刘世明，男，医学博士，二级教授，主任医师，博士研究生导师，广州医科大学附属第二医院党委书记。担任呼吸疾病国家重点实验室PI、广东省临床重点专科学科带头人、广州市重点学科（心血管病学）学科带头人、广州市心血管疾病重点实验室学术带头人。现任中国医院协会理事、中国医师协会心血管分会常务委员、中国医疗保健国际交流促进会动脉粥样硬化血栓疾病防治分会常务委员、中华医学会起搏电生理分会委员、广东省肺栓塞和深静脉血栓防治联盟主席、广东省医院协会血栓与栓塞性疾病防治管理专业委员会主任委员、广东省医师协会心血管分会主任委员、广州市医学会心血管病学分会主任委员、广东省医学会心血管病学分会副主任委员、广东省医师协会心脏起搏与电生理学分会副主任委员、广东省医院协会心血管疾病质控委员会副主任委员等。获得广东省科技进步一等奖、广东省科技进步二等奖和广东省教育教学成果奖一等奖。近年先后荣获“广东省教学名师”、“广州医师奖”、“广东省医院优秀院长”、“首批广东省医学领军人才”、“全国优秀医院院长”。
刘世明教授长期从事医疗、教学及科研工作。从事心血管内科临床工作30多年，对心血管疾病的诊断、治疗具有丰富的实际工作经验，擅长心血管疾病危重病诊治及心血管疾病的介入治疗。承担了研究生、本科生、年青医生和进修生等各个层次的诊断学、内科学教学工作。是我校国家级精品课程和双语示范课程《内科学》的主讲教师、内科学国家级教学团队的骨干教师。主持省市教研教改项目3项，先后获得教学奖励多项，其中“体格检查多媒体网络课件”获得2009年第十三届全国多媒体教育软件大奖赛高等教育组多媒体课件类一等奖。主编科学出版社五年制本科案例式教材《内科学》及其配套教材《内科学学习指导》，副主编教材2部。其中《内科学》2010年被评为第一批市属高校优秀教材二等奖。
结合临床开展心血管疾病的基础研究。近年来主持国家自然科学基金2项，广东省科技计划项目重大项目、省自然科学基金重点项目各1项，省、市级面上项目8项。目已作为通讯作者在Basic Research in Cardiology、European Heart Journal-Cardiovascular Pharmacotherapy、Theranostics、Aging Cell、Cell Death & Disease、Frontiers in Cardiovascular Medicine等杂志发表高水平论文40余篇，授权（申请）国家发明专利10项，编写论著4部，参与制定指南1部。
代表性期刊论文如下：
1）Liu Benrong, Fang Lei, Xiong Yujuan, Du Qiqi, Xiang Yang, Chen Xiaohui, Tian Chaowei*,Liu Shiming*. A Machine Learning Model Based on Genetic and Traditional Cardiovascular Risk Factors to Predict Premature Coronary Artery Disease.Frontiers in bioscience (Landmark edition). 2022;4;27(7):211.
2）Xu Qiong#, Liu Mingke#, Gu Jielei, Ling Sisi, Liu Xiaolin, Luo Zhenyu, Jin Yangshuo, Chai Renjie, Ou Wenchao,Liu Shiming*, Liu Ningning*. Ubiquitin-specific protease 7 regulates myocardial ischemia/reperfusion injury by stabilizing Keap1.Cell Death Discovery. 2022;16;8(1):291.
3）Ji Yang#, Chen Jing#, Pang Lihua#, Chen Changnong, Ye Jinhao, Liu Hao, Chen Huanzhen, Zhang Songhui, Liu Shaojun, Liu Benrong, Cheng Chuanfang,Liu Shiming*, Zhong Yun*. The Acid Sphingomyelinase Inhibitor Amitriptyline Ameliorates TNF-α-Induced Endothelial Dysfunction.Cardiovascular drugs and therapy. 2022.
4）Liu Benrong#, Pang Lihua#, Ji Yang#, Fang Lei, Tian Chao Wei, Chen Jing, Chen Changnong, Zhong Yun, Ou Wen-Chao, Xiong Yujuan*andLiu Shiming*. MEF2A Is the Trigger of Resveratrol Exerting Protection on Vascular Endothelial Cell.Frontiers in Cardiovascular Medicine. 2022;8:775392.
5）Zhou Wenyi#, Zheng Xuefei#, Cheng Chuanfang, Guo Guixian, Zhong Yun, Liu Weihua, Liu Kefeng, Chen Yanfang,Liu Shiming*and Liu Shaojun*. Rab27a deletion impairs the therapeutic potential of endothelial progenitor cells for myocardial infarction.Molecular and Cellular Biochemistry. 2021;476:797-807.
