中心，获邀于“欧洲胸心血管外科年会”进行大会主题手术直播展示并全球推广应用。

4、2021年，该技术体系“Tubeless Procedure”正式写入国际胸外科专著《Cohen’s Comprehensive Thoracic Anesthesia》,标志着“无管化”气管外科手术体系正式纳入现代胸科手术体系。

（二）“无管化腔镜技术”应用于气管重建领域，简化重建流程，提高重建精准性，让复杂手术更容易深化推广，得到国际肯定并推广应用

1、近5年，相继完成多个国际首例“无管化”简化气管重建手术，并先后获邀在全球胸外科四大学术盛会主题发言。

2、2020年，于《Thorac Surg Clin》发表国际首个Tubeless气管各段重建全覆盖的大宗病例报道。

3、该技术体系得到全球气管外科之父，全球气管外科中心，哈佛大学附属麻省总院胸外科Mathisen教授肯定。2018年，他亲自攥写同行评价肯定该技术体系，成果发表于《Journal of Thoracic Disease》。

4、2020年，建立国际多中心课题协作组，围绕中心核心“无管化”技术，成果沉淀并转化，《NonintubatedThoracic Surgery》专著出版受到国际胸外科同道高度认可。

5、2020年起，联合哈佛大学医学院，哈佛大学附属医院，科研结果沉淀，多次联名发表文章于全球胸外科权威杂志《The Annals of Thoracic Surgery》。

（三）整合并优化多学科核心技术，解决了胸外科中晚期肺癌复杂重建领域的一些技术问题。

1、2020年，将“无管化”技术应用于机器人中晚期肺癌重建手术中，完成全球首个“无管化”机器人隆突重建系列手术，成果发表于外科临床领域殿堂级杂志《Annals of Surgery》（外科学年鉴），填补了机器人手术于隆突重建手术领域应用的空白。

2、2019年，完成国际首例新辅助免疫治疗后“自体肺叶移植术”，首次应用“段支气管-气管端侧吻合”技术，解决了国际上自体肺叶移植气管重建吻合口不匹配的技术瓶颈难题。成果沉淀，发表于国家胸外科权威杂志《ATS》。

3、2019年，完成国际首例新辅助治疗后“胸腹腔镜联合微创大网膜包埋隆突成形术”，首次应用“胸腹腔镜联合”微创技术，解决了国际上复杂隆突成形吻合口缺血的技术瓶颈难题，大大降低了手术并发症和死亡率。成果沉淀，发表于国家胸外科权威杂志《ATS》。与此同时，该技术体系得到日本胸外科腔镜协会主席肯定，并撰写同行评议发表于《TLCR》。

4、2018年，应用“针形胸腔镜技术”施行并完成国际首个小儿复杂胸外伤气管/支气管断裂重建报道，解决了儿童气管重建微创技术应用及快速康复的难题。成果沉淀，发表于国际胸外科权威杂志《ATS》。

【研究方向】

全呼吸道肿瘤的外科及综合治疗

气管肺外科的临床和基础研究

【科研项目】

1． 国家重点研发专项，电磁导航系统在胸腔镜手术切除早期周围型肺癌中的应用（2017YFC0112704），于2017-7-1至2021-7-31， 408万，已结题，主持。

2． 广东省教育厅，“2016年广东省临床教学基地教学改革研究项目”《新应用裸眼3D电子资源库的实践教学改革研究》（2016JDB071），2016-2018，已结题，主持。

3． 广东省科技厅，自主呼吸麻醉联合单孔胸腔镜技术在胸外科快速康复手术的应用研究（A2015049），2015.6-2017.6，20万，已结题，主持。

【代表性论文及著作】

一、代表性论文

1. Qin Z, Xin C, Zhenzhen H, Liang X, Wei Y, Shuben L. Solitary Renal Metastases From Stage IA Primary Lung Adenocarcinoma With Co-Alteration of EGFR, RB1, and MAP3K1: A Case Report. Clin Respir J 2024;18:e70018. doi: 10.1111/crj.70018.

2. Wang R, Gonzalez-Rivas D, Wang C, Gao J, Lan L, He J, et al. Non-intubated uniportal robotic-assisted thoracic surgery: the future of thoracic surgery? Ann Cardiothorac Surg 2023;12:49–51. doi: 10.21037/acs-2022-urats-15.

3. Tang R, Liang H, Guo Y, Li Z, Liu Z, Lin X, et al. Pan-mediastinal neoplasm diagnosis via nationwide federated learning: a multicentre cohort study. Lancet Digit Health 2023;5:e560–70. doi: 10.1016/S2589-7500(23)00106-1.

