【个人简介】

广州呼吸健康研究院慢性咳嗽病区主任，内科学博士，主任医师，呼吸疾病国家重点实验室博士研究生导师（学术型），中国医师协会呼吸医师分会青年委员（第一届），中国医师协会呼吸医师分会哮喘工作组副组长（2026年-今），中国健康促进与教育协会县域呼吸专委会副主任委员，中国医药教育协会慢性气道疾病专业青委会副主任委员，广东省呼吸与健康学会呼吸困难专委会主任委员，广东省胸部疾病学会重度哮喘精准诊治专委会主任委员，慢性咳嗽亚专科建设计划广东工作组组长，欧洲呼吸学会长期奖学金项目Fellow，《结核与肺部疾病杂志》编委。曾获欧洲呼吸学会长期奖学金留学于英国国家心肺疾病研究所；主要方向慢性咳嗽、哮喘、嗜酸性粒细胞增多肺疾病。《嗜酸性粒细胞增多相关性肺疾病鉴别诊断》（第一主编，人民卫生出版社，2021年）。《中国哮喘标准术语集》（中国医药科技出版社，副主编，2025年）

【研究方向】

临床医学；内科学；慢性咳嗽、哮喘、嗜酸性粒细胞增多肺疾病

【科研项目】

1.国家自然科学基金面上项目，82670035，SP-NK1R/MRGPRB2信号轴介导鼻感觉神经敏化在过敏性鼻炎相关咳嗽高敏中的机制研究，主持，49万，2027-01至2030-12

2.广州国家实验室项目慢性咳嗽发病机制与诊疗新技术研究，GZNL2024A02001，子课题：咳嗽自动监测仪开发负责人。150万，2024-01至2028-10。

3.广州医科大学2024年科研能力提升计划重大临床研究项目培育项目，GMUCR2024-02017，广州呼研院哮喘患者在线登记数据库系统建设，主持，2024-4至2027

4.国家自然科学基金面上项目，82270035，感觉神经环路及TRPA1在变应性鼻炎相关咳嗽高敏感性中的作用及机制研究，主持，53万，2023-01至2025-12

5.广州市科技局，市校（院）联合资助项目，异位淋巴组织介导的气道自身免疫在重症嗜酸粒细胞型哮喘发病机制的作用，2022-01至2022-12，25万元，主持

6.广东省科技厅，创新项目，新型冠状病毒肺炎与慢性阻塞性肺疾病的多中心回顾性研究，2020-05至2020-12，2020B1111340019，10万元，主持

7.国家自然科学基金委员会，青年科学基金项目，81100028，TRPV1和TRPA1在变应性鼻炎继发下气道炎症及高反应性中的作用，2012-01至2014-12，23万元，结题，主持

【代表性论文及著作】

咳嗽与哮喘方向

1. Deng YL, Jiang M, Yu L, Xie JX*. Clinical diagnosis and treatment of eosinophilic asthma by respiratory physicians in China: a cross-sectional survey. Journal of Thoracic Disease. 2026

2. 谢佳星#,徐镶怀,余莉,等. 慢性咳嗽年度进展2025[J]. 中华结核和呼吸杂志,2026,49(04)：434-442.DOI:10.3760/cma.j.cn112147-20251217-00801

3. Chen Y, Xie J*. Severe Dry Cough Followed by Eosinophilia Without Pulmonary Infiltrates After Dupilumab Treatment in Patients with Severe Asthma: A Series of Five Cases. J Inflamm Res. 2025 Dec 17;18:17759-17768. doi: 10.2147/JIR.S545661. PMID: 41439127; PMCID: PMC12719626.

4. Li J, Li Y, Zhan W, Chen X, Huang L, Yi F, Xie J*, Lai K*. Validation of cough evaluation test in subacute cough. J Thorac Dis. 2025 Nov 30;17(11):9451-9458. doi: 10.21037/jtd-2025-661. Epub 2025 Nov 26. PMID: 41377015; PMCID:PMC12688596.

5. Fang ZF, Fu Y, Yi F, Chen Z, Li YZ, Wang ZN, Dong JY, Yang PC, Xu D*, Liu XY*, Xie JX*. Neural control of the pathophysiology of allergic airway disease and its clinical implications: A focus on allergic rhinitis and asthma. J Allergy Clin Immunol. 2025 Aug;156(2):259-269. doi: 10.1016/j.jaci.2025.05.017. Epub 2025 May 28. PMID: 40447196.

6. Changxing Ou et al. Qingling Zhang*, Jiaxing Xie*, on behalf of the C-BIOPRED Consortium. C-BIOPRED severe asthma clinical phenotypes: link to complement and coagulation pathways and galectin 10. ERJ Open Res. 2025 Aug 11;11(4):01016-2024. doi: 10.1183/23120541.01016-2024. eCollection 2025 Jul.

7. Chen Y, Wang L, Xie J*. Combining Dual Biologics Therapy for Severe Asthma: A Series of Ten Cases. J Asthma Allergy. 2025 Apr 5;18:507-517. doi: 10.2147/JAA.S507008. eCollection 2025.

