【个人简介】
呼吸疾病全国重点实验室教授，博士生导师。吉林大学博士，哈佛大学医学院博士后。研究领域为血管重构的免疫和代谢调控，系统探讨炎症微环境和代谢重编程对肺动脉高压等疾病的影响及其机制。近五年研究成果以（共同）第一作者发表于European Heart Journal，Journal of Hepatology，JCI Insight，Cardiovascular Research，Environmental Health Perspectives等高水平期刊上。获国家授权发明专利1项。
【研究方向】
肺血管相关疾病发病机制的研究及创新药物开发。
【科研项目】
1. 南山学者科研启动基金, 2023-7-13至2028-07-12，300万，在研，主持。
2. 呼吸疾病全国重点实验室自主课题，嗜酸性粒细胞来源的ECP在肺动脉高压中的作用及机制研究，2024-01-01至2026-12-31，20万，在研，主持。
3. 广州国家实验室专项课题，肺动脉高压早期风险评价及干预新策略研究，2023-11-01至2028-10-31，600万，在研，骨干。
【代表性论文及著作】
1. Meng Z*, Zhang S*, Li W*, Wang Y, Wang M, Liu X, Liu CL, Liao S, Liu T, Yang C, Lindholt J, Rasmussen L, Obel L, Stubbe J, Diederichsen A, Sun Y, Chen Y, Yu P, Libby P, Shi GP, Guo J. Cationic proteins from eosinophils bind bone morphogenetic protein receptors promoting vascular calcification and atherogenesis. Eur Heart J. 2023 Aug 1;44(29):2763-2783.
2. Meng Z*, Yu Y*, Zhang Y, Yang X, Lv X, Guan F, Hatch GM, Zhang M, Chen L. Highly bioavailable Berberine formulation improves Glucocorticoid Receptor-mediated Insulin Resistance via reduction in association of the Glucocorticoid Receptor with phosphatidylinositol-3-kinase. Int J Biol Sci. 2020 Jul 19;16(14):2527-2541.
3. Meng Z*, Gwag T*, Sui Y, Park SH, Zhou X, Zhou C. The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling. JCI Insight. 2019 Feb 7; 4(3). pii: 125657.
4. Meng Z, Hernandez R, Liu J, Gwag T, Lu W, Marcus Kaul, Hsiai T, Zhou T, Zhou C. HIV Protein Tat Induces Macrophage Dysfunction and Atherosclerosis Development in Low-Density Lipoprotein Receptor-Deficient Mice. Cardiovasc Drugs Ther. 2021 Jan 18; 10.1007/s10557-021-07141-x.
5. Gwag T*, Meng Z*, Sui Y, Helsley RN, Park SH, Wang S, Greenberg RN, Zhou C. Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis. J Hepatol. 2019 Jan 21. pii: S0168-8278(19)30029-7.
6. Liu T*, Meng Z*, Liu J*, Li J, Zhang Y, Deng Z, Luo S, Wang M, Huang Q, Zhang S, Fendt P, Devouassoux J, Li D, McKenzie ANJ, Nahrendorf M, Libby P, Guo J, Shi GP. Group 2 innate lymphoid cells protect mouse heart from myocardial infarction injury via interleukin 5, eosinophils, and dendritic cells. Cardiovasc Res. 2022 Sep 5: cvac144.
7. Satta S*, Meng Z*, Hernandez R, Cavallero S, Zhou T, Hsiai TK, Zhou C. An engineered nano-liposome-human ACE2 decoy neutralizes SARS-CoV-2 Spike protein-induced inflammation in both murine and human macrophages. Theranostics. 2022; 12(6):2639-2657.
8. Sui Y*, Meng Z*, Chen J, Liu J, Hernandez R, Gonzales M, Gwag T, Morris A, Zhou C. Effects of Dicyclohexyl Phthalate Exposure on PXR Activation and Lipid Homeostasis in Mice. Environ Health Perspect. 2021 Dec;129(12):127001.