4. Jiang Y, Lin Y, Wen Y, Fu W, Wang R, He J, et al. Global trends in the burden of esophageal cancer, 1990-2019: results from the Global Burden of Disease Study 2019. J Thorac Dis 2023;15:348–64. doi: 10.21037/jtd-22-856.

5. Gonzalez-Rivas D, Bosinceanu M, Manolache V, Gallego-Poveda J, Paradela M, Li S, et al. Uniportal fully robotic-assisted sleeve resections: surgical technique and initial experience of 30 cases. Ann Cardiothorac Surg 2023;12:9–22. doi: 10.21037/acs-2022-urats-23.

6. Chen J, Ang K-L, Wang Z, Lei F, He J, Li S. Impacts of additional cycles of neoadjuvant immunotherapy on surgery in non-small-cell lung cancer. Thorac Cancer 2023;14:1260–7. doi: 10.1111/1759-7714.14867.

7. Zhou Y, Liang H, Xu K, Yang C, Liang L, Dong Q, et al. The strategy of non-intubated spontaneous ventilation anesthesia for upper tracheal surgery: a retrospective case series study. Transl Lung Cancer Res 2022;11:880–9. doi: 10.21037/tlcr-22-302.

8. Wang R, Jiang Y, He J, Lin Y, Wang Z, Li S. Electromagnetic Navigation Bronchoscopy Integrated Non-intubated Uniportal VATS in Localization and Resection of Pulmonary Nodules. Front Surg 2022;9:872496. doi: 10.3389/fsurg.2022.872496.

9. Wang C, Dong J, Zhuang X, Yang C, Chen H, Inage T, et al. Intraoperative methods for wrapping anastomoses after airway reconstruction: a case series. Transl Lung Cancer Res 2022;11:1145–53. doi: 10.21037/tlcr-22-406.

10. Madariaga MLL, Soni ML, Mathisen DJ, Wright CD, Li S, Lee H, et al. Evaluation of Release Maneuvers After Airway Reconstruction. Ann Thorac Surg 2022;113:406–12. doi: 10.1016/j.athoracsur.2021.03.001.

11. Liang W, Cai K, Cao Q, Chen C, Chen H, Chen J, et al. International expert consensus on immunotherapy for early-stage non-small cell lung cancer. Transl Lung Cancer Res 2022;11:1742–62. doi: 10.21037/tlcr-22-617.

12. Li S, Ai Q, Liang H, Liu H, Yang C, Deng H, et al. Nonintubated Robotic-assisted Thoracic Surgery for Tracheal/Airway Resection and Reconstruction: Technique Description and Preliminary Results. Ann Surg 2022;275:e534–6. doi: 10.1097/SLA.0000000000004887.

13. He J, Zhong Y, Suen H-C, Sengupta A, Murthy RA, Stoelben E, et al. The procedure and effectiveness of release maneuvers in tracheobronchial resection and reconstruction. Transl Lung Cancer Res 2022;11:1154–64. doi: 10.21037/tlcr-22-385.

14. He J, Yang C, Yang H, Chen H, He J, Li S. Resection and reconstruction via median sternotomy incision for tracheal tumors. Transl Lung Cancer Res 2022;11:600–6. doi: 10.21037/tlcr-22-177.

15. He J, Xu X, Lan L, Chen H, He J, Li S. End-to-side anastomosis in complex tracheal resection and reconstruction: a case series study. Transl Lung Cancer Res 2022;11:165–72. doi: 10.21037/tlcr-22-32.

16. Guo Z, He J, Yang C, Liang H, Chen H, He J, et al. Video-assisted Thoracic Surgery for Main Bronchial Rupture After Blunt Chest Trauma in Children. Ann Thorac Surg 2022;114:e241–3. doi: 10.1016/j.athoracsur.2021.12.018.

17. Dong J, Gonzalez-Rivas D, Lv P, Wang Z, He J, Yao F, et al. Limited airway resection and reconstruction for paediatric tracheobronchial inflammatory myofibroblastic tumour. Interact Cardiovasc Thorac Surg 2022;35:ivac117. doi: 10.1093/icvts/ivac117.

18. Chen J, Deng H, He J, Wang Z, Li S. Impact of the interval between neoadjuvant immunochemotherapy and surgery on surgical-pathological outcomes in non-small cell lung cancer. Front Oncol 2022;12:909726. doi: 10.3389/fonc.2022.909726.

19. Chen J, Ang K-L, Wang C, He J, Li S. Minimally Invasive Carinal Reconstruction Using Bronchial Flap and Omental Flap Reinforcement. Ann Thorac Surg 2022;113:e255–7. doi: 10.1016/j.athoracsur.2021.06.014.

