【个人简介】

赖克方教授，男，医学博士，广州呼吸健康研究院/国家呼吸医学中心/呼吸疾病国家重点实验室/广州医科大学附属第一医院临床实验部主任。

【研究方向】

慢性咳嗽与哮喘的相关研究

【科研项目】

1.国家自然科学基金面上项目, 中缝背核-中央杏仁核环路介导焦虑与慢性咳嗽相互作用的神经机制研究，2024-01-01至2027-12-31，49万，在研，主持。

2.国家重点专项，慢性咳嗽发病机制与诊疗新技术研究，2024-01-01至2028-10-31，3000万，在研，主持。

3.国家自然科学基金面上项目,干扰素-γ诱导气道感觉神经重塑在咳嗽高敏感性发生中的作用及机制研究，2022-01-01至2025-12-31，57万，在研，主持。

【代表性论文及著作】

1.1. 赖克方,陈如冲,林玲,沈璐,郑燕冰,王法霞,李斌恺,姜华,肖焕,刘春丽,张清玲,谢佳星,罗炜,陈桥丽,曾运祥,钟淑卿,钟南山．不同病因慢性咳嗽临床特征的诊断价值．中华结核和呼吸杂志,2009,32(6):418-421.

2.Lai K, Chen R, Lin J, Huang K, Shen H, Kong L, Zhou X, Luo Z, Yang L, Wen F, Zhong N. A prospective, multicenter survey on causes of chronic cough in China. Chest. 2013 Mar;143(3):613-620. (IF=8.303)

3.Lai K, Liu B, Xu D, Han L, Lin L, Xi Y, Wang F, Chen R, Luo W, Chen Q, Zhong N. Will nonasthmatic eosinophilic bronchitis develop chronic airway obstruction? A prospective, observational study. Chest, 2015,148 (4): 887-894. (IF=6.044)

4.Zhong S, Nie YC, Gan ZY, Liu XD, Fang ZF, Zhong BN, Tian J, Huang CQ, Lai KF, Zhong NS. Effects of Schisandra chinensis extracts on cough and pulmonary inflammation in a cough hypersensitivity guinea pig model induced by cigarette smoke exposure. J Ethnopharmacol. 2015 May 13;165:73-82. (IF=3.055)

5.Yi F, Chen RC, Luo W, Xu DY, Han LN, Liu BJ, Jiang SQ, Chen QL, Lai KF. Validity of Fractional Exhaled Nitric Oxide in Diagnosis of Corticosteroids Responsive Cough. Chest. 2016;149(4):1042-1051. (IF=5.94)

6.Jiang M, Guan WJ, Fang ZF, Xie YQ, Xie JX, Chen H, Wei D, Lai KF, Zhong NS. A critical review of the quality of cough clinical practice guidelines. Chest. 2016 Oct;150(4):777-788. (IF=5.94)

7.Nie Y, Huang C, Zhong S, Wortley MA, Luo Y, Luo W, Xie Y, Lai K, Zhong N. Cigarette smoke extract (CSE) induces transient receptor potential ankyrin 1(TRPA1) expression via activation of HIF1αin A549 cells. Free Radic Biol Med. 2016 Oct;99:498-507. (IF=5.784)

8.Deng Z, Zhou W, Sun J, Li C, Zhong B, Lai K. Interferon-γ Enhances the Cough Reflex Sensitivity via Calcium Influx in Vagal Sensory Neurons. Am J Respir Crit Care Med. 2018 Oct 1;198(7):868-879. (IF=13.204)

9.Lai K, Long L, Yi F, Tang J, Chen Z, Chen F, Zhou J, Peng W, Zhang L, Li H, Zhan W, Chen R, Luo W, Chen Q, Chung KF, Zhong N. Age and Sex Distribution of Chinese Chronic Cough Patients and Their Relationship With Capsaicin Cough Sensitivity. Allergy Asthma Immunol Res. 2019 Nov;11(6):871-884. (IF=5.764)

10.Long L, Yao H, Tian J, Luo W, Yu X, Yi F, Chen Q, Xie J, Zhong N, Chung KF, Lai K. Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough. Respir Res. 2019 Jun 6;20(1):112. (IF=5.631)

