【个人简介】

李时悦，男，主任医师、二级教授，博士生导师，广州医科大学附属第一医院呼吸与危重症学科主任，广州呼吸健康研究院副院长，国家呼吸医学中心副主任。

【研究方向】

介入呼吸病学、再生医学、肺癌

【科研项目】

1. 科技部国家重点研发计划, 医疗机构生物气溶胶防控关键技术标准及评价技术研究与应用，2022-01-01至2025-12-31，1500万，在研，主持。

2. 国家自然科学基金面上项目，呼吸道传染病应急检疫机器人基础理论及关键技术研究-子课题，2021-11-01至2024-12-31，48万，在研，主持

3. 广东省重点领域研发计划项目，骨髓间充质干细胞治疗急危重症的临床研究与产品研发，2023-01-01至2025-12-31,500万，在研，主持

4. 广州实验室专项项目，慢阻肺主要亚型演进的病理细胞基础-子课题，350万，2024-04-01-2028-11-30，在研，主持

【代表性论文及著作】

1. Junfeng Huang#, Zikai Lin#, Jinsheng Lin#, Shuojia Xie#, Shixin Xia, Gengjia Chen, Ziwen Zheng, Zhe Xu, Fangcheng Liu, Hongkai Wu, Shi-yue Li*. Causal role of lipid metabolism in pulmonary alveolar proteinosis: an observational and mendelian randomisation study. Thorax. 2024 Jan 18;79(2):135-143.

2. Ziwen Zheng#, Junfeng Huang#, Ziyuan Xiang# , Tong Wu, Xiaoqing Lan , Shuojia Xie , Zikai Lin , Kailun Tang , Alyn Morice , Shi-yue Li* , Woo-Jung Song* , Ruchong Chen* . Efficacy and safety of pharmacotherapy for refractory or unexplained chronic cough: a systematic review and network meta-analysis. EClinicalMedicine. 2023 Jul 20;62:102100.

3. Chunli Tang#, Chenting Zhang #, Qian Jiang #, Rongmei Geng , Jingnan Zhai , Jian Wang *, Shi-yue Li* , Kai Yang * . Impacts of anaesthesia strategies on mouth-lung microbial signature: Evidence from bronchoscopy sampling and sequencing. Clinical and Translational Medicine. 2023 Aug;13(8):e1355.

4. Junfeng Huang#, Jinsheng Lin # , Ziwen Zheng#, Yuheng Liu # , Qiaoyan Lian , Qing Zang , Song Huang , Jiaming Guo , Chunrong Ju* , Changhao Zhong* , Shi-yue Li* . Risk factors and prognosis of airway complications in lung transplant recipients: A systematic review and meta-analysis. Journal of Heart and Lung Transplantation. 2023，42(9):1251-1260.

5. Yong-Shun Ye#, Di-Fei Chen#, Ming Liu#, Yu-Long Luo, Huan-Jie Chen, Hai-Kang Zeng, Jing-Wei Liu, Yi-Ping Zhu, Xin-Yu Song, Chang-Qin Lin, Zhu-Quan Su*, Shi-yue Li*. Autologous Airway Basal Cell Transplantation Alleviates Airway Epithelium Defect in Recurrent Benign Tracheal Stenosis. Stem Cells Transl Med. 2023 Dec 18;12(12):838-848.

6. Li-Qin Lin #, Hai-Kang Zeng #, Yu-Long Luo, Di-Fei Chen, Xiao-Qian Ma, Huan-Jie Chen, Xin-Yu Song, Hong-Kai Wu, Shi-yue Li*. Mechanical stretch promotes apoptosis and impedes ciliogenesis of primary human airway basal stem cells. Respir Res. 2023 Sep 29;24(1):237.

7. Huanjie Chen#, Yulong Luo#, Yiping Zhu#, Yongshun Ye， Difei Chen, Xinyu Song , Zhulin Xiao , Ming Liu*, Shiyue Li*. Enhanced secretion of hepatocyte growth factor in human umbilical cord mesenchymal stem cells ameliorates pulmonary fibrosis induced by bleomycin in rats. Front Pharmacol. 2023 Jan 6;13:1070736.