20. Ao Y, Wen Y, Li Y, Peng H, Wu X, Wang Z, et al. Ankylosing Spondylitis and the Risk of Lung Cancer: A Meta-Analysis and Mendelian Randomization. Front Genet 2022;13:861984. doi: 10.3389/fgene.2022.861984.

21. Zhang J, He J, Chen J, Zhong Y, He J, Li S. Application of indocyanine green injection guided by electromagnetic navigation bronchoscopy in localization of pulmonary nodules. Transl Lung Cancer Res 2021;10:4414–22. doi: 10.21037/tlcr-21-699.

22. Wang L, Yan X, Zhao J, Chen C, Chen C, Chen J, et al. Expert consensus on resection of chest wall tumors and chest wall reconstruction. Transl Lung Cancer Res 2021;10:4057–83. doi: 10.21037/tlcr-21-935.

23. Shi J, He J, He J, Li S. Electromagnetic navigation-guided preoperative localization: the learning curve analysis. J Thorac Dis 2021;13:4339–48. doi: 10.21037/jtd-21-490.

24. Liang H, Yang C, Gonzalez-Rivas D, Zhong Y, He P, Deng H, et al. Sleeve lobectomy after neoadjuvant chemoimmunotherapy/chemotherapy for local advanced non-small cell lung cancer. Transl Lung Cancer Res 2021;10:143–55. doi: 10.21037/tlcr-20-778.

25. Li Y, Jiang Y, Su Z, Liang H, He J, Li S. Radical resection of solitary tracheal extramedullary plasmacytoma under non-intubated anesthesia: a case report. Ann Transl Med 2021;9:1265. doi: 10.21037/atm-21-1786.

26. He J, Yang C, Suen HC, He J, Li S. A novel lung autotransplantation technique for treating central lung cancer: a case report. Transl Lung Cancer Res 2021;10:2290–7. doi: 10.21037/tlcr-20-1242.

27. He J, Pan H, He J, Li S. Effectiveness and safety of bevacizumab in extensive-disease small cell lung cancer: a systemic review and meta-analysis. Ann Transl Med 2021;9:1285. doi: 10.21037/atm-21-963.

28. He J, Liang H, Wang W, Akopov A, Aiolfi A, Ang K-L, et al. Tubeless video-assisted thoracic surgery for pulmonary ground-glass nodules: expert consensus and protocol (Guangzhou). Transl Lung Cancer Res 2021;10:3503–19. doi: 10.21037/tlcr-21-663.

29. Wen Y, Jiang Y, Liang H, Jiang L, Guo Z, Musonza C, et al. Tubeless video-assisted thoracic surgery for lung cancer: is it ready for prime time? Future Oncol 2020;16:1229–34. doi: 10.2217/fon-2020-0278.

30. Liang W, Cai K, Chen C, Chen H, Chen Q, Fu J, et al. Expert consensus on neoadjuvant immunotherapy for non-small cell lung cancer. Transl Lung Cancer Res 2020;9:2696–715. doi: 10.21037/tlcr-2020-63.

31. Liang H, Gonzalez-Rivas D, Zhou Y, Liu J, Wu X, He J, et al. Nonintubated Anesthesia for Tracheal/Carinal Resection and Reconstruction. Thorac Surg Clin 2020;30:83–90. doi: 10.1016/j.thorsurg.2019.08.007.

32. Liang H, Deng H, Liang W, Guo K, Gao Z, Wiesel O, et al. Perioperative chemoimmunotherapy in a patient with stage IIIB non-small cell lung cancer. Ann Transl Med 2020;8:245. doi: 10.21037/atm.2020.01.118.

33. He J, Xu S, Pan H, Li S, He J. Treatments for combined small cell lung cancer patients. Transl Lung Cancer Res 2020;9:1785–94. doi: 10.21037/tlcr-20-437.

34. He J, Xu S, Pan H, Li S, He J. Does size matter? -a population-based analysis of malignant pleural mesothelioma. Transl Lung Cancer Res 2020;9:1041–52. doi: 10.21037/tlcr-19-488.

35. He J, Li S, Pan H, He J. Treatment for Patients With Early Stage Adenosquamous Lung Cancer. JTO Clin Res Rep 2020;1:100021. doi: 10.1016/j.jtocrr.2020.100021.

36. Han D, Cao Y, Wu H, Wang H, Jiang L, Zhao D, et al. Uniportal video-assisted thoracic surgery for the treatment of lung cancer: a consensus report from Chinese Society for Thoracic and Cardiovascular Surgery (CSTCVS) and Chinese Association of Thoracic Surgeons (CATS). Transl Lung Cancer Res 2020;9:971–87. doi: 10.21037/tlcr-20-576.

