李晏丽
学科方向：内分泌代谢病学
医学博士，内分泌科副主任医师，硕士研究生导师
（一）教育经历：
(1) 2011-09 至 2016-06, 上海交通大学医学院附属瑞金医院, 内科学, 硕博连读，博士
(2) 2006-09 至 2011-06, 南昌大学, 临床医学, 学士
（二）工作经历
(1) 2021-07 至 今, 广州医科大学附属第二医院, 副主任医师
(2) 2019-06 至 2021-06, 广州医科大学附属第二医院, 主治医师
(3) 2016-07 至 2019-05, 广州医科大学附属第二医院，住院医师
（三）主要学术任职：
广东省医学教育协会糖尿专业委员会第一届常委委员
广东省医师协会内分泌科医师分会第三届委员青年专业组组员
广州市医师协会内分泌代谢医师分会第二届委员会常务委
广州市医学会内分泌学分会第九届委员会委员
（四）研究方向：
2型糖尿病及垂体瘤的基础与临床研究
（五）科研项目：
(1) 国家自然科学基金委员会, 青年科学基金项目, 81800682, 胰岛中miR-15b介导的Kcnq1ot1在母代低蛋白饮食的子代糖代谢过程中的作用及机制研究, 2019-01-01 至 2021-12-31, 21万元, 结题。
(2) 国家自然科学基金委员会, 青年科学基金项目, 81800726, TRAP1通过调节线粒体功能及内质网应激对糖尿病心肌病的保护作用及机制研究, 2019-01-01 至 2021-12-31, 21万元, 结题, 参与。
（3）广州市科技计划局, 基础研究计划, 202201020550, 胰岛中lncRNA- Gm33732-miR-299a-3p在母代低蛋白饮食的子代糖代谢中的作用及机制研究, 2022-04 至 2024-03, 20万元, 结题，主持。
（4）广州市卫生健康委员会, 西医类-一般引导项目, 20201A011079, 胰岛中let-7b在母代低蛋白饮食的子代糖代谢过程中的作用及其机制研究, 2020-02 至 2022-02, 3万元, 结题, 主持。
（六）代表性论文：
（1）A maternal low-protein diet impaired glucose metabolism and altered the lncRNA profiles of islets in adult offspring. J Nutr Biochem.
（2）Downregulation of Kcnq1ot1 attenuates β-cell proliferation and insulin secretion via the miR-15b-5p/Ccnd1 and Ccnd2 axis. Acta Diabetol.
（3）Efficacy and safety of basal-bolus insulin at 1:1.5 ratio compared to 1:1 ratio using a weight-based initiation and titration (WIT2) algorithm in hospitalized patients with type 2 Diabetes: a multicenter, randomized, clinical study. Diabetol Metab Syndr Obes.
（4）Blood glucose may be another index to initiate insulin treatment besides glycated hemoglobin A1c after oral antidiabetic medications failure for glycemic control: A real-world survey. Front Endocrinol.
（5）Comparison of Efficacy and Adherence of Patient-Preferred (1 Unit Daily) and ADA/EASD Guideline-Recommended (2 Units Every 3 Days) Basal Insulin Titration Algorithms: Multicenter, Randomized, Clinical Study. Patient Prefer Adher.
（6）Evaluation of the Thyroid Characteristics and Correlated Factors in Hospitalized Patients with Newly Diagnosed Type 2 Diabetes. Diabetes Metab Syndr Obes.
（7）lncRNA-mRNA Expression Patterns in Invasive Pituitary Adenomas: A Microarray Analysis. Biomed Res Int.
（8）Characteristic of Tumor Regrowth After Gamma Knife Radiosurgery and Outcomes of Repeat Gamma Knife Radiosurgery in Nonfunctioning Pituitary Adenomas. Front Oncol.
（9）Pituitary hemorrhage in pituitary adenomas treated with gamma knife radiosurgery: incidence, risk factors and prognosis. J Cancer.
(10) Initial Gamma Knife radiosurgery for nonfunctioning pituitary adenomas: results from a 26-year experience. Endocrine.
(11) Long-term results of Gamma Knife Radiosurgery for Postsurgical residual or recurrent nonfunctioning Pituitary Adenomas.Int J Med Sci.
(12) Gamma Knife Radiosurgery (GKRS) for Patients with Prolactinomas: Long-Term Results From a Single-Center Experience. Med Sci Monit.
(13) Comparative Study of Liraglutide and Insulin Glargine on Glycemic Control and Pancreatic β-Cell Function in db/db Mice. Med Sci Monit.
(14) Glycated hemoglobin is independently associated with albuminuria in young nondiabetic people with obesity: A cross-sectional study. Med Sci Monitor.
(15) Whole exome sequencing of thymic neuroendocrine tumor with ectopic ACTH syndrome. Eur J Endocrinol.
(16) Maternal low protein isocaloric diet suppresses pancreatic β-cell proliferation in mouse offspring via miR-15b. Endocrinology.
(17) Conditional Deletion of Men1 in the Pancreatic β-Cell Leads to Glucagon-Expressing Tumor Development. Endocrinology.
(18) Targeting ß-catenin signaling for therapeutic intervention in MEN1-deficient pancreatic neuroendocrine tumours. Nat Commun.
(19) Activating Hotspot L205R Mutation in PRKACA and Adrenal Cushing’s Syndrome. Science.
(20) Whole exome sequencing of insulinoma reveals recurrent T372R mutations in YY1. Nat Commun.
（七）所获荣誉及奖励
2019-2020年度广东省优秀共青团干部
2019-2020年广州医科大学优秀共青团干部
2019-2020学年广州医科大学优秀班主任
2022年广州医科大学第二临床学院优秀教师
