【个人简介】
陈爱兰，广州医科大学附属第一医院心血管内科主任、心衰中心主任、主任医师、教授、医学博士、ClevelandClinic博后、研究生导师、博士后合作导师。
2005年7月-2008年5月，广州医学院第一附属医院医师
2008年5月-2009年6月，广州医学院第一附属医院主治医师
2009年9月-2012年6月，广州医学院第一附属医院主治医师、讲师
2012年6月-2019年11月，广州医学院第一附属医院副主任医师、讲师
2019年12月-2022年3月，广州医科大学附属第一医院主任医师、讲师、副教授
2022年4月-2024年11月 广州医科大学附属第一医院主任医师、教授
2020年广东首批援助湖北疫情防控医疗队(医疗组组长、临时党委委员和第八临时联合党支部书记，广医一院队长)
2024年11月-至今广州医科大学附属第一医院心血管内科主任、主任医师、教授
【研究方向】
长期致力于心力衰竭、冠状动脉粥样硬化、心房颤动的临床与基础研究，重点攻关心脏肿瘤、罕见心肌病等疑难心血管疾病，积极开展心肺共病领域的临床转化研究。
【科研项目】
1.国家自然科学基金委员会，青年科学基金项目(C类)[原青年科学基金项目]，81903421，ln cRNA H19在细颗粒物(PM2.5)致心力衰竭发生发展的作用研究，2020-01-01至2022-12-31,20万元，结题，主持
2.广州市科技局，基础研究计划，202102010515，PM2.5通过lncRNA HULC调控巨噬细胞脂质摄取致AS的机制研究，2021-03至2023-03，20万元，结题，主持
3.广东省高等学校优秀青年教师培养计划资助项目，YQ2015138，NPY受体亚型在压力超负荷诱导的心力衰竭大鼠心肌能量代谢中的作用，2016.1-2018/12，30万元，结题，主持
4.广东省自然科学基金-博士启动基金，2014A030310077，NPY受体亚型在压力超负荷心肌能量代谢中的作用，2015.11-2018.10,10万，结题，主持
【代表性论文及著作】
1.林宜乐,张舒妍,陈泽跃,等. CHA2DS2-VASc评分与R2CHA2DS2-VASc评分对心房颤动合并心力衰竭患者预后的预测价值[J]. 中国循环杂志,2025,40(7):674-680. DOI:10.3969/j.issn.1000-3614.2025.07.006.
2.Liang W, Liang H, Ou L, Chen B, Chen A, Li C, Li Y, Guan W, Sang L, Lu J, Xu Y, Chen G, Guo H, Guo J, Chen Z, Zhao Y, Li S, Zhang N, Zhong N, He J; China Medical Treatment Expert Group for COVID-19. Development and Validation of a Clinical Risk Score to Predict the Occurrence of Critical Illness in Hospitalized Patients With COVID-19. JAMA Intern Med. 2020 Aug 1;180(8):1081-1089. doi: 10.1001/jamainternmed.2020.2033. PMID: 32396163; PMCID: PMC7218676.
3.Xue H, Wang L, Wu Y, Liao Y, Wang S, Chen A, Chan SO, Ling W, Chen X, Yu C. Differential associations of cardiometabolic risk factors with liver-related events by alcohol consumption category: Results from a large population-based study. Hepatology. 2026 Aug 1;84(2):503-513. doi: 10.1097/HEP.0000000000001628. Epub 2025 Nov 26. PMID: 41295565.
4.Ding N, Qiu W, Chen J, Wang K, Chen Z, Cai R, Chen A. Prevalence and Risk Factors of Arrhythmias in Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis. Int J Chron Obstruct Pulmon Dis. 2025 Sep 3;20:3059-3072. doi: 10.2147/COPD.S545658. PMID: 40922983; PMCID: PMC12414452.
5.Zhou M, Deng Y, Huang Y, Yu C, Chen X, Yang Q, Liao Y, Wang S, Zhang P, Chen A, Ling W, Chen X, Li J, Xue H. Dietary index for gut microbiota, plasma metabolome, and risks of metabolic dysfunction-associated steatotic liver disease and other chronic liver diseases. Nutr Metab (Lond). 2026 Jun 19;23(1):106. doi: 10.1186/s12986-026-01145-w. PMID: 42321912; PMCID: PMC13587448.
6.Liao Y, Deng Y, Yu C, Huang Y, Sun B, Yang Q, Wang S, Zhang P, Zhou M, Chen A, Ling W, Chen X, Xue H. Dietary Index for Gut Microbiota, Plasma Metabolic Signature, and Risk of All-Cause and Cardiovascular Disease Mortality. Endocrinol Metab (Seoul). 2026 Jul 13. doi: 10.3803/EnM.2025.2787. Epub ahead of print. PMID: 42438999.