8. Zikai Lin# , Junfeng Huang# , Shuojia Xie# , Ziwen Zheng , Kailun Tang , Shiyue Li * , Ruchong Chen *. The Association Between Insulin Use and Asthma: An Epidemiological Observational Analysis and Mendelian Randomization Study. Lung. 2023 Apr;201(2):189- 199.

9. Lin-Ling Cheng# , Wei-Jie Guan# , Chang-Hao Zhong , Chong-Yang Duan , Zhu-Quan Su , Shi-yue Li* , Nan-Shan Zhong *. Endobronchial optical coherence tomography or computed tomography for evaluating progression of bronchiectasis. ERJ OPEN RESEARCH. 2023 Jun 26;9(3):00490-2022.

10. Li-Qin Lin# , Di-Fei Chen# , Hong-Kai Wu , Yu Chen , Chang-Hao Zhong , Xiao-Bo Chen , Chun-Li Tang , Zi-Qing Zhou , Shi-yue Li* . Long-term efficacy and safety of the Dumon stent for treatment of benign airway stenosis. Therapeutic Advances in Respiratory Disease. 2023;17:17534666231181269.

11. Chang-Hao Zhong,# Zhu-Quan Su,# Wei-Zhan Luo,# Wan-Yuan Rao,# Jia-Xin Feng, Chun-Li Tang, Yu Chen, Xiao-Bo Chen, Ming-Yue Fan, and Shi-yue Li* （唯一通讯）, Hierarchical clock-scale hand-drawn mapping as a simple method for bronchoscopic navigation in peripheral pulmonary nodule. Respiratory Research. 2022 Sep 14;23(1):245.

12. Zhu-Quan Su#, Zi-Qing Zhou#, Wei-Jie Guan#, Ming-Yue Fan, Wan-Yuan Rao, Yu Chen, Xiao-Bo Chen, Chang-Hao Zhong, Chun-Li Tang, Shi-yue Li*（共同通讯）, Nan-Shan Zhong*.Airway remodeling and bronchodilator responses in asthma assessed by endobronchial optical coherence tomography.Allergy. 2022 Feb;77(2):646-649.

13. Yu-Long Luo#, Yan-Qiuzi Cheng, # Zi-Qing Zhou#, Ming-Yue Fan , Di-Fei Chen, Yu Chen, Xiao-Bo Chen, Chang-Hao Zhong, Chun-Li Tang , Shi-yue Li*, Zhu-Quan Su*.A clinical and canine experimental study in small-airway response to bronchial thermoplasty: Role of the neuronal effect, Allergol Int, 2022 Jan;71(1):66-72.

14. Mu Chen#, Jingwei Liu#, Ping Peng#, Wenhua Jian#, Yi Gao#, Liman Fang, Yanhui Yu, Shuxin Zhong , Hui Peng , Xilong Deng, Yuqi Zhou, Sheng Du, Ruchong Chen*, Xiaoneng Mo*, Nanshan Zhong*, Shi-yue Li*. Dynamic changes of pulmonary diffusion capacity in survivors of non-critical COVID-19 during the first six months. EClinicalMedicine. 2022 Jan;43:101255.

15. Chang-Hao Zhong#, Zi-Qing Zhou, Feng Ye, Wen-Liang Guo, Wei-Li Gu, Zu-Yuan Guo, Shi-yue Li*. Prognosis of Severe and Critical Patients Who Have Recovered from COVID-19: A Three-Month Follow-Up. Respiration. 2021;100(4):364-367.

16. Zi-Qing Zhou# , Jia-Xin Feng#, Yu Chen#, Zhu-Quan Su#, Chang-Hao Zhong, Xiao-Bo Chen,Chun-Li Tang, Jie-Rong Huang and Shi-yue Li*. Self-expanding covered metallic stents as a transition to silicone stent implantation in management of severe post-tuberculosis bronchial stenosis.Ther Adv Respir Dis. Jan-Dec 2021;15:1753466621 1019564.