11.Fang Z, Huang C, Zhang JJ, Xie J, Dai S, Ge E, Xiang J, Yao H, Huang R, Bi X, Wang B, Zhong N, Lai K. Traffic-related air pollution induces non-allergic eosinophilic airway inflammation and cough hypersensitivity in guinea-pigs. Clin Exp Allergy. 2019 Mar;49(3):366-377. (IF=5.018)

12.Long L, Zeng X, Zhang X, Xiao W, Guo E, Zhan W, Yang X, Li C, Wu C, Xu T, Zhan C, Chen Y, Jiang M, Zhong N, Lai K. Short-term outcomes of COVID-19 and risk factors for progression. Eur Respir J. 2020 May 27;55(5):2000990. ( IF=16.671)

13.Lai K, Zhan W, Li H, Yi F, Peng W, Zhou J, Tang J, Zhang L, Long L, Chen R, Luo W, Chen Q, Jiang M, Zhong N. The Predicative Clinical Features Associated with Chronic Cough That Has a Single Underlying Cause. J Allergy Clin Immunol Pract. 2021 Jan;9(1):426-432.e2. (IF=10.793)

14.Fang Z, Yi F, Peng Y, Zhang JJ, Zhang L, Deng Z, Chen F, Li C, He Y, Huang C, Zhang Q, Lai K, Xie J. Inhibition of TRPA1 reduces airway inflammation and hyperresponsiveness in mice with allergic rhinitis. FASEB J. 2021 May;35(5):e21428. (IF=5.191)

15.Zhang Q, Luo W, Zhan W, Xie J, Wang H, Chung KF, Lai K. Non-asthmatic eosinophilic bronchitis is characterized by proximal airway eosinophilic inflammation as compared with classic asthma and cough variant asthma. Clin Exp Allergy. 2021 Dec;51(12):1637-1640. (IF=5.018)

16.Chen Z, Lin MT, Zhan C, Zhong NS, Mu D, Lai KF, Liu MJ. A descending pathway emanating from the periaqueductal gray mediates the development of cough-like hypersensitivity. iScience. 2021 Dec 16;25(1):103641. (IF=5.45)

17.Sun J, Zhan C, Deng Z, Luo W, Chen Q, Jiang M, Zhong N, Lai K. Expression of interferon-γ and its effect on cough hypersensitivity in chronic refractory cough patients. Thorax. 2022 Jun;77(6):621-624. (IF=10)

18.Chung KF, McGarvey L, Song WJ, Chang AB, Lai K, Canning BJ, Birring SS, Smith JA, Mazzone SB.  Cough hypersensitivity and chronic cough. Nat Rev Dis Primers. 2022 Jun 30;8(1):45. (IF=65.038)

19.Lai K, Satia I, Song WJ, Wang G, Niimi A, Pattemore P, Chang AB, Gibson PG, Chung KF. Cough and cough hypersensitivity as treatable traits of asthma. Lancet Respir Med. 2023 Jul;11(7):650-662.(IF: 76.2)

20.Zhan W, Wu F, Zhang Y, Lin L, Li W, Luo W, Yi F, Dai Y, Li S, Lin J, Yuan Y, Qiu C, Jiang Y, Zhao L, Chen M, Qiu Z, Chen R, Xie J, Guo C, Jiang M, Yang X, Shi G, Sun D, Chen R, Zhong N, Shen H, Lai K.Identification of cough-variant asthma phenotypes based on clinical and pathophysiologic data.J Allergy Clin Immunol.2023;152(3):622-632. (IF: 14.2)

21.Ding W, Li R, Song T, Yang Z, Xu D, Huang C, Shen S, Zhong N, Lai K, Deng Z. AMG487 alleviates influenza A (H1N1) virus-induced pulmonary inflammation through decreasing IFN-γ-producing lymphocytes and IFN-γ concentrations. Br J Pharmacol. 2024;181(13):2053-2069. (IF: 9.473)

主编著作

1.《慢性咳嗽》，人民卫生出版社，2008年

2.《慢性咳嗽第2版》，人民卫生出版社，2019年

3.《慢性咳嗽诊治常见问题》，人民卫生出版社，2023年

【所获荣誉和奖励】

1.2021年荣获上海医学科技奖三等奖

2.2021年荣获中华医学科技奖三等奖

3.2020年荣获国家科学技术进步奖（创新团队）

4.2008年荣获科学技术进步奖一等奖