7.Zeng X, Wang S, Zhang P, Chen A, Xue H. Relationship between sleep patterns and incident liver related events: retrospective analysis of prospectively collected data from UK Biobank participants. Ann Hepatol. 2025 Oct 30;31(2):102151. doi: 10.1016/j.aohep.2025.102151. Epub ahead of print. PMID: 41175938.
8.Qiu W, Lv M, Chen A. Trends in prevalence, associated comorbid burden, and subsequent mortality of social isolation: A gender perspective. J Affect Disord. 2026 Jan 15;393(Pt A):120307. doi: 10.1016/j.jad.2025.120307. Epub 2025 Sep 10. PMID: 40939995
9.Li J, Chen J, Qiu W, Han D, Wang K, Gao W, Chen A. Association of hemoglobin glycation index with the risk of chronic lung disease in individuals with CKM stages 0-3: evidence from two large prospective cohorts in Europe and East Asia. Diabetes Res Clin Pract. 2026 Aug 25;241:113523. doi: 10.1016/j.diabres.2026.113523. Epub ahead of print. PMID: 42641803.
10.Liang W, Yao J, Chen A, Lv Q, Zanin M, Liu J, Wong S, Li Y, Lu J, Liang H, Chen G, Guo H, Guo J, Zhou R, Ou L, Zhou N, Chen H, Yang F, Han X, Huan W, Tang W, Guan W, Chen Z, Zhao Y, Sang L, Xu Y, Wang W, Li S, Lu L, Zhang N, Zhong N, Huang J, He J. Early triage of critically ill COVID-19 patients using deep learning. Nat Commun. 2020 Jul 15;11(1):3543. doi: 10.1038/s41467-020-17280-8. PMID: 32669540; PMCID: PMC7363899.
11.Chen A, Chen X, Shen Y, Li W. Modalities of ventricular pacing for cardiac resynchronization therapy in patients with heart failure: a meta-analysis and systematic review. Arch Med Sci. 2017 Aug;13(5):1006-1017. doi: 10.5114/aoms.2017.65660. Epub 2017 Jan 31. PMID: 28883840; PMCID: PMC5575218.
12.Liang H, Guo Y, Chen X, Ang KL, He Y, Jiang N, Du Q, Zeng Q, Lu L, Gao Z, Li L, Li Q, Nie F, Ding G, Huang G, Chen A, Li Y, Guan W, Sang L, Xu Y, Chen H, Chen Z, Li S, Zhang N, Chen Y, Huang D, Li R, Li J, Cheng B, Zhao Y, Li C, Xiong S, Wang R, Liu J, Wang W, Huang J, Cui F, Xu T, Lure FYM, Zhan M, Huang Y, Yang Q, Dai Q, Liang W, He J, Zhong N. Artificial intelligence for stepwise diagnosis and monitoring of COVID-19. Eur Radiol. 2022 Apr;32(4):2235-2245. doi: 10.1007/s00330-021-08334-6. Epub 2022 Jan 6. PMID: 34988656; PMCID: PMC8731211.
13.Gou D, Zhou J, Song Q, Wang Z, Bai X, Zhang Y, Zuo M, Wang F, Chen A, Yousaf M, Yang Z, Peng H, Li K, Xie W, Tang J, Yao Y, Han M, Ke T, Chen Q, Xu C, Wang Q. Mog1 knockout causes cardiac hypertrophy and heart failure by downregulating tbx5-cryab-hspb2 signalling in zebrafish. Acta Physiol (Oxf). 2021 Mar;231(3):e13567. doi: 10.1111/apha.13567. Epub 2020 Oct 22. PMID: 33032360.
14.Yu G, Chakrabarti S, Tischenko M, Chen AL, Wang Z, Cho H, French BA, Naga Prasad SV, Chen Q, Wang QK. Gene therapy targeting protein trafficking regulator MOG1 in mouse models of Brugada syndrome, arrhythmias, and mild cardiomyopathy. Sci Transl Med. 2022 Jun 8;14(648):eabf3136. doi: 10.1126/scitranslmed.abf3136. Epub 2022 Jun 8. PMID: 35675436.
15.Liang W, Yao J, Chen A, Lv Q, Zanin M, Liu J, Wong S, Li Y, Lu J, Liang H, Chen G, Guo H, Guo J, Zhou R, Ou L, Zhou N, Chen H, Yang F, Han X, Huan W, Tang W, Guan W, Chen Z, Zhao Y, Sang L, Xu Y, Wang W, Li S, Lu L, Zhang N, Zhong N, Huang J, He J. Addendum: Early triage of critically ill COVID-19 patients using deep learning. Nat Commun. 2021 Feb 1;12(1):826. doi: 10.1038/s41467-021-21044-3. PMID: 33526778; PMCID: PMC7849611.