17. Zhufeng Wang#,Yingzhi Wang#,Zhaowei Yang#,Hongkai Wu#, Jingyi Liang,Hanwen Liang, Huimin Lin, Ruchong Chen, Younger Ou, Fengyan Wanga,Yuan Wang, Yan Wang, Weizhan Luo, Naijian Li, Zhengtu Li, Jiaxing Xie*,Mei Jiang*, Shi-yue Li*.The use of non-invasive ventilation in COVID-19: A systematic review. Int J Infect Dis. 2021 May;106:254-261.

18. Tao Wang#, Ruchong Chen#, Chunli Liu#, Wenhua Liang,Weijie Guan, Ruidi Tang, Chunli Tang, NuofuZhang, Nanshan Zhong, Shi-yue Li*. Attention should be paid to venous thromboembolism prophylaxis in the management of COVID-19[J]. Lancet Haematol.2020May.7(5):e362-e363.

19. Wen-Liang Guo#, Qian Jiang#, Feng Ye, Shao-Qiang Li, Cheng Hong, Li-Yan Chen, Shi-yue Li*. Effect of throat washings on detection of 2019 novel coronavirus[J]. Clin Infect Dis. 2020 Nov 5;71(8):1980-1981.

20. Tao Wang, Chunli Tang, Ruchong Chen, Honglian Ruan, Wenhua Liang, Weijie Guan, Ling Sang, Ruidi Tang, Nanshan Zhong, Shi-yue Li*. Clinical Features of Coronavirus Disease 2019 Patients With Mechanical Ventilation: A Nationwide Study in China. Crit Care Med. 2020 Sep;48(9):e809-e812.

21. Ruchong Chen, Yi Gao, Mu Chen, Wenhua Jian, Chunliang Lei, Jinping Zheng, Shi-yue Li*. Impaired pulmonary function in discharged patients with COVID-19: more work ahead. Eur Respir J. 2020 Jul 23;56(1):2002194.

22. Xiaoneng Mo#, Wenhua Jian#, Zhuquan Su#, Mu Chen, Hui Peng, Ping Peng, Chunliang Lei, Shi-yue Li*, Ruchong Chen*, Nanshan Zhong*. Abnormal pulmonary function in COVID-19 patients at time of hospital discharge[J]. Eur Respir J. 2020 18;55(6):2001217.

23. Shao-Qiang Li#, Wen-Liang Guo#, Hao Liu#, Tao Wang , Yuan-Yuan Zhou , Tao Yu, Chong-Yang Wang, Yong-Ming Yang, Nan-Shan Zhong, Nuo-Fu Zhang*, Shi-yue Li*.Clinical Application of Intelligent Oropharyngeal-swab Robot: Implication for COVID-19 Pandemic. Eur Respir J. 2020 Aug 20;56(2):2001912.

24. Zhu-Quan Su#, Wei-Jie Guan#, Shi-yue Li#, Jia-Xin Feng, Zi-Qing Zhou, Yu Chen, Ming-Lu Zhong and Nan-Shan Zhong*. Evaluation of the Normal Airway Morphology Using Optical Coherence Tomography[J]. Chest. 2019 Nov;156(5):915-925.

【所获荣誉和奖励】

1. 呼吸介入关键技术开发、应用和推广，2022年1月第三届广东医学科技二等奖，排名第1（GDMA202103203）

2. 2020年8月获“广东医师奖”

3. 广州医科大学新冠肺炎疫情防控研究南山团队，2020年5月，全国创新争先奖牌，排名第12

4. 2018年12月入选广东省医学领军人才

5. 2017年6月当选“中国优秀呼吸医师”

6. 2016年入选广州市高层次卫生重点人才

7. 支气管镜介入诊疗技术临床应用及创新,2012年广东省科学技术奖三等奖,排名第1（B14-0-3-03-R01）

8. 广东省HIV/AIDS流行病学、预防控制与临床诊断、救治系列研究,2004年广东省科技进步二等奖，排名第3（2002-医-2-014-R03）