8. 谢佳星#，赖克方.咳嗽频率监测及其临床研究应用.中华结核和呼吸杂志. 2025, DOI: 10.3760/cma.j.cn112147-20250313-00139.

9. 李锡容, 谢佳星* . 重度嗜酸粒细胞性哮喘的抗 IL 5 疗法研究进展. 中华内科杂志, 2025,64(8): 93-100. DOI: 10.3760/cma.j.cn112138-20250117-00046.

10. 李锡容, 谢佳星*.度普利尤单抗诱导重度哮喘患者血液嗜酸性粒细胞增多研究进展[J].中国呼吸与危重监护杂志, 2025, 24(2):140-146.

11. 谢佳星#, 赖克方.重视嗜酸性粒细胞性重度哮喘的治疗.国际呼吸杂志,2025,45(8):670-680.DOI:10.3760/cma.j.cn131368-20241210-00755.

12. You Li, Chang-Xing Ou, Xiao-Xian Zhang, Jia-Xing Xie#. A case of eosinophilic otitis media with successful symptomatic improvement in a patient treated with dupilumab: A case report and literature review.  Acta Oto-Laryngologica Case Reports. Dec 2025 Vol. 10, no. 1 pp. 37 – 45. DOI https://doi.org/10.1080/23772484.2025.2483683

13. Fang ZF, Wang ZN, Chen Z, Peng Y, Fu Y, Yang Y, Han HL, Teng YB, Zhou W, Xu D, Liu XY, Xie JX*, Zhang JJ*, Zhong NS*. Fine particulate matter contributes to COPD-like pathophysiology: experimental evidence from rats exposed to diesel exhaust particles. Respir Res. 2024 Jan 4;25(1):14. doi:10.1186/s12931-023-02623-y. PMID: 38178075; PMCID: PMC10765838.

14. 符昱; 王柱锋; 杨漾; 谢佳星*; 嗜酸性粒细胞增高在健康人群和患病人群中发生率的研究进展, 中华预防医学杂志,2024, 58(4)：552-560.

15. Li Y, Deng Z, Wen J, Ou C, Cen X, Liao Y, Zhang Q*, Xie J*. Efficacy of dupilumab and risk factors for dupilumab-induced hypereosinophilia in severe asthma: a preliminary study from China. Ann Med. 2024 Dec;56(1):2311843. doi:10.1080/07853890.2024.2311843. Epub 2024 Feb 5. PMID: 38316016; PMCID:PMC10846423.

16. 李游,林慧敏,张筱娴,欧昌星,谢佳星*,张清玲. 度普利尤单抗治疗重度哮喘初步疗效的临床观察研究. 中华结核和呼吸杂志.12 Sep 2023, Vol. 46, Issue 9, pages 909 – 915

17. 谢佳星,赖克方*.加强中国基层医院支气管哮喘的规范化诊疗.国际呼吸杂志, 2023,43(12):1378-1382.DOI:10.3760/cma.j.cn131368-20231119-00343.

18. Chen B, Rong Q, Fu Y, Liang H, Kong X, Zhang Q, Jiang M*, Wang Z*, Xie J*. Characteristics of patients with incidental eosinophilia admitted to a tertiary hospital in southern China. Heliyon. 2023 Apr 20;9(5):e15569. doi:10.1016/j.heliyon.2023.e15569. PMID: 37144198

19. Chen B, Fu Y, Wang Z, Rong Q, Zhang Q, Xie J*, Kong X*, Jiang M*. Eosinophilia attention, diagnosis, treatment, and awareness in physicians: a cross-sectional survey. Ther Adv Chronic Dis. 2023 Jan 24;14:20406223221146938. doi:10.1177/20406223221146938. PMID: 36712467; PMCID: PMC9880572.

20. Qin R#, An J#, Xie J#(共同第一作者), Huang R, Xie Y, He L, Xv H, Qian G, Li J*. FEF25-75% Is a More Sensitive Measure Reflecting Airway Dysfunction in Patients with Asthma: A Comparison Study Using FEF25-75% and FEV1. J Allergy Clin Immunol Pract. 2021 Jun 30:S2213-2198(21)00715-7. doi: 10.1016/j.jaip.2021.06.027. Epub ahead of print.PMID: 34214706.

21. Xie J#, Chung KF, Lai K*. Uncommon causes of chronic cough associated with airway eosinophilia. J Thorac Dis. 2021 May;13(5):3191-3196. doi: 10.21037/jtd-20-2324.

22. Zhangfu Fang, Fang Yi, Yang Peng, Kefang Lai*, Jiaxing Xie*. Inhibition of TRPA1 reduces airway inflammation and hyperresponsiveness in mice with allergic rhinitis. The FASEB Journal. 2021, 35(5), e21428. doi:10.1096/fj.201902627R

23. Qiu M, Wei S, Lai Z, Huang P, Wang Z, Zhong C, Chen Y, Zhang X, Lin X, Zeng Q, Chung KF, Zhang Q, Xie J*, Li S*. Early radiologic and bronchoscopic changes after bronchial thermoplasty in patients with severe asthma. Exp Ther Med. 2020 Dec;20(6):278. doi: 10.3892/etm.2020.9408. Epub 2020 Oct 27. PMID: 33200003;PMCID: PMC7664609.