16.Zhao Y, Liang W, Luo Y, Chen Y, Liang P, Zhong R, Chen A, He J. Personal protective equipment protecting healthcare workers in the Chinese epicentre of COVID-19. Clin Microbiol Infect. 2020 Dec;26(12):1716-1718. doi: 10.1016/j.cmi.2020.07.029. Epub 2020 Jul 23. PMID: 32712241; PMCID: PMC7377698.
17.Feng W, Zhang Z, Liu Y, Li Z, Guo W, Huang F, Zhang J, Chen A, Ou C, Zhang K, Chen M. Association of Chronic Respiratory Symptoms With Incident Cardiovascular Disease and All-Cause Mortality: Findings From the Coronary Artery Risk Development in Young Adults Study. Chest. 2022 Apr;161(4):1036-1045. doi: 10.1016/j.chest.2021.10.029. Epub 2021 Nov 2. PMID: 34740593; PMCID: PMC9248281.
18.Lin H, Tao J, Kan H, Qian Z, Chen A, Du Y, Liu T, Zhang Y, Qi Y, Ye J, Li S, Li W, Xiao J, Zeng W, Li X, Stamatakis KA, Chen X, Ma W. Ambient particulate matter air pollution associated with acute respiratory distress syndrome in Guangzhou, China. J Expo Sci Environ Epidemiol. 2018 Jun;28(4):392-399. doi: 10.1038/s41370-018-0034-0. Epub 2018 Apr 30. PMID: 29706622.
19.Guo P, Liang Q, Zheng J, Chen J, Guan Y, Ding L, Jiang F, Chen X, Huang M, Chen A, Zhong G. Simultaneous determination of canrenone, digoxin and tolvaptan by UHPLC-MS/MS: application in heart failure patients. Bioanalysis. 2020 May;12(9):569-582. doi: 10.4155/bio-2020-0037. Epub 2020 May 29. PMID: 32469241
20.Wu Z, Xu D, Wu Z, Chen A, Liu L, Ling L, Zhou Y, Liu D, Liu Y, Dong Y, Chen Y. Efficacy of INtensive Treatment vs. Standard Treatment of COmpound DanshEn Dripping Pills in Refractory Angina Patients With Incomplete Revascularization (INCODER Study): Study Protocol for a Multicenter, Double-Blind, Randomized Controlled, Superiority Trial. Front Cardiovasc Med. 2022 Apr 26;9:860059. doi: 10.3389/fcvm.2022.860059. PMID: 35557513; PMCID: PMC9088738.
21.Yang C, Chen A, Chen R, Qi Y, Ye J, Li S, Li W, Liang Z, Liang Q, Guo D, Kan H, Chen X. Acute effect of ambient air pollution on heart failure in Guangzhou, China. Int J Cardiol. 2014 Dec 15;177(2):436-41. doi: 10.1016/j.ijcard.2014.09.003. Epub 2014 Oct 13. PMID: 25442978.
22.Cheng LL, Guan WJ, Duan CY, Zhang NF, Lei CL, Hu Y, Chen AL, Li SY, Zhuo C, Deng XL, Cheng FJ, Gao Y, Zhang JH, Xie JX, Peng H, Li YX, Wu XX, Liu W, Peng H, Wang J, Xiao GM, Chen PY, Wang CY, Yang ZF, Zhao JC, Zhong NS. Effect of Recombinant Human Granulocyte Colony-Stimulating Factor for Patients With Coronavirus Disease 2019 (COVID-19) and Lymphopenia: A Randomized Clinical Trial. JAMA Intern Med. 2021 Jan 1;181(1):71-78. doi: 10.1001/jamainternmed.2020.5503. PMID: 32910179; PMCID: PMC7489414.
23.Wu Z, Wu D, Jiang J, Chen A, Zheng DD, Li J, Dong Y, Chen Y. Efficacy and safety of xuezhikang once per day versus two times per day in patients with mild to moderate hypercholesterolaemia (APEX study): a protocol for a multicentre, prospective randomised controlled, open-label, non-inferiority study. BMJ Open. 2020 May 17;10(5):e034585. doi: 10.1136/bmjopen-2019-034585. PMID: 32423930; PMCID: PMC7239523.
24.Lu J, Dong B, Chen A, He F, Peng B, Wu Z, Cao J, Li W. Escherichia coli promotes DSS‑induced murine colitis recovery through activation of the TLR4/NF‑κB signaling pathway. Mol Med Rep. 2019 Mar;19(3):2021-2028. doi: 10.3892/mmr.2019.9848. Epub 2019 Jan 11. PMID: 30664156; PMCID: PMC6390074.