37. Zhou Y, Liu H, Wu X, Li S, Liang L, Dong Q. Spontaneous breathing anesthesia for cervical tracheal resection and reconstruction. J Thorac Dis 2019;11:5336–42. doi: 10.21037/jtd.2019.11.70.

38. Wright CD, Li S, Geller AD, Lanuti M, Gaissert HA, Muniappan A, et al. Postintubation Tracheal Stenosis: Management and Results 1993 to 2017. Ann Thorac Surg 2019;108:1471–7. doi: 10.1016/j.athoracsur.2019.05.050.

39. He J, Yang H, He J, Li S. Electromagnetic navigation bronchoscopy fluorescence localization and VATS subxiphoid bilateral wedge resection under non-intubated anesthesia. J Thorac Dis 2019;11:3186–90. doi: 10.21037/jtd.2019.06.66.

40. Cen R-L, Cui F, Wan Q, Chen L, Huang X-Y, Zhou J-X, et al. Preoperative localisation of pulmonary ground-glass opacity using medical adhesive before thoracoscopic resection. Eur Radiol 2018;28:4048–52. doi: 10.1007/s00330-018-5394-2.

41. Li S, Jiang L, Ang K-L, Chen H, Dong Q, Yang H, et al. New tubeless video-assisted thoracoscopic surgery for small pulmonary nodules. Eur J Cardiothorac Surg 2017;51:689–93. doi: 10.1093/ejcts/ezw364.

42. Guo Z, Li S, Yin W, He J. Implementation of a novel enhanced recovery after surgery program in thoracoscopic bilateral bullectomy. J Thorac Cardiovasc Surg 2017;153:e115–8. doi: 10.1016/j.jtcvs.2016.10.058.

43. Liu J, Li S, Shen J, Dong Q, Liang L, Pan H, et al. Non-intubated resection and reconstruction of trachea for the treatment of a mass in the upper trachea. J Thorac Dis 2016;8:594–9. doi: 10.21037/jtd.2016.01.56.

44. Liu J, Cui F, Pompeo E, Gonzalez-Rivas D, Chen H, Yin W, et al. The impact of non-intubated versus intubated anaesthesia on early outcomes of video-assisted thoracoscopic anatomical resection in non-small-cell lung cancer: a propensity score matching analysis. Eur J Cardiothorac Surg 2016;50:920–5. doi: 10.1093/ejcts/ezw160.

45. Li S, Liu J, He J, Dong Q, Liang L, Cui F, et al. Video-assisted transthoracic surgery resection of a tracheal mass and reconstruction of trachea under non-intubated anesthesia with spontaneous breathing. J Thorac Dis 2016;8:575–85. doi: 10.21037/jtd.2016.01.62.

46. Li S, Liu J, He J, Dong Q, Liang L, Yin W, et al. Video-assisted thoracoscopic surgery resection and reconstruction of thoracic trachea in the management of a tracheal neoplasm. J Thorac Dis 2016;8:600–7. doi: 10.21037/jtd.2016.01.60.

47. Huang J, Li S, Hao Z, Chen H, He J, Xu X, et al. Complete video-assisted thoracoscopic surgery (VATS) bronchial sleeve lobectomy. J Thorac Dis 2016;8:553–74. doi: 10.21037/jtd.2016.01.63.

48. Cui F, Liu J, Li S, Yin W, Xin X, Shao W, et al. Tubeless video-assisted thoracoscopic surgery (VATS) under non-intubated, intravenous anesthesia with spontaneous ventilation and no placement of chest tube postoperatively. J Thorac Dis 2016;8:2226–32. doi: 10.21037/jtd.2016.08.02.

49. Liu J, Cui F, Li S, Chen H, Shao W, Liang L, et al. Nonintubated video-assisted thoracoscopic surgery under epidural anesthesia compared with conventional anesthetic option: a randomized control study. Surg Innov 2015;22:123–30. doi: 10.1177/1553350614531662.

50. Li S, Cui F, Liu J, Xu X, Shao W, Yin W, et al. Nonintubated uniportal video-assisted thoracoscopic surgery for primary spontaneous pneumothorax. Chin J Cancer Res 2015;27:197–202. doi: 10.3978/j.issn.1000-9604.2015.03.01.

51. Shao W, Xiong X, Chen H, Liu J, Yin W, Li S, et al. Long-term survival outcomes of video-assisted thoracic surgery for patients with non-small cell lung cancer. Chin J Cancer Res 2014;26:391–8. doi: 10.3978/j.issn.1000-9604.2014.08.04.