24. Xie J#, Zhang J, Zhang X, Zhang Q, Chung KF, Wang C, Lai K*. Cough in hypereosinophilic syndrome: case report and literature review. BMC Pulm Med. 2020 Apr 15;20(1):90. doi: 10.1186/s12890-020-1134-x

25. Qiu R#，Xie J# (共同第一作者)，Chung KF，Li N，Yang Z，He M，Li J，Chen R，Zhong N，Zhang Q*. Asthma Phenotypes Defined From Parameters Obtained During Recovery From a Hospital-Treated Exacerbation. J Allergy Clin Immunol Pract. 2018 Mar 1. pii: S2213-2198(18)30104-1

26. Jiaxing Xie#, Xu Shi, Jing Li, Qingling Zhang*. Obstructive sleep apnea-induced chronic cough: Three case reports and a review of the literature. International Journal of Clinical and Experimental Medicine. 2017;10(8):12733-12741

27. Wang H^#, Chen R^#, Xie J^#(共同第一作者), Zhang Q, Deng Y, Zeng Q, Zhu Z, Ding M, Lai Z, Kolb M,O'Byrne P, Chen R*, Zhong N. A 43-year-old man with cough, expectoration and recurrent wheezing. J Thorac Dis. 2016 Dec;8(12):3468-3477. doi:10.21037/jtd.2016.12.106.

28. Jiaxing Xie#，Yin Xi，Qingling Zhang，Kefang Lai*，Nanshan Zhong. Impact of short term forced oral breathing induced by nasal occlusion on respiratory function in mice. Respiratory Physiology & Neurobiology. 2015;205:37-41 （国青基金论文）

29. Jiaxing Xie#，Yin Xi，Qingling Zhang，Guoqin Chen，Luo Wei，Kefang Lai*，Nanshan Zhong. Intratracheal challenged murine model of asthma: Can bronchial inflammation influence the nose? Allergy，Asthma & Immunology Research. 2015 Jan;7(1):76-82（国青基金论文）

30. Xie J#, Zhang Q, Zhong N, Lai K*. BAL fluid 8-isoprostane concentrations in eosinophilic bronchitis and asthma. J Asthma. 2009; 46(7):712-5. (IF:1.330)

31. Xie J#, Zhang Q, Lai K*, Zhong N. Measurement of Nasal Airway Resistance and Response in Mice. Int Arch Allergy Immunol. 2009; 151(3):262-264. (IF:2.131)

非咳嗽与哮喘方向

32. Wang Z, Wang Y, Yang Z, Wu H, Liang J, Liang H, Jiang M*, Xie J*, Li, S*. (2021). The use of non-invasive ventilation in COVID-19: a systematic review. Int J Infect Dis. 2021 May;106:254-261. doi:10.1016/j.ijid.2021.03.078

33. Wang Z, Chen B, Fu Y, Ou C, Rong Q, Kong X, Xu W, Deng Y, Jiang M*, Xie J*. Eosinophilia and Lung Cancer: Analysis From Real-World Data and Mendelian. Randomization Study. Front Med (Lausanne). 2022 Mar 9;9:830754. doi: 10.3389/fmed.2022.830754. eCollection 2022.

34. Xie J#, Wang Z#, Liang J#, Lin H#, Yang Z#, Wang Y, Liang H, Wu H, Chen R, Ou Y et al. Critical Review of the Scientific Evidence and Recommendations in COVID-19 Management Guidelines. Open Forum Infect Dis. 2021 Jul 14;8(8):ofab376. doi: 10.1093/ofid/ofab376. eCollection 2021 Aug.

35. Ailan Chen, Qingquan Lv, Zhifang Cai, Yingjie Song, Jianheng Zhang, Jiaxing Xie*. (2021) Oxygen Deficiency at a COVID-19 Epicenter: A Buying-Time Solution. International Journal of Clinical and Experimental Medicine Research, 5(3), 260-263.

36. Luo Q#，Xie J# (共同第一作者)，Han Q#，Tang C，Chen X，Wu L，Chen R*. Prevalence of Venous Thromboembolic Events and Diagnostic Performance of the Wells Score and Revised Geneva Scores for Pulmonary Embolism in Patients with Interstitial Lung Disease: A Prospective Study. Heart Lung Circ. 2014;23(8):778-85

专著

1. 谢佳星，李靖，张清玲主编，《嗜酸性粒细胞增多相关性肺疾病鉴别诊断》，人民卫生出版社，2021.9.--；ISBN978-7-117-31761-0

2. 《中国哮喘标准术语集》（中国医药科技出版社，谢佳星副主编，2025年）/赖克方主编.--北京：中国医药科技出版社，2025.2.--ISBN978-7-5214-5190.

【所获荣誉和奖励】

1.2001年国家卫健委新冠防控先进个人

2.近年来每年均获医院和呼研院优秀员工