25.Ding N, Qiu W, Chen J, Lu Y, Chen Z, Cai R, Chen A. Holter-detected arrhythmias and early readmission risk in acute exacerbations of COPD. Heart Lung. 2026 Jul 13;80:102888. doi: 10.1016/j.hrtlng.2026.102888. Epub ahead of print. PMID: 42442256.
26.Niu Y, Chen R, Liu C, Ran P, Chen A, Chen X, Kan H. The association between ambient temperature and out-of-hospital cardiac arrest in Guangzhou, China. Sci Total Environ. 2016 Dec 1;572:114-118. doi: 10.1016/j.scitotenv.2016.07.205. Epub 2016 Aug 3. PMID: 27497032.
27.Liang LK, Ye Q, Li JL, Shi LY, Wang SP, Liang WJ, Chen AL, Feng GS. The Cardio-Onco-Immune Axis: immunopathological mechanisms in the cardiac microenvironment of checkpoint inhibitor-induced myocarditis. Acta Pharmacol Sin. 2026 Sep 29. doi: 10.1038/s41401-026-01947-x. Epub ahead of print. PMID: 42806001.
28.Guan WJ, Wei CH, Chen AL, Sun XC, Guo GY, Zou X, Shi JD, Lai PZ, Zheng ZG, Zhong NS. Hydrogen/oxygen mixed gas inhalation improves disease severity and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label clinical trial. J Thorac Dis. 2020 Jun;12(6):3448-3452. doi: 10.21037/jtd-2020-057. Erratum in: J Thorac Dis. 2020 Aug;12(8):4591-4592. doi: 10.21037/jtd-2020-062. PMID: 32642277; PMCID: PMC7330772.
29.Chen AL, Ou CW, He ZC, Liu QC, Dong Q, Chen MS. Effect of hepatocyte growth factor and angiotensin II on rat cardiomyocyte hypertrophy. Braz J Med Biol Res. 2012 Dec;45(12):1150-6. doi: 10.1590/s0100-879x2012007500159. Epub 2012 Oct 9. PMID: 23044624; PMCID: PMC3854218.
30.Dai W, Dong Q, Chen M, Zhao L, Chen A, Li Z, Liu S. Changes in cardiac structure and function in a modified rat model of myocardial hypertrophy. Cardiovasc J Afr. 2016 May/Jun;27(3):134-142. doi: 10.5830/CVJA-2015-053. PMID: 27841899; PMCID: PMC5101493.
31.Wang Y, Liu Y, Lv Q, Zheng D, Zhou L, Ouyang W, Ding B, Zou X, Yan F, Liu B, Chen J, Liu T, Fu C, Fang Q, Wang Y, Li F, Chen A, Lundborg CS, Guo J, Wen Z, Zhang Z. Effect and safety of Chinese herbal medicine granules in patients with severe coronavirus disease 2019 in Wuhan, China: a retrospective, single-center study with propensity score matching. Phytomedicine. 2021 May;85:153404. doi: 10.1016/j.phymed.2020.153404. Epub 2020 Nov 5. PMID: 33637412; PMCID: PMC7642753.
32.Chen A, Li W, Chen X, Shen Y, Dai W, Dong Q, Li X, Ou C, Chen M. Trimetazidine attenuates pressure overload-induced early cardiac energy dysfunction via regulation of neuropeptide Y system in a rat model of abdominal aortic constriction. BMC Cardiovasc Disord. 2016 Nov 17;16(1):225. doi: 10.1186/s12872-016-0399-8. PMID: 27855650; PMCID: PMC5112876.
33.陈爱兰,罗福全,林峰丞,等.苯磺酸左旋氨氯地平对腹主动脉缩窄大鼠心肌能量代谢的影响[J].今日药学,2016,26(11):766-769.
34.陈爱兰,林峰丞,潘秀娣,何志裕,王慧勇,许玲玲,范婷婷.神经肽 Y 受体亚型在压力超负荷大鼠心肌中的动态表达[J].岭南心血管病杂志,2017,23(04):462-467
【所获荣誉和奖励】
1.2020年中国女医师协会“最美抗疫巾帼人物”
2.2021年全国三八红旗手
3.2020广东省五一劳动奖章
4.中华人民共和国第十五届运动会火炬手
5.2020年中国医师协会第二届“中青年心血管病菁英”“抗疫”英雄奖
6.2024年首届广州市优秀健康科普专家
7.2023年健康科普公益践行者
8.2020年广东省三八红旗手标兵