52. Shao W, Liu J, Liang W, Chen H, Li S, Yin W, et al. Safety and feasibility of video-assisted thoracoscopic surgery for stage IIIA lung cancer. Chin J Cancer Res 2014;26:418–22. doi: 10.3978/j.issn.1000-9604.2014.08.05.

53. Li S, Chai H, Huang J, Zeng G, Shao W, He J. Hybrid video-assisted thoracic surgery with segmental-main bronchial sleeve resection for non-small cell lung cancer. Surg Innov 2014;21:180–6. doi: 10.1177/1553350613492026.

54. Shen J-F, Zhang X-X, Li S-B, Guo Z-H, Xu Z-Q, Shi X-S, et al. Complete video-assisted thoracoscopic surgery for pulmonary sequestration. J Thorac Dis 2013;5:31–5. doi: 10.3978/j.issn.2072-1439.2013.01.01.

55. Liu J, Cui F, Li S-B. Radical treatment for left upper-lobe cancer via complete VATS. J Thorac Dis 2013;5:868–72. doi: 10.3978/j.issn.2072-1439.2013.11.21.

56. Li S, He J, Li S, Chen H, Yin W, Cheng X, et al. [Value of endobronchial ultrasound-transbronchial needle aspiration biopsy for diagnosis of PET-CT positive mediastinal lymph nodes]. Zhonghua Zhong Liu Za Zhi 2012;34:613–5. doi: 10.3760/cma.j.issn.0253-3766.2012.08.012.

57. Liu J, He J, Cai C, Chen H, Wei B, Shao W, et al. [The analysis on the misdiagnosis of solitary fibrous tumor of the pleura]. Zhonghua Jie He He Hu Xi Za Zhi 2010;33:432–5.

58. Liu J, Cai C, Wang D, Chen H, Cheng L, Shao W, et al. Video-assisted thoracoscopic surgery (VATS) for patients with solitary fibrous tumors of the pleura. J Thorac Oncol 2010;5:240–3. doi: 10.1097/JTO.0b013e3181c6b6b2.

59. He J, Li S, Shao W, Wang D, Chen M, Yin W, et al. Activated carbon nanoparticles or methylene blue as tracer during video-assisted thoracic surgery for lung cancer can help pathologist find the detected lymph nodes. J Surg Oncol 2010;102:676–82. doi: 10.1002/jso.21684.

60. He J, Xu X, Chen M, Li S, Yin W, Wang S, et al. Novel method to repair tracheal defect by pectoralis major myocutaneous flap. Ann Thorac Surg 2009;88:288–91. doi: 10.1016/j.athoracsur.2008.11.030.

61. He J, Shao W, Li S, Chen M, Chen H, Liu J, et al. Feasibility Of Administering Adjuvant Chemotherapy Of Pemetrexed Followed By Pemetrexed/oxaliplatin Immediately Post-VATS In Patients With Completely Resected NSCLC. J Thorac Dis 2009;1:55–62.

62. He J, Chen M, Shao W, Li S, Yin W, Gu Y, et al. Surgical Management Of 3 Cases With Huge Tracheoesophageal Fistula With Esophagus Segment in situ As Replacement Of The Posterior Membranous Wall Of The Trachea. J Thorac Dis 2009;1:39–45.

63. Li S-B, He J-X, Chen H-Z, Ge L-H, Wei B, Yin W-Q, et al. [Injection of activated carbon nanoparticles for guiding lymphadenectomy during minimal invasive surgery in lung cancer]. Zhonghua Zhong Liu Za Zhi 2008;30:228–30.

64. Cheng X-Y, Xiong X-G, Chen H, Wei B, Li S, He J. [Treatment and timing of re-operation for postoperative recurrence of spontaneous pneumothorax]. Zhonghua Jie He He Hu Xi Za Zhi 2007;30:170–2.

二、著作

1、2020-2发表著作《Nonintubated Thoracic Surgery》 （主编委之一）

2、2021-9发表著作《Cohen’s Comprehensive Thoracic Anesthesia》（主编委之一）

3、2023-11发表著作《气管外科》主译

【所获荣誉和奖励】

1. 2017年获得华夏医学科技奖一等奖（主要完成人）

2. 2017年获得中华医学科技一等奖（主要完成人）

3. 2018被评为广州市高层次卫生人才医学重点人才

4. 2019年被评为广州市高层次人才优秀专家

5．2022年获“羊城好医生”、“广东实力中青年医生”

6. 2023年入选第三届（2023）"人民好医生·金山茶花计划——优秀典范专家（肺癌领域）"

7. 2023年获“医院科技创新奖” （主要完成人）