6）Xu Qiong#, Liu Mingke#, Zhang Fangcheng, Liu Xiaolin, Ling Sisi, Chen Xuke, Gu Jielei, Ou Wenchao,Liu Shiming*and Liu Ningning*. Ubiquitin-specific protease 2 regulates AngⅡ -induced cardiac fibroblasts activation by up-regulating cyclin D1 and stabilizing beta-catenin in vitro.Journal of Cellular and Molecular Medicine. 2021;25:1001-1011.
7）Ying Fan, Liu Hao, Ching Tang Eva Hoi, Lakhani Ishan, Liu Ningning, Xia Zhengyuan andLiu Shiming*. Prostaglandin E receptor subtype 4 protects against diabetic cardiomyopathy by modulating cardiac fatty acid metabolism via FOXO1/CD36 signalling.Biochemical and Biophysical Research Communications. 2021;548:196-203.
8）Xia Xiaohong#, Liu Xiaolin#, Chai Renjie#, Xu Qiong, Luo Zhenyu, Gu Jielei, Jin Yangshuo, Hu Tumei, Yu Cuifu, Du Bijun, Huang Hongbiao, Ou Wenchao,Liu Shiming*and Liu Ningning*. USP10 exacerbates neointima formation by stabilizing Skp2 protein in vascular smooth muscle cells.Journal of Biological Chemistry.2021;297:101258.
9）Wu Feima, Chen Yan, You Kai, Tan Shenglin, Xu Yingying, Wang Pei-Hui,Liu Shiming*and Li Yin-Xiong*. Generation of WAe001-A-58 human embryonic stem cell line with inducible expression of the SARS-CoV-2 nucleocapsid protein.Stem Cell Research. 2021;53:102197.
10）Luo Chengfeng, Mo Pei, Li Guoqiang andLiu Shiming*. Aspirin-omitted dual antithrombotic therapy in non-valvular atrial fibrillation patients presenting with acute coronary syndrome or undergoing percutaneous coronary intervention: results of a meta-analysis.European Heart Journal-Cardiovascular Pharmacotherapy. 2021;7:218-224.
11）Gu Jielei#, Chen Xuke#, Jin Yangshuo, Liu Mingke, Xu Qiong, Liu Xiaolin, Luo Zhenyu, Ling Sisi, Liu Ningning* andLiu Shiming*. A Neonatal Mouse Model for Pressure Overload: Myocardial Response Corresponds to Severity.Frontiers in Cardiovascular Medicine. 2021;8:660246.
12）Zhang Fangcheng#, Xia Xiaohong#, Chai Renjie#, Xu Ruqin, Xu Qiong, Liu Mingke, Chen Xuke, Liu Bin,Liu Shiming*and Liu Ningning*. Inhibition of USP14 suppresses the formation of foam cell by promoting CD36 degradation.Journal of Cellular and Molecular Medicine. 2020;24:3292-3302.
13）Xia Xiaohong, Xu Qiong, Liu Mingke, Chen Xuke, Liu Xiaolin, He Jinchan, Hu Tumei, Yu Cuifu, Huang Hongbiao,Liu Shiming*and Liu Ningning*. Deubiquitination of CD36 by UCHL1 promotes foam cell formation.Cell Death & Disease.2020;11:636.
14）Wang Jinju, Li Jiao, Cheng Chuanfang andLiu Shiming*. Angiotensin converting enzyme 2 augments the effects of endothelial progenitor cells-exosomes on vascular smooth muscle cell phenotype transition.Cell and tissue research. 2020;382:509-518.
15）Liu Shaojun#*, Chen Jing#, Shi Jian#, Zhou Wenyi, Wang Li, Fang Weilun, Zhong Yun, Chen Xiaohui, Chen Yanfang, Sabri Abdelkarim andLiu Shiming*. M1-like macrophage-derived exosomes suppress angiogenesis and exacerbate cardiac dysfunction in a myocardial infarction microenvironment.Basic Research in Cardiology.2020;115:22.
16）Dong Jun#, Liu Jianwei#, Wen Yueqiang#, Tobin Stephanie W, Zhang Chongyu, Zheng Huiling, Huang Zehan, Feng Yongtao, Zhang Dongcheng,Liu Shiming*, Zhang Zhenhui*and Li Jiao*. Down-Regulation of Lnc-CYP7A1-1 Rejuvenates Aged Human Mesenchymal Stem Cells to Improve Their Efficacy for Heart Repair Through SYNE1.Frontiers in Cell and Developmental Biology.2020;8:600304.
17）Chen Xing, Jiang Xingzuan, Cheng Chuanfang, Chen Jing, Huang Shuyan, Xu Miqing* andLiu Shiming*. Berberine Attenuates Cardiac Hypertrophy Through Inhibition of mTOR Signaling Pathway.Cardiovascular Drugs and Therapy.2020;34:463-473.
18）Zhang Jingzhi#, Deng Bo#, Jiang Xiaoli#, Cai Min#, Liu Ningning, Zhang Shuangwei, Tan Yongzhen, Huang Guiqiong, Jin Wen, Liu Bin* andLiu Shiming*. All-Trans-Retinoic Acid Suppresses Neointimal Hyperplasia and Inhibits Vascular Smooth Muscle Cell Proliferation and Migration via Activation of AMPK Signaling Pathway.Frontiers in Pharmacology. 2019;10:485.
19）Xu Ruqin#, Zhang Fangcheng#, Chai Renjie#, Zhou Wenyi, Hu Ming, Liu Bin, Chen Xuke, Liu Mingke, Xu Qiong, Liu Ningning* andLiu Shiming*. Exosomes derived from pro-inflammatory bone marrow-derived mesenchymal stem cells reduce inflammation and myocardial injury via mediating macrophage polarization.Journal of Cellular and Molecular Medicine. 2019;23:7617-7631.
20）Xiong Yujuan#, Wang Lin#, Jiang Wenyi, Pang Lihua, Liu Weihua, Li Aiqun, Zhong Yun, Ou Wenchao, Liu Benrong* andLiu Shiming*. MEF2A alters the proliferation, inflammation-related gene expression profiles and its silencing induces cellular senescence in human coronary endothelial cells.BMC Molecular Biology. 2019;20:8.
21）Liu Benrong#*, Wang Lin#, Jiang Wenyi#, Xiong Yujuan, Pang Lihua, Zhong Yun, Zhang Chongyu, Ou Wenchao, Tian Chaowei, Chen Xiaohui andLiu Shiming*. Myocyte enhancer factor 2A delays vascular endothelial cell senescence by activating the PI3K/p-Akt/SIRT1 pathway.Aging-US. 2019;11:3768-3784.
22）Li Jiao, Li Shuhong, Dong Jun, Alibhai Faisal J, Zhang Chongyu, Shao Zhengbo, Song Hui-Fang, He Sheng, Yin Wenjuan, Wu Jun, Weisel Richard D,Liu Shiming*and Li Renke*. Long-term repopulation of aged bone marrow stem cells using young Sca-1 cells promotes aged heart rejuvenation.Aging Cell.2019;18:e13026.
23）Lin Xiaozhen, Cheng Chuanfang, Zhong Junyang, Liu Benrong, Luo Chengfeng, Ou Wenchao, Mo Pei, Huang Qiang andLiu Shiming*. Resveratrol inhibits angiotensin II induced proliferation of A7r5 cells and decreases neointimal hyperplasia by inhibiting the CaMKII HDAC4 signaling pathway.Molecular Medicine Reports.2018;18:1007-1014.
24）Li Jiao, Li Shu-Hong, Wu Jun, Weisel Richard D, Yao Alina, Stanford William L,LiuShi-Ming*and Li Ren-Ke*. Young Bone Marrow Sca-1 Cells Rejuvenate the Aged Heart by Promoting Epithelial-to-Mesenchymal Transition.Theranostics.2018;8:1766-1781.
25）Hu Ming, Guo Guixian, Huang Qiang, Cheng Chuanfang, Xu Ruqin, Li Aiqun, Liu Ningning* andLiu Shiming*. The harsh microenvironment in infarcted heart accelerates transplanted bone marrow mesenchymal stem cells injury: the role of injured cardiomyocytes-derived exosomes.Cell Death & Disease.2018;9:357.
26）Xiong Yujuan#, Wang Lin#, Mo Pei#, Huang Guoying, Li Aiqun, Chai Renjie, Lin Xiaozhen, Zhong Yun, Liu Bin, Ou Wenchao, Liu Benrong* andLiu Shiming*. Association between HLA-DQB1 alleles and susceptibility to coronary artery disease in Southern Han Chinese.Human immunology.2017;78:540-546.
27）Liu Bin, Fu Xiu-Qiong, Li Ting, Su Tao, Guo Hui, Zhu Pei-Li, Tse Anfernee Kai-Wing,Liu Shi-Ming*and Yu Zhi-Ling*. Computational and experimental prediction of molecules involved in the anti-melanoma action of berberine.Journal of ethnopharmacology.2017;208:225